| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Olcina, K B Leszczynska, J M Senra, N F Isa, H Harada, E M Hammon. H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. Oncogene. vol 35. issue 6. 2016-06-29. PMID:25961932. |
together, these data demonstrate the functional importance of h3k9me3 in hypoxia, and they provide a novel mechanistic link between h3k9me3, p53 and apoptosis in physiologically relevant conditions of hypoxia. |
2016-06-29 |
2023-08-13 |
human |
| Jinhua Jiang, Shenggan Wu, Xinju Liu, Yanhua Wang, Xuehua An, Leiming Cai, Xueping Zha. Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish. Environmental toxicology and pharmacology. vol 40. issue 2. 2016-06-29. PMID:26318563. |
results demonstrated that the transcription patterns of many key genes involved in the hypothalamic-pituitary-gonadal/thyroid (hpg/hpt) axis (e.g., vtg1, erβ1, cyp19a and trα), cell apoptosis pathway (e.g., bcl2, bax, p53 and cas8), as well as innate immunity (e.g., cxcl-c1c, il-1β and tnfα) were affected in newly hatched zebrafish after exposure to acetochlor. |
2016-06-29 |
2023-08-13 |
cat |
| Clare M Adams, Scott W Hiebert, Christine M Eische. Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer research. vol 76. issue 3. 2016-06-28. PMID:26676759. |
taken together, our results reveal a previously unknown mechanism by which myc induces apoptosis independent of the p53 pathway and as a response to hdaci in malignant hematopoietic cells. |
2016-06-28 |
2023-08-13 |
Not clear |
| Shuang Chang, Xiumei Shan, Xingliang Li, Weiwei Fan, Steven Qian Zhang, Jin Zhang, Nan Jiang, Duan Ma, Zuohua Ma. Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53. International journal of biological sciences. vol 11. issue 10. 2016-06-27. PMID:26327815. |
toxoplasma gondii rhoptry protein rop16 mediates partially sh-sy5y cells apoptosis and cell cycle arrest by directing ser15/37 phosphorylation of p53. |
2016-06-27 |
2023-08-13 |
human |
| Shuang Chang, Xiumei Shan, Xingliang Li, Weiwei Fan, Steven Qian Zhang, Jin Zhang, Nan Jiang, Duan Ma, Zuohua Ma. Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53. International journal of biological sciences. vol 11. issue 10. 2016-06-27. PMID:26327815. |
in the present study, we found that overexpression of rop16 could partially mediate human neuroblastoma sh-sy5y apoptosis (12.47%) and cell cycle arrest in g1 phase (60.77%) in a p53 dependent manner by influencing the expression of bax/bcl-2 and p21/cdks. |
2016-06-27 |
2023-08-13 |
human |
| Shuang Chang, Xiumei Shan, Xingliang Li, Weiwei Fan, Steven Qian Zhang, Jin Zhang, Nan Jiang, Duan Ma, Zuohua Ma. Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53. International journal of biological sciences. vol 11. issue 10. 2016-06-27. PMID:26327815. |
furthermore, sh-sy5y apoptosis via the mitochondria-dependent p53 pathway and cell cycle arrest caused by rop16 dealt with direct serine 15/37 phosphorylation of p53. |
2016-06-27 |
2023-08-13 |
human |
| Da-wei Li, Jing-yi Sun, Kun Wang, Shuai Zhang, Ya-jun Hou, Ming-feng Yang, Xiao-yan Fu, Zong-yong Zhang, Lei-lei Mao, Hui Yuan, Jie Fang, Cun-dong Fan, Mei-jia Zhu, Bao-liang Su. Attenuation of Cisplatin-Induced Neurotoxicity by Cyanidin, a Natural Inhibitor of ROS-Mediated Apoptosis in PC12 Cells. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25895624. |
cisplatin caused dna damage, activated p53, and subsequently induced pc12 cells apoptosis by triggering ros overproduction. |
2016-06-24 |
2023-08-13 |
Not clear |
| Da-wei Li, Jing-yi Sun, Kun Wang, Shuai Zhang, Ya-jun Hou, Ming-feng Yang, Xiao-yan Fu, Zong-yong Zhang, Lei-lei Mao, Hui Yuan, Jie Fang, Cun-dong Fan, Mei-jia Zhu, Bao-liang Su. Attenuation of Cisplatin-Induced Neurotoxicity by Cyanidin, a Natural Inhibitor of ROS-Mediated Apoptosis in PC12 Cells. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25895624. |
however, cyanidin administration effectively inhibited dna damage, attenuated p53 phosphorylation, and eventually reversed cisplatin-induced pc12 cell apoptosis through inhibition ros accumulation. |
2016-06-24 |
2023-08-13 |
Not clear |
| Qingchang Chen, Qianqian Yu, Yanan Liu, Dhairya Bhavsar, Licong Yang, Xiaofan Ren, Dongdong Sun, Wenjing Zheng, Jie Liu, Lan-mei Che. Multifunctional selenium nanoparticles: Chiral selectivity of delivering MDR-siRNA for reversal of multidrug resistance and real-time biofluorescence imaging. Nanomedicine : nanotechnology, biology, and medicine. vol 11. issue 7. 2016-06-23. PMID:25959925. |
cisplatin-resistant a549r cells treated with ru@l-senps-sirna demonstrated significant downregulation of p-glycoprotein (p-gp) expression, resulting in unprecedented enhanced cytotoxicity through the induction of apoptosis with the involvement of phosphorylation of p53, mapk and pi3k/akt signaling pathways. in vivo investigation confirmed that ru@l-senps-sirna nanoparticles exhibited high tumor-targeted fluorescence, enhanced anti-tumor efficacy, and decreased systemic toxicity. |
