| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Guadagno, P Swan, R Shaikh, S P Crega. Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells. Cell death & disease. vol 6. 2016-02-18. PMID:26043079. |
mechanistically, we show that il-1β activates the tumor suppressor p53 through an oxidative stress-dependent mechanism resulting in p53-mediated induction of the cyclin-dependent kinase inhibitor p21 and the proapoptotic bcl-2 (b-cell lymphoma-2) family members puma (p53-upregulated modulator of apoptosis) and noxa. |
2016-02-18 |
2023-08-13 |
Not clear |
| T L Slatter, N Hung, S Bowie, H Campbell, C Rubio, D Speidel, M Wilson, M Baird, J A Royds, A W Braithwait. Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell death & disease. vol 6. 2016-02-18. PMID:26068791. |
it is overexpressed in many tumors, stimulates pathways involved in tumor progression, and inhibits some activities of wild-type p53, including transactivation and apoptosis. |
2016-02-18 |
2023-08-13 |
mouse |
| N Mohell, J Alfredsson, Å Fransson, M Uustalu, S Byström, J Gullbo, A Hallberg, V J N Bykov, U Björklund, K G Wima. APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells. Cell death & disease. vol 6. 2016-02-18. PMID:26086967. |
apr-246 (prima-1(met)) is the first clinical-stage compound that reactivates mutant p53 and induces apoptosis. |
2016-02-18 |
2023-08-13 |
human |
| Qingshan Li, Xin Xu, Weijie Zhong, Qinghua Du, Bizhen Yu, Huabao Xion. IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis. Cellular & molecular immunology. vol 12. issue 3. 2016-02-17. PMID:25544504. |
il-17 induces radiation resistance of b lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis. |
2016-02-17 |
2023-08-13 |
human |
| Qingshan Li, Xin Xu, Weijie Zhong, Qinghua Du, Bizhen Yu, Huabao Xion. IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis. Cellular & molecular immunology. vol 12. issue 3. 2016-02-17. PMID:25544504. |
collectively, irradiated k1106 cells induce the expression of il-17 in tregs, which interferes with the expression of p53 protein in k1106 cells and thereby represses irradiation-triggered apoptosis in k1106 cells. |
2016-02-17 |
2023-08-13 |
human |
| Ting Liu, Lilan Zeng, Wenting Jiang, Yuanting Fu, Wenjie Zheng, Tianfeng Che. Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells. Nanomedicine : nanotechnology, biology, and medicine. vol 11. issue 4. 2016-02-17. PMID:25680543. |
internalized nanoparticles triggered ros overproduction and induced apoptosis by activating p53 and mapks pathways. |
2016-02-17 |
2023-08-13 |
Not clear |
| Benjamin Dannenmann, Simon Lehle, Dominic G Hildebrand, Ayline Kübler, Paula Grondona, Vera Schmid, Katharina Holzer, Mirjam Fröschl, Frank Essmann, Oliver Rothfuss, Klaus Schulze-Osthof. High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells. Stem cell reports. vol 4. issue 5. 2016-02-17. PMID:25937369. |
the low apoptosis threshold was mediated by constitutive p53 expression and a marked upregulation of proapoptotic p53 target genes of the bcl-2 family, ensuring the efficient ipsc removal upon genotoxic insults. |
2016-02-17 |
2023-08-13 |
human |
| F T Lu, D C Ma, W Yan, J Guo, L H Ba. Antitumour activity of 3-nitropropionic acid from Phomopsis sp. and optimization of fermentation conditions. Letters in applied microbiology. vol 61. issue 2. 2016-02-17. PMID:25963711. |
through quantitative detection of the genes that are closely related to the bcl-2 signalling pathway, there was an increased expression of p53 and bax and a decreased expression of bcl-2, which indicated apoptosis in these cells. |
2016-02-17 |
2023-08-13 |
Not clear |
| Chang-Rong Wei, Jun Liu, Xiao-Jun Y. Targeting SLUG sensitizes leukemia cells to ADR-induced apoptosis. International journal of clinical and experimental medicine. vol 8. issue 12. 2016-02-17. PMID:26885188. |
slug is an e-cadherin repressor and a suppressor of puma (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that slug plays an important role in controlling apoptosis. |
2016-02-17 |
2023-08-13 |
Not clear |
| Jianxu Zhang, Di Wu, Zhen Xing, Shaojun Liang, Haobo Han, Hui Shi, Yan Zhang, Yan Yang, Quanshun L. N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells. Colloids and surfaces. B, Biointerfaces. vol 129. 2016-02-16. PMID:25829127. |
due to the exogenous p53 expression, the inhibition of cell proliferation was observed through mtt analysis, attributing to the activation of apoptosis and cell cycle arrest. |
2016-02-16 |
2023-08-13 |
Not clear |
| Jianxu Zhang, Di Wu, Zhen Xing, Shaojun Liang, Haobo Han, Hui Shi, Yan Zhang, Yan Yang, Quanshun L. N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells. Colloids and surfaces. B, Biointerfaces. vol 129. 2016-02-16. PMID:25829127. |
