| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beata Hat, Marek Kochańczyk, Marta N Bogdał, Tomasz Lipniack. Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System. PLoS computational biology. vol 12. issue 2. 2016-07-14. PMID:26928575. |
the p53 transcription factor is a regulator of key cellular processes including dna repair, cell cycle arrest, and apoptosis. |
2016-07-14 |
2023-08-13 |
Not clear |
| Beata Hat, Marek Kochańczyk, Marta N Bogdał, Tomasz Lipniack. Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System. PLoS computational biology. vol 12. issue 2. 2016-07-14. PMID:26928575. |
our analysis provides an explanation why cancer cell lines known to have vastly diverse expression levels of wip1 and pten exhibit a broad spectrum of responses to dna damage: from a fast transition to a high level of p53 killer (a p53 phosphoform which promotes commitment to apoptosis) in cells characterized by high pten and low wip1 levels to long-lasting p53 level oscillations in cells having pten promoter methylated (as in, e.g., mcf-7 cell line). |
2016-07-14 |
2023-08-13 |
Not clear |
| Nurmaa Dashzeveg, Satomi Yogosawa, Kiyotsugu Yoshid. Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage. Cancer letters. vol 374. issue 1. 2016-07-13. PMID:26884258. |
p53 induces apoptosis by promoting pro-apoptotic genes in response to dna damage. |
2016-07-13 |
2023-08-13 |
human |
| Nurmaa Dashzeveg, Satomi Yogosawa, Kiyotsugu Yoshid. Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage. Cancer letters. vol 374. issue 1. 2016-07-13. PMID:26884258. |
protein kinase c delta (pkcδ) also induces apoptosis via various mechanisms including modification of p53. |
2016-07-13 |
2023-08-13 |
human |
| Nurmaa Dashzeveg, Satomi Yogosawa, Kiyotsugu Yoshid. Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage. Cancer letters. vol 374. issue 1. 2016-07-13. PMID:26884258. |
thus, our findings suggest that the transcriptional regulation of pkcδ is controlled by p53 in a positive feedback mechanism to induce apoptosis in response to dna damage. |
2016-07-13 |
2023-08-13 |
human |
| Y Takei, S Okamoto, K Kawamura, Y Jiang, T Morinaga, M Shingyoji, I Sekine, S Kubo, Y Tada, K Tatsumi, H Shimada, K Hiroshima, N Yamaguchi, M Tagaw. Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells. Cancer gene therapy. vol 22. issue 9. 2016-07-12. PMID:26251031. |
expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells. |
2016-07-12 |
2023-08-13 |
human |
| Y Takei, S Okamoto, K Kawamura, Y Jiang, T Morinaga, M Shingyoji, I Sekine, S Kubo, Y Tada, K Tatsumi, H Shimada, K Hiroshima, N Yamaguchi, M Tagaw. Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells. Cancer gene therapy. vol 22. issue 9. 2016-07-12. PMID:26251031. |
these data collectively indicated that replication-competent ad augmented susceptibility of pancreatic cells to apoptosis through upregulated p53 expression. |
2016-07-12 |
2023-08-13 |
human |
| Kislay Roy, Rupinder K Kanwar, Jagat R Kanwa. LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging. Biomaterials. vol 71. 2016-07-12. PMID:26318819. |
from tumor tissue analyses of 35 apoptotic markers, 55 angiogenesis markers, 40 cytokines, 15 stem cell markers and gene expression studies of important signaling molecules, it was revealed that the anti-cancer mechanism of fe3o4-blf was intervened through trail, fas, fas-associated protein with death domain (fadd) mediated phosphorylation of p53, to induce activation of second mitochondria-derived activator of caspases (smac)/diablo (inhibiting survivin) and mitochondrial depolarization leading to release of cytochrome c. induction of apoptosis was observed by inhibition of the akt pathway and activation of cytokines released from monocytes/macrophages and dendritic cells (interleukin (il) 27, keratinocyte chemoattractant (kc)). |
2016-07-12 |
2023-08-13 |
mouse |
| Arnab Sarkar, Shamee Bhattacharjee, Deba Prasad Manda. Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells--Elucidating the Role of p53. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 15. 2016-07-12. PMID:26434906. |
induction of apoptosis by eugenol and capsaicin in human gastric cancer ags cells--elucidating the role of p53. |
2016-07-12 |
2023-08-13 |
human |
| Arnab Sarkar, Shamee Bhattacharjee, Deba Prasad Manda. Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells--Elucidating the Role of p53. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 15. 2016-07-12. PMID:26434906. |
