| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Wu, C Xu, X Ling, C Fan, B P Buckley, M V Chernov, L Ellis, F Li, I G Muñoz, X Wan. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell death & disease. vol 6. 2016-09-19. PMID:26720344. |
owing to the distinct mechanisms of action of mmri64 and nutlin3a, their combination synergistically induces p53 and apoptosis. |
2016-09-19 |
2023-08-13 |
mouse |
| Canan Eroğlu, Mücahit Seçme, Pelin Atmaca, Oğuzhan Kaygusuz, Kutret Gezer, Gülseren Bağcı, Yavuz Dodurg. Extract of Calvatia gigantea inhibits proliferation of A549 human lung cancer cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26820971. |
c. gigantea extract induced cell cycle arrest and apoptosis by decreasing the ccnd1, ccnd2, cdk4, akt and bcl-2 expression and by increasing bax, p53, caspase-3 and caspase-9 expression in a549 cells. |
2016-09-16 |
2023-08-13 |
human |
| Jian Li, Fang Wang, Jun Zhou, Wenwen L. [Effects of tanshinone IIA on the expressions of p53, pp53 and apoptosis in the rats with Alzheimer's disease]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 40. issue 11. 2016-09-15. PMID:26643424. |
[effects of tanshinone iia on the expressions of p53, pp53 and apoptosis in the rats with alzheimer's disease]. |
2016-09-15 |
2023-08-13 |
rat |
| Jian Li, Fang Wang, Jun Zhou, Wenwen L. [Effects of tanshinone IIA on the expressions of p53, pp53 and apoptosis in the rats with Alzheimer's disease]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 40. issue 11. 2016-09-15. PMID:26643424. |
to observe effects of tanshinone (tan) iia on the apoptosis and expressions of p53 and pp53 in brain tissues of rats with alzheimer's disease (ad).
|
2016-09-15 |
2023-08-13 |
rat |
| Ensaf M Al-Hujaily, Yong Tang, De-Sheng Yao, Euridice Carmona, Kenneth Garson, Barbara C Vanderhyde. Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer. Cancer prevention research (Philadelphia, Pa.). vol 8. issue 12. 2016-09-14. PMID:26373819. |
in rm cells (mose transformed by k-ras and c-myc), pax2 expression inhibited p53 and induced perk1/2 and cox2, resulting in enhanced angiogenesis and decreased apoptosis of tumors arising from these cells. |
2016-09-14 |
2023-08-13 |
Not clear |
| Shashi Rajput, Nagaprasad Puvvada, B N Prashanth Kumar, Siddik Sarkar, Suraj Konar, Rashmi Bharti, Goutam Dey, Abhijit Mazumdar, Amita Pathak, Paul B Fisher, Mahitosh Manda. Overcoming Akt Induced Therapeutic Resistance in Breast Cancer through siRNA and Thymoquinone Encapsulated Multilamellar Gold Niosomes. Molecular pharmaceutics. vol 12. issue 12. 2016-09-14. PMID:26505213. |
immunoblot studies revealed enhanced apoptosis by inducing p53 and inhibiting mdm2 expression, which was consistent with in vivo xenograft studies. |
2016-09-14 |
2023-08-13 |
Not clear |
| Jincheng Li, Lynn Htet Htet Aung, Bo Long, Danian Qin, Shejuan An, Peifeng L. miR-23a binds to p53 and enhances its association with miR-128 promoter. Scientific reports. vol 5. 2016-09-14. PMID:26553132. |
in exploring the molecular mechanism by which mir-23a promotes apoptosis, we found that it sensitized the effect of p53 on mir-128 regulation. |
2016-09-14 |
2023-08-13 |
Not clear |
| V Kh Khavinson, N S Linkova, E O Kukanova, O A Orlov. [Molecular Mechanisms of Functional Activity Decreasing of the Skin Cells With Its Aging]. Uspekhi fiziologicheskikh nauk. vol 47. issue 2. 2016-09-13. PMID:27530044. |
molecules of apoptosis and cells skin aging are p53, p21, p15, cdk 4/6 and bcl-2. |
2016-09-13 |
2023-08-13 |
Not clear |
| Changjing Zhuge, Xiaojuan Sun, Yingyu Chen, Jinzhi Le. PDCD5 functions as a regulator of p53 dynamics in the DNA damage response. Journal of theoretical biology. vol 388. 2016-09-13. PMID:26433055. |
programmed cell death 5 (pdcd5) interacts with the p53 pathway to promote cell apoptosis. |
2016-09-13 |
2023-08-13 |
human |
| X Zhu, H Zhao, Z Lin, G Zhan. Functional studies of miR-130a on the inhibitory pathways of apoptosis in patients with chronic myeloid leukemia. Cancer gene therapy. vol 22. issue 12. 2016-09-13. PMID:26494558. |
transfection of mir130a mimics into cml cells from 30 patients without p53 aberrations led to significant increases in apoptosis compared with transfection with the mirna control. |
2016-09-13 |
2023-08-13 |
Not clear |
| Eline Boons, Els Vanstreels, Maarten Jacquemyn, Tatiane C Nogueira, Jasper E Neggers, Thomas Vercruysse, Joost van den Oord, Sharon Tamir, Sharon Shacham, Yosef Landesman, Robert Snoeck, Christophe Pannecouque, Graciela Andrei, Dirk Daeleman. Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma. EBioMedicine. vol 2. issue 9. 2016-09-12. PMID:26501108. |
at the same time, sine caused the nuclear accumulation of p53 tumor suppressor protein as well as inhibition of nf-κb activity in pel cells resulting in cell cycle arrest and effective apoptosis induction. |
