| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Kong, Qi Hao, Ying Wang, Ping Zhou, Binbin Zou, Yu-xiang Zhan. Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26318295. |
regulation of p53 expression and apoptosis by vault rna2-1-5p in cervical cancer cells. |
2016-08-02 |
2023-08-13 |
human |
| Lu Kong, Qi Hao, Ying Wang, Ping Zhou, Binbin Zou, Yu-xiang Zhan. Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26318295. |
vtrna2-1-5p inhibition decreased cervical cancer cell invasion, proliferation, and tumorigenicity while increasing apoptosis and p53 expression. |
2016-08-02 |
2023-08-13 |
human |
| Lu Kong, Qi Hao, Ying Wang, Ping Zhou, Binbin Zou, Yu-xiang Zhan. Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26318295. |
we propose that vtrna2-1-5p is a direct regulator of p53 and suggest that it plays an essential role in the apoptosis and proliferation of cervical cancer cells. |
2016-08-02 |
2023-08-13 |
human |
| Ellen Weisberg, Ensar Halilovic, Vesselina G Cooke, Atsushi Nonami, Tao Ren, Takaomi Sanda, Irene Simkin, Jing Yuan, Brandon Antonakos, Louise Barys, Moriko Ito, Richard Stone, Ilene Galinsky, Kristen Cowens, Erik Nelson, Martin Sattler, Sebastien Jeay, Jens U Wuerthner, Sean M McDonough, Marion Wiesmann, James D Griffi. Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097. Molecular cancer therapeutics. vol 14. issue 10. 2016-08-01. PMID:26206331. |
the tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating bcl-2 family proteins. |
2016-08-01 |
2023-08-13 |
mouse |
| Ellen Weisberg, Ensar Halilovic, Vesselina G Cooke, Atsushi Nonami, Tao Ren, Takaomi Sanda, Irene Simkin, Jing Yuan, Brandon Antonakos, Louise Barys, Moriko Ito, Richard Stone, Ilene Galinsky, Kristen Cowens, Erik Nelson, Martin Sattler, Sebastien Jeay, Jens U Wuerthner, Sean M McDonough, Marion Wiesmann, James D Griffi. Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097. Molecular cancer therapeutics. vol 14. issue 10. 2016-08-01. PMID:26206331. |
inhibition of hdm2:p53 interaction activates p53 and causes apoptosis or cell-cycle arrest. |
2016-08-01 |
2023-08-13 |
mouse |
| L R de Oliveira, J C M Mombach, G Castellan. A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis. Molecular bioSystems. vol 11. issue 11. 2016-08-01. PMID:26281034. |
a simple stochastic model for the feedback circuit between p16ink4a and p53 mediated by p38mapk: implications for senescence and apoptosis. |
2016-08-01 |
2023-08-13 |
Not clear |
| L R de Oliveira, J C M Mombach, G Castellan. A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis. Molecular bioSystems. vol 11. issue 11. 2016-08-01. PMID:26281034. |
based on experimental evidence we propose a simple network that might operate at the core of the cell control machinery for the choice between apoptosis and senescence involving the cross-talk between p38mapk, the tumor suppressor protein p53 and the cyclin-dependent kinase inhibitor (p16ink4a). |
2016-08-01 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Batzaya Davaadelger, Elena N Dedkova, Lothar A Blatter, Carl G Mak. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. vol 6. issue 27. 2016-08-01. PMID:26337205. |
canonical p53 functions include inducing apoptosis, growth arrest, and senescence. |
2016-08-01 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Batzaya Davaadelger, Elena N Dedkova, Lothar A Blatter, Carl G Mak. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. vol 6. issue 27. 2016-08-01. PMID:26337205. |
to address this, we compared cells resistant or sensitive to apoptosis by the p53 activator nutlin-3a. |
2016-08-01 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Batzaya Davaadelger, Elena N Dedkova, Lothar A Blatter, Carl G Mak. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. vol 6. issue 27. 2016-08-01. PMID:26337205. |
in contrast, in apoptosis sensitive cells activated p53 increased superoxide levels and inhibited glycolysis through repression of glycolytic pathway genes. |
2016-08-01 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Batzaya Davaadelger, Elena N Dedkova, Lothar A Blatter, Carl G Mak. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. vol 6. issue 27. 2016-08-01. PMID:26337205. |
