| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mukesh K Jaiswal, Varkha Agrawal, Gajendra K Katara, Sahithi Pamarthy, Arpita Kulshrestha, Gerard Chaouat, Alice Gilman-Sachs, Kenneth D Beama. Male fertility and apoptosis in normal spermatogenesis are regulated by vacuolar-ATPase isoform a2. Journal of reproductive immunology. vol 112. 2016-08-29. PMID:26226211. |
the expression of pro-apoptotic molecules (bax, p53, and p21) and molecules involved in the intrinsic pathway of apoptosis (caspase-9, caspase-3, and parp), which are crucial for normal spermatogenesis was significantly reduced in testes from anti-a2v-treated males compared with the control. |
2016-08-29 |
2023-08-13 |
mouse |
| Zhaosong Meng, Guoqing Chen, Jinlong Chen, Bo Yang, Mei Yu, Lian Feng, Zongting Jiang, Weihua Guo, Weidong Tia. Tumorigenicity analysis of heterogeneous dental stem cells and its self-modification for chromosome instability. Cell cycle (Georgetown, Tex.). vol 14. issue 21. 2016-08-29. PMID:26322910. |
cell apoptosis were not detected in sub-clones, which exhibited strong tumorigenesis tendency, coupled with weak expression of p53 and aberrant ultra-structure. |
2016-08-29 |
2023-08-13 |
Not clear |
| Jinlian Wei, Yingrui Yang, Mengchen Lu, Lili Xu, Fang Liu, Zhenwei Yuan, Qichao Bao, Zhengyu Jiang, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Qidong You, Haopeng Su. Escape, or Vanish: Control the Fate of p53 through MDM2-Mediated Ubiquitination. Anti-cancer agents in medicinal chemistry. vol 16. issue 2. 2016-08-29. PMID:26343143. |
p53 protein is a prominent tumor suppressor to induce cell cycle arrest, apoptosis and senescence, which attracts significant interest to cancer treatment. |
2016-08-29 |
2023-08-13 |
Not clear |
| Ignacio López, Anne-Sophie Tournillon, Karin Nylander, Robin Fåhraeu. p53-mediated control of gene expression via mRNA translation during Endoplasmic Reticulum stress. Cell cycle (Georgetown, Tex.). vol 14. issue 21. 2016-08-29. PMID:26397130. |
p53 is activated by different stress and damage pathways and regulates cell biological responses including cell cycle arrest, repair pathways, apoptosis and senescence. |
2016-08-29 |
2023-08-13 |
Not clear |
| Xin Li, Xiao Miao, Hongshen Wang, Zhixiang Xu, Bin L. The tissue dependent interactions between p53 and Bcl-2 in vivo. Oncotarget. vol 6. issue 34. 2016-08-29. PMID:26452131. |
to further investigate the role of p53 in apoptosis in vivo and the interaction between p53 and bcl-2 in the regulation of cellular apoptosis in vivo, we depleted p53 in bcl-2-null mice. |
2016-08-29 |
2023-08-13 |
mouse |
| Xin Li, Xiao Miao, Hongshen Wang, Zhixiang Xu, Bin L. The tissue dependent interactions between p53 and Bcl-2 in vivo. Oncotarget. vol 6. issue 34. 2016-08-29. PMID:26452131. |
furthermore, p53 deficiency overcomes loss of melanocyte stem cell (msc)-induced apoptosis and subsequently prevents hair graying in bcl-2- null mice. |
2016-08-29 |
2023-08-13 |
mouse |
| Xin Li, Xiao Miao, Hongshen Wang, Zhixiang Xu, Bin L. The tissue dependent interactions between p53 and Bcl-2 in vivo. Oncotarget. vol 6. issue 34. 2016-08-29. PMID:26452131. |
in addition, p53 deletion partly inhibits apoptosis in hair follicle keratinocytes, leading to the alleviation of hair growth delay in bcl-2-null mice. |
2016-08-29 |
2023-08-13 |
mouse |
| Olivier Albagl. [Punish or cherish: p53, metabolism and tumor suppression]. Medecine sciences : M/S. vol 31. issue 10. 2016-08-29. PMID:26481026. |
upon genotoxic or oncogenic stresses, increased p53 activity induces transient cell cycle arrest, senescence or apoptosis, the three cornerstones of the so-called triumvirate. |
2016-08-29 |
2023-08-13 |
mouse |
| Olivier Albagl. [Punish or cherish: p53, metabolism and tumor suppression]. Medecine sciences : M/S. vol 31. issue 10. 2016-08-29. PMID:26481026. |
conversely, destructive activities elicited by high p53 levels and leading to senescence or apoptosis provide a shield against partially or overtly transformed cells. |
2016-08-29 |
2023-08-13 |
mouse |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
trigonella foenum (fenugreek) induced apoptosis in hepatocellular carcinoma cell line, hepg2, mediated by upregulation of p53 and proliferating cell nuclear antigen. |
2016-08-29 |
2023-08-13 |
Not clear |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
