| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noemi A Zambetti, Eric M J Bindels, Paulina M H Van Strien, Marijke G Valkhof, Maria N Adisty, Remco M Hoogenboezem, Mathijs A Sanders, Johanna M Rommens, Ivo P Touw, Marc H G P Raaijmaker. Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes. Haematologica. vol 100. issue 10. 2016-04-06. PMID:26185170. |
mechanistically, sbds deficiency activated the p53 tumor suppressor pathway and induced apoptosis in these cells. |
2016-04-06 |
2023-08-13 |
mouse |
| Christine E Hellweg, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Christa Baumstark-Kha. Transcription Factors in the Cellular Response to Charged Particle Exposure. Frontiers in oncology. vol 6. 2016-04-06. PMID:27047795. |
depending on dose, radiation quality, and tissue, p53 induces apoptosis or cell-cycle arrest. |
2016-04-06 |
2023-08-13 |
human |
| Yuxin Zhou, Libin Wei, Haiwei Zhang, Qinsheng Dai, Zhiyu Li, Boyang Yu, Qinglong Guo, Na L. FV-429 Induced Apoptosis Through ROS-Mediated ERK2 Nuclear Translocation and p53 Activation in Gastric Cancer Cells. Journal of cellular biochemistry. vol 116. issue 8. 2016-04-05. PMID:25650185. |
fv-429 induced apoptosis through ros-mediated erk2 nuclear translocation and p53 activation in gastric cancer cells. |
2016-04-05 |
2023-08-13 |
mouse |
| Jung-Hyun Cho, Su-Jin Lee, Ah-Young Oh, Min-Ho Yoon, Tae-Geun Woo, Bum-Joon Par. NF2 blocks Snail-mediated p53 suppression in mesothelioma. Oncotarget. vol 6. issue 12. 2016-04-05. PMID:25823924. |
importantly, gn25, an inhibitor of p53-snail interaction, induced p53 and apoptosis. |
2016-04-05 |
2023-08-13 |
Not clear |
| Zhiyang Chen, Weiwei Yi, Yohei Morita, Hu Wang, Yusheng Cong, Jun-Ping Liu, Zhicheng Xiao, K Lenhard Rudolph, Tao Cheng, Zhenyu J. Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways. Nature communications. vol 6. 2016-04-05. PMID:25879755. |
deletion of p53 rescued the multilineage repopulation defect of wip1(-/-) hscs without affecting cellular senescence or apoptosis, indicating that the wip1-p53 axis regulates hsc differentiation in a manner independent of conventional p53 pathways. |
2016-04-05 |
2023-08-13 |
mouse |
| A A Daks, A V Petukhov, O Yu Shuvalov, E A Vasilieva, G Melino, N A Barlev, O A Fedorov. [TUMOR SUPPRESSOR p63 REGULATES EXPRESSION OF UBIQUITIN LIGASE Pirh2]. Tsitologiia. vol 57. issue 12. 2016-04-05. PMID:26995965. |
due to the high degree of structural similarity p53, p63, and p73 are known to have overlapping functions relating to cell cycle regulation, apoptosis and tumor transformation. |
2016-04-05 |
2023-08-13 |
Not clear |
| Kun Qian, Jing Wu, Enqi Zhang, Yingge Zhang, Ailing F. Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging. International journal of nanomedicine. vol 10. 2016-04-01. PMID:26203242. |
further studies suggested that the co-delivery of transcription factor p53 and lipophilic drug paclitaxel with the nanocapsules acted synergistically to induce hela cell apoptosis, and the fluorescence of apoptotic cells was clearly observed under a fluorescence microscope. |
2016-04-01 |
2023-08-13 |
cattle |
| Vidya C Sinha, Lan Qin, Yi L. A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis. Molecular cancer research : MCR. vol 13. issue 2. 2016-03-29. PMID:25253740. |
here, it is demonstrated that apoptosis unexpectedly remains robust in erbb2 (erbb2/her2)-initiated mammary early lesions arising in adult mice null for either p53 or arf. |
2016-03-29 |
2023-08-13 |
mouse |
| Che-Pei Kung, Sakina Khaku, Matthew Jennis, Yan Zhou, Maureen E Murph. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Molecular cancer research : MCR. vol 13. issue 2. 2016-03-29. PMID:25256710. |
the tumor-suppressor protein p53, encoded by tp53, inhibits tumorigenesis by inducing cell-cycle arrest, senescence, and apoptosis. |
2016-03-29 |
2023-08-13 |
human |
| Artur Zajkowicz, Agnieszka Gdowicz-Kłosok, Małgorzata Krześniak, Dorota Ścieglińska, Marek Rusi. Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin. Cellular signalling. vol 27. issue 9. 2016-03-29. PMID:25989210. |
other p53 target genes (sesn1, sesn2, tigar, dram1) were also efficiently upregulated; however, a marker of apoptosis (active caspase-3) appeared only in some cancer cell lines (e.g., a375 and other cell lines derived from melanoma) indicating that phosphorylation of p53 on serine 46 is not straightforwardly associated with induction of apoptosis. |
