| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soyoung Kim, Jung Hyun Lee, Igojo Kang, Soonsil Hyun, Jaehoon Yu, Chanseok Shi. An Amphiphilic Peptide Induces Apoptosis Through the miR29b-p53 Pathway in Cancer Cells. Molecular therapy. Nucleic acids. vol 5. issue 7. 2016-07-06. PMID:27377134. |
by targeting the suppressors of p53, a tumor suppressor protein, mir29 induces apoptosis of cancer cells through p53 stabilization. |
2016-07-06 |
2023-08-13 |
Not clear |
| Soyoung Kim, Jung Hyun Lee, Igojo Kang, Soonsil Hyun, Jaehoon Yu, Chanseok Shi. An Amphiphilic Peptide Induces Apoptosis Through the miR29b-p53 Pathway in Cancer Cells. Molecular therapy. Nucleic acids. vol 5. issue 7. 2016-07-06. PMID:27377134. |
furthermore, lk-l1c/k6w/l8c stimulates apoptosis by improving p53 stability in mir29-inducible hela and mcf7 cells. |
2016-07-06 |
2023-08-13 |
Not clear |
| Kohei Kitada, Akane Kizu, Takeshi Teramura, Toshiyuki Takehara, Masami Hayashi, Daisuke Tachibana, Hideki Wanibuchi, Shoji Fukushima, Masayasu Koyama, Kayo Yoshida, Takashi Morit. Gene-modified embryonic stem cell test to characterize chemical risks. Environmental science and pollution research international. vol 22. issue 22. 2016-07-06. PMID:26206128. |
the p53 gene is a well-known tumor suppressor and controls programmed cell death (apoptosis) and cellular senescence that is triggered by dna-damaging agents such as alkylating agents and radiation. |
2016-07-06 |
2023-08-13 |
mouse |
| Kohei Kitada, Akane Kizu, Takeshi Teramura, Toshiyuki Takehara, Masami Hayashi, Daisuke Tachibana, Hideki Wanibuchi, Shoji Fukushima, Masayasu Koyama, Kayo Yoshida, Takashi Morit. Gene-modified embryonic stem cell test to characterize chemical risks. Environmental science and pollution research international. vol 22. issue 22. 2016-07-06. PMID:26206128. |
in the present study, p53-deficient es cells were found to be more resistant to a tumor initiator, diethylnitrosamine (den), than wild-type es cells, suggesting the inhibition of apoptosis or senescence by a dysfunction in p53. |
2016-07-06 |
2023-08-13 |
mouse |
| Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer biology & therapy. vol 16. issue 9. 2016-07-06. PMID:26252178. |
decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. |
2016-07-06 |
2023-08-13 |
Not clear |
| Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer biology & therapy. vol 16. issue 9. 2016-07-06. PMID:26252178. |
following a genotoxic stress, the tumor suppressor p53 translocates to mitochondria to take part in direct induction of apoptosis, via interaction with bcl-2 family members such as bak and bax. |
2016-07-06 |
2023-08-13 |
Not clear |
| Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer biology & therapy. vol 16. issue 9. 2016-07-06. PMID:26252178. |
we show that the serine 20 phosphorylated form of p53 is present at the mitochondria and that the decrease of p53 mitochondrial level during late apoptosis correlates with a decrease of ser-20 phosphorylation. |
2016-07-06 |
2023-08-13 |
Not clear |
| Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer biology & therapy. vol 16. issue 9. 2016-07-06. PMID:26252178. |
moreover, the s20a p53 mutant translocates well to mitochondria after a genotoxic stress but its mitochondrial localization is very low during late apoptosis when compared to wt p53. |
2016-07-06 |
2023-08-13 |
Not clear |
| Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer biology & therapy. vol 16. issue 9. 2016-07-06. PMID:26252178. |
we propose here that the level of serine 20 phosphorylation is influential on p53 mitochondrial localization during late apoptosis. |
2016-07-06 |
2023-08-13 |
Not clear |
| Na He, Xuewei Zhu, Wei He, Shiwei Zhao, Weiyan Zhao, Chunlei Zh. Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells. Bioscience, biotechnology, and biochemistry. vol 79. issue 11. 2016-07-06. PMID:26406155. |
we determined the deregulation of sirt 1 activity, p53 acetylation, bcl-2 expression, and mitochondria-dependent apoptosis in mouse osteoblast mc3t3-e1 cells which were exposed to h2o2. |
2016-07-06 |
2023-08-13 |
mouse |
| Na He, Xuewei Zhu, Wei He, Shiwei Zhao, Weiyan Zhao, Chunlei Zh. Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells. Bioscience, biotechnology, and biochemistry. vol 79. issue 11. 2016-07-06. PMID:26406155. |
instead, rsv inhibited the h2o2-induced both p53 acetylation and the caspase 9 activation, whereas ameliorated the h2o2-induced bcl-2 inhibition and apoptosis. |
2016-07-06 |
2023-08-13 |