growth-inhibitory effect and apoptosis induction of hepg2 cells were evidenced by mtt assay, cell morphology alteration, apoptosis enzyme-linked immunosorbent assay, flow cytometric analysis, caspase-3 activity, and expression of p53, proapoptotic protein, bax, and proliferating cell nuclear antigen (pcna) after (100 ∼ 500 μg/ml) fce treatment for 48 h. furthermore, fce was analyzed by chromatography-mass spectrometry (gc/ms). |
2016-08-29 |
2023-08-13 |
Not clear |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
our results revealed that fce treatment for 48 h showed a cytotoxic effect and apoptosis induction in a dose-dependent manner that was mediated by upregulation of p53, bax, pcna, and caspase-3 activation in hepg2 cells. |
2016-08-29 |
2023-08-13 |
Not clear |
| Mahmoud I M Khalil, Mohamed M Ibrahim, Gehan A El-Gaaly, Ahmed S Sulta. Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed research international. vol 2015. 2016-08-29. PMID:26557712. |
our data introduced fce as a promising nontoxic herbal with therapeutic potential to induce apoptosis in hepg2 cells through p53, bax, and pcna upregulation in caspase-3 dependent manner. |
2016-08-29 |
2023-08-13 |
Not clear |
| Shulan Ma, Rongfei Jia, Dongju Li, Bo She. Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells. BioMed research international. vol 2015. 2016-08-26. PMID:26558272. |
2dg significantly inhibited the viability of mcf-7/mdr cells and enhanced dox-induced apoptosis by upregulating protein expression of ampkα, p53, and caspase-3. |
2016-08-26 |
2023-08-13 |
human |
| Matthew Jennis, Che-Pei Kung, Subhasree Basu, Anna Budina-Kolomets, Julia I-Ju Leu, Sakina Khaku, Jeremy P Scott, Kathy Q Cai, Michelle R Campbell, Devin K Porter, Xuting Wang, Douglas A Bell, Xiaoxian Li, David S Garlick, Qin Liu, Monica Hollstein, Donna L George, Maureen E Murph. An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model. Genes & development. vol 30. issue 8. 2016-08-26. PMID:27034505. |
here we report that, in human cell lines and a mouse model, the s47 variant exhibits a modest decrease in apoptosis in response to most genotoxic stresses compared with wild-type p53 but exhibits a significant defect in cell death induced by cisplatin. |
2016-08-26 |
2023-08-13 |
mouse |
| Lv-Cui Zhao, Jing Li, Ke Liao, Nian Luo, Qing-Qiang Shi, Zi-Qiang Feng, Di-Long Che. Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. International journal of molecular sciences. vol 16. issue 11. 2016-08-24. PMID:26580615. |
taken together, our results suggest that evo modulates the activity of the p53 signaling pathway to induce apoptosis and downregulate mmp3 expression by inactivating the jak2/stat3 pathway through the downregulation of pgi to inhibit migration of hct-116 human colorectal cancer cells. |
2016-08-24 |
2023-08-13 |
human |
| Bhaswati Banerjee, Supriya Chakraborty, Debidas Ghosh, Sanghamitra Raha, Parimal C Sen, Kuladip Jan. Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol. Frontiers in pharmacology. vol 7. 2016-08-23. PMID:27551266. |
benzo(a)pyrene induced p53 mediated male germ cell apoptosis: synergistic protective effects of curcumin and resveratrol. |
2016-08-23 |
2023-08-13 |
rat |
| Bhaswati Banerjee, Supriya Chakraborty, Debidas Ghosh, Sanghamitra Raha, Parimal C Sen, Kuladip Jan. Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol. Frontiers in pharmacology. vol 7. 2016-08-23. PMID:27551266. |
our present study in isolated testicular germ cell population from adult male wistar rats, highlighted the synergistic protective effect of curcumin and resveratrol against b(a)p induced p53 mediated germ cell apoptosis. |
2016-08-23 |
2023-08-13 |
rat |
| Bhaswati Banerjee, Supriya Chakraborty, Debidas Ghosh, Sanghamitra Raha, Parimal C Sen, Kuladip Jan. Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol. Frontiers in pharmacology. vol 7. 2016-08-23. PMID:27551266. |
the study concludes that curcumin-resveratrol synergistically modulated mapks and p53, prevented oxidative stress, regulated the expression of pro and anti-apoptotic proteins as well as the proteins involved in b(a)p metabolism thus protected germ cells from b(a)p induced apoptosis. |
2016-08-23 |
2023-08-13 |
rat |
| S Shirazi Fard, Mke Blixt, F Hallböö. The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells. Cell death discovery. vol 1. 2016-08-23. PMID:27551456. |
the p53 co-activator zac1 neither induces cell cycle arrest nor apoptosis in chicken lim1 horizontal progenitor cells. |
2016-08-23 |
2023-08-13 |
mouse |