| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyuk-Kwon Kwon, Hyeon-Jun Shin, Jae-Hyeok Lee, Seol-Hee Park, Min-Cheol Kwon, Suresh Panneerselvam, Chan Gyu Lee, Sang Geon Kim, Jae-Ho Kim, Sangdun Cho. Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 1. 2016-08-16. PMID:26259609. |
thus, our study demonstrated that p53 protects against apoptosis, and leads to etoposide-induced necrosis. |
2016-08-16 |
2023-08-13 |
human |
| Nourdine Hamdane, Chelsea Herdman, Jean-Clement Mars, Victor Stefanovsky, Michel G Tremblay, Tom Mos. Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26317157. |
apoptosis is not affected by homozygous deletion of the p53 gene and occurs equally in cells transformed by sv40 t antigens, by myc or by a combination of ras & myc oncogenes. |
2016-08-16 |
2023-08-13 |
Not clear |
| Shujun Gao, Lekun Fang, Liem Minh Phan, Aiham Qdaisat, Sai-Ching J Yeung, Mong-Hong Le. COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26318036. |
we characterized that csn6 associated with e6ap and stabilized e6ap expression by reducing e6ap poly-ubiquitination, thereby regulating p53 activity in cell proliferation and apoptosis. |
2016-08-16 |
2023-08-13 |
mouse |
| Wen-Ying Lee, Wai-Theng Lee, Chia-Hsiung Cheng, Ku-Chung Chen, Chih-Ming Chou, Chu-Hung Chung, Min-Siou Sun, Hung-Wei Cheng, Meng-Ni Ho, Cheng-Wei Li. Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26363315. |
activation of c-jun n-terminal kinase (jnk) was crucial for cpz-induced p53 expression and the subsequent induction of tumor apoptosis. |
2016-08-16 |
2023-08-13 |
human |
| Wen-Ying Lee, Wai-Theng Lee, Chia-Hsiung Cheng, Ku-Chung Chen, Chih-Ming Chou, Chu-Hung Chung, Min-Siou Sun, Hung-Wei Cheng, Meng-Ni Ho, Cheng-Wei Li. Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26363315. |
induction of p53 acetylation at lysine382 was involved in cpz-mediated tumor apoptosis, and this induction was attenuated by sirtuin 1 (sirt1), a class iii histone deacetylase. |
2016-08-16 |
2023-08-13 |
human |
| Kamila A Marzec, Mike Z Lin, Janet L Martin, Robert C Baxte. Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26378048. |
chemotherapy drugs that induce apoptosis by causing dna double-strand breaks, upregulate the tumor suppressor p53. |
2016-08-16 |
2023-08-13 |
Not clear |
| Ibrahim Y Abdelrahman, Reham Helwa, Hausein Elkashef, Nagwa H A Hassa. Induction of P3NS1 Myeloma Cell Death and Cell Cycle Arrest by Simvastatin and/or γ-Radiation. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 16. 2016-08-16. PMID:26514497. |
the cell viability, induction of apoptosis, cell death, cell cycling, generation of ros, and expression of p53, bax, bcl2, caspase3, parp1 and fas genes were estimated. |
2016-08-16 |
2023-08-13 |
Not clear |
| Fredrick J Bohanon, Xiaofu Wang, Brittany M Graham, Anesh Prasai, Sadhashiva J Vasudevan, Chunyong Ding, Ye Ding, Geetha L Radhakrishnan, Cristiana Rastellini, Jia Zhou, Ravi S Radhakrishna. Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells. Molecular and cellular biochemistry. vol 410. issue 1-2. 2016-08-15. PMID:26346163. |
after cyd0692 treatment on lx-2 cells, apoptosis and s-phase cell cycle arrest were induced; cleaved-parp, p21, and p53 were activated while cyclin-b1 levels declined. |
2016-08-15 |
2023-08-13 |
human |
| Sijie Zhao, Xinfeng Fei, Te Liu, Yan Li. Low temperature induces cryoinjury in mouse corneal endothelial cells by stimulating the Stk11-p53 signal pathway. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26352900. |
thus, the results of the present study suggest that cryoinjury leads to the damage and apoptosis of mouse cecs by activation of the stk11‑p53 signaling pathway, phosphorylation of p53 serine 15 and p21 gene transcription. |
2016-08-15 |
2023-08-13 |
mouse |
| Bing Z Carter, Po Yee Mak, Duncan H Mak, Vivian R Ruvolo, Wendy Schober, Teresa McQueen, Jorge Cortes, Hagop M Kantarjian, Richard E Champlin, Marina Konopleva, Michael Andreef. Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells. Oncotarget. vol 6. issue 31. 2016-08-15. PMID:26431162. |
these results demonstrate that p53 activation by mdm2 blockade can sensitize bc cml cells, including quiescent cd34+ cells, to bcl-2 inhibitor- and tki-induced apoptosis. |
2016-08-15 |
2023-08-13 |
Not clear |