mouse |
| Na He, Xuewei Zhu, Wei He, Shiwei Zhao, Weiyan Zhao, Chunlei Zh. Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells. Bioscience, biotechnology, and biochemistry. vol 79. issue 11. 2016-07-06. PMID:26406155. |
and the chemical activation of sirt 1 inhibited the h2o2-induced apoptosis via the downregulation of p53 acetylation. |
2016-07-06 |
2023-08-13 |
mouse |
| Ali A Alshatwi, Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ramesh Elang. Synergistic anticancer activity of dietary tea polyphenols and bleomycin hydrochloride in human cervical cancer cell: Caspase-dependent and independent apoptotic pathways. Chemico-biological interactions. vol 247. 2016-07-06. PMID:26800624. |
cervical cancer cells (siha) were treated with various concentrations of tpp, blm and tpp combined with blm (tpp-blm), and their effects on cell growth, intracellular reactive oxygen species, poly-caspase activity, early apoptosis and the expression of caspase-3, caspase-8 and caspase-9, bcl-2 and p53 were assessed. |
2016-07-06 |
2023-08-13 |
human |
| Ali A Alshatwi, Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ramesh Elang. Synergistic anticancer activity of dietary tea polyphenols and bleomycin hydrochloride in human cervical cancer cell: Caspase-dependent and independent apoptotic pathways. Chemico-biological interactions. vol 247. 2016-07-06. PMID:26800624. |
the tpp-blm treatment synergistically induced apoptosis through caspase-3, caspase-8 and caspase-9 activation, bcl-2 upregulation and p53 overexpression. |
2016-07-06 |
2023-08-13 |
human |
| Taiki Shimizu, Yoshimasa Bamba, Yosuke Kawabe, Tomokazu Fukuda, Fumihiro Fujimori, Katsuhiko Takahashi, Chiyoko Uchida, Takafumi Uchid. Prolyl isomerase Pin1 regulates doxorubicin-inducible P-glycoprotein level by reducing Foxo3 stability. Biochemical and biophysical research communications. vol 471. issue 2. 2016-07-06. PMID:26874277. |
pin1 binds phosphorylated p53 and stabilizes p53 to cause cell cycle arrest and apoptosis quickly in response to doxorubicin. |
2016-07-06 |
2023-08-13 |
Not clear |
| Takahiro Oike, Hiro Sato, Shin-Ei Noda, Takashi Nakan. Translational Research to Improve the Efficacy of Carbon Ion Radiotherapy: Experience of Gunma University. Frontiers in oncology. vol 6. 2016-07-04. PMID:27376029. |
intratumoral oxygen levels, radiation-induced cellular apoptosis, the capacity to repair dna double-strand breaks, and the mutational status of tumor protein p53 and epidermal growth factor receptor genes are all associated with x-ray sensitivity. |
2016-07-04 |
2023-08-13 |
Not clear |
| Chuan-chuan Zhou, Fu Yang, Sheng-xian Yuan, Jin-zhao Ma, Feng Liu, Ji-hang Yuan, Feng-rui Bi, Kong-ying Lin, Jian-hua Yin, Guang-wen Cao, Wei-ping Zhou, Fang Wang, Shu-han Su. Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. Hepatology (Baltimore, Md.). vol 63. issue 3. 2016-07-04. PMID:26663434. |
we found that lncrna-pral could inhibit hcc growth and induce apoptosis in vivo and in vitro through p53. |
2016-07-04 |
2023-08-13 |
Not clear |
| Ting Zhang, Yuanyuan Hu, Meng Tang, Lu Kong, Jiali Ying, Tianshu Wu, Yuying Xue, Yuepu P. Liver Toxicity of Cadmium Telluride Quantum Dots (CdTe QDs) Due to Oxidative Stress in Vitro and in Vivo. International journal of molecular sciences. vol 16. issue 10. 2016-07-01. PMID:26404244. |
an increase in ros generation with a concomitant increase in the gene expression of the tumor suppressor gene p53, the pro-apoptotic gene bcl-2 and a decrease in the anti-apoptosis gene bax, suggested that a mitochondria mediated pathway was involved in cdte qds' induced apoptosis. |
2016-07-01 |
2023-08-13 |
mouse |
| Chia-Yi Tseng, Jhih-Syuan Wang, Yu-Jung Chang, Jing-Fen Chang, Ming-Wei Cha. Exposure to High-Dose Diesel Exhaust Particles Induces Intracellular Oxidative Stress and Causes Endothelial Apoptosis in Cultured In Vitro Capillary Tube Cells. Cardiovascular toxicology. vol 15. issue 4. 2016-06-29. PMID:25488805. |
nevertheless, 100 µg/ml dep augments tube cell apoptosis up to 70 % but disrupts the p53 negative regulator mdm2. |
2016-06-29 |
2023-08-13 |
Not clear |
| M M Olcina, K B Leszczynska, J M Senra, N F Isa, H Harada, E M Hammon. H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. Oncogene. vol 35. issue 6. 2016-06-29. PMID:25961932. |
despite the absence of detectable dna damage, severe hypoxia (<0.1% o2) induces a dna damage response, including the activation of p53 and subsequent induction of p53-dependent apoptosis. |
2016-06-29 |
2023-08-13 |
human |