| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Waye, Aisha Naeem, Muhammad Umer Choudhry, Erika Parasido, Lucas Tricoli, Angiela Sivakumar, John P Mikhaiel, Venkata Yenugonda, Olga C Rodriguez, Sana D Karam, Brian R Rood, Maria Laura Avantaggiati, Chris Albanes. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging. vol 7. issue 10. 2016-09-06. PMID:26540407. |
the inhibition of p53 in the presence of vmy revealed increased late stage apoptosis, increased dna fragmentation and increased expression of genes involved in apoptosis, including capn12 and trpm8, p63, p73, bik, endog, cideb, p27kip1 and p21cip1. |
2016-09-06 |
2023-08-13 |
human |
| Ping Yan, Hui Gong, Xiaoyan Zhai, Yi Feng, Jun Wu, Sheng He, Jian Guo, Xiaoxia Wang, Rui Guo, Jun Xie, Ren-Ke L. Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. The American journal of pathology. vol 186. issue 4. 2016-09-06. PMID:26835537. |
the p53 activation increased cyclin-dependent kinase inhibitor p21 and decreased cyclin-dependent kinase 2, thereby inhibiting tumor cell growth, inducing cell apoptosis, and reducing angiogenesis both in vitro and in vivo. |
2016-09-06 |
2023-08-13 |
mouse |
| Ping Yan, Hui Gong, Xiaoyan Zhai, Yi Feng, Jun Wu, Sheng He, Jian Guo, Xiaoxia Wang, Rui Guo, Jun Xie, Ren-Ke L. Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. The American journal of pathology. vol 186. issue 4. 2016-09-06. PMID:26835537. |
cnpy2 may play a critical role in crc development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway. |
2016-09-06 |
2023-08-13 |
mouse |
| Thangavelu Soundara Rajan, Gina Rosalinda De Nicola, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzo. Anticancer activity of glucomoringin isothiocyanate in human malignant astrocytoma cells. Fitoterapia. vol 110. 2016-09-06. PMID:26882972. |
moringin showed to be effective in inducing apoptosis through p53 and bax activation and bcl-2 inhibition. |
2016-09-06 |
2023-08-13 |
human |
| Masaru Matsumoto, Wataru Nakajima, Masahiro Seike, Akihiko Gemma, Nobuyuki Tanak. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochemical and biophysical research communications. vol 473. issue 2. 2016-09-06. PMID:26996126. |
cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on bax- and bak-induction pathway and synergistically activated by bh3-mimetic abt-263 in p53 wild-type and mutant cells. |
2016-09-06 |
2023-08-13 |
human |
| Masaru Matsumoto, Wataru Nakajima, Masahiro Seike, Akihiko Gemma, Nobuyuki Tanak. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochemical and biophysical research communications. vol 473. issue 2. 2016-09-06. PMID:26996126. |
from this result, we tested the effect of abt-263 (navitoclax), the specific inhibitor of bcl-2 and bcl-xl, but not mcl-1, and found that abt-263 synergistically enhanced cisplatin-induced apoptosis in nsclc cells in the presence or absence of p53. |
2016-09-06 |
2023-08-13 |
human |
| Wanjing Zou, Shu Yang, Tie Zhang, Haimei Sun, Yuying Wang, Hong Xue, Deshan Zho. Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells. Journal of bone and mineral metabolism. vol 33. issue 6. 2016-09-05. PMID:25230819. |
moreover, overexpression of akt abrogated the mpsl activation of p53, p21, and cleaved caspase 3 and the attenuation of cyclin d1 expression and rescued osteoblasts from mpsl-induced cell cycle arrest and apoptosis, indicating that phosphatidylinositol 3-kinase (pi3k)/akt signaling might play an essential role in mpsl-induced inhibition of osteoblasts. |
2016-09-05 |
2023-08-13 |
Not clear |
| b' A Rodr\\xc3\\xadguez-Hern\\xc3\\xa1ndez, E Navarro-Villar\\xc3\\xa1n, R Gonz\\xc3\\xa1lez, S Pereira, L B Soriano-De Castro, A Sarrias-Gim\\xc3\\xa9nez, L Barrera-Pulido, J M \\xc3\\x81lamo-Mart\\xc3\\xadnez, A Serrablo-Requejo, G Blanco-Fern\\xc3\\xa1ndez, A Nogales-Mu\\xc3\\xb1oz, A Gila-Boh\\xc3\\xb3rquez, D Pacheco, M A Torres-Nieto, J Serrano-D\\xc3\\xadaz-Canedo, G Su\\xc3\\xa1rez-Artacho, C Bernal-Bellido, L M Mar\\xc3\\xadn-G\\xc3\\xb3mez, J A Barcena, M A G\\xc3\\xb3mez-Bravo, C A Padilla, F J Padillo, J Muntan\\xc3\\xa. Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells. Redox biology. vol 6. 2016-09-02. PMID:26233703.' |
the overexpression of nitric oxide synthase type iii (nos-3) induces oxidative and nitrosative stress, p53 and cell death receptor expression and apoptosis in hepatoblastoma cells. |
2016-09-02 |
2023-08-13 |
Not clear |
| Gabriela Hollmann, Rafael Linden, Angela Giangrande, Silvana Allod. Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean. Aquatic toxicology (Amsterdam, Netherlands). vol 173. 2016-09-02. PMID:26807499. |
increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean. |
2016-09-02 |
2023-08-13 |
Not clear |