although the pro-apoptotic roles of eugenol and capsaicin have been amply reported, their dependence on p53 for apoptosis induction in gastric cancer cells is not well elucidated. |
2016-07-12 |
2023-08-13 |
human |
| Arnab Sarkar, Shamee Bhattacharjee, Deba Prasad Manda. Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells--Elucidating the Role of p53. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 15. 2016-07-12. PMID:26434906. |
the aim of the study was to elucidate the role of p53 in the induction of apoptosis by eugenol and capsaicin in a human gastric cancer cell line, ags. |
2016-07-12 |
2023-08-13 |
human |
| Xia Zhang, Dage Liu, Yushi Hayashida, Homare Okazoe, Takeshi Hashimoto, Nobufumi Ueda, Mikio Sugimoto, Yoshiyuki Kakeh. G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells. International journal of molecular sciences. vol 16. issue 10. 2016-07-12. PMID:26473854. |
as represented by a wild-type p53 rt112 cell, ad-shgpr87 infection significantly enhanced p53 and p21 expression and caused caspase-dependent apoptosis. |
2016-07-12 |
2023-08-13 |
human |
| Baolong Pan, Shuandong Guo, Liang Guo, Xin Li, Qiao Ni. [Effect of chronic aluminum exposure on neuron apoptosis and expression of P53 phosphorylation in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 33. issue 7. 2016-07-12. PMID:26653654. |
[effect of chronic aluminum exposure on neuron apoptosis and expression of p53 phosphorylation in rats]. |
2016-07-12 |
2023-08-13 |
rat |
| Baolong Pan, Shuandong Guo, Liang Guo, Xin Li, Qiao Ni. [Effect of chronic aluminum exposure on neuron apoptosis and expression of P53 phosphorylation in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 33. issue 7. 2016-07-12. PMID:26653654. |
to explore the role of p53 phosphorylation in neuron apoptosis of rats by chronic aluminum exposure. |
2016-07-12 |
2023-08-13 |
rat |
| Min Hwa Shin, Yunlong He, Eryney Marrogi, Sajida Piperdi, Ling Ren, Chand Khanna, Richard Gorlick, Chengyu Liu, Jing Huan. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. PLoS genetics. vol 12. issue 2. 2016-07-12. PMID:26925584. |
the inactivation of p53 creates a major challenge for inducing apoptosis in cancer cells. |
2016-07-12 |
2023-08-13 |
Not clear |
| Min Hwa Shin, Yunlong He, Eryney Marrogi, Sajida Piperdi, Ling Ren, Chand Khanna, Richard Gorlick, Chengyu Liu, Jing Huan. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. PLoS genetics. vol 12. issue 2. 2016-07-12. PMID:26925584. |
using the crispr technology, we demonstrate that p53 loss enhances the apoptosis caused by runx2 knockdown. |
2016-07-12 |
2023-08-13 |
Not clear |
| Min Hwa Shin, Yunlong He, Eryney Marrogi, Sajida Piperdi, Ling Ren, Chand Khanna, Richard Gorlick, Chengyu Liu, Jing Huan. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. PLoS genetics. vol 12. issue 2. 2016-07-12. PMID:26925584. |
two inhibitors of the menin/mll1 complex induce apoptosis in p53 defective cancer cells. |
2016-07-12 |
2023-08-13 |
Not clear |
| Sofie Deschoemaeker, Giusy Di Conza, Sergio Lilla, Rosa Martín-Pérez, Daniela Mennerich, Lise Boon, Stefanie Hendrikx, Oliver D K Maddocks, Christian Marx, Praveen Radhakrishnan, Hans Prenen, Martin Schneider, Johanna Myllyharju, Thomas Kietzmann, Karen H Vousden, Sara Zanivan, Massimiliano Mazzon. PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO molecular medicine. vol 7. issue 10. 2016-07-11. PMID:26290450. |
active p53 allows nucleotide excision repair by interacting with the dna helicase xpb, thereby protecting from chemotherapy-induced apoptosis. |
2016-07-11 |
2023-08-13 |
mouse |
| Tsung Chi Lu, Guan-Hao Zhao, Yao Yun Chen, Chia-Ying Chien, Chi-Hung Huang, Kwang Hui Lin, Shen Liang Che. Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. Journal of Cancer. vol 7. issue 10. 2016-07-08. PMID:27390612. |
tumor suppressor protein p53 plays important roles in initiating cell cycle arrest and promoting tumor cell apoptosis. |
2016-07-08 |
2023-08-13 |
human |
| Bo Kong, Yan Zhu, Guodong Li, Jessica A Williams, Kyle Buckley, Ossama Tawfik, James P Luyendyk, Grace L Gu. Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis. American journal of physiology. Gastrointestinal and liver physiology. vol 310. issue 5. 2016-07-08. PMID:26744468. |
interestingly, fxr(hep-/-) mouse livers increased basal expression of tumor suppressor p53 protein, apoptosis, and decreased basal cyclin d1 expression, which may prevent tumor development in fxr(hep-/-) mice. |
2016-07-08 |
2023-08-13 |
mouse |