| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianming He, Xi Liang, Fen Luo, Xuedan Chen, Xueqing Xu, Fengchao Wang, Zhenping Zhan. P53 Is Involved in a Three-Dimensional Architecture-Mediated Decrease in Chemosensitivity in Colon Cancer. Journal of Cancer. vol 7. issue 8. 2016-06-17. PMID:27313779. |
knockdown of p53 decreased cleaved caspase 3 and apoptosis induced by cisplatin. |
2016-06-17 |
2023-08-13 |
Not clear |
| Shang-Jui Wang, Yang Ou, Le Jiang, Wei G. Ferroptosis: A missing puzzle piece in the p53 blueprint? Molecular & cellular oncology. vol 3. issue 3. 2016-06-17. PMID:27314071. |
recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. |
2016-06-17 |
2023-08-13 |
Not clear |
| N D Marchenko, U M Mol. Mitochondrial death functions of p53. Molecular & cellular oncology. vol 1. issue 2. 2016-06-16. PMID:27308326. |
a well-characterized biochemical function of p53 in the regulation of apoptosis is its role as a potent transcriptional regulator. |
2016-06-16 |
2023-08-13 |
Not clear |
| Sophie C Cazanave, Arun J Sanya. KEAP the balance between life and death. Molecular & cellular oncology. vol 2. issue 2. 2016-06-16. PMID:27308418. |
in our recent study, we established that cellular degradation of kelch-like ech-associated protein 1 (keap1) through sequestrosome (sqstm)1/p62-dependent autophagy activates c-jun nh2 terminal kinase (jnk), upregulates expression of bcl-2-interacting mediator (bim) and p53 upregulated modulator of apoptosis (puma), and contributes to hepatocyte apoptosis induced by saturated free fatty acids. |
2016-06-16 |
2023-08-13 |
Not clear |
| Emira Ayroldi, Cristina Marchetti, Carlo Riccard. The novel partnership of L-GILZ and p53: a new affair in cancer? Molecular & cellular oncology. vol 2. issue 2. 2016-06-16. PMID:27308427. |
a recent report from our laboratory reveals how long glucocorticoid-induced leucine zipper (l-gilz) protein binds to p53 and mouse double minute 2 homolog (mdm2), thus dissociating the p53/mdm2 complex and activating p53 with subsequent activation of downstream genes p21 and p53 upregulated modulator of apoptosis (puma). |
2016-06-16 |
2023-08-13 |
mouse |
| Lu Gong, Jun Che. Δ113p53/Δ133p53 converts P53 from a repressor to a promoter of DNA double-stand break repair. Molecular & cellular oncology. vol 3. issue 1. 2016-06-16. PMID:27308550. |
in response to dna damage, p53 (tp53, best known as p53) is quickly activated leading to cell cycle arrest or apoptosis to ensure genomic integrity; however, this represses dna double-strand break (dsb) repair. |
2016-06-16 |
2023-08-13 |
Not clear |
| Muthuraman Pandurangan, Gansukh Enkhtaivan, Bhupendra Mistry, Murugesan Chandrasekaran, Rafi Noorzai, Doo Hwan Ki. Investigation of role of aspartame on apoptosis process in HeLa cells -->. Saudi journal of biological sciences. vol 23. issue 4. 2016-06-14. PMID:27298583. |
aspartame suppresses apoptosis process in cancer cells by down-regulation of mrna expression of tumor suppressor gene p53, and pro-apoptotic gene bax. |
2016-06-14 |
2023-08-13 |
Not clear |
| A Iglesias-Ara, O Zenarruzabeitia, L Buelta, J Merino, A M Zubiag. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Cell death and differentiation. vol 22. issue 10. 2016-06-14. PMID:25656653. |
we show that pancreas atrophy in e2f1/e2f2 double-knockout (dko) mice is associated with mitochondrial apoptosis and activation of the p53 pathway in young animals, before the development of diabetes. |
2016-06-14 |
2023-08-13 |
mouse |
| A Iglesias-Ara, O Zenarruzabeitia, L Buelta, J Merino, A M Zubiag. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Cell death and differentiation. vol 22. issue 10. 2016-06-14. PMID:25656653. |
we further show that activation of the p53 pathway has a key role in the aberrant phenotype of dko mice, since targeted inactivation of p53 gene abrogated cellular apoptosis and prevented organ involution and insulin-dependent diabetes in mice lacking e2f1/e2f2. |
2016-06-14 |
2023-08-13 |
mouse |
| A M ElKeeb, M E W Collier, A Maraveyas, C Ettelai. Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis. vol 114. issue 2. 2016-06-14. PMID:25903973. |
accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. |
2016-06-14 |
2023-08-13 |
Not clear |
| A M ElKeeb, M E W Collier, A Maraveyas, C Ettelai. Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis. vol 114. issue 2. 2016-06-14. PMID:25903973. |
cell proliferation, apoptosis and the expression of cyclin d1, p53, bax and p21 were measured following activation of cells with par2-agonist peptide. |
2016-06-14 |
2023-08-13 |
Not clear |
| A M ElKeeb, M E W Collier, A Maraveyas, C Ettelai. Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis. vol 114. issue 2. 2016-06-14. PMID:25903973. |
finally, sirna-mediated suppression of p38α, or inhibition using sb202190 significantly reduced the p53 protein levels, p53 nuclear localisation and transcriptional activity, suppressed bax expression and prevented cellular apoptosis. |
2016-06-14 |
2023-08-13 |
Not clear |
| A M ElKeeb, M E W Collier, A Maraveyas, C Ettelai. Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis. vol 114. issue 2. 2016-06-14. PMID:25903973. |
in conclusion, accumulation of tf within endothelial cells, or sequestered from the surrounding can induce cellular apoptosis through mechanisms mediated by p38, and involves the stabilisation of p53. |
2016-06-14 |
2023-08-13 |
Not clear |
| Sandra Chrusciel, Maéva Zysman, Philippe Caramelle, Arnaud Tiendrebeogo, Indoumady Baskara, Sabine Le Gouvello, François Chabot, Stéphane Giraudier, Jorge Boczkowski, Laurent Boye. Lack of Transcription Factor p53 Exacerbates Elastase-Induced Emphysema in Mice. American journal of respiratory cell and molecular biology. vol 54. issue 2. 2016-06-14. PMID:26106979. |
the increased number of macrophages in p53(-/-) mice was not a consequence of reduced apoptosis or an excess of chemotaxis toward ccl2. |
2016-06-14 |
2023-08-13 |
mouse |
| Eun Young Choi, Kyeong-Cheol Shin, Jinho Lee, Taeg Kyu Kwon, Shin Kim, Jong-Wook Par. Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 14. 2016-06-14. PMID:26320467. |
treatment with a small synthetic compound, kmu-193, induces apoptosis in a549 human lung carcinoma cells through p53 up-regulation. |
2016-06-14 |
2023-08-13 |
human |
| Eun Young Choi, Kyeong-Cheol Shin, Jinho Lee, Taeg Kyu Kwon, Shin Kim, Jong-Wook Par. Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 14. 2016-06-14. PMID:26320467. |
importantly, p53 sirna transfection attenuated kmu-193-induced apoptosis. |
2016-06-14 |
2023-08-13 |
human |
| Hong Wu, Roger P Len. MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26025930. |
the protein p73, a homologue of the tumor suppressor protein p53, is capable of inducing apoptosis and cell cycle arrest. |
2016-06-10 |
2023-08-13 |
Not clear |
| Marina E Tourlakis, Siyi Zhang, Heather L Ball, Rikesh Gandhi, Hongrui Liu, Jian Zhong, Julie S Yuan, Cynthia J Guidos, Peter R Durie, Johanna M Rommen. In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency. PLoS genetics. vol 11. issue 6. 2016-06-10. PMID:26057580. |
moreover, p53 ablation resulted in expression of acinar dedifferentiation markers and extensive apoptosis. |
2016-06-10 |
2023-08-13 |
mouse |
| Rupa Mishra, Vinayak Palve, Sadhana Kannan, Sagar Pawar, Tanuja Ten. High expression of survivin and its splice variants survivin ΔEx3 and survivin 2 B in oral cancers. Oral surgery, oral medicine, oral pathology and oral radiology. vol 120. issue 4. 2016-06-10. PMID:26346910. |
survivin, a p53 target gene and an inhibitor of apoptosis protein (iap), is overexpressed in several cancers, including oral cancers. |
2016-06-10 |
2023-08-13 |
Not clear |
| Kazushi Inoue, Elizabeth A Fry, Donna P Frazie. Transcription factors that interact with p53 and Mdm2. International journal of cancer. vol 138. issue 7. 2016-06-09. PMID:26132471. |
the tumor suppressor p53 is activated upon cellular stresses such as dna damage, oncogene activation, hypoxia, which transactivates sets of genes that induce dna repair, cell cycle arrest, apoptosis, or autophagy, playing crucial roles in the prevention of tumor formation. |
2016-06-09 |
2023-08-13 |
Not clear |