| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Shirazi Fard, Mke Blixt, F Hallböö. The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells. Cell death discovery. vol 1. 2016-08-23. PMID:27551456. |
the activity of p53 is regulated by positive and negative modulators, including the zinc finger containing transcription factor zac1 (zinc finger protein that regulates apoptosis and cell cycle arrest). |
2016-08-23 |
2023-08-13 |
mouse |
| S Shirazi Fard, Mke Blixt, F Hallböö. The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells. Cell death discovery. vol 1. 2016-08-23. PMID:27551456. |
zac1 interacts with and enhances the activity of p53, thereby inducing cell cycle arrest and apoptosis. |
2016-08-23 |
2023-08-13 |
mouse |
| A Boyko, K Riabowo. Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis. Cell death discovery. vol 1. 2016-08-23. PMID:27551477. |
using a doxycycline-regulated inducible p53 expression system demonstrated that apoptosis induced by the ing1b fragment was p53 independent. |
2016-08-23 |
2023-08-13 |
Not clear |
| N B Ghate, A Das, D Chaudhuri, S Panja, N Manda. Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio. Cell death discovery. vol 2. 2016-08-23. PMID:27551490. |
sundew plant, a potential source of anti-inflammatory agents, selectively induces g2/m arrest and apoptosis in mcf-7 cells through upregulation of p53 and bax/bcl-2 ratio. |
2016-08-23 |
2023-08-13 |
Not clear |
| N B Ghate, A Das, D Chaudhuri, S Panja, N Manda. Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio. Cell death discovery. vol 2. 2016-08-23. PMID:27551490. |
dbme induced g2/m phase arrest and apoptosis in mcf-7 cells by suppressing the expression of cyclin a1, cyclin b1 and cdk-1 and increasing the expression of p53, bax/bcl-2 ratio leading to activation of caspases and parp degradation. |
2016-08-23 |
2023-08-13 |
Not clear |
| D Ding, Y Zhang, J Wang, X Zhang, Y Gao, L Yin, Q Li, J Li, H Che. Induction and inhibition of the pan-nuclear gamma-H2AX response in resting human peripheral blood lymphocytes after X-ray irradiation. Cell death discovery. vol 2. 2016-08-23. PMID:27551505. |
moreover, atm/dna-pkcs inhibitor ku55933, p53 inhibitor pft-μ and pan-caspase inhibitor zvad-fmk significantly decreased x-irradiation-induced pan-nuclear γh2ax signals and tunel staining, protected hpbls from apoptosis, but decreased the proliferative response to mitogen in x-irradiated hpbls. |
2016-08-23 |
2023-08-13 |
human |
| M-L Gao, W-L Deng, N Huang, Y-Y Wang, X-L Lei, Z-Q Xu, D-N Hu, J-Q Cai, F Lu, Z-B Ji. Upregulation of GADD45α in light-damaged retinal pigment epithelial cells. Cell death discovery. vol 2. 2016-08-23. PMID:27551507. |
collectively, our findings reveal that light irrigation induces human rpe cellular apoptosis through upregulation of gadd45α expression mediated through both the p53 and phosphatidylinositol 3-kinase-akt signaling pathways. |
2016-08-23 |
2023-08-13 |
human |
| Kiyoko Setoguchi, Tara TeSlaa, Carla M Koehler, Michael A Teitel. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. Journal of molecular biology. vol 428. issue 7. 2016-08-23. PMID:26239243. |
p53 regulates rapid apoptosis in human pluripotent stem cells. |
2016-08-23 |
2023-08-13 |
human |
| Kiyoko Setoguchi, Tara TeSlaa, Carla M Koehler, Michael A Teitel. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. Journal of molecular biology. vol 428. issue 7. 2016-08-23. PMID:26239243. |
finally, p53 is degraded rapidly in an ubiquitin-proteasome-dependent pathway in hpscs at steady state but quickly accumulates and induces apoptosis when mdm2 function is impaired. |
2016-08-23 |
2023-08-13 |
human |
| Kiyoko Setoguchi, Tara TeSlaa, Carla M Koehler, Michael A Teitel. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. Journal of molecular biology. vol 428. issue 7. 2016-08-23. PMID:26239243. |
rapid degradation of p53 ensures the survival of healthy hpscs but avails these cells for immediate apoptosis upon cellular damage by p53 stabilization. |
2016-08-23 |
2023-08-13 |
human |
| Lisa K Mullany, Kwong-Kwok Wong, David C Marciano, Panagiotis Katsonis, Erin R King-Crane, Yi Athena Ren, Olivier Lichtarge, JoAnne S Richard. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia (New York, N.Y.). vol 17. issue 10. 2016-08-23. PMID:26585234. |
