| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' M Seifrtov\\xc3\\xa1, T Cochlarov\\xc3\\xa1, R Havelek, M \\xc5\\x98ez\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa. Benfluron Induces Cell Cycle Arrest, Apoptosis and Activation of p53 Pathway in MOLT-4 Leukemic Cells. Folia biologica. vol 61. issue 4. 2016-05-18. PMID:26441204.' |
benfluron induces cell cycle arrest, apoptosis and activation of p53 pathway in molt-4 leukemic cells. |
2016-05-18 |
2023-08-13 |
human |
| Jihye Park, Robert S Welner, Mei-Yee Chan, Logan Troppito, Philipp B Staber, Daniel G Tenen, Catherine T Ya. The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 1. 2016-05-18. PMID:26608917. |
activated lig4(r/r)hl b cells consistently accumulated high frequencies of activation-induced cytidine deaminase-dependent igh locus chromosomal breaks and translocations and were more prone to apoptosis, effects that appeared to be p53-independent, as p53 deficiency did not markedly influence these events. |
2016-05-18 |
2023-08-13 |
mouse |
| Yang Xia, Zhicheng He, Bin Liu, Pengli Wang, Yijiang Che. Downregulation of Meg3 enhances cisplatin resistance of lung cancer cells through activation of the WNT/β-catenin signaling pathway. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26059239. |
the results of the present study also demonstrated that the meg3‑mediated chemosensitivity enhancement was associated with the induction of cell-cycle arrest and increased apoptosis, through regulation of p53, β‑catenin and survivin, which is a target gene of the wnt/β‑catenin signaling pathway. |
2016-05-17 |
2023-08-13 |
human |
| Chao-Yu Hsu, Chun-Hsiang Lin, Jiun-Tsai Lin, Yi-Fang Cheng, Han-Min Chen, Shao-Hsuan Ka. Purine analogue ENERGI-F706 induces apoptosis of 786-O renal carcinoma cells via 5'-adenosine monophosphate-activated protein kinase activation. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26062651. |
in conclusion, the findings of the present study revealed that energi‑f706 significantly suppressed the viability of 786‑o cells via induction of cell cycle arrest and apoptosis, attributing to ampk and p53 activation and subsequent cell cycle regulatory and apoptotic signaling. |
2016-05-17 |
2023-08-13 |
human |
| Qiang Chen, Hui Lu, Hu Yan. Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26126698. |
furthermore, downregulation of sirt1 by rna interference abrogated the effects of chitosan on the levels of p65 and p53 acetylation, and the rate of tenocyte apoptosis. |
2016-05-17 |
2023-08-13 |
human |
| Z T Gu, L Li, F Wu, P Zhao, H Yang, Y S Liu, Y Geng, M Zhao, L S. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports. vol 5. 2016-05-16. PMID:26105784. |
heat stress induced apoptosis is triggered by transcription-independent p53, ca(2+) dyshomeostasis and the subsequent bax mitochondrial translocation. |
2016-05-16 |
2023-08-13 |
Not clear |
| Z T Gu, L Li, F Wu, P Zhao, H Yang, Y S Liu, Y Geng, M Zhao, L S. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports. vol 5. 2016-05-16. PMID:26105784. |
furthermore, we demonstrated that generation of reactive oxygen species (ros) is a critical mediator in heat stress induced apoptosis and that the antioxidant mntbap significantly decreased heat stress induced p53 mitochondrial translocation and ca(2+) signal mediated mptp opening, as well as the subsequent bax mitochondrial translocation and activation of the caspase cascade. |
2016-05-16 |
2023-08-13 |
Not clear |
| Z T Gu, L Li, F Wu, P Zhao, H Yang, Y S Liu, Y Geng, M Zhao, L S. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports. vol 5. 2016-05-16. PMID:26105784. |
taken together, our results indicate that heat stress induces apoptosis through the mitochondrial pathway with ros dependent mitochondrial p53 translocation and ca(2+) dyshomeostasis, and the ensuing intro bax mitochondrial translocation as the upstream events involved in triggering the apoptotic process observed upon cellular exposure to heat stress. |
2016-05-16 |
2023-08-13 |
Not clear |
| Hyun Kyung Lim, Woori Bae, Hyi-Seung Lee, Joohee Jun. Anticancer activity of marine sponge Hyrtios sp. extract in human colorectal carcinoma RKO cells with different p53 status. BioMed research international. vol 2014. 2016-05-15. PMID:25243139. |
extract induced apoptosis via different pathways depending on p53 status and could be a good natural product for developing new anticancer drugs. |
2016-05-15 |
2023-08-13 |
human |
| A Somal, A Aggarwal, R C Upadhya. Effect of thermal stress on expression profile of apoptosis related genes in peripheral blood mononuclear cells of transition Sahiwal cow. Iranian journal of veterinary research. vol 16. issue 2. 2016-05-13. PMID:27175165. |