specifically, the findings indicate 1) that glycolysis plays an essential role in autophagy by limiting superoxide levels and maintaining expression of atg genes required for autophagic vesicle maturation, 2) that p53 can promote or inhibit autophagy depending on the status of glycolysis, and 3) that inhibiting protective autophagy can expand the breadth of cells susceptible to nutlin-3a induced apoptosis. |
2016-08-01 |
2023-08-13 |
Not clear |
| Mei Ha, Li Wei, Xie Guan, Lianbing Li, Changjiang Li. p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity. Environmental pollution (Barking, Essex : 1987). vol 208. issue Pt B. 2016-08-01. PMID:26549752. |
p53 protein is a central sensor in cell apoptosis. |
2016-08-01 |
2023-08-13 |
human |
| Mei Ha, Li Wei, Xie Guan, Lianbing Li, Changjiang Li. p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity. Environmental pollution (Barking, Essex : 1987). vol 208. issue Pt B. 2016-08-01. PMID:26549752. |
activated p53 mediated hepatocyte apoptosis via the intrinsic mitochondrial pathway, inhibiting anti-apoptotic bcl-2 and bcl-xl and inducing pro-apoptotic bax, cytochrome c and caspases. |
2016-08-01 |
2023-08-13 |
human |
| Mei Ha, Li Wei, Xie Guan, Lianbing Li, Changjiang Li. p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity. Environmental pollution (Barking, Essex : 1987). vol 208. issue Pt B. 2016-08-01. PMID:26549752. |
in p53-silenced brl cells, hepatocyte apoptosis mediated by p53 was attenuated. |
2016-08-01 |
2023-08-13 |
human |
| Yuan Cui, Wei Liu, Wenping Xie, Wenlian Yu, Cheng Wang, Huiming Che. Investigation of the Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Apoptosis and Cell Cycle in a Zebrafish (Danio rerio) Liver Cell Line. International journal of environmental research and public health. vol 12. issue 12. 2016-08-01. PMID:26690195. |
cell apoptosis and cell cycle were detected by flow cytometry and the protein levels of p53, bcl-2, bax, caspase-3 and nf-κb p65 were determined by western blotting. |
2016-08-01 |
2023-08-13 |
zebrafish |
| Xinyan Lu, Yonglong Wei, Feng Li. Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell discovery. vol 1. 2016-07-27. PMID:27462426. |
further analysis showed that the diminished proliferation and excessive apoptosis in mir-142a-3p mutants were attributed to the increased p53 signaling. |
2016-07-27 |
2023-08-13 |
zebrafish |
| Nivedita Tiwari, Amarnath S Marudamuthu, Yoshikazu Tsukasaki, Mitsuo Ikebe, Jian Fu, Sreerama Shett. p53- and PAI-1-mediated induction of C-X-C chemokines and CXCR2: importance in pulmonary inflammation due to cigarette smoke exposure. American journal of physiology. Lung cellular and molecular physiology. vol 310. issue 6. 2016-07-27. PMID:26747783. |
we recently demonstrated that preventing p53 from binding to the endogenous pai-1 mrna in aecs by either suppressing p53 expression or blockading p53 interactions with the pai-1 mrna mitigates apoptosis and lung injury. |
2016-07-27 |
2023-08-13 |
mouse |
| Cheng Bi, Yinong Jiang, Tingting Fu, Yu Hao, Xifang Zhu, Yan L. Naringin inhibits lipopolysaccharide-induced damage in human umbilical vein endothelial cells via attenuation of inflammation, apoptosis and MAPK pathways. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:27006302. |
moreover, nar significantly down-regulated the protein or mrna levels of il-1, il-6, tnf-α, vcam-1, icam-1, nf-κb, ap-1, cleaved-3,-7,-9, p53, bak and bax, and up-regulated the expressions of bcl-xl, bcl-2 to suppress inflammation and apoptosis. |
2016-07-26 |
2023-08-13 |
human |
| Yang Zhao, Jia-Wei Tang, Zhi Yang, Yi-Bin Cao, Ji-Long Ren, Yuval Ben-Abu, Kexin Li, Xue-Qun Chen, Ji-Zeng Du, Eviatar Nev. Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 8. 2016-07-25. PMID:26858405. |
diverse expression levels of p53 between the incipiently sympatrically speciating chalk-basalt abutting populations of s. galili selectively affected cell-cycle arrest but not apoptosis. |
2016-07-25 |
2023-08-13 |
rat |
| Sharad Verma, Sonam Grover, Chetna Tyagi, Sukriti Goyal, Salma Jamal, Aditi Singh, Abhinav Grove. Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. PloS one. vol 11. issue 2. 2016-07-25. PMID:26863418. |
p53, a tumor suppressor protein, has been proven to regulate the cell cycle, apoptosis, and dna repair to prevent malignant transformation. |
2016-07-25 |
2023-08-13 |
Not clear |