| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luiz Gustavo A Chuffa, Michelly S Alves, Marcelo Martinez, Isabel Cristina C Camargo, Patricia F F Pinheiro, Raquel F Domeniconi, Luiz Antonio L Júnior, Francisco Eduardo Martine. Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma. Endocrine-related cancer. vol 23. issue 2. 2016-10-05. PMID:26555801. |
notably, mel therapy and etoh intake promoted apoptosis along with the upregulation of p53, bax, and cleaved caspase-3. |
2016-10-05 |
2023-08-13 |
rat |
| Ruchi Saxena, Garima Gupta, Murli Manohar, Utsab Debnath, Pooja Popli, Yenamandra S Prabhakar, Rituraj Konwar, Sandeep Kumar, Atul Kumar, Anila Dwived. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. The international journal of biochemistry & cell biology. vol 70. 2016-10-05. PMID:26556313. |
spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. |
2016-10-05 |
2023-08-13 |
Not clear |
| Ruchi Saxena, Garima Gupta, Murli Manohar, Utsab Debnath, Pooja Popli, Yenamandra S Prabhakar, Rituraj Konwar, Sandeep Kumar, Atul Kumar, Anila Dwived. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. The international journal of biochemistry & cell biology. vol 70. 2016-10-05. PMID:26556313. |
the activation of p53 led to upregulation of p53 dependent pro-apoptotic proteins, bax, pumaα and noxa and enhanced interaction of p53 with bcl2 member proteins thus triggering both transcription-dependent and transcription-independent apoptosis, respectively. |
2016-10-05 |
2023-08-13 |
Not clear |
| Ling Hui, Chunyan Sang, Donghong Wang, Xiaohui Wang, Meiliang Wang, Qinghua Jia, Mingren Ma, Shiwu Che. Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non-small cell lung cancer cells in vitro. Molecular medicine reports. vol 13. issue 1. 2016-10-05. PMID:26573436. |
furthermore, lj12 induced tumor cell apoptosis and the protein expression of b cell lymphoma‑2‑associated x protein, caspase‑3 and p53. |
2016-10-05 |
2023-08-13 |
human |
| Nafiseh Sadat Alamolhodaei, Kobra Shirani, Gholamreza Karim. Arsenic cardiotoxicity: An overview. Environmental toxicology and pharmacology. vol 40. issue 3. 2016-10-05. PMID:26606645. |
several evidences have shown that mitochondrial disruption, caspase activation, mapk signaling and p53 are the pathways for arsenic induced apoptosis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Mei-Hua Bao, Jian-Ming Li, Qi-Liang Zhou, Guang-Yi Li, Jie Zeng, Juan Zhao, Yi-Wen Zhan. Effects of miR‑590 on oxLDL‑induced endothelial cell apoptosis: Roles of p53 and NF‑κB. Molecular medicine reports. vol 13. issue 1. 2016-10-05. PMID:26648441. |
effects of mir‑590 on oxldl‑induced endothelial cell apoptosis: roles of p53 and nf‑κb. |
2016-10-05 |
2023-08-13 |
Not clear |
| Mei-Hua Bao, Jian-Ming Li, Qi-Liang Zhou, Guang-Yi Li, Jie Zeng, Juan Zhao, Yi-Wen Zhan. Effects of miR‑590 on oxLDL‑induced endothelial cell apoptosis: Roles of p53 and NF‑κB. Molecular medicine reports. vol 13. issue 1. 2016-10-05. PMID:26648441. |
the overexpression of mir‑590 inhibited oxldl‑induced endothelial cell apoptosis, expression of p53 and bax, reduction of bcl‑2 and activation of caspase‑3. |
2016-10-05 |
2023-08-13 |
Not clear |
| Koji Kajitani, Ken-Ichi Honda, Hiroyuki Terada, Tomoyo Yasui, Toshiyuki Sumi, Masayasu Koyama, Osamu Ishik. Human Papillomavirus E6 Knockdown Restores Adenovirus Mediated-estrogen Response Element Linked p53 Gene Transfer in HeLa Cells. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 18. 2016-10-05. PMID:26745067. |
apoptosis, as measured by annexin v binding, was higher after adenovirus-mediated ere-linked p53 gene (proline variant at codon 72) transfer compared with that after non-ere-linked p53 gene transfer in sirna-treated cells. |
2016-10-05 |
2023-08-13 |
human |
| Jalil Pirayesh Islamian, Fahimeh Aghaee, Alireza Farajollahi, Behzad Baradaran, Mona Faze. Combined Treatment with 2-Deoxy-D-Glucose and Doxorubicin Enhances the in Vitro Efficiency of Breast Cancer Radiotherapy. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 18. 2016-10-05. PMID:26745097. |
we have studied the effects of 1μm dox and 500 μm 2dg on radiation induced cell death, apoptosis and also on the expression levels of p53 and pten genes in t47d and skbr3 breast cancer cells irradiated with 100, 150 and 200 cgy x-rays. |
2016-10-05 |
2023-08-13 |
Not clear |