| Gabriela Hollmann, Rafael Linden, Angela Giangrande, Silvana Allod. Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean. Aquatic toxicology (Amsterdam, Netherlands). vol 173. 2016-09-02. PMID:26807499. |
ultraviolet (uv) radiation can produce biological damage, leading the cell to apoptosis by the p53 pathway. |
2016-09-02 |
2023-08-13 |
Not clear |
| Gabriela Hollmann, Rafael Linden, Angela Giangrande, Silvana Allod. Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean. Aquatic toxicology (Amsterdam, Netherlands). vol 173. 2016-09-02. PMID:26807499. |
after the fifth day of exposure, uvb radiation and sim increased the protein content of p53, increasing the content of akt and, somehow, blocking p21, increasing the content of activated caspase-3, which led the cells to apoptosis. |
2016-09-02 |
2023-08-13 |
Not clear |
| Gabriela Hollmann, Rafael Linden, Angela Giangrande, Silvana Allod. Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean. Aquatic toxicology (Amsterdam, Netherlands). vol 173. 2016-09-02. PMID:26807499. |
in conclusion, environmental doses of uv can cause apoptosis by increasing p53 and decreasing p21, revealing an uv-damage pathway for u. cordatus. |
2016-09-02 |
2023-08-13 |
Not clear |
| J Zhu, C Zhao, T Zhuang, P Jonsson, I Sinha, C Williams, S Strömblad, K Dahlman-Wrigh. RING finger protein 31 promotes p53 degradation in breast cancer cells. Oncogene. vol 35. issue 15. 2016-09-01. PMID:26148235. |
interestingly, rnf31 decreased p53 stability, whereas depletion of rnf31 in breast cancer cells caused cell cycle arrest and cisplatin-induced apoptosis in a p53-dependent manner. |
2016-09-01 |
2023-08-13 |
human |
| X Chen, N Gohain, C Zhan, W-Y Lu, M Pazgier, W L. Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene. vol 35. issue 15. 2016-09-01. PMID:26148237. |
under stressed conditions such as dna damage, p53 escapes mdm2- and mdmx-mediated functional inhibition and degradation, acting to prevent damaged cells from proliferating through induction of cell cycle arrest, dna repair, senescence or apoptosis. |
2016-09-01 |
2023-08-13 |
Not clear |
| Martin Breuss, Tanja Fritz, Thomas Gstrein, Kelvin Chan, Lyubov Ushakova, Nuo Yu, Frederick W Vonberg, Barbara Werner, Ulrich Elling, David A Keay. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development (Cambridge, England). vol 143. issue 7. 2016-08-31. PMID:26903504. |
these mice present with profound microcephaly due to a loss of upper-layer neurons that correlates with massive apoptosis and upregulation of p53. |
2016-08-31 |
2023-08-13 |
mouse |
| Hong-Xia Zhang, Shan-Shan Jiang, Xiao-Fei Zhang, Zi-Qi Zhou, Qiu-Zhong Pan, Chang-Long Chen, Jing-Jing Zhao, Yan Tang, Jian-Chuan Xia, De-Sheng Wen. Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma. Oncotarget. vol 6. issue 33. 2016-08-30. PMID:26430962. |
ck2α-silenced resulted in significant apoptosis in cells that was demonstrated been associated with downregulation of expression of bcl-2, p-akt (ser473) and upregulation of expression of total p53, p-p53, bax, caspase3 and cleaved-caspase3 in hcc cells. |
2016-08-30 |
2023-08-13 |
mouse |
| Fung-Yu Huang, Danny Ka-Ho Wong, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yue. Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development. Oncotarget. vol 6. issue 33. 2016-08-30. PMID:26439986. |
estradiol induces apoptosis via activation of mirna-23a and p53: implication for gender difference in liver cancer development. |
2016-08-30 |
2023-08-13 |
Not clear |
| Xiufang Song, Lingrui Li, Qiong Shi, Hans-Joachim Lehmler, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Son. Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells. Chemical research in toxicology. vol 28. issue 11. 2016-08-30. PMID:26451628. |
moreover, p53 plays a pivotal role in pcb29-pq-induced cell cycle arrest and apoptosis via the activation of atm/chk2 and atr/chk1 checkpoints. |
2016-08-30 |
2023-08-13 |
human |
| Csaba Tóth, Jeannine Meinrath, Esther Herpel, Jutta Derix, Jochen Fries, Reinhard Buettner, Peter Schirmacher, Sebastian Heikau. Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. Journal of cancer research and clinical oncology. vol 142. issue 5. 2016-08-30. PMID:26721253. |
expression of the apoptosis repressor with caspase recruitment domain (arc) in liver metastasis of colorectal cancer and its correlation with dna mismatch repair proteins and p53. |
2016-08-30 |
2023-08-13 |
Not clear |
| B Zhang, M Rotelli, M Dixon, B R Calv. The function of Drosophila p53 isoforms in apoptosis. Cell death and differentiation. vol 22. issue 12. 2016-08-29. PMID:25882045. |
the function of drosophila p53 isoforms in apoptosis. |
2016-08-29 |
2023-08-13 |
drosophila_melanogaster |