| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian J Bock, Maria C Tanzer, Manuel D Haschka, Gerhard Krumschnabel, Bénédicte Sohm, Katrin Goetsch, Reinhard Kofler, Andreas Villunge. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Scientific reports. vol 5. 2016-05-31. PMID:26062895. |
altogether, our results suggest a role of pdcd5 in the regulation of p53 function but unrelated to cell cycle arrest or apoptosis, at least in the cell types investigated. |
2016-05-31 |
2023-08-13 |
Not clear |
| Xiongwei Cai, Long Gao, Li Teng, Jingping Ge, Zaw Min Oo, Ashish R Kumar, D Gary Gilliland, Philip J Mason, Kai Tan, Nancy A Spec. Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells. Cell stem cell. vol 17. issue 2. 2016-05-31. PMID:26165925. |
runx1-deficient hspcs have lower p53 levels, reduced apoptosis, an attenuated unfolded protein response, and accordingly are resistant to genotoxic and er stress. |
2016-05-31 |
2023-08-13 |
Not clear |
| Huiqing Li, Chunying We. Mechanism studies on anti-HepG2 cell proliferation of phenanthroline derivatives as G-quadruplex DNA stabilizers. Bioorganic & medicinal chemistry letters. vol 25. issue 18. 2016-05-31. PMID:26253636. |
the current results suggested that the decreases of c-myc, sp1, and htert expressions and the increase of p53 expression, together with the reduction of cyclins/cdks proteins in the regulation of the cell cycle, and/or the telomeric chromatin alteration led to cell cycle arrest, apoptosis, and growth inhibition induced by both ligands. |
2016-05-31 |
2023-08-13 |
human |
| Qunying Hong, Li-Jin Hsu, Pei-Yi Chou, Ying-Tsen Chou, Chen-Yu Lu, Yu-An Chen, Nan-Shan Chan. Self-aggregating TIAF1 in lung cancer progression. Translational respiratory medicine. vol 1. issue 1. 2016-05-28. PMID:27234387. |
in vitro experiments revealed that tiaf1 is a crucial component for tumor suppressors p53 and wwox-mediated tumor suppression and apoptosis. |
2016-05-28 |
2023-08-13 |
Not clear |
| Aihong Li, Lei Li, Xiaolei Sun, Yaohui Ni, Xin Chen, Aisong Guo, Xiaomei Che. Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats. Neurochemical research. vol 40. issue 8. 2016-05-27. PMID:26123482. |
furthermore, immunofluorescent staining revealed that mpv17 co-localized with p53, bax and active caspase-3 in neurons, suggesting its biological function in the process of neuronal apoptosis. |
2016-05-27 |
2023-08-13 |
rat |
| Safia, Mohd Kamil, Pooja Jadiya, Saba Sheikh, Ejazul Haque, Aamir Nazir, Vijai Lakshmi, Snober S Mi. The Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) Pathway. PloS one. vol 10. issue 9. 2016-05-27. PMID:26405812. |
results from western blotting suggest that rohitukine triggered apoptosis in a549 cell line through upregulation of p53, caspase9 and down regulation of bcl-2 protein. |
2016-05-27 |
2023-08-13 |
human |
| Jialing Wu, Chong Chen, Xi Hu, Xianbin Cai, Yinghong Guan, Hui Hu, Qinjia Wang, Xiaofeng Chen, Bozhi Cai, Xubin Jin. Suppressing cyclooxygenase-2 prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. Biochemical and biophysical research communications. vol 469. issue 4. 2016-05-27. PMID:26723251. |
after that, liver histology, serum alanine aminotransferase (alt) levels, hepatic triglyceride (tg) levels, hepatocyte apoptosis, phosphorylated akt (ser473, pakt) and p53 protein levels in mice livers were assessed. |
2016-05-27 |
2023-08-13 |
mouse |
| Weiwei Li, Wenxiao Han, Yiming Ma, Liang Cui, Yantao Tian, Zhixiang Zhou, Hongying Wan. P53-dependent miRNAs mediate nitric oxide-induced apoptosis in colonic carcinogenesis. Free radical biology & medicine. vol 85. 2016-05-26. PMID:25912478. |
loss of p53 not only blocked no-induced apoptosis but also dramatically inhibited the expression of no-related mirnas, such as mir-34, mir-203, and mir-1301. |
2016-05-26 |
2023-08-13 |
mouse |
| Weiwei Li, Wenxiao Han, Yiming Ma, Liang Cui, Yantao Tian, Zhixiang Zhou, Hongying Wan. P53-dependent miRNAs mediate nitric oxide-induced apoptosis in colonic carcinogenesis. Free radical biology & medicine. vol 85. 2016-05-26. PMID:25912478. |
furthermore, forced expression of these mirnas rendered ht-29 cells, which are resistant to apoptosis with mutant p53, more sensitive to no-induced apoptotic cell death. |
2016-05-26 |
2023-08-13 |
mouse |
| Weijun Ma, Jianping Li, Juan Hu, Ying Cheng, Junli Wang, Xiaotong Zhang, Min X. miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26768586. |
over-expression of p53 suppressed the inhibitory effects of gb on nox4 and p66(shc) expression and superoxide generation and the protective effects of gb on loss of cell viability and apoptosis associated with cisplatin. |