| Qing-jun Liu, Hong-liang Shen, Jun Lin, Xiu-hong Xu, Zheng-guo Ji, Xiao Han, Dong-hao Shang, Pei-qian Yan. Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways. Drug design, development and therapy. vol 10. 2016-10-05. PMID:26937175. |
synergistic roles of p53 and hif1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mtor and mdm2 signaling pathways. |
2016-10-05 |
2023-08-13 |
human |
| Reshma Thamkachy, Rohith Kumar, K N Rajasekharan, Suparna Sengupt. ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells. Molecular cancer. vol 15. 2016-09-30. PMID:26956619. |
erk mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole dat1 induced apoptosis in colon cancer models: efficiency of dat1 in ras-raf mutated cells. |
2016-09-30 |
2023-08-13 |
Not clear |
| Reshma Thamkachy, Rohith Kumar, K N Rajasekharan, Suparna Sengupt. ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells. Molecular cancer. vol 15. 2016-09-30. PMID:26956619. |
p53 is a tumour suppressor protein that plays a key role in many steps of apoptosis, and malfunctioning of this transcription factor leads to tumorigenesis. |
2016-09-30 |
2023-08-13 |
Not clear |
| Reshma Thamkachy, Rohith Kumar, K N Rajasekharan, Suparna Sengupt. ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells. Molecular cancer. vol 15. 2016-09-30. PMID:26956619. |
most of the clinically used anticancer compounds activate p53 dependent pathway of apoptosis and hence require p53 for their mechanism of action. |
2016-09-30 |
2023-08-13 |
Not clear |
| Correction: p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. Cancer research. vol 76. issue 6. 2016-09-30. PMID:26979793. |
correction: p53: protection against tumor growth beyond effects on cell cycle and apoptosis. |
2016-09-30 |
2023-08-13 |
Not clear |
| Ket Hing Chong, Sandhya Samarasinghe, Don Kulasir. Mathematical modelling of p53 basal dynamics and DNA damage response. Mathematical biosciences. vol 259. 2016-09-29. PMID:25433195. |
the p53 tumour suppressor protein is a transcription factor that activates genes that result in cell cycle arrest, dna damage repair, senescence or apoptosis. |
2016-09-29 |
2023-08-13 |
Not clear |
| Claudia Claus, Lena Manssen, Denise Hübner, Sarah Roßmark, Viktoria Bothe, Alice Petzold, Claudia Große, Mareen Reins, Annette Mankertz, Teryl K Frey, Uwe G Lieber. Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection. Viruses. vol 7. issue 12. 2016-09-29. PMID:26703711. |
in summary, the results presented indicate that the transcription-independent mitochondrial p53 program contributes to rv-induced apoptosis. |
2016-09-29 |
2023-08-13 |
Not clear |
| D G Mercurio, T A L Wagemaker, V M Alves, C G Benevenuto, L R Gaspar, P M B G Maia Campo. In vivo photoprotective effects of cosmetic formulations containing UV filters, vitamins, Ginkgo biloba and red algae extracts. Journal of photochemistry and photobiology. B, Biology. vol 153. 2016-09-28. PMID:26402714. |
immunohistochemical analysis showed that uv radiation caused an increase in the expression of p53 and active caspase-3, confirming that the damage caused by uv radiation exposure led to apoptosis. |
2016-09-28 |
2023-08-13 |
mouse |
| Wen-Jing Lu, Mei-Sze Chua, Samuel K S. Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling. Oncotarget. vol 6. issue 39. 2016-09-28. PMID:26497681. |
furthermore, we identified p53 and p38 as key proteins that mediate apoptosis induced by atad2 suppression. |
2016-09-28 |
2023-08-13 |
Not clear |
| J Li, J Xiong, B Yang, Q Zhou, Y Wu, H Luo, H Zhou, N Liu, Y Li, Z Song, Q Zhen. Endothelial Cell Apoptosis Induces TGF-β Signaling-Dependent Host Endothelial-Mesenchymal Transition to Promote Transplant Arteriosclerosis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 15. issue 12. 2016-09-27. PMID:26372910. |
we induced apoptosis in cultured ecs by overexpressing p53 through lentivirus-mediated transfection. |
2016-09-27 |
2023-08-13 |
rat |
| Ming Zhao, Juan Fan, Yong Liu, Yanxin Yu, Jinhui Xu, Qinglian Wen, Jianwen Zhang, Shaozhi Fu, Biqiong Wang, Li Xiang, Jing Feng, Jingbo Wu, Linglin Yan. Oncogenic role of the TP53-induced glycolysis and apoptosis regulator in nasopharyngeal carcinoma through NF-κB pathway modulation. International journal of oncology. vol 48. issue 2. 2016-09-27. PMID:26691054. |
the tp53-induced glycolysis and apoptosis regulator (tigar) is a p53 target gene, which functions to suppress reactive oxygen species (ros) damage and protect cells from apoptosis. |
2016-09-27 |
2023-08-13 |
Not clear |