| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuhai Xie, Boyi Wu, Binwei Chen, Qunwei Shi, Jianhong Guo, Ziwen Fan, Yan Huan. Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2-p53 signaling. OncoTargets and therapy. vol 9. 2016-07-22. PMID:27445491. |
then, cell proliferation and apoptosis were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and flow cytometry assays, respectively; the expression of ki67, bax, bcl-2, mdm2, and p53 proteins was determined by using western blot assay. |
2016-07-22 |
2023-08-13 |
mouse |
| Chuhai Xie, Boyi Wu, Binwei Chen, Qunwei Shi, Jianhong Guo, Ziwen Fan, Yan Huan. Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2-p53 signaling. OncoTargets and therapy. vol 9. 2016-07-22. PMID:27445491. |
p53 inhibited proliferation and promoted apoptosis, whereas mdm2 promoted proliferation and suppressed apoptosis, which indicated that functional effect of sb on os cell lines at least in part depended on the mdm2-p53 signaling. |
2016-07-22 |
2023-08-13 |
mouse |
| Nang T T Htike, Fumihiko Maekawa, Haruka Soutome, Kazuhiro Sano, Sho Maejima, Kyaw H Aung, Masaaki Tokuda, Shinji Tsukahar. Arsenic Exposure Induces Unscheduled Mitotic S Phase Entry Coupled with Cell Death in Mouse Cortical Astrocytes. Frontiers in neuroscience. vol 10. 2016-07-22. PMID:27445668. |
however, naaso2 did not increase the amount of nucleosomes generated from dna fragmentation and failed to alter the gene expression of molecules relevant to unscheduled s phase entry-coupled apoptosis (p21, p53, e2f1, e2f4, and gm36566). |
2016-07-22 |
2023-08-13 |
mouse |
| H Jiang, C Acharya, G An, M Zhong, X Feng, L Wang, N Dasilva, Z Song, G Yang, F Adrian, L Qiu, P Richardson, N C Munshi, Y-T Tai, K C Anderso. SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide. Leukemia. vol 30. issue 2. 2016-07-22. PMID:26338273. |
sar and its f(ab)'2 fragments trigger caspase 3/7-dependent apoptosis in mm cells highly expressing cd38, even with p53 mutation. |
2016-07-22 |
2023-08-13 |
Not clear |
| May Al-Maghrebi, Waleed M Renn. Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate. PeerJ. vol 4. 2016-07-21. PMID:27441124. |
elisa and immunohistochemistry were used to evaluate the expression of p53 and tp53-induced glycolysis and apoptosis regulator (tigar). |
2016-07-21 |
2023-08-13 |
rat |
| Lei Zheng, Yanmin Zhang, Yanping Liu, Xiaoyan Ou Yang, Yingzhuan Zha. Momordica cochinchinensis Spreng. seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis. Molecular medicine reports. vol 12. issue 4. 2016-07-21. PMID:26252798. |
in addition, esmc2 dose‑dependently induced cell apoptosis, which was mediated via upregulation of the apoptosis-associated proteins p53, b-cell lymphoma 2 (bcl‑2)‑associated x protein, bcl-2 homologous antagonist killer and bcl-2-associated death promoter expression, as well as downregulation of nuclear factor kappa b, bcl‑2 and myeloid cell leukemia‑1. |
2016-07-21 |
2023-08-13 |
mouse |
| Yinhui Dong, Shutao Yin, Xinhua Song, Yazhen Huo, Lihong Fan, Min Ye, Hongbo H. Involvement of ROS-p38-H2AX axis in novel curcumin analogues-induced apoptosis in breast cancer cells. Molecular carcinogenesis. vol 55. issue 4. 2016-07-20. PMID:25647442. |
