| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liye Yang, Wenying Li, Yanyu Huang, Yangliang Zhou, Tianfeng Che. Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics. Macromolecular rapid communications. vol 36. issue 17. 2016-06-09. PMID:26205253. |
internalized nanoparticles trigger glioma cell apoptosis by activation of ros-mediated p53 phosphorylation. |
2016-06-09 |
2023-08-13 |
human |
| Peng Li, Lina Zhang, Changyong Zhou, Nan Lin, Aiguo Li. Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells. The Journal of toxicological sciences. vol 40. issue 5. 2016-06-09. PMID:26354378. |
sirt 1 activator inhibits the age-induced apoptosis and p53 acetylation in human vascular endothelial cells. |
2016-06-09 |
2023-08-13 |
human |
| Peng Li, Lina Zhang, Changyong Zhou, Nan Lin, Aiguo Li. Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells. The Journal of toxicological sciences. vol 40. issue 5. 2016-06-09. PMID:26354378. |
in the present study, we treated human endothelial eahy926 cells with ages, and determined the apoptosis induction, caspase activation, the sirt 1 activity, the expression and acetylation of p53. |
2016-06-09 |
2023-08-13 |
human |
| Peng Li, Lina Zhang, Changyong Zhou, Nan Lin, Aiguo Li. Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells. The Journal of toxicological sciences. vol 40. issue 5. 2016-06-09. PMID:26354378. |
then we manipulated sirt 1 activity with a sirt 1 activator, resveratrol (rsv), and a sirt 1 inhibitor, sirtinol, in the age-bsa-treated eahy926 cells, and then re-evaluated the apoptosis induction, caspase activation, the expression and acetylation of p53. |
2016-06-09 |
2023-08-13 |
human |
| Peng Li, Lina Zhang, Changyong Zhou, Nan Lin, Aiguo Li. Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells. The Journal of toxicological sciences. vol 40. issue 5. 2016-06-09. PMID:26354378. |
on the other hand, the sirt 1 inhibitor/activator not only deteriorated/ameliorated the promotion to p53 level and ac p53, but also aggravated/inhibited the age-induced apoptosis and the promotion to apoptosis-associated signaling molecules. |
2016-06-09 |
2023-08-13 |
human |
| Peng Li, Lina Zhang, Changyong Zhou, Nan Lin, Aiguo Li. Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells. The Journal of toxicological sciences. vol 40. issue 5. 2016-06-09. PMID:26354378. |
in conclusion, the present study confirmed the apoptosis promotion by ages in endothelial eahy926 cells, by regulating the sirt 1 activity and p53 signaling, it also implies the protective role of sirt 1 activator against the age-induced apoptosis. |
2016-06-09 |
2023-08-13 |
human |
| Juliana Noguti, Tathiana A Alvarenga, Patrícia Marchi, Celina T F Oshima, Monica L Andersen, Daniel A Ribeir. The influence of sleep restriction on expression of apoptosis regulatory proteins p53, Bcl-2 and Bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 44. issue 3. 2016-06-07. PMID:25169245. |
the influence of sleep restriction on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. |
2016-06-07 |
2023-08-13 |
rat |
| M Mousai, S M Hosseini, M Hajian, F Jafarpour, V Asgari, M Forouzanfar, M H Nasr-Esfahan. Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. Zygote (Cambridge, England). vol 23. issue 5. 2016-06-07. PMID:25314965. |
the expression levels of bcl2 and p53 were significantly affected in tsa-treated cells compared with untreated cells, whereas sah treatment had no significant effect on cell apoptosis. |
2016-06-07 |
2023-08-13 |
dog |
| Kirti Kumar Tiwari, Bhagavatula Moorthy, Krithika Lingappa. Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-07. PMID:26004619. |
gdf15 (growth and differentiation factor 15) is a secreted cytokine, a direct target of p53 and plays a role in cell proliferation and apoptosis. |
2016-06-07 |
2023-08-13 |
human |
| Jinhua Jiang, Shenggan Wu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zhao, Changxing W. Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-07. PMID:26055223. |
the up-regulation of p53, apaf1, cas8 and the down-regulation of bcl2, mdm2, cas3 in the apoptosis pathway, as well as the increased expression of cytokines and chemokines, including cxcl-c1c, ccl1, il-1b, ifn, il-8, and tnfα, suggested carbendazim might trigger apoptosis and immune response during zebrafish larval development. |
2016-06-07 |
2023-08-13 |
mouse |
| Eda Acikgoz, Ummu Guven, Fahriye Duzagac, Ruchan Uslu, Mikail Kara, Burak Cem Soner, Gulperi Okte. Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells. PloS one. vol 10. issue 10. 2016-06-07. PMID:26485709. |