2016-03-29 |
2023-08-13 |
Not clear |
| Yassmine Chebaro, Andrew J Ballard, Debayan Chakraborty, David J Wale. Intrinsically disordered energy landscapes. Scientific reports. vol 5. 2016-03-29. PMID:25999294. |
we focus on the p53 upregulated modulator of apoptosis (puma) protein, which adopts an α-helical conformation when bound to its partner, and is involved in the activation of apoptosis. |
2016-03-29 |
2023-08-13 |
Not clear |
| Varsha Tembe, Estefania Martino-Echarri, Kamila A Marzec, Myth T S Mok, Kirsty M Brodie, Kate Mills, Ying Lei, Anna DeFazio, Helen Rizos, Emma Kettle, Ross Boadle, Beric R Henderso. The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cellular signalling. vol 27. issue 9. 2016-03-29. PMID:26022179. |
deletion of the brct sequence caused major defects in the ability of bard1 to (1) bind p53, (2) localize to the cytoplasm and mitochondria, and (3) induce bax oligomerization and apoptosis. |
2016-03-29 |
2023-08-13 |
human |
| S Ohno, Y Naito, S Mukai, N Yabuta, H Nojim. ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53. Oncogene. vol 34. issue 49. 2016-03-28. PMID:25915850. |
elas1-mediated inhibition of the cyclin g1-b'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53. |
2016-03-28 |
2023-08-13 |
human |
| Chuanxiang Chen, Litao Qincao, Jingtao Xu, Sihao Du, Enping Huang, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicology letters. vol 240. issue 1. 2016-03-28. PMID:26524635. |
p53 upregulated modulator of apoptosis (puma) is a key mediator in neuronal apoptosis. |
2016-03-28 |
2023-08-13 |
Not clear |
| b' Juan Ramirez, Juline Poirson, Cl\\xc3\\xa9mence Foltz, Yassmine Chebaro, Maxime Schrapp, Amandine Meyer, Ana\\xc3\\xablle Bonetta, Anne Forster, Yves Jacob, Murielle Masson, Fran\\xc3\\xa7ois Deryck\\xc3\\xa8re, Gilles Trav\\xc3\\xa. Targeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High-Affinity Bivalent Ligand. Angewandte Chemie (International ed. in English). vol 54. issue 27. 2016-03-27. PMID:26014966.' |
adenovirus-mediated expression of the chimera specifically induces the death of hpv-positive cells, concomitant with increased levels of the tumour suppressor p53, its transcriptional target p21, and the apoptosis marker cleaved caspase 3. |
2016-03-27 |
2023-08-13 |
human |
| Xiaoyu Li, Junguo Ma, Jianji Wan. Cytotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by ionic liquid 1-methyl-3-octylimidazolium bromide. Ecotoxicology and environmental safety. vol 120. 2016-03-25. PMID:26099465. |
the transcriptions of p53 and bax were markedly up-regulated while bcl-2 was significantly down-regulated in hepg2 cells after [c8mim]br-exposure, suggesting that p53 and bcl-2 family may be involved in the cytotoxicity and apoptosis of hepg2 cells caused by [c8mim]br. |
2016-03-25 |
2023-08-13 |
human |
| Chencheng Xie, Huarui Lu, Alice Nomura, Eric Allan Hanse, Colleen Lynn Forster, Josh Berken Parker, Michael Andrew Linden, Chris Karasch, Timothy Curtis Hallstro. Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. Molecular cancer. vol 14. 2016-03-24. PMID:25907958. |
although p53 accumulation and apoptosis induction is believed to be a primary mechanism to eliminate cells with excess e2f activity, p53 deletion doesn't suppress rb/e2f induced apoptosis in vivo in the retina. |
2016-03-24 |
2023-08-13 |
mouse |
| Chia-Hao Hsu, Ji-Sheng Lin, Keng Po Lai, Jing-Woei Li, Ting-Fung Chan, May-Su You, William Ka Fai Tse, Yun-Jin Jian. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Scientific reports. vol 5. 2016-03-24. PMID:26039894. |
apoptosis began around 16-somite stage with p53 up-regulation. |
2016-03-24 |
2023-08-13 |
Not clear |
| Takuya Kumazawa, Kazuho Nishimura, Naohiro Katagiri, Sayaka Hashimoto, Yuki Hayashi, Keiji Kimur. Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. Scientific reports. vol 5. 2016-03-24. PMID:26044764. |
gradual reduction in rrna transcription triggers p53 acetylation and apoptosis via mybbp1a. |
2016-03-24 |
2023-08-13 |
Not clear |
| Takuya Kumazawa, Kazuho Nishimura, Naohiro Katagiri, Sayaka Hashimoto, Yuki Hayashi, Keiji Kimur. Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. Scientific reports. vol 5. 2016-03-24. PMID:26044764. |
the acetylated p53 enhanced p21 and bax expression and induced apoptosis. |
2016-03-24 |
2023-08-13 |
Not clear |