| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Yong Lee, Maki Tokumoto, Yuta Hattori, Yasuyuki Fujiwara, Akinori Shimada, Masahiko Sato. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicological research. vol 32. issue 1. 2016-03-15. PMID:26977261. |
these results suggest that cd-induced apoptosis through p53 protein is associated with renal toxicity but not hepatic toxicity, and the modification of p53 protein by cd may vary depending on cell type. |
2016-03-15 |
2023-08-13 |
mouse |
| Cecilia Savorani, Valentina Manfé, Edyta Biskup, Robert Gniadeck. Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage. Leukemia & lymphoma. vol 56. issue 3. 2016-03-14. PMID:24898668. |
ellipticine caused apoptosis in myla2000 and seax and restored the transcriptional activity of (g245s)p53 in seax. |
2016-03-14 |
2023-08-13 |
human |
| Cecilia Savorani, Valentina Manfé, Edyta Biskup, Robert Gniadeck. Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage. Leukemia & lymphoma. vol 56. issue 3. 2016-03-14. PMID:24898668. |
however, p53 sirna knockdown experiments revealed that p53 was not required for ellipticine-induced apoptosis in ctcl. |
2016-03-14 |
2023-08-13 |
human |
| Cecilia Savorani, Valentina Manfé, Edyta Biskup, Robert Gniadeck. Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage. Leukemia & lymphoma. vol 56. issue 3. 2016-03-14. PMID:24898668. |
our results provide evidence that ellipticine-induced apoptosis is exerted through dna damage and does not require p53 activation in t-cell lymphoma. |
2016-03-14 |
2023-08-13 |
human |
| Eleni C Georgiadi, Georgios S Dimtsas, Theodoros P Vassilakopoulos, Gerassimos A Pangalis, Christos Kittas, Ipatia A Doussis-Anagnostopoulo. Functional p53 can modulate the relationship between E2F-1 expression and tumor kinetics in Hodgkin lymphoma. Leukemia & lymphoma. vol 56. issue 3. 2016-03-14. PMID:24925209. |
our purpose was to examine the immunohistochemical expression of e2f-1 in hodgkin lymphoma (hl) and to correlate it with proliferation and apoptosis of the tumor, clinicopathological parameters and patient outcome, as well as with expression of the downstream molecules p53 and p21. |
2016-03-14 |
2023-08-13 |
Not clear |
| M A P C Piyathilaka, M M Pathmalal, K H Tennekoon, B G D N K De Silva, S R Samarakoon, S Chanthirik. Microcystin-LR-induced cytotoxicity and apoptosis in human embryonic kidney and human kidney adenocarcinoma cell lines. Microbiology (Reading, England). vol 161. issue Pt 4. 2016-03-14. PMID:25635275. |
similarly, fluorescence microscopic observations following acridine orange-ethidium bromide (ao/eb) staining confirmed that both cell types were undergoing apoptosis after treatment with mc-lr for 24 h. expression of three apoptosis-related genes, bax, survivin and p53, was analysed by quantitative reverse transcriptase pcr analysis. |
2016-03-14 |
2023-08-13 |
human |
| M A P C Piyathilaka, M M Pathmalal, K H Tennekoon, B G D N K De Silva, S R Samarakoon, S Chanthirik. Microcystin-LR-induced cytotoxicity and apoptosis in human embryonic kidney and human kidney adenocarcinoma cell lines. Microbiology (Reading, England). vol 161. issue Pt 4. 2016-03-14. PMID:25635275. |
both bax and p53 functioned as promoters of mc-lr-mediated apoptosis in achn and hek-293 cells. |
2016-03-14 |
2023-08-13 |
human |
| Wen-Bin Ou, Jiaqing Zhu, Grant Eilers, Xuhui Li, Ye Kuang, Li Liu, Adrián Mariño-Enríquez, Ziqin Yan, Hailong Li, Fanguo Meng, Haimeng Zhou, Qing Sheng, Jonathan A Fletche. HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status. Oncotarget. vol 6. issue 12. 2016-03-14. PMID:25888633. |
we demonstrated that simultaneous knockdown of mdm2 and p53 in p53-mutant lps lines resulted in increased apoptosis, anti-proliferative effects, and cell cycle arrest, as compared to either intervention alone. |
2016-03-14 |
2023-08-13 |
Not clear |
| Zheng Wang, Xingan Cheng, Qianqian Meng, Peidan Wang, Benshui Shu, Qiongbo Hu, Meiying Hu, Guohua Zhon. Azadirachtin-induced apoptosis involves lysosomal membrane permeabilization and cathepsin L release in Spodoptera frugiperda Sf9 cells. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25849458. |
we previously reported that azadirachtin could induce apoptosis of spodoptera litura cultured cell line sl-1, which involves in the up-regulation of p53 protein. |
2016-03-11 |
2023-08-13 |
Not clear |
| Xia Wang, Jin Gao, Lan Qian, Jing Gao, Shunying Zhu, Mingyuan Wu, Yang Zhang, Wen Guan, Hao Ye, Yan Yu, Wei Ha. Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis. Anti-cancer drugs. vol 26. issue 1. 2016-03-10. PMID:24999837. |
rhil-1ra suppressed crypt apoptosis by reducing the levels of proapoptotic proteins in wild-type, but not in il-1ri or p53 mice. |
2016-03-10 |
2023-08-13 |
mouse |
| Shinya Ariyasu, Akiko Sawa, Akinori Morita, Kengo Hanaya, Misato Hoshi, Ippei Takahashi, Bing Wang, Shin Aok. Design and synthesis of 8-hydroxyquinoline-based radioprotective agents. Bioorganic & medicinal chemistry. vol 22. issue 15. 2016-03-10. PMID:25002230. |