according to the results, trabectedin induced cytotoxicity and apoptosis at the ic50 dose, resulting in a significant increase expression of caspase-3, caspase-8, caspase-9, p53 and decrease expression of bcl-2 in dose-dependent manner. |
2016-06-07 |
2023-08-13 |
human |
| Gibok Lee, Taek-In Oh, Ki Bum Um, Hyeshin Yoon, Jaekyoung Son, Byeong Mo Kim, Hong-Il Kim, Hackyoung Kim, Young Jun Kim, Chang-Soo Lee, Ji-Hong Li. Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells. Biochemical and biophysical research communications. vol 470. issue 1. 2016-06-07. PMID:26768359. |
in fact, several studies have reported that functional inhibition of usp7 induces cancer cell apoptosis through activation of p53. |
2016-06-07 |
2023-08-13 |
Not clear |
| Gibok Lee, Taek-In Oh, Ki Bum Um, Hyeshin Yoon, Jaekyoung Son, Byeong Mo Kim, Hong-Il Kim, Hackyoung Kim, Young Jun Kim, Chang-Soo Lee, Ji-Hong Li. Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells. Biochemical and biophysical research communications. vol 470. issue 1. 2016-06-07. PMID:26768359. |
in contrast to previous reports, we show that p53 is not critical during usp7 inhibitor-induced apoptosis in several cancer cells. |
2016-06-07 |
2023-08-13 |
Not clear |
| Alexia M Carrillo, Mellissa Hicks, Dineo Khabele, Christine M Eische. Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells. Molecular cancer research : MCR. vol 13. issue 8. 2016-06-06. PMID:25964101. |
nutlin-3 is a small-molecule inhibitor of mdm2-p53 interaction that can induce apoptosis in cancer cells through activation of p53. |
2016-06-06 |
2023-08-13 |
human |
| Alexia M Carrillo, Mellissa Hicks, Dineo Khabele, Christine M Eische. Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells. Molecular cancer research : MCR. vol 13. issue 8. 2016-06-06. PMID:25964101. |
in ovarian cancer cells, where >90% have inactivated p53, nutlin combined with the genotoxic agents, cisplatin or etoposide, had a cooperative lethal effect resulting in increased dna damage and apoptosis. |
2016-06-06 |
2023-08-13 |
human |
| Eveline A I F Queiroz, Zuleica B Fortes, Mário A A da Cunha, Aneli M Barbosa, Neelam Khaper, Robert F H Dekke. Antiproliferative and pro-apoptotic effects of three fungal exocellular β-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a. The international journal of biochemistry & cell biology. vol 67. 2016-06-06. PMID:26255117. |
exposure to β-glucans increased apoptosis, necrosis, oxidative stress, mrna expression of p53, p27 and bax; the activity of amp-activated protein-kinase, forkhead transcription factor foxo3a, bax and caspase-3; and decreased the activity of p70s6k in mcf-7 cells. |
2016-06-06 |
2023-08-13 |
Not clear |
| Yosra Kamoun, Imed Mabrouk, Agnes Delahodde, Fatma Boukid, Ines Yacoubi-Hadj Amor, Raja Mokdad-Gargouri, Ali Gargour. Overexpression of yeast thioredoxin TRX2 reduces p53-mediated cell death in yeast. Applied microbiology and biotechnology. vol 99. issue 20. 2016-06-06. PMID:26264138. |
in the present work, the impact of trx2 overexpression on apoptosis mediated by p53 overexpression in yeast is investigated. |
2016-06-06 |
2023-08-13 |
human |
| Martin Fischer, Marianne Quaas, Lydia Steiner, Kurt Engelan. The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes. Nucleic acids research. vol 44. issue 1. 2016-06-06. PMID:26384566. |
the tumor suppressor p53 functions predominantly as a transcription factor by activating and downregulating gene expression, leading to cell cycle arrest or apoptosis. |
2016-06-06 |
2023-08-13 |
Not clear |
| Gautam Borthakur, Seshagiri Duvvuri, Vivian Ruvolo, Durga Nand Tripathi, Sujan Piya, Jared Burks, Rodrigo Jacamo, Kensuke Kojima, Peter Ruvolo, Juan Fueyo-Margareto, Marina Konopleva, Michael Andreef. MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. PloS one. vol 10. issue 10. 2016-06-06. PMID:26440941. |
mdm2 (mouse double minute 2) inhibitors that activate p53 and induce apoptosis in a non-genotoxic manner are in clinical development for treatment of leukemias. |
2016-06-06 |
2023-08-13 |
mouse |
| Peter P Ruvolo, Vivian R Ruvolo, Christopher B Benton, Ahmed AlRawi, Jared K Burks, Wendy Schober, James Rolke, George Tidmarsh, Numsen Hail, R Eric Davis, Michael Andreef. Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells. Biochimica et biophysica acta. vol 1863. issue 4. 2016-06-06. PMID:26704388. |
this activity may involve wild-type p53 as shrna knockdown of lgals3 or galectin 1 (lgals1) sensitized wild-type p53 oci-aml3 cells to gcs-100/abt-737-induced apoptosis to a much greater extent than p53 null thp-1 cells. |
2016-06-06 |
2023-08-13 |
Not clear |