| Tao Yun, Kaiwen Yu, ShuangShuang Yang, Yifan Cui, Zixi Wang, Huiyu Ren, She Chen, Lin Li, Xiaoyun Liu, Min Fang, Xuejun Jian. Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway. The Journal of biological chemistry. vol 291. issue 14. 2016-08-15. PMID:26851285. |
here we demonstrate that acetylation of p53 at lys-120 up-regulates its transcriptional activity toward apaf-1, a core component in the mitochondrial apoptotic pathway, and thus sensitizes caspase activation and apoptosis. |
2016-08-15 |
2023-08-13 |
Not clear |
| Tao Yun, Kaiwen Yu, ShuangShuang Yang, Yifan Cui, Zixi Wang, Huiyu Ren, She Chen, Lin Li, Xiaoyun Liu, Min Fang, Xuejun Jian. Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway. The Journal of biological chemistry. vol 291. issue 14. 2016-08-15. PMID:26851285. |
therefore, hdac inhibitors can induce p53 acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of apaf-1. |
2016-08-15 |
2023-08-13 |
Not clear |
| Rajkumar S Kalra, Caroline T Cheung, Anupama Chaudhary, Jay Prakash, Sunil C Kaul, Renu Wadhw. CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis. Molecular oncology. vol 9. issue 9. 2016-08-11. PMID:26278998. |
whereas its knockdown caused apoptosis, its over- and super-expressions caused senescence and increase in malignant properties of cancer cells, respectively, and were closely linked to increase and decrease in p53 activity. |
2016-08-11 |
2023-08-13 |
human |
| Haizhi Huang, Allen Y Chen, Xingqian Ye, Bingyun Li, Yon Rojanasakul, Gary O Rankin, Yi Charlie Che. Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. International journal of oncology. vol 47. issue 4. 2016-08-10. PMID:26315556. |
p53, a multifunctional tumor suppressor, regulated apoptosis in ovcar-3 cells through a bcl-2 family protein-dependent pathway. |
2016-08-10 |
2023-08-13 |
Not clear |
| Liang Chen, Daniel P Foreman, Derek B Sant'Angelo, Michael S Krange. Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 6. 2016-08-10. PMID:26843327. |
mechanistically, we found that the increased apoptosis in yy1-deficient thymocytes was attributed to overexpression of p53, because concurrent loss of p53 completely rescued the developmental defects of yy1-deficient thymocytes. |
2016-08-10 |
2023-08-13 |
mouse |
| M Trivedi, M Talekar, P Shah, Q Ouyang, M Amij. Modification of tumor cell exosome content by transfection with wt-p53 and microRNA-125b expressing plasmid DNA and its effect on macrophage polarization. Oncogenesis. vol 5. issue 8. 2016-08-09. PMID:27500388. |
the mirnas in the exosomes were mainly related to the activation of genes associated with apoptosis as well as p53 signaling. |
2016-08-09 |
2023-08-13 |
Not clear |
| SweeKeong Yeap, Muhammad Nadeem Akhtar, Kian Lam Lim, Nadiah Abu, Wan Yong Ho, Seema Zareen, Kiarash Roohani, Huynh Ky, Sheau Wei Tan, Nordin Lajis, Noorjahan Banu Alithee. Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line. Drug design, development and therapy. vol 9. 2016-08-09. PMID:25733816. |
western blot analysis also indicated that the dhaqc (2) increased bax, p53, and cytochrome c levels in mcf-7 cells, which subsequently activated apoptosis as observed in annexin v/propidium iodide and cell cycle analyses. |
2016-08-09 |
2023-08-13 |
human |
| France-Hélène Paradis, Barbara F Hale. Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs. Birth defects research. Part B, Developmental and reproductive toxicology. vol 104. issue 5. 2016-08-09. PMID:26305274. |
moreover, p53, the master regulator of apoptosis, is an established hdac target. |
2016-08-09 |
2023-08-13 |
mouse |
| France-Hélène Paradis, Barbara F Hale. Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs. Birth defects research. Part B, Developmental and reproductive toxicology. vol 104. issue 5. 2016-08-09. PMID:26305274. |
the purpose of this study was to investigate the effects of vpa on p53 signaling and markers of apoptosis during midorganogenesis in vitro limb development. |
2016-08-09 |
2023-08-13 |
mouse |
| France-Hélène Paradis, Barbara F Hale. Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs. Birth defects research. Part B, Developmental and reproductive toxicology. vol 104. issue 5. 2016-08-09. PMID:26305274. |
quantitative rt-pcr and western blots were used to assess the expression of candidate genes and proteins involved in p53 signaling and apoptosis. |
2016-08-09 |
2023-08-13 |
mouse |