the radiation-induced cell death of normal cells is caused, at least in part, by apoptosis, which undergoes via activation of p53 and increase in the p53 protein, a zinc-containing transcriptional factor, in response to cellular damage. |
2016-03-10 |
2023-08-13 |
Not clear |
| Shinya Ariyasu, Akiko Sawa, Akinori Morita, Kengo Hanaya, Misato Hoshi, Ippei Takahashi, Bing Wang, Shin Aok. Design and synthesis of 8-hydroxyquinoline-based radioprotective agents. Bioorganic & medicinal chemistry. vol 22. issue 15. 2016-03-10. PMID:25002230. |
however, mechanistic studies revealed that the interaction of these drugs with p53 is weak and the mechanism for inhibiting apoptosis appears to be different from that of previously reported radioprotectors such as bispicen, which inhibits apoptosis via the denaturation of p53 as well as by blocking both transcription-dependent and -independent apoptotic pathways. |
2016-03-10 |
2023-08-13 |
Not clear |
| Lu-Lu Wang, Zhong Xu, Yang Peng, Lu-Chun Li, Xiao-Ling W. Downregulation of inhibitor of apoptosis‑stimulating protein of p53 inhibits proliferation and promotes apoptosis of gastric cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25846425. |
downregulation of inhibitor of apoptosis‑stimulating protein of p53 inhibits proliferation and promotes apoptosis of gastric cancer cells. |
2016-03-10 |
2023-08-13 |
mouse |
| Wen-Jing Lu, Nishant Saxena, John M Luk, Sunil C Kaul, Renu Wadhw. Circulating mortalin autoantibody--a new serological marker of liver cirrhosis. Cell stress & chaperones. vol 20. issue 4. 2016-03-10. PMID:25905813. |
frequently enriched in cancers, it is a multifunctional protein and regulates cell proliferation, apoptosis, mitochondrial functions, and the activity of tumor suppressor protein p53. |
2016-03-10 |
2023-08-13 |
Not clear |
| Wei Zhang, En-hai Cu. [Study on effect of lycorine in inducing apoptosis of pulmonary carcinoma cell A549]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790307. |
the results showed that lycorine significantly inhibited the proliferation of a549 cells (p < 0.05), induced the apoptosis on a549 cells (p < 0.05), increased the activities of bax and p53, reduced bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of bcl-2, bax, p53 and survivin (p < 0.05). |
2016-03-10 |
2023-08-13 |
human |
| Yin-Xu Zhang, Xiao-Mei Liu, Jing Wang, Jun Li, Ying Liu, Hua Zhang, Xue-Wen Yu, Ning We. Inhibition of AKT/FoxO3a signaling induced PUMA expression in response to p53-independent cytotoxic effects of H1: A derivative of tetrandrine. Cancer biology & therapy. vol 16. issue 6. 2016-03-08. PMID:25893985. |
puma (p53 unregulated modulator of apoptosis), a bh3-only bcl-2 family member, can be induced by p53-dependent and p53-independent manners. |
2016-03-08 |
2023-08-13 |
Not clear |
| Francesca Luchetti, Barbara Canonico, Erica Cesarini, Michele Betti, Luca Galluzzi, Laura Galli, John Tippins, Chiara Zerbinati, Stefano Papa, Luigi Iulian. 7-Ketocholesterol and 5,6-secosterol induce human endothelial cell dysfunction by differential mechanisms. Steroids. vol 99. issue Pt B. 2016-03-07. PMID:25697053. |
our data provide evidence that 7-ketocholesterol and 5,6-secosterol are efficient instigators of apoptosis, which for 5,6-secosterol is associated to pkc and p53 up-regulation. |
2016-03-07 |
2023-08-13 |
human |
| Audrey Laurent, Francesco Blas. Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblast-specific hypersensitivity to radiation. Development (Cambridge, England). vol 142. issue 21. 2016-03-07. PMID:26395482. |
thus, even after low-dose irradiation, the cytoplasmic priming of epiblast cells allows p53 to rapidly induce apoptosis via a partially transcription-independent mechanism. |
2016-03-07 |
2023-08-13 |
mouse |
| Jun Chen, He Zhu, Yan Zhang, Man-Hua Cui, Li-Ying Han, Zhan-Hui Jia, Ling Wang, Hong Teng, Li-Ning Mia. Low expression of phosphatase and tensin homolog in clear‑cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway. Molecular medicine reports. vol 12. issue 2. 2016-03-04. PMID:25954860. |
it has been demonstrated that most chemotherapy drugs exert their anti-cancer effects via p53-mediated apoptosis, and in accordance, with this, the present study showed that treatment with etoposide significantly increased p53 levels. |
2016-03-04 |
2023-08-13 |
Not clear |
| Julhiany de Fátima da Silva, Juliana Vicentim, Haroldo Cesar de Oliveira, Caroline Maria Marcos, Patricia Akemi Assato, Patrícia Ferrari Andreotti, Juliana Leal Monteiro da Silva, Christiane Pienna Soares, Gil Benard, Ana Marisa Fusco Almeida, Maria José Soares Mendes-Giannin. Influence of the Paracoccidioides brasiliensis 14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells. Memorias do Instituto Oswaldo Cruz. vol 110. issue 4. 2016-03-04. PMID:26038961. |
accordingly, epithelial cells were treated with these molecules for different periods of time and the expression of the apoptosis regulating-proteins bak, bax, bcl-2, p53 and caspases were evaluated by terminal deoxynucleotidyl transferase dutp nick end labelling, flow cytometry and real-time polymerase chain reaction analysis. |
2016-03-04 |
2023-08-13 |
human |