| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katarzyna Taran, Anna Wysocka, Anna Sitkiewicz, Józef Kobos, Ewa Andrzejewsk. Evaluation of potential prognostic value of Bmi-1 gene product and selected markers of proliferation (Ki-67) and apoptosis (p53) in the neuroblastoma group of tumors. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. 2016-06-06. PMID:26943308. |
evaluation of potential prognostic value of bmi-1 gene product and selected markers of proliferation (ki-67) and apoptosis (p53) in the neuroblastoma group of tumors. |
2016-06-06 |
2023-08-13 |
Not clear |
| Jianwu Zhu, Chong Zhang, Yi Qing, Yi Cheng, Xiaolin Jiang, Mengxia Li, Zhenzhou Yang, Dong Wan. Genistein induces apoptosis by stabilizing intracellular p53 protein through an APE1-mediated pathway. Free radical biology & medicine. vol 86. 2016-06-03. PMID:26032169. |
genistein induces apoptosis by stabilizing intracellular p53 protein through an ape1-mediated pathway. |
2016-06-03 |
2023-08-13 |
human |
| Jianwu Zhu, Chong Zhang, Yi Qing, Yi Cheng, Xiaolin Jiang, Mengxia Li, Zhenzhou Yang, Dong Wan. Genistein induces apoptosis by stabilizing intracellular p53 protein through an APE1-mediated pathway. Free radical biology & medicine. vol 86. 2016-06-03. PMID:26032169. |
one of its intracellular targets, ape1, protects against apoptosis under genotoxic stress and interacts with p53. |
2016-06-03 |
2023-08-13 |
human |
| Jianwu Zhu, Chong Zhang, Yi Qing, Yi Cheng, Xiaolin Jiang, Mengxia Li, Zhenzhou Yang, Dong Wan. Genistein induces apoptosis by stabilizing intracellular p53 protein through an APE1-mediated pathway. Free radical biology & medicine. vol 86. 2016-06-03. PMID:26032169. |
by examining both protein synthesis and degradation, we found that gen enhances p53 intracellular stability by interfering with the interaction of ape1 and p53, which provided a plausible explanation for how gen initiates apoptosis. |
2016-06-03 |
2023-08-13 |
human |
| Wei Wang, Jianwen Cheng, Yizhun Zh. The JNK Signaling Pathway Is a Novel Molecular Target for S-Propargyl- L-Cysteine, a Naturally-Occurring Garlic Derivatives: Link to Its Anticancer Activity in Pancreatic Cancer In Vitro and In Vivo. Current cancer drug targets. vol 15. issue 7. 2016-06-03. PMID:26033085. |
our results demonstrated that sprc reduced cell viability and colony formation, inhibited cell proliferation, induced g2/m phase cell cycle arrest and apoptosis in human pda cells with various p53 statuses (hpac, p53 wt; panc-1, p53 mt). |
2016-06-03 |
2023-08-13 |
human |
| Fei Zhang, Maolan Li, Xiangsong Wu, Yunping Hu, Yang Cao, Xu'an Wang, Shanshan Xiang, Huaifeng Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Shu, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Ping Dong, Jun Gu, Yingbin Li. 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway. Drug design, development and therapy. vol 9. 2016-06-03. PMID:26309394. |
20(s)-ginsenoside rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway. |
2016-06-03 |
2023-08-13 |
mouse |
| Fei Zhang, Maolan Li, Xiangsong Wu, Yunping Hu, Yang Cao, Xu'an Wang, Shanshan Xiang, Huaifeng Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Shu, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Ping Dong, Jun Gu, Yingbin Li. 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway. Drug design, development and therapy. vol 9. 2016-06-03. PMID:26309394. |
20(s)-rg3 attenuated gbc growth probably via activation of the p53 pathway, and subsequent induction of cellular senescence and mitochondrial-dependent apoptosis. |
2016-06-03 |
2023-08-13 |
mouse |
| Umut Fahrioğlu, Yavuz Dodurga, Levent Elmas, Mücahit Seçm. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. vol 576. issue 1 Pt 3. 2016-06-03. PMID:26516023. |
expression profiles of certain cell cycle and apoptosis genes such as ccnd1 (cyclin d1),cdk4, cdk6, rb, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, bcl-2, bcl-xl,bid, dr4,dr5,fadd,tradd,parp, apaf, bax, akt, pten, puma, noxa, mmp2, mmp9, timp1 and timp2 were determined by real-time pcr. |
2016-06-03 |
2023-08-13 |
human |
| Jeanine L Van Nostrand, Alice Brisac, Stephano S Mello, Suzanne B R Jacobs, Richard Luong, Laura D Attard. The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development. Cancer discovery. vol 5. issue 6. 2016-06-02. PMID:25813352. |
siva is a p53 target gene essential for p53-dependent apoptosis, although it can also promote proliferation through inhibition of p53 in some settings. |
2016-06-02 |
2023-08-13 |
mouse |
| Lois Resnick-Silverman, James J Manfred. Two Faces of SIVA. Cancer discovery. vol 5. issue 6. 2016-06-02. PMID:26037915. |
in non-small cell lung cancer cells that contain a mutated kras gene, siva, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mtor signaling. |
2016-06-02 |
2023-08-13 |
mouse |
