| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samira Goldar, Mahmoud Shekari Khaniani, Sima Mansoori Derakhshan, Behzad Baradara. Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 6. 2016-01-08. PMID:25824729. |
these novel targeted therapies include those targeting anti-apoptotic bcl-2 family members, p53, the extrinsic pathway, flice-inhibitory protein (c-flip), inhibitor of apoptosis (iap) proteins, and the caspases. |
2016-01-08 |
2023-08-13 |
human |
| Guo-Hai Zhang, Wen-Bin Xue, Yun-Feng An, Jing-Mei Yuan, Jiang-Ke Qin, Cheng-Xue Pan, Gui-Fa S. Distinct novel quinazolinone exhibits selective inhibition in MGC-803 cancer cells by dictating mutant p53 function. European journal of medicinal chemistry. vol 95. 2016-01-08. PMID:25828929. |
molecular mechanism studies indicated that p53 phosphorylation and acetylation dual-targeting inhibitor 6c exerted anti-cancer activities with a special mechanism in evoking cell apoptosis by arresting mutant p53 function to trigger the deregulation of cdk2 caused bim-mediated apoptosis. |
2016-01-08 |
2023-08-13 |
Not clear |
| Xinwei Wang, Liang Wei, Julie M Cramer, Brian J Leibowitz, Colleen Judge, Michael Epperly, Joel Greenberger, Fengchao Wang, Linheng Li, Matthias G Stelzner, James C Y Dunn, Martin G Martin, Eric Lagasse, Lin Zhang, Jian Y. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Scientific reports. vol 5. 2016-01-06. PMID:25858503. |
using three-dimensional mouse crypt culture, we demonstrated that p53 target puma mediates radiation-induced apoptosis via a cell-intrinsic mechanism, and identified the gsk-3 inhibitor chir99021 as a potent radioprotector. |
2016-01-06 |
2023-08-13 |
mouse |
| Xinwei Wang, Liang Wei, Julie M Cramer, Brian J Leibowitz, Colleen Judge, Michael Epperly, Joel Greenberger, Fengchao Wang, Linheng Li, Matthias G Stelzner, James C Y Dunn, Martin G Martin, Eric Lagasse, Lin Zhang, Jian Y. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Scientific reports. vol 5. 2016-01-06. PMID:25858503. |
chir99021 treatment specifically blocked apoptosis and puma induction and k120 acetylation of p53 mediated by acetyl-transferase tip60, while it had no effect on p53 stabilization, phosphorylation or p21 induction. |
2016-01-06 |
2023-08-13 |
mouse |
| Simona Daniele, Barbara Costa, Elisa Zappelli, Eleonora Da Pozzo, Simona Sestito, Giulia Nesi, Pietro Campiglia, Luciana Marinelli, Ettore Novellino, Simona Rapposelli, Claudia Martin. Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells. Scientific reports. vol 5. 2016-01-06. PMID:25898313. |
in gbm cells, fc85 efficiently inhibited akt/mtor signalling and reactivated p53 functionality, triggering cellular apoptosis. |
2016-01-06 |
2023-08-13 |
Not clear |
| Jennifer Law, Mohamed Salla, Alaa Zare, Yoke Wong, Le Luong, Natalia Volodko, Orysya Svystun, Kayla Flood, Jonathan Lim, Miranda Sung, Jason R B Dyck, Chong Teik Tan, Yu-Chin Su, Victor C Yu, John Mackey, Shairaz Baks. Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein. The Journal of biological chemistry. vol 290. issue 40. 2016-01-06. PMID:26269600. |
overexpression of moap-1 in several cancer cell lines resulted in reduced tumorigenesis and up-regulation of genes involved in cancer regulatory pathways that include apoptosis (p53, fas, and mst1), dna damage control (poly(adp)-ribose polymerase and ataxia telangiectasia mutated), those within the cell metabolism (ir-α, ir-β, and amp-activated protein kinase), and a stabilizing effect on microtubules. |
2016-01-06 |
2023-08-13 |
Not clear |
| J S Long, P M Schoonen, D Graczyk, J O'Prey, K M Rya. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene. vol 34. issue 40. 2016-01-05. PMID:25659586. |
in almost half of all human cancers, the capability to induce cell death is reduced by the mutation and inactivation of p53, a tumour suppressor protein that is a central regulator of apoptosis. |
2016-01-05 |
2023-08-13 |
human |
| J S Long, P M Schoonen, D Graczyk, J O'Prey, K M Rya. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene. vol 34. issue 40. 2016-01-05. PMID:25659586. |
importantly, we show that p73-dependent stimulation of a2b signalling markedly enhances apoptosis in cancer cells that are devoid of p53. |
2016-01-05 |
2023-08-13 |
human |
| Maryam Shafagh, Fatemeh Rahmani, Norouz Delirez. CuO nanoparticles induce cytotoxicity and apoptosis in human K562 cancer cell line via mitochondrial pathway, through reactive oxygen species and P53. Iranian journal of basic medical sciences. vol 18. issue 10. 2016-01-05. PMID:26730334. |
cuo nanoparticles induce cytotoxicity and apoptosis in human k562 cancer cell line via mitochondrial pathway, through reactive oxygen species and p53. |
2016-01-05 |
2023-08-13 |
human |