inhibition of p38/h2ax led to a significant reduction of apoptosis, whereas inactivation of p53 caused a dramatically enhanced h2ax phosphorylation and apoptosis induction, suggesting activation of p38/h2ax contributed to apoptosis induction by t1, whereas p53 activation protected novel curcumins-induced apoptosis via suppression of h2ax activation. |
2016-07-20 |
2023-08-13 |
Not clear |
| R M Ruggeri, T M Vicchio, S Giovinazzo, R Certo, A Alibrandi, F Trimarchi, S Benvenga, M Trovat. TP53 polymorphism may contribute to genetic susceptibility to develop Hashimoto's thyroiditis. Journal of endocrinological investigation. vol 38. issue 11. 2016-07-20. PMID:25935255. |
p53, which is encoded by the tumor suppressor gene tp53, plays a crucial role in the regulation of mechanisms of cell cycle arrest and apoptosis. |
2016-07-20 |
2023-08-13 |
Not clear |
| Z-l Qin, X-x Zheng, Y-h X. Increased Angiogenesis and Decreased Programmed Cell Death Increases the Risk of Uterine Cervical Cancer. Drug research. vol 65. issue 10. 2016-07-19. PMID:25333653. |
in the present study we made an attempt to determine the extent of angiogenesis, apoptosis, accumulation of mutant p53 protein, cell proliferation rate in the uterine cervical cancer tissues. |
2016-07-19 |
2023-08-13 |
Not clear |
| Qian Qiu, Chun Yang, Wei Xiong, Houda Tahiri, Mathieu Payeur, Rosanne Superstein, Anne-Sophie Carret, Patrick Hamel, Benjamin Ellezam, Bussières Martin, Mark Vezina, Przemyslaw Sapieha, Guoxiang Liu, Pierre Hard. SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 12. 2016-07-19. PMID:26404525. |
perturbing syk activity in rb cells induced cell apoptosis and upregulated expression of p53 and p21. |
2016-07-19 |
2023-08-13 |
human |
| Qian Qiu, Chun Yang, Wei Xiong, Houda Tahiri, Mathieu Payeur, Rosanne Superstein, Anne-Sophie Carret, Patrick Hamel, Benjamin Ellezam, Bussières Martin, Mark Vezina, Przemyslaw Sapieha, Guoxiang Liu, Pierre Hard. SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 12. 2016-07-19. PMID:26404525. |
blocking oxidized phospholipid-rich lmps with a specific antibody significantly prevented lmp-induced rb apoptosis and reversed the expression patterns of syk, p53, p21. |
2016-07-19 |
2023-08-13 |
human |
| Fu-Lan Yang, Fang-Zhi Chen, Xin-Xing Wan, Xi Zhou, Mei-Juan Zhou, Han-Chun Chen, Jun-Jiang Fu, Dian-Zheng Zhan. Effects of a Particular Heptapeptide on the IFN-α-Sensitive CML Cells. BioMed research international. vol 2015. 2016-07-19. PMID:26421285. |
the viability of the kt-1/a3 cells was inhibited and apoptosis was induced by either expression of the heptapeptide klwvipq or ifn-α treatment with concurrent upregulation of p53 and downregulation of p210(bcr/abl). |
2016-07-19 |
2023-08-13 |
Not clear |
| Rebekka K Schneider, Monica Schenone, Monica Ventura Ferreira, Rafael Kramann, Cailin E Joyce, Christina Hartigan, Fabian Beier, Tim H Brümmendorf, Ulrich Germing, Uwe Platzbecker, Guntram Büsche, Ruth Knüchel, Michelle C Chen, Christopher S Waters, Edwin Chen, Lisa P Chu, Carl D Novina, R Coleman Lindsley, Steven A Carr, Benjamin L Eber. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nature medicine. vol 22. issue 3. 2016-07-19. PMID:26878232. |
we generated mice with conditional inactivation of rps14 and demonstrated an erythroid differentiation defect that is dependent on the tumor suppressor protein p53 (encoded by trp53 in mice) and is characterized by apoptosis at the transition from polychromatic to orthochromatic erythroblasts. |