2016-06-23 |
2023-08-13 |
Not clear |
| Ingiridur Skirnisdottir, Tomas Seidal, Helena Åkeru. Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 25. issue 7. 2016-06-23. PMID:26035126. |
the objective of this study was to compare immunohistochemical profile for the apoptosis regulators p53, c-myc, bax, puma, and pten and the cell cycle regulatory proteins p21 and p27, as well as clinical factors between types i and ii tumors. |
2016-06-23 |
2023-08-13 |
Not clear |
| Qiang Lin, Yurong Mao, Yunlin Song, Dongfeng Huan. MicroRNA‑34a induces apoptosis in PC12 cells by reducing B‑cell lymphoma 2 and sirtuin‑1 expression. Molecular medicine reports. vol 12. issue 4. 2016-06-23. PMID:26252661. |
microrna‑34a (mir‑34a) is a direct target of p53 and was reported to induce cell cycle arrest, apoptosis and senescence. |
2016-06-23 |
2023-08-13 |
Not clear |
| Qiang Lin, Yurong Mao, Yunlin Song, Dongfeng Huan. MicroRNA‑34a induces apoptosis in PC12 cells by reducing B‑cell lymphoma 2 and sirtuin‑1 expression. Molecular medicine reports. vol 12. issue 4. 2016-06-23. PMID:26252661. |
inhibition of the nad‑dependent deacetylase sirtuin‑1 (sirt1) by mir‑34a leads to an increase in acetylated p53, which promotes cell apoptosis. |
2016-06-23 |
2023-08-13 |
Not clear |
| Tzu-Chin Wu, Yi-Chin Lin, Hsiao-Ling Chen, Pei-Ru Huang, Shang-Yu Liu, Shu-Lan Ye. The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. Toxicology and applied pharmacology. vol 292. 2016-06-22. PMID:26768552. |
the enhancing effect of genistein on apoptosis induced by trichostatin a in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. |
2016-06-22 |
2023-08-13 |
mouse |
| Massimo Bonora, Carlotta Giorgi, Paolo Pinto. Novel frontiers in calcium signaling: A possible target for chemotherapy. Pharmacological research. vol 99. 2016-06-21. PMID:26028552. |
recent advances from in vivo investigations into these regions highlight the role of the master oncosuppressor p53 in regulating ca(2+) transmission and apoptosis, and we propose that ca(2+) signals are relevant targets when developing new therapeutic approaches. |
2016-06-21 |
2023-08-13 |
Not clear |
| Jing Wang, Zaoli Jiang, Wing Lam, Elizabeth A Gullen, Zhe Yu, Ying Wei, Lihui Wang, Caroline Zeiss, Amanda Beck, Ee-Chun Cheng, Chunfu Wu, Yung-Chi Cheng, Yixuan Zhan. Study of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer Drug. PloS one. vol 10. issue 11. 2016-06-21. PMID:26540166. |
moreover, we observed up-regulated expression of phospho-histone h2a.x, p53, cleaved caspase 3 and lc3 after malformin c treatment, while the apoptosis assay indicated an increased population of necrotic and late apoptotic cells. |
2016-06-21 |
2023-08-13 |
mouse |
| Hyun-Jin Shin, Eun-Ran Park, Sun-Hee Yun, Su-Hyeon Kim, Won-Hee Jung, Seon Rang Woo, Hyun-Yoo Joo, Su Hwa Jang, Hee Yong Chung, Sung Hee Hong, Myung-Haing Cho, Joong-Jean Park, Miyong Yun, Kee-Ho Le. p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2. PloS one. vol 10. issue 11. 2016-06-21. PMID:26544187. |
cancer cells with p31comet overexpression underwent distinct apoptosis and/or senescence, irrespective of p53 status, confirming the cytotoxicity of p31comet. |
2016-06-21 |
2023-08-13 |
human |
| J Xue, Y Chi, Y Chen, S Huang, X Ye, J Niu, W Wang, L M Pfeffer, Z-M Shao, Z-H Wu, J W. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene. vol 35. issue 4. 2016-06-20. PMID:25867061. |
accordingly, mir-621-dependent fbxo11 suppression enhanced p53 activity and increased apoptosis in breast cancer cells exposed to chemotherapeutics. |
2016-06-20 |
2023-08-13 |
Not clear |
| D Shi, C Dai, J Qin, W G. Negative regulation of the p300-p53 interplay by DDX24. Oncogene. vol 35. issue 4. 2016-06-20. PMID:25867071. |
notably, rna interference-mediated knockdown of endogenous ddx24 significantly increases the acetylation levels of endogenous p53 in human cancer cells and subsequently promotes p53-mediated activation of its transcriptional targets such as p21 and p53 upregulated modulator of apoptosis (puma). |
2016-06-20 |
2023-08-13 |
human |
| Y K Satija, S Da. Tyr99 phosphorylation determines the regulatory milieu of tumor suppressor p73. Oncogene. vol 35. issue 4. 2016-06-20. PMID:25893286. |
p73 is a member of the p53 tumor suppressor family, which mediates genotoxic stress response by triggering cell cycle arrest and apoptosis. |
2016-06-20 |
2023-08-13 |
mouse |
| Jeffrey M Sifford, James A Stahl, Eduardo Salinas, J Craig Forres. Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. Journal of virology. vol 90. issue 5. 2016-06-20. PMID:26676792. |
infected cells also failed to initiate p53-dependent gene expression and undergo apoptosis in response to treatment with exogenous p53 agonists. |
2016-06-20 |
2023-08-13 |
mouse |