| Tatsuya Tominaga, Rajesh K Dutta, Darukeshwara Joladarashi, Toshio Doi, Janardan K Reddy, Yashpal S Kanwa. Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES. The Journal of biological chemistry. vol 291. issue 3. 2016-06-02. PMID:26578517. |
in addition, rapamycin treatment reduced p53 expression and apoptosis. |
2016-06-02 |
2023-08-13 |
mouse |
| Esther Belade, Sandra Chrusciel, Lucie Armand, Angélique Simon-Deckers, Cyrill Bussy, Philippe Caramelle, Jean-Marie Gagliolo, Laurent Boyer, Sophie Lanone, Jean-Claude Pairon, Ali Kermanizadeh, Jorge Boczkowsk. The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials. Archives of toxicology. vol 89. issue 9. 2016-06-01. PMID:25098341. |
mnm internalisation, cellular viability, p53 protein induction and activation, oxidative stress, inflammation and apoptosis were measured in murine cell line and primary pulmonary macrophage models. |
2016-06-01 |
2023-08-13 |
human |
| Esther Belade, Sandra Chrusciel, Lucie Armand, Angélique Simon-Deckers, Cyrill Bussy, Philippe Caramelle, Jean-Marie Gagliolo, Laurent Boyer, Sophie Lanone, Jean-Claude Pairon, Ali Kermanizadeh, Jorge Boczkowsk. The role of p53 in lung macrophages following exposure to a panel of manufactured nanomaterials. Archives of toxicology. vol 89. issue 9. 2016-06-01. PMID:25098341. |
however, p53 was neither involved in mnm-induced cellular toxicity, nor in the apoptosis induced by these mnms. |
2016-06-01 |
2023-08-13 |
human |
| Yiwen Bu, Xiaoning Li, Yingchun He, Chenfei Huang, Yi Shen, Yu Cao, Dan Huang, Chuan Cai, Yuhong Wang, Ziqi Wang, Duan-Fang Liao, Deliang Ca. A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation. International journal of cancer. vol 138. issue 5. 2016-06-01. PMID:26375985. |
in colon (hct116 p53 wt and p53 -/-), breast (mcf7), and prostate (lncap and du145) cancer cells, a phosphomimetic mutation of rela/p65 at ser536 (named p65/s536d) triggered dramatic apoptosis through affecting expression of a wide range of cell death/survival genes, such as bim, puma, noxa, bcl-2 and survivin. |
2016-06-01 |
2023-08-13 |
mouse |
| Jinwei Luan, Xianglan Li, Rutao Guo, Shanshan Liu, Hongyu Luo, Qingshan Yo. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu). Radiology and oncology. vol 50. issue 2. 2016-06-01. PMID:27247549. |
next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (rita)-enhancing x-ray susceptibility in fadu cells. |
2016-06-01 |
2023-08-13 |
Not clear |
| Han Zhuo, Junwei Tang, Zhe Lin, Runqiu Jiang, Xudong Zhang, Jie Ji, Ping Wang, Beicheng Su. The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma. Molecular carcinogenesis. vol 55. issue 2. 2016-05-31. PMID:25641194. |
the inhibition affection in proliferation and inducing affection in apoptosis was further confirmed in vivo and vitro, we also demonstrated that meg3 regulates hcc cell proliferation and apoptosis partially via the accumulation of p53. |
2016-05-31 |
2023-08-13 |
Not clear |
| Gati Krushna Panigrahi, Ashish Yadav, Ashish Srivastava, Anurag Tripathi, S Raisuddin, Mukul Da. Mechanism of rhein-induced apoptosis in rat primary hepatocytes: beneficial effect of cyclosporine A. Chemical research in toxicology. vol 28. issue 6. 2016-05-31. PMID:25915446. |
at the molecular level, rhein-induced dna damage results in overexpression of γ-h2ax protein (2.5-fold), thereby causing enhancement of p53 (4.5-fold) and p21 (3.6-fold), leading to intrinsic pathway-mediated apoptosis involving bax, bcl2, cytochrome c, caspases 3 and 9, and poly-adp ribose polymerase. |
2016-05-31 |
2023-08-13 |
rat |
| Jing-Ping Wang, Ya-Chu Yu, Shih-Ping Chen, Huan-Chang Liang, Chia-Wei Lin, Kang Fan. The collective nuclear migration of p53 and phosphorylated S473 of Akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. Molecular and cellular biochemistry. vol 407. issue 1-2. 2016-05-31. PMID:26014912. |
the collective nuclear migration of p53 and phosphorylated s473 of akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. |
2016-05-31 |
2023-08-13 |
human |
| Florian J Bock, Maria C Tanzer, Manuel D Haschka, Gerhard Krumschnabel, Bénédicte Sohm, Katrin Goetsch, Reinhard Kofler, Andreas Villunge. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Scientific reports. vol 5. 2016-05-31. PMID:26062895. |
the tumour suppressor p53 is an important mediator of cell cycle arrest and apoptosis in response to dna damage, acting mainly by transcriptional regulation of specific target genes. |
2016-05-31 |
2023-08-13 |
Not clear |
| Florian J Bock, Maria C Tanzer, Manuel D Haschka, Gerhard Krumschnabel, Bénédicte Sohm, Katrin Goetsch, Reinhard Kofler, Andreas Villunge. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Scientific reports. vol 5. 2016-05-31. PMID:26062895. |
pdcd5 was dispensable for dna damage induced apoptosis and cell cycle arrest and we observed no significant changes in p53 target gene transcription. |
2016-05-31 |
2023-08-13 |
Not clear |