2016-07-19 |
2023-08-13 |
mouse |
| Yi Gong, Chenyu Ju, Xiaobo Zhan. The miR-1000-p53 pathway regulates apoptosis and virus infection in shrimp. Fish & shellfish immunology. vol 46. issue 2. 2016-07-18. PMID:26220644. |
the p53 protein plays an important role in apoptosis which is involved in the immunity of animals. |
2016-07-18 |
2023-08-13 |
Not clear |
| Yi Gong, Chenyu Ju, Xiaobo Zhan. The miR-1000-p53 pathway regulates apoptosis and virus infection in shrimp. Fish & shellfish immunology. vol 46. issue 2. 2016-07-18. PMID:26220644. |
however, effects of the mirna-mediated regulation of p53 expression on apoptosis and virus infection are not extensively investigated. |
2016-07-18 |
2023-08-13 |
Not clear |
| Yi Gong, Chenyu Ju, Xiaobo Zhan. The miR-1000-p53 pathway regulates apoptosis and virus infection in shrimp. Fish & shellfish immunology. vol 46. issue 2. 2016-07-18. PMID:26220644. |
the results of in vivo experiments showed that the mir-1000 overexpression led to significant decreases of shrimp apoptotic activity and the capacity of wssv infection, while the mir-1000 silencing resulted in significant increases of apoptotic activity and virus infection, indicating that mir-1000 took great effects on apoptosis and virus infection by targeting p53. |
2016-07-18 |
2023-08-13 |
Not clear |
| N Chi, Z Z Yun, Z H Tan, X Z Li, B T B G Chen, J Liu, L B Xu, K W Ma, S X Li, J F Liu, C X Li. Effect of p53 gene polymorphism on functions of prostate cancer cells. Genetics and molecular research : GMR. vol 14. issue 4. 2016-07-18. PMID:26436494. |
prostate cancer cells were transfected with plasmids [empty plasmids, wild-type pcdna3.1-p53 (v/v), mutant type pcdna3.1- p53 (g/g)] to analyze the effect of p53 gene polymorphisms on the proliferation, cycle, and apoptosis of prostatic cancer cells. |
2016-07-18 |
2023-08-13 |
Not clear |
| N Chi, Z Z Yun, Z H Tan, X Z Li, B T B G Chen, J Liu, L B Xu, K W Ma, S X Li, J F Liu, C X Li. Effect of p53 gene polymorphism on functions of prostate cancer cells. Genetics and molecular research : GMR. vol 14. issue 4. 2016-07-18. PMID:26436494. |
the p53 gene polymorphism affects the proliferation, apoptosis, and cycle of prostate cancer cells and may serve as a reliable index for the diagnosis and treatment of prostate cancer. |
2016-07-18 |
2023-08-13 |
Not clear |
| Fatima Z Saddouk, Li-Yan Sun, Yong Feng Liu, Miao Jiang, Diane V Singer, Johannes Backs, Dee Van Riper, Roman Ginnan, John J Schwarz, Harold A Singe. Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 3. 2016-07-18. PMID:26567004. |
in cultured vsm, camkiiγ overexpression induced p53 mrna (1.7 fold) and protein (1.8-fold) expression; induced the p53 target gene p21 (3-fold); decreased vsm cell proliferation (>50%); and had no effect on expression of apoptosis markers. |
2016-07-18 |
2023-08-13 |
mouse |
| Wensheng Yan, Ariane Scoumanne, Yong-Sam Jung, Enshun Xu, Jin Zhang, Yanhong Zhang, Cong Ren, Pei Sun, Xinbin Che. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes & development. vol 30. issue 5. 2016-07-15. PMID:26915821. |
finally, we showed that knockdown of zfp871 markedly enhances p53 expression, leading to growth suppression and apoptosis in a p53-dependent manner. |
2016-07-15 |
2023-08-13 |
mouse |