through western blotting, activity analysis of caspase-3, caspase-8 and caspase-9 and mitochondrial membrane potential measurement, the apoptosis induced by pen-mediated p53 transfection was conducted in a mitochondria-dependent apoptosis pathway. |
2016-02-16 |
2023-08-13 |
Not clear |
| R Barzalobre-Gerónimo, Barzalobre-Gerónimo Raúl, L A Flores-López, Flores-López Luis Antonio, L A Baiza-Gutman, Baiza-Gutman Luis Arturo, M Cruz, Cruz Miguel, R García-Macedo, García-Macedo Rebeca, A Ávalos-Rodríguez, Ávalos-Rodríguez Alejandro, A Contreras-Ramos, Contreras-Ramos Alejandra, A Díaz-Flores, Díaz-Flores Margarita, C Ortega-Camarillo, Ortega-Camarillo Clar. Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells. Molecular and cellular biochemistry. vol 405. issue 1-2. 2016-02-16. PMID:25912675. |
the apoptosis of β cells induced by hyperglycemia has been associated with p53 mobilization to mitochondria and p53 phosphorylation. |
2016-02-16 |
2023-08-13 |
Not clear |
| R Barzalobre-Gerónimo, Barzalobre-Gerónimo Raúl, L A Flores-López, Flores-López Luis Antonio, L A Baiza-Gutman, Baiza-Gutman Luis Arturo, M Cruz, Cruz Miguel, R García-Macedo, García-Macedo Rebeca, A Ávalos-Rodríguez, Ávalos-Rodríguez Alejandro, A Contreras-Ramos, Contreras-Ramos Alejandra, A Díaz-Flores, Díaz-Flores Margarita, C Ortega-Camarillo, Ortega-Camarillo Clar. Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells. Molecular and cellular biochemistry. vol 405. issue 1-2. 2016-02-16. PMID:25912675. |
murine double minute 2 (mdm2) induces the degradation of p53 and thereby protects cells from apoptosis. |
2016-02-16 |
2023-08-13 |
Not clear |
| Sayed Mohammad Shafiee, Mozhgan Rasti, Atefeh Seghatoleslam, Tayebeh Azimi, Ali Akbar Owj. UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 9. 2016-02-16. PMID:25987028. |
the p53 tumor suppressor protein is a principal mediator of growth arrest, senescence, and apoptosis in response to a broad array of cellular damage. |
2016-02-16 |
2023-08-13 |
human |
| Maolan Li, Fei Zhang, Xu'an Wang, Xiangsong Wu, Bingtai Zhang, Ning Zhang, Wenguang Wu, Zheng Wang, Hao Weng, Shibo Liu, Guofeng Gao, Jiasheng Mu, Yijun Shu, Runfa Bao, Yang Cao, Jianhua Lu, Jun Gu, Jian Zhu, Yingbin Li. Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway. Cancer science. vol 106. issue 10. 2016-02-16. PMID:26250568. |
magnolol also blocked cell cycle progression at g0 /g1 phase and induced mitochondrial-related apoptosis by upregulating p53 and p21 protein levels and by downregulating cyclin d1, cdc25a, and cdk2 protein levels. |
2016-02-16 |
2023-08-13 |
human |
| Maolan Li, Fei Zhang, Xu'an Wang, Xiangsong Wu, Bingtai Zhang, Ning Zhang, Wenguang Wu, Zheng Wang, Hao Weng, Shibo Liu, Guofeng Gao, Jiasheng Mu, Yijun Shu, Runfa Bao, Yang Cao, Jianhua Lu, Jun Gu, Jian Zhu, Yingbin Li. Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway. Cancer science. vol 106. issue 10. 2016-02-16. PMID:26250568. |
when cells were pretreated with a p53 inhibitor (pifithrin-a), followed by magnolol treatment, pifithrin-a blocked magnolol-induced apoptosis and g0 /g1 arrest. |
2016-02-16 |
2023-08-13 |
human |
| Satoru Hayano, Yoshihiro Komatsu, Haichun Pan, Yuji Mishin. Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25742798. |
injection of pifithrin-α, a chemical inhibitor of p53, into pregnant mice prevented neonatal lethality while concomitantly reducing apoptosis in nasal cartilage primordia, suggesting that enhanced bmp signaling induces p53-mediated apoptosis in the nasal cartilage. |
2016-02-13 |
2023-08-13 |
mouse |
| Satoru Hayano, Yoshihiro Komatsu, Haichun Pan, Yuji Mishin. Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25742798. |
our previous finding that the bmp signaling component smad1 prevents mdm2-mediated p53 degradation coupled with our new data indicate that augmented bmp signaling induces p53-mediated apoptosis by prevention of p53 degradation in developing nasal cartilage. |
2016-02-13 |
2023-08-13 |
mouse |
| Vladimir J N Bykov, Qiang Zhang, Meiqiongzi Zhang, Sophia Ceder, Lars Abrahmsen, Klas G Wima. Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy. Frontiers in oncology. vol 6. 2016-02-12. PMID:26870698. |
the p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism, and other processes. |
2016-02-12 |
2023-08-13 |
Not clear |
| Vladimir J N Bykov, Qiang Zhang, Meiqiongzi Zhang, Sophia Ceder, Lars Abrahmsen, Klas G Wima. Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy. Frontiers in oncology. vol 6. 2016-02-12. PMID:26870698. |
missense mutations in tp53 abolish specific dna binding of p53 and allow evasion of apoptosis and accelerated tumor progression. |
2016-02-12 |
2023-08-13 |
Not clear |