| Atanu Ghorai, Asitikantha Sarma, Nitai P Bhattacharyya, Utpal Ghos. Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis. Apoptosis : an international journal on programmed cell death. vol 20. issue 4. 2016-01-04. PMID:25670618. |
cib irradiation further intensified both intrinsic and extrinsic pathways of apoptosis synergistically along with up-regulation of p53 in hsii cells resulting overall higher apoptosis in hsii than h-vector. |
2016-01-04 |
2023-08-13 |
Not clear |
| Yanhong Li, Hongxue Qi, Xiaobo Li, Xueling Hou, Xueying Lu, Xiangwen Xia. A novel dithiocarbamate derivative induces cell apoptosis through p53-dependent intrinsic pathway and suppresses the expression of the E6 oncogene of human papillomavirus 18 in HeLa cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 6. 2016-01-04. PMID:25772545. |
it was shown that dtc1 induced hela cells apoptosis through a p53-dependent pathway as tested by the wild type p53 inhibitor, pifithrin-α. |
2016-01-04 |
2023-08-13 |
human |
| R Kamaraj Kennedy, V Veena, P Ravindra Naik, Pragna Lakshmi, R Krishna, S Sudharani, N Sakthive. Phenazine-1-carboxamide (PCN) from Pseudomonas sp. strain PUP6 selectively induced apoptosis in lung (A549) and breast (MDA MB-231) cancer cells by inhibition of antiapoptotic Bcl-2 family proteins. Apoptosis : an international journal on programmed cell death. vol 20. issue 6. 2016-01-04. PMID:25820140. |
at molecular level, pcn instigates apoptosis by mitochondrial intrinsic apoptotic pathway via the overexpression of p53, bax, cytochrome c release and activation of caspase-3 with the inhibition of oncogenic anti-apoptotic proteins such as parp and bcl-2 family proteins (bcl-2, bcl-w and bcl-xl). |
2016-01-04 |
2023-08-13 |
Not clear |
| YuZhen Li, Qi Guo, XiuHua Liu, Chen Wang, DanDan Son. PUMA-mediated mitochondrial apoptotic disruption by hypoxic postconditioning. Apoptosis : an international journal on programmed cell death. vol 20. issue 8. 2016-01-04. PMID:26043893. |
p53 upregulated modulator of apoptosis (puma) is involved in lethal i/r injury. |
2016-01-04 |
2023-08-13 |
rat |
| Mauro Provinciali, Elisa Pierpaoli, Beatrice Bartozzi, Giovanni Bernardin. Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408691. |
zinc induces apoptosis of human melanoma cells, increasing reactive oxygen species, p53 and fas ligand. |
2016-01-04 |
2023-08-13 |
human |
| Mauro Provinciali, Elisa Pierpaoli, Beatrice Bartozzi, Giovanni Bernardin. Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408691. |
the aim of this study was to examine the in vitro effect of zinc on the apoptosis of human melanoma cells, by studying the zinc-dependent modulation of intracellular levels of reactive oxygen species (ros) and of p53 and fas ligand proteins. |
2016-01-04 |
2023-08-13 |
human |
| Mauro Provinciali, Elisa Pierpaoli, Beatrice Bartozzi, Giovanni Bernardin. Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408691. |
this apoptosis was associated with an increased production of intracellular ros, and of p53 and fas ligand protein. |
2016-01-04 |
2023-08-13 |
human |
| Mauro Provinciali, Elisa Pierpaoli, Beatrice Bartozzi, Giovanni Bernardin. Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408691. |
treatment of tumor cells with the antioxidant n-acetylcysteine was able to prevent zn(2+)-induced apoptosis, as well as the increase of p53 and fas ligand protein induced by zinc. |
2016-01-04 |
2023-08-13 |
human |
| Mauro Provinciali, Elisa Pierpaoli, Beatrice Bartozzi, Giovanni Bernardin. Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408691. |
zinc induces apoptosis in melanoma cells by increasing ros and this effect may be mediated by the ros-dependent induction of p53 and fas/fas ligand. |
2016-01-04 |
2023-08-13 |
human |
| Ajay Bommareddy, Karryn Crisamore, Sarah Fillman, Sarah Brozena, James Steigerwalt, Terra Landis, Adam L Vanwert, Chandradhar Dwived. Survivin Down-regulation by α-Santalol Is Not Mediated Through PI3K-AKT Pathway in Human Breast Cancer Cells. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408696. |
this study was performed to investigate the anticancer properties of α-santalol associated with the induction of apoptosis in cultured mcf-7 [estrogen receptor (er)-positive, and wild-type p53)] and mda-mb-231 (er-negative and mutant p53) breast cancer cells. |
2016-01-04 |
2023-08-13 |
human |
| Meng-Liang Lin, Shih-Shun Chen, Tian-Shung W. Synthetic Bichalcone TSWU-BR23 Induces Apoptosis of Human Colon Cancer HT-29 Cells by p53-Mediated Mitochondrial Oligomerization of BAX/BAK and Lipid Raft Localization of CD95/FADD. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408703. |
blockade of p53 expression by short-hairpin rna (shrna) suppressed oligomeric bcl-2-associated x protein (bax)/bcl-2 antagonist killer 1 (bak)-mediated mitochondrial apoptosis but did not inhibit lipid raft localization of cd95/fadd and pro-caspase-8 cleavage induced by tswu-br23. |
2016-01-04 |
2023-08-13 |
human |