comparison between the two temperature conditions showed that expression of casp-3, bcl-2, bak, p53 and ratio of bax/bcl-2 in pbmc increased during summer as compared to thermoneutral condition suggesting the susceptibility of these cells to apoptosis. |
2016-05-13 |
2023-08-13 |
Not clear |
| M F Maioral, L D S Bubniak, M A L Marzarotto, A C R De Moraes, P Leal, R Nunes, R A Yunes, M C Santos-Silv. Molecular Cytotoxic Mechanisms of 1-(3,4,5-Trihydroxyphenyl)-dodecylbenzoate in Human Leukemia Cell Lines. Indian journal of pharmaceutical sciences. vol 78. issue 1. 2016-05-12. PMID:27168690. |
thus, it is possible to conclude that 1-(3,4,5-trihydroxyphenyl)-dodecylbenzoate induces apoptosis by inhibiting the antiapoptotic protein bcl-2 and by increasing the release of aif, bax and p53. |
2016-05-12 |
2023-08-13 |
human |
| Rashid Mir, Mirza Masroor, Jamsheed Javid, Imtiyaz Ahamad, Shazia Farooq, Prasant Yadav, Mariyam Zuberi, Maqbool Lone, P C Ray, Alpana Saxen. Clinical implications of cytosine deletion of exon 5 of P53 gene in non small cell lung cancer patients. South Asian journal of cancer. vol 5. issue 1. 2016-05-12. PMID:27169122. |
in humans, about 50% or more cancers have a mutated tumor suppressor p53 gene thereby resulting in accumulation of p53 protein and losing its function to activate the target genes that regulate the cell cycle and apoptosis. |
2016-05-12 |
2023-08-13 |
Not clear |
| Anushree Mondal, Urmi Chatterj. Artemisinin Represses Telomerase Subunits and Induces Apoptosis in HPV-39 Infected Human Cervical Cancer Cells. Journal of cellular biochemistry. vol 116. issue 9. 2016-05-10. PMID:25755006. |
increased expression of p53 with concomitant decrease in expression of the p53 inhibitor mdm2 further supported that artemisinin-induced apoptosis was p53-dependent. |
2016-05-10 |
2023-08-13 |
human |
| Yunyun Geng, Xiaojian Wang, Luo Yang, Haili Sun, Yongqiang Wang, Yue Zhao, Ruiping She, Mei-Xiang Wang, De-Xian Wang, Jun Tan. Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo. PloS one. vol 10. issue 6. 2016-05-10. PMID:26042776. |
further analysis indicated that 1d preferentially induced dna damage and p53 activation in hct116 cells and that 1d-induced apoptosis is partly dependent on p53. |
2016-05-10 |
2023-08-13 |
Not clear |
| D Escobar, M I Hepp, C Farkas, T Campos, N M Sodir, M Morales, C I Álvarez, L Swigart, G I Evan, J L Gutiérrez, R Nishinakamura, A F Castro, R Pincheir. Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin. Cell death & disease. vol 6. 2016-05-10. PMID:26181197. |
importantly, sall2 was required for apoptosis even in the presence of fully activated p53. |
2016-05-10 |
2023-08-13 |
mouse |
| Hui Chen, Xiaorong Yang, Zhiping Wan. Association between p53 Arg72Pro polymorphism and recurrent pregnancy loss: an updated systematic review and meta-analysis. Reproductive biomedicine online. vol 31. issue 2. 2016-05-09. PMID:26099444. |
the p53 tumour suppressor gene plays an important role in angiogenesis and apoptosis. |
2016-05-09 |
2023-08-13 |
Not clear |
| Jinye Xu, Junbo Cai, Xiaoyan Jin, Jingjin Yang, Qinyan Shen, Xiaofei Ding, Yong Lian. PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway. Oncology reports. vol 34. issue 3. 2016-05-09. PMID:26133772. |
the p53-inducible gene 3 (pig3 or tp53i3) is a downstream gene of p53, which can be involved in the process of apoptosis induced by p53 via the production of reactive oxygen species (ros). |
2016-05-09 |
2023-08-13 |
Not clear |
| Hong Zhu, Muyasha Abulimiti, Huan Liu, Xiang-Jiang Su, Cai-Hong Liu, Hai-Ping Pe. RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling. Oncology reports. vol 34. issue 3. 2016-05-09. PMID:26134873. |
a recent study demonstrated that small-molecule rita (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53). |
2016-05-09 |
2023-08-13 |
human |
| Hong Zhu, Muyasha Abulimiti, Huan Liu, Xiang-Jiang Su, Cai-Hong Liu, Hai-Ping Pe. RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling. Oncology reports. vol 34. issue 3. 2016-05-09. PMID:26134873. |
treatment with 1 µm of rita for 24 h before irradiation markedly decreased survival and increased apoptosis in c-33a and ht-3 cells; the effects were not significantly altered by knockdown of p53. |
2016-05-09 |
2023-08-13 |
human |
| Fan An, Wei-Jie Zhao, Li Tang, Rong-Guo Qi. Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling. Oncology reports. vol 34. issue 3. 2016-05-09. PMID:26177745. |
the tumor-suppressor protein p53 is considered to be one of the most important transport hubs of cell signal transduction, playing critical roles in the control of cell cycle arrest, apoptosis and many other processes as a nuclear transcription factor. |
2016-05-09 |
2023-08-13 |
Not clear |