2016-05-26 |
2023-08-13 |
Not clear |
| Bin-bin Wang, Xiao-hu Wang, Kai Liu, Shao-bo Sun, Peng Song, Ying-dong L. [Enhanced radiosensitivity of H22 ascitic tumor to 12C6+ ions radiation in ultra-filtration extract mixture from Astragalus mongholicus-treated mice]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 12. 2016-05-26. PMID:27169282. |
the body weights, abdomen circumference of the mice were measured and the mouse behavior was monitored every day; survival time was recorded to evaluate life extension effect; flow cytometry technique was used to detect h22 cell apoptosis and cell cycle; protein levels of p53, bax, bcl-2 and cleaved caspase-3 were analyzed by western blot; the single cell gel electrophoresis was used to detect the level of deoxyribonucleic acid damage (dna damage). |
2016-05-26 |
2023-08-13 |
mouse |
| Nikhil Moorchung, Biju Vasudevan, S Dinesh Kumar, Archit Muralidha. Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis. Indian journal of pathology & microbiology. vol 58. issue 4. 2016-05-25. PMID:26549060. |
expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis. |
2016-05-25 |
2023-08-13 |
Not clear |
| Nikhil Moorchung, Biju Vasudevan, S Dinesh Kumar, Archit Muralidha. Expression of apoptosis regulating proteins p53 and bcl-2 in psoriasis. Indian journal of pathology & microbiology. vol 58. issue 4. 2016-05-25. PMID:26549060. |
p53 and bcl-2 are two proteins which control apoptosis. |
2016-05-25 |
2023-08-13 |
Not clear |
| Louis-Jan Pilaz, John J McMahon, Emily E Miller, Ashley L Lennox, Aussie Suzuki, Edward Salmon, Debra L Silve. Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. Neuron. vol 89. issue 1. 2016-05-25. PMID:26748089. |
we show that apoptosis, but not differentiation, is p53 dependent, demonstrating that these are distinct outcomes of mitotic delay. |
2016-05-25 |
2023-08-13 |
Not clear |
| Xiao-Fei Zhang, Qiu-Zhong Pan, Ke Pan, De-Sheng Weng, Qi-Jing Wang, Jing-Jing Zhao, Jia He, Qing Liu, Dan-Dan Wang, Shan-Shan Jiang, Hai-Xia Zheng, Lin Lv, Chang-Long Chen, Hong-Xia Zhang, Jian-Chuan Xi. Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma. Molecular carcinogenesis. vol 55. issue 1. 2016-05-24. PMID:25557723. |
silencing of ube4b expression by sirna inhibited the proliferation, colony formation, migration and invasion of hcc cells in vitro, and resulted in significant apoptosis that was associated with downregulation of expression of bcl-2 and upregulation of expression of total p53, p-p53, bax and cleaved-caspase3 in hcc cells. |
2016-05-24 |
2023-08-13 |
human |
| Shan-Bu Xie, Xing-Xing He, Shu-Kun Ya. Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26034977. |
next, in hepg2 cells, autophagy induced by matrine was regulated by p53 inactivation through amp-activated protein kinase (ampk) signaling transduction, then ampk suppression switched autophagy to apoptosis. |
2016-05-24 |
2023-08-13 |
human |
| Lei Zhang, Yi Li, Liang Qiao, Yongxun Zhao, Yucai Wei, Yumin L. Protective effects of hepatic stellate cells against cisplatin-induced apoptosis in human hepatoma G2 cells. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26035065. |
the lx-2 cells pretreatment inhibited the cisplatin-induced apoptosis, which was related with the incomplete blockage in p53 activation. |
2016-05-24 |
2023-08-13 |
human |
| Lei Zhang, Yi Li, Liang Qiao, Yongxun Zhao, Yucai Wei, Yumin L. Protective effects of hepatic stellate cells against cisplatin-induced apoptosis in human hepatoma G2 cells. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26035065. |
in summary, the results of our present study demonstrate that hscs protect hepg2 cells against cisplatin-induced apoptosis and its protective effects occur via inhibiting the activation of p53, which is of critical importance for enhanced understanding of fundamental cancer biology. |
2016-05-24 |
2023-08-13 |
human |
| Sandeep S Negi, Patrick Brow. rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. Oncotarget. vol 6. issue 20. 2016-05-24. PMID:26061708. |
cx-5461 treated cells undergo caspase-dependent apoptosis independent of their p53 status. |
2016-05-24 |
2023-08-13 |
Not clear |
| Su Bog Yee, Hye Joung Choi, Sang Woon Chung, Dong Heun Park, Bokyung Sung, Hae Young Chung, Nam Deuk Ki. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26096942. |
taken together, we conclude that luteolin induces apoptosis from g1 arrest via three signaling pathways of tgf‑β1, p53, and fas/fas-ligand in hcc cells. |
2016-05-24 |
2023-08-13 |
Not clear |