using human and mouse cell lines, we show that specific p53 mutants differentially alter endogenous wt p53 activity; target gene expression; and responses to nutlin-3a, a small molecular that activates wt p53 leading to apoptosis, providing "proof of principle" that ovarian cancer cells expressing wt and mutant alleles represent a distinct ovarian cancer subtype. |
2016-08-23 |
2023-08-13 |
mouse |
| Lisa K Mullany, Kwong-Kwok Wong, David C Marciano, Panagiotis Katsonis, Erin R King-Crane, Yi Athena Ren, Olivier Lichtarge, JoAnne S Richard. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia (New York, N.Y.). vol 17. issue 10. 2016-08-23. PMID:26585234. |
we also show that sirna knock down of endogenous p53 in cells expressing homozygous mutant alleles causes apoptosis, whereas cells expressing wt p53 (or are heterozygous for wt and mutant p53 alleles) are highly resistant. |
2016-08-23 |
2023-08-13 |
mouse |
| D Robbins, M Cherian, J Wu, T Che. Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. Cell death discovery. vol 2. 2016-08-22. PMID:27547448. |
the tumor suppressor p53 can be activated in the presence of dna damage and induce cell cycle arrest to allow for dna repair or, ultimately, apoptosis to suppress tumor formation. |
2016-08-22 |
2023-08-13 |
human |
| D Robbins, M Cherian, J Wu, T Che. Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. Cell death discovery. vol 2. 2016-08-22. PMID:27547448. |
pxr expression reduced p53 transactivation and the expression of its downstream target genes involved in cell cycle arrest and apoptosis by decreasing p53 recruitment to the promoter regions of these genes. |
2016-08-22 |
2023-08-13 |
human |
| Chun-Fu Hong, Shu-Yu Lin, Yu-Ting Chou, Cheng-Wen W. MicroRNA-7 Compromises p53 Protein-dependent Apoptosis by Controlling the Expression of the Chromatin Remodeling Factor SMARCD1. The Journal of biological chemistry. vol 291. issue 4. 2016-08-22. PMID:26542803. |
microrna-7 compromises p53 protein-dependent apoptosis by controlling the expression of the chromatin remodeling factor smarcd1. |
2016-08-22 |
2023-08-13 |
Not clear |
| Chun-Fu Hong, Shu-Yu Lin, Yu-Ting Chou, Cheng-Wen W. MicroRNA-7 Compromises p53 Protein-dependent Apoptosis by Controlling the Expression of the Chromatin Remodeling Factor SMARCD1. The Journal of biological chemistry. vol 291. issue 4. 2016-08-22. PMID:26542803. |
additionally, upon chemotherapy drug treatment, mir-7 down-regulated p53-dependent apoptosis-related gene bax (bcl2-associated x protein) and p21 expression by interfering with the interaction between smarcd1 and p53, thereby reducing caspase3 cleavage and the downstream apoptosis cascades. |
2016-08-22 |
2023-08-13 |
Not clear |
| Somanathapura K NaveenKumar, Ram M Thushara, Mahalingam S Sundaram, Mahadevappa Hemshekhar, Manoj Paul, Chinnasamy Thirunavukkarasu, Basappa, Ganesh Nagaraju, Sathees C Raghavan, Kesturu S Girish, Kempaiah Kemparaju, Kanchugarakoppal S Rangapp. Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation. Scientific reports. vol 5. 2016-08-19. PMID:26459859. |
all these parameters conclude that elevated unconjugated bilirubin causes thrombocytopenia by stimulating platelet apoptosis via mitochondrial ros-induced p38 and p53 activation. |
2016-08-19 |
2023-08-13 |
human |
| Kosuke Sakitani, Yoshihiro Hirata, Yohko Hikiba, Yoku Hayakawa, Sozaburo Ihara, Hirobumi Suzuki, Nobumi Suzuki, Takako Serizawa, Hiroto Kinoshita, Kei Sakamoto, Hayato Nakagawa, Keisuke Tateishi, Shin Maeda, Tsuneo Ikenoue, Shoji Kawazu, Kazuhiko Koik. Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress. BMC cancer. vol 15. 2016-08-18. PMID:26496833. |
inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and er stress. |
2016-08-18 |
2023-08-13 |
Not clear |
| Lanfu Zhao, Yuan Wang, Quan Yan, Wenhai Lv, Yufu Zhang, Shiming H. Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells. Biological chemistry. vol 396. issue 11. 2016-08-17. PMID:26040007. |
p38 mapk and p53 play an important role in nahs-induced apoptosis in c6 cells. |
2016-08-17 |
2023-08-13 |
Not clear |
| Arnold Y Seo, Christiaan Leeuwenburg. The Role of Genome Instability in Frailty: Mitochondria versus Nucleus. Nestle Nutrition Institute workshop series. vol 83. 2016-08-17. PMID:26524430. |
nuclear damage, such as telomere shortening, also appears to cause an abnormal expression of several proteins, including p53, which leads to impaired mitochondrial biogenesis, mitochondrial permeability transition pore opening, apoptosis, and other biological events. |
2016-08-17 |
2023-08-13 |
Not clear |