| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| France-Hélène Paradis, Barbara F Hale. Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs. Birth defects research. Part B, Developmental and reproductive toxicology. vol 104. issue 5. 2016-08-09. PMID:26305274. |
thus, in vitro exposure to an hdaci such as vpa leads to p53 hyperacetylation, enhances the expression of p53 target genes, and triggers an increase in apoptosis that may contribute to teratogenicity. |
2016-08-09 |
2023-08-13 |
mouse |
| Xun-Xun Wan, Hong Yi, Jia-Quan Qu, Qiu-Yan He, Zhi-Qiang Xia. Integrated analysis of the differential cellular and EBV miRNA expression profiles in microdissected nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues. Oncology reports. vol 34. issue 5. 2016-08-08. PMID:26330189. |
in addition, ebv-mirnas such as bart3 and bart5 target genes in the p53, tgf-β and wnt signaling pathways to modulate npc apoptosis and transformation. |
2016-08-08 |
2023-08-13 |
Not clear |
| Yari Ciribilli, Prashant Singh, Reinhard Spanel, Alberto Inga, Jürgen Borla. Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas. Oncotarget. vol 6. issue 31. 2016-08-08. PMID:26427040. |
using histological well-defined tumors, transcriptome analysis identified novel c-myc responsive cell cycle and apoptosis genes that were validated as direct c-myc targets using emsa, western blotting, gene reporter and chip assays.through computational analyses c-myc cooperating transcription factors emerged for repressed and up-regulated genes in cancer samples, namely klf7, gata3, sox18, p53 and elf5 and cebpα, respectively. |
2016-08-08 |
2023-08-13 |
mouse |
| Q-C Luan, Y-R Sun, P Han, Y Che. Ad-PUMA sensitizes ovarian cancer cells to chemotherapeutic agents. European review for medical and pharmacological sciences. vol 19. issue 23. 2016-08-08. PMID:26698248. |
we sought to evaluate the therapeutic potential of p53 up-regulated modulator of apoptosis (puma) in ovarian cancer. |
2016-08-08 |
2023-08-13 |
Not clear |
| Qiuzhen Zhu, Yuefan Zhang, Yulan Liu, Hao Cheng, Jing Wang, Yue Zhang, Yaocheng Rui, Tiejun L. MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2. PloS one. vol 11. issue 2. 2016-08-08. PMID:26918757. |
we observed that mlif enhanced cell survival and inhibited apoptosis and necrosis by inhibiting p-jnk, p53, c-caspase9 and c-caspase3 expression. |
2016-08-08 |
2023-08-13 |
human |
| Yael Aylon, Anat Gershoni, Ron Rotkopf, Inbal E Biton, Ziv Porat, Anna P Koh, Xiaochen Sun, Youngmin Lee, Maria-Isabel Fiel, Yujin Hoshida, Scott L Friedman, Randy L Johnson, Moshe Ore. The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. Genes & development. vol 30. issue 7. 2016-08-08. PMID:27013235. |
surprisingly, apoptosis, inflammation, and fibrosis were actually attenuated relative to wild-type mice, in association with impaired p53 activation. |
2016-08-08 |
2023-08-13 |
mouse |
| Lin Shi, Yanjun Lei, Ranjana Srivastava, Weihua Qin, Jason J Che. Gallic acid induces apoptosis in human cervical epithelial cells containing human papillomavirus type 16 episomes. Journal of medical virology. vol 88. issue 1. 2016-08-05. PMID:26059022. |
the anti-proliferative effect of ga on hpvep and hela cells was associated with apoptosis and upregulation of p53. |
2016-08-05 |
2023-08-13 |
human |
| Naotake Funamizu, Curtis R Lacy, Minori Kamada, Katsuhiko Yanaga, Yoshinobu Manom. MicroRNA-203 induces apoptosis by upregulating Puma expression in colon and lung cancer cells. International journal of oncology. vol 47. issue 5. 2016-08-05. PMID:26397233. |
the present study investigated the relationship between microrna-203 (mir-203) and the p53 upregulated modulator of apoptosis (puma) in colon (hct116) and lung cancer (a549) cells. |
2016-08-05 |
2023-08-13 |
Not clear |
| Xiaodong Tan, Peng Liu, Yinpeng Huang, Lei Zhou, Yifan Yang, Huaitao Wang, Boqiang Yu, Xiangli Meng, Xiaobo Zhang, Feng Ga. Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancreatic Cancer Cells. PloS one. vol 11. issue 3. 2016-08-05. PMID:27014871. |
bid and brca1) were closely involved in apoptosis and p53 signaling pathways. |
2016-08-05 |
2023-08-13 |
Not clear |
| M Nikbakht Dastjerdi, A Valiani, M Mardani, M Zamani R. Adenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7. Bratislavske lekarske listy. vol 117. issue 4. 2016-08-05. PMID:27075390. |
adenosine a1 receptor modifies p53 expression and apoptosis in breast cancer cell line mcf-7. |
2016-08-05 |
2023-08-13 |
Not clear |