2016-09-12 |
2023-08-13 |
mouse |
| Lei Cao, Lei Fan, Wei Xu, Jian-Yong L. Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies. Current cancer drug targets. vol 15. issue 9. 2016-09-12. PMID:26567881. |
tumor suppressor protein p53 plays a crucial role in cell cycle arrest, apoptosis and homeostasis. |
2016-09-12 |
2023-08-13 |
mouse |
| Serkan Senol, Asif Yildirim, Bahar Ceyran, Fatih Uruc, Ebru Zemheri, Seyma Ozkanli, Ibrahim Akalin, Ismail Ulus, Turhan Caskurlu, Abdullah Aydi. Prognostic significance of survivin, β-catenin and p53 expression in urothelial carcinoma. Bosnian journal of basic medical sciences. vol 15. issue 4. 2016-09-12. PMID:26614845. |
survivin, β-catenin, and p53 are well-known cell-cycle and apoptosis regulators of tumorigenesis. |
2016-09-12 |
2023-08-13 |
human |
| Tenghui Dong, Meiying Zhang, Yan Dong, James G Herman, Manon van Engeland, Guanglin Zhong, Mingzhou Gu. Methylation of RASSF10 promotes cell proliferation and serves as a docetaxel resistant marker in human breast cancer. Discovery medicine. vol 20. issue 111. 2016-09-12. PMID:26645898. |
rassf10 induced apoptosis and activated p53 signaling in breast cancer cells. |
2016-09-12 |
2023-08-13 |
human |
| Mohan Shrestha, Pil-Hoon Par. p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 5. 2016-09-09. PMID:27610035. |
in addition, we also showed that knockdown of p53 restored suppression of caspase-3 activity by leptin through modulating bax expression and prevented leptin-induced cell cycle progression, implying the involvement of p53 signaling in the regulation of both apoptosis and cell cycle progression in cancer cells treated with leptin. |
2016-09-09 |
2023-08-13 |
Not clear |
| Michael Koldehoff, Monika Lindemann, Bertram Opalka, Sebastian Bauer, Rudolf Stefan Ross, Ahmet H Elmaagacl. Cytomegalovirus induces apoptosis in acute leukemia cells as a virus-versus-leukemia function. Leukemia & lymphoma. vol 56. issue 11. 2016-09-09. PMID:25818505. |
although hcmv induced a significant up-regulation of the anti-apoptotic gene cflip and the anti-stress gene gadd45a, and simultaneously down-regulated the pro-apoptotic genes p53, gadd45gamma in kasumi-1 and sd-1 cells, we found that these anti-apoptotic mechanisms failed in hcmv-infected acute leukemia cells and apoptosis occurred via a caspase-dependent pathway. |
2016-09-09 |
2023-08-13 |
Not clear |
| Shu-Ling Hsieh, Chi-Tsai Chen, Jyh-Jye Wang, Yu-Hao Kuo, Chien-Chun Li, Lan-Chi Hsieh, Chih-Chung W. Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. International journal of oncology. vol 47. issue 6. 2016-09-07. PMID:26500073. |
in addition, sn treatment upregulated nuclear p53 and damage-regulated autophagy modulator (dram) and downregulated cytosolic p53 and tp53-induced glycolysis and apoptosis regulator (tigar) expression in j5 cells. |
2016-09-07 |
2023-08-13 |
human |
| C Huang, G F Zhang, J Han, G J Liao, B G Zo. Mechanism of age-related changes of bone marrow mesenchymal stem cells in senile osteoporosis. Journal of biological regulators and homeostatic agents. vol 30. issue 2. 2016-09-06. PMID:27358149. |
bmmscs aging-associated protein acetylation p53, p21 and p16 expressions in young and senile mice, protein expression of telomerase reverse transcriptase (tert) as well as reactive oxygen species (ros) level were detected and compared; the expression of bmmscs autophagy associated gene, autophagy related protein molecule and lc3 molecule were detected; the influence of differently concentrated rapamycin and 3-ma on bmmscs autophagy level was observed to select effective concentrations; the influence of rapamycin and 3-ma on bmmscs cell cycle-related gene expression, apoptosis related gene expression and ros level were discussed. |
2016-09-06 |
2023-08-13 |
mouse |
| C Huang, G F Zhang, J Han, G J Liao, B G Zo. Mechanism of age-related changes of bone marrow mesenchymal stem cells in senile osteoporosis. Journal of biological regulators and homeostatic agents. vol 30. issue 2. 2016-09-06. PMID:27358149. |
it can therefore be concluded that senile bmmscs have multiple age-related changes, performing as decrease of osteogenic capability and multiplication capacity, increase of acetylation p53, p21 and p16 protein expression, apoptosis and ros level as well as decrease of telomerase activity. |
2016-09-06 |
2023-08-13 |
mouse |
| Sarah Waye, Aisha Naeem, Muhammad Umer Choudhry, Erika Parasido, Lucas Tricoli, Angiela Sivakumar, John P Mikhaiel, Venkata Yenugonda, Olga C Rodriguez, Sana D Karam, Brian R Rood, Maria Laura Avantaggiati, Chris Albanes. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging. vol 7. issue 10. 2016-09-06. PMID:26540407. |
the p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. |
2016-09-06 |
2023-08-13 |
human |