| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiyuan Li, Liu Zhang, Quanshun L. Induction of apoptosis in cancer cells through N-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery. Colloids and surfaces. B, Biointerfaces. vol 135. 2016-09-26. PMID:26322477. |
induction of apoptosis in cancer cells through n-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery. |
2016-09-26 |
2023-08-13 |
Not clear |
| Zhiyuan Li, Liu Zhang, Quanshun L. Induction of apoptosis in cancer cells through N-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery. Colloids and surfaces. B, Biointerfaces. vol 135. 2016-09-26. PMID:26322477. |
flow cytometric analysis showed that the derivative-mediated p53 delivery could induce stronger early apoptosis than pei25k and lipofectamine(2000). |
2016-09-26 |
2023-08-13 |
Not clear |
| Zhiyuan Li, Liu Zhang, Quanshun L. Induction of apoptosis in cancer cells through N-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery. Colloids and surfaces. B, Biointerfaces. vol 135. 2016-09-26. PMID:26322477. |
the mechanism for inducing apoptosis was determined to be up-regulation of p53 expression at both mrna and protein levels using rt-pcr and western blotting analysis. |
2016-09-26 |
2023-08-13 |
Not clear |
| Zhiyuan Li, Liu Zhang, Quanshun L. Induction of apoptosis in cancer cells through N-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery. Colloids and surfaces. B, Biointerfaces. vol 135. 2016-09-26. PMID:26322477. |
expression level and activity analysis of caspase-3, -8 and -9, and mitochondrial membrane potential measurement revealed that p53 transfection mediated by these derivatives facilitated early apoptosis of tumor cells via a mitochondria-dependent apoptosis pathway. |
2016-09-26 |
2023-08-13 |
Not clear |
| Md Zubbair Malik, Shahnawaz Ali, Md Jahoor Alam, Romana Ishrat, R K Brojen Sing. Dynamics of p53 and Wnt cross talk. Computational biology and chemistry. vol 59 Pt B. 2016-09-26. PMID:26375870. |
we, further, demonstrate the change of p53 and gsk3 interaction rate, due to hypothetical catalytic reaction or external stimuli, can able to regulate the dynamics of the two network modules, and even can control their dynamics to protect the system from cycle arrest (apoptosis). |
2016-09-26 |
2023-08-13 |
Not clear |
| Hong-Bin Xu, Fu-Ming Shen, Qian-Zhou L. Celecoxib enhanced the cytotoxic effect of cisplatin in drug-resistant human gastric cancer cells by inhibition of cyclooxygenase-2. European journal of pharmacology. vol 769. 2016-09-26. PMID:26407653. |
celecoxib-induced apoptosis of sgc-7901/ddp cells led to increased p53 expression, decreased bcl-2/bax ratio and up-regulated caspase-3 level. |
2016-09-26 |
2023-08-13 |
human |
| Y Li, A Ahmad, F H Sarka. ASPP and iASPP: Implication in cancer development and progression. Cellular and molecular biology (Noisy-le-Grand, France). vol 61. issue 6. 2016-09-26. PMID:26518890. |
the well-known guardian of genome, p53 plays critical roles in the induction of apoptosis typically upon dna damage whereas mutant p53 containing cells are unable to undergo apoptosis which leads to aggressive tumor growth and drug resistance. |
2016-09-26 |
2023-08-13 |
Not clear |
| Y Li, A Ahmad, F H Sarka. ASPP and iASPP: Implication in cancer development and progression. Cellular and molecular biology (Noisy-le-Grand, France). vol 61. issue 6. 2016-09-26. PMID:26518890. |
moreover, another molecule regulating wild-ype p53 function is aspp (apoptosis stimulating proteins of p53) family. |
2016-09-26 |
2023-08-13 |
Not clear |
| Y Li, A Ahmad, F H Sarka. ASPP and iASPP: Implication in cancer development and progression. Cellular and molecular biology (Noisy-le-Grand, France). vol 61. issue 6. 2016-09-26. PMID:26518890. |
by binding to apoptosis regulating proteins such as p53, p63, p73, bcl-2, nf-κb p65, etc., aspp1 and aspp2 promote apoptosis while overexpression of iaspp inhibits apoptotic cell death typically after dna damage. |
2016-09-26 |
2023-08-13 |
Not clear |
| A A Farooqi, M Ismai. Editorial. Cellular and molecular biology (Noisy-le-Grand, France). vol 61. issue 6. 2016-09-26. PMID:26520390. |
sarkar et al review summarized multifunctional roles of aspp (apoptosis stimulating proteins of p53) family in cancer. |
2016-09-26 |
2023-08-13 |
mouse |
| Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, Hideki Mochizuk. A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease. Neurobiology of aging. vol 37. 2016-09-26. PMID:26545632. |
inactivation of mitogen-activated protein kinase cascades, reduced p53 phosphorylation, and down-regulation of p53-upregulated modulator of apoptosis on k560 treatment were also observed. |
2016-09-26 |
2023-08-13 |
mouse |
| Pingzhao Zhang, Yuanyuan Zhang, Kun Gao, Yuqi Wang, Xiaofeng Jin, Youheng Wei, Heige Saiyin, Dejie Wang, Jintao Peng, Jian Ma, Yan Tang, Reziya Wumaier, Hongxiu Yu, Yimin Dong, Haojie Huang, Long Yu, Chenji Wan. ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments. Oncotarget. vol 6. issue 39. 2016-09-26. PMID:26595804. |
tumor suppressor proteins aspp1 and aspp2, two members of the apoptosis stimulating proteins of p53 (aspp) family, are frequently down-regulated in human cancers. |
2016-09-26 |
2023-08-13 |
human |
| Elsayed I Salim, Afaf D Abd El-Magid, Khalid M Farara, Dina S M Mari. Antitumoral and Antioxidant Potential of Egyptian Propolis Against the PC3 Prostate Cancer Cell Line. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 17. 2016-09-26. PMID:26625775. |
dna fragmentation assay and semi quantitative rt-pcr analyses for p53 and bax genes showed that eep activated cellular apoptosis and increased the mrna expression levels more than other treatment. |
2016-09-26 |
2023-08-13 |
human |
| Taweesak Tongtawee, Chavaboon Dechsukhum, Krajang Talabnin, Wilairat Leeanansaksiri, Soraya Kaewpitoon, Natthawut Kaewpitoon, Ryan A Loyd, Likit Matrakool, Sukij Panpimanma. Correlation between Patterns of Mdm2 SNIP 309 and Histopathological Severity of Helicobacter pylori Associated Gastritis in Thailand. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 17. 2016-09-26. PMID:26625797. |
the commonly held view of the tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. |
2016-09-26 |
2023-08-13 |
Not clear |
| Sorina Nicoleta Petrache Voicu, Diana Dinu, Cornelia Sima, Anca Hermenean, Aurel Ardelean, Elena Codrici, Miruna Silvia Stan, Otilia Zărnescu, Anca Dinischiot. Silica Nanoparticles Induce Oxidative Stress and Autophagy but Not Apoptosis in the MRC-5 Cell Line. International journal of molecular sciences. vol 16. issue 12. 2016-09-26. PMID:26690408. |
similarly, the expression of p53, mdm2 and bcl-2 was significantly decreased for all time intervals, while the expression of bax, a marker for apoptosis, was insignificantly downregulated. |
2016-09-26 |
2023-08-13 |
human |
| Ali A Alshatwi, P Subash-Babu, P Antonisam. Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 68. issue 1. 2016-09-23. PMID:26521020. |
violacein induces apoptosis in human breast cancer cells through up regulation of bax, p53 and down regulation of mdm2. |
2016-09-23 |
2023-08-13 |
human |
| Ali A Alshatwi, P Subash-Babu, P Antonisam. Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 68. issue 1. 2016-09-23. PMID:26521020. |
in conclusion, lower dose of violacein treatment induced apoptosis in human breast cancer mcf-7 cells through tnf-α and p53 dependent mitochondrial pathways. |
2016-09-23 |
2023-08-13 |
human |
| Xiaojuan Liu, Chi Zhang, Long Qian, Chao Zhang, Kunpeng Wu, Chen Yang, Daliang Yan, Xiang Wu, Jiahai Sh. NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury. Pathology, research and practice. vol 211. issue 12. 2016-09-23. PMID:26573128. |
overexpression of nf45 in h9c2 cells reduced cell apoptosis, as evidenced by increased bcl-2 level, as well as decreased cleaved caspase-3, p53 and p21 expression. |
2016-09-23 |
2023-08-13 |
human |
| Yanhua Fan, Hongyuan Lu, Hongda Ma, Fan Feng, Xiaolong Hu, Qiao Zhang, Jian Wang, Yongnan Xu, Qingchun Zha. Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition. Food & function. vol 6. issue 12. 2016-09-22. PMID:26369427. |
the data indicate that the e. sieboldianum extract and its two active compounds, hpdl and qggp, could effectively induce apoptosis via p53, mapks and the mitochondrial apoptotic pathways. |
2016-09-22 |
2023-08-13 |
Not clear |
| Sanjay Kumar, Paul B Tchounwo. Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells. Oncotarget. vol 6. issue 38. 2016-09-22. PMID:26486083. |
we hypothesized that cisplatin induces cytotoxicity through dna adduct formation, oxidative stress, transcriptional factors (p53 and ap-1), cell cycle regulation, stress signaling and apoptosis in apl cells. |
2016-09-22 |
2023-08-13 |
human |