| M Nikbakht Dastjerdi, A Valiani, M Mardani, M Zamani R. Adenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7. Bratislavske lekarske listy. vol 117. issue 4. 2016-08-05. PMID:27075390. |
because of this finding and relationship between a1 receptor and cell apoptosis and proliferation, this study aimed to determine the effect of agonist and antagonist of a1 receptor on cell apoptosis and proliferation and recognize the relationship between this receptor and p53 expression. |
2016-08-05 |
2023-08-13 |
Not clear |
| Qianling Liu, Jie Jin, Jianming Ying, Yun Cui, Mengkui Sun, Lian Zhang, Yu Fan, Ben Xu, Qian Zhan. Epigenetic inactivation of the candidate tumor suppressor gene ASC/TMS1 in human renal cell carcinoma and its role as a potential therapeutic target. Oncotarget. vol 6. issue 26. 2016-08-04. PMID:26093088. |
knockdown of asc/tms1 reduced dna damaging agents-induced p53 activation and cell apoptosis. |
2016-08-04 |
2023-08-13 |
mouse |
| Christophe Deben, An Wouters, Ken Op de Beeck, Jolien van Den Bossche, Julie Jacobs, Karen Zwaenepoel, Marc Peeters, Jan Van Meerbeeck, Filip Lardon, Christian Rolfo, Vanessa Deschoolmeester, Patrick Pauwel. The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer. Oncotarget. vol 6. issue 26. 2016-08-04. PMID:26125230. |
the mdm2-inhibitor nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer. |
2016-08-04 |
2023-08-13 |
Not clear |
| Yu-Jen Jou, Chao-Jung Chen, Yu-Ching Liu, Tzong-Der Way, Chih-Ho Lai, Chun-Hung Hua, Ching-Ying Wang, Su-Hua Huang, Jung-Yie Kao, Cheng-Wen Li. Quantitative phosphoproteomic analysis reveals γ-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation. Proteomics. vol 15. issue 19. 2016-08-04. PMID:26194454. |
phosphoproteome profiling revealed that γ-bisabolene increased the phosphorylation of erk1/2, protein phosphatases 1 (pp1), and p53, as well as decreased the phosphorylation of histone deacetylase 2 (hdac2) in the process of apoptosis induction. |
2016-08-04 |
2023-08-13 |
human |
| Le Jiang, Justin H Hickman, Shang-Jui Wang, Wei G. Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses. Cell cycle (Georgetown, Tex.). vol 14. issue 18. 2016-08-03. PMID:26218928. |
triggered by a wide variety of stress stimuli, p53 transcriptionally regulates genes involved in the canonical tumor suppression pathways of apoptosis, cell-cycle arrest, and senescence. |
2016-08-03 |
2023-08-13 |
human |
| Le Jiang, Justin H Hickman, Shang-Jui Wang, Wei G. Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses. Cell cycle (Georgetown, Tex.). vol 14. issue 18. 2016-08-03. PMID:26218928. |
here, we report that wild type p53 can induce both apoptosis and ferroptosis upon reactive oxygen species (ros)-induced stress. |
2016-08-03 |
2023-08-13 |
human |
| Chun-Hong Zhou, Xiao-Peng Zhang, Feng Liu, Wei Wan. Modeling the interplay between the HIF-1 and p53 pathways in hypoxia. Scientific reports. vol 5. 2016-08-03. PMID:26346319. |
we showed that both the transrepression and transactivation activities of p53 promote apoptosis induction. |
2016-08-03 |
2023-08-13 |
Not clear |
| Mohd Javed Akhtar, Hisham A Alhadlaq, Aws Alshamsan, M A Majeed Khan, Maqusood Ahame. Aluminum doping tunes band gap energy level as well as oxidative stress-mediated cytotoxicity of ZnO nanoparticles in MCF-7 cells. Scientific reports. vol 5. 2016-08-03. PMID:26347142. |
p53, bax/bcl2 ratio, caspase-3 &caspase-9) along with loss of mitochondrial membrane potential suggested that al-doped zno nanoparticles induced apoptosis in mcf-7 cells through mitochondrial pathway. |
2016-08-03 |
2023-08-13 |
human |
| Anne Largeot, Flor Maria Perez-Campo, Elli Marinopoulou, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacau. Expression of the MOZ-TIF2 oncoprotein in mice represses senescence. Experimental hematology. vol 44. issue 4. 2016-08-03. PMID:26854485. |
finally, we report that inhibition of senescence by moz-tif2 is associated with increased apoptosis, suggesting a role for the fusion protein in p53 apoptosis-versus-senescence balance. |
2016-08-03 |
2023-08-13 |
mouse |
| Tetsuo Sato, Kazuko Kita, Chihomi Sato, Atsushi Kaned. Hochu‑ekki‑to (Bu‑zhong‑yi‑qi‑tang), a herbal medicine, enhances cisplatin‑induced apoptosis in HeLa cells. Molecular medicine reports. vol 12. issue 4. 2016-08-02. PMID:26239548. |
proteins associated with cell viability and apoptosis, including phosphorylated (p‑)akt, p53, b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax) and active caspase‑3 were analyzed by immunoblotting. |
2016-08-02 |
2023-08-13 |
Not clear |