| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingyue Yang, Bo Qiu, Xiao Li, Hongmei Zhang, Wenchao Li. p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma. Toxicology letters. vol 238. issue 3. 2015-12-30. PMID:26222667. |
these results demonstrated that p53 is responsible for the anti-tumor effect of ba through up-regulation of p66(shc) and mir-21 and down-regulation of sod2 expression, leading to mitochondrial ros accumulation and apoptosis. |
2015-12-30 |
2023-08-13 |
mouse |
| Jia-Dong Fan, Pin-Ji Lei, Jun-Yi Zheng, Xiang Wang, Shangze Li, Huan Liu, Yi-Lei He, Zhao-Ning Wang, Gang Wei, Xiaodong Zhang, Lian-Yun Li, Min W. The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death. PloS one. vol 10. issue 1. 2015-12-29. PMID:25562686. |
bix-01294 selectively activates the downstream genes of p53 signaling, such as p21 and dor, but not puma, a typical p53 target gene inducing apoptosis. |
2015-12-29 |
2023-08-13 |
Not clear |
| Anna Lechanteur, Tania Furst, Brigitte Evrard, Philippe Delvenne, Pascale Hubert, Géraldine Pie. Development of anti-E6 pegylated lipoplexes for mucosal application in the context of cervical preneoplastic lesions. International journal of pharmaceutics. vol 483. issue 1-2. 2015-12-29. PMID:25701628. |
e6 interferes with the apoptosis process in stressed cells by degradation of p53 tumor suppressor gene. |
2015-12-29 |
2023-08-13 |
human |
| Laura J Payne, Robert L Eves, Lilly Jia, Alan S Ma. p53 Down regulates PDGF-induced formation of circular dorsal ruffles in rat aortic smooth muscle cells. PloS one. vol 9. issue 9. 2015-12-24. PMID:25247424. |
the tumor suppressor, p53, negatively regulates cell migration and invasion in addition to its role in apoptosis, cell cycle regulation and senescence. |
2015-12-24 |
2023-08-13 |
rat |
| Jing-Ping Wang, Ya-Chu Yu, Shih-Ping Chen, Huan-Chang Liang, Chia-Wei Lin, Kang Fan. Erratum to: The collective nuclear migration of p53 and phosphorylated S473 of Akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. Molecular and cellular biochemistry. vol 409. issue 1-2. 2015-12-24. PMID:26377961. |
erratum to: the collective nuclear migration of p53 and phosphorylated s473 of akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. |
2015-12-24 |
2023-08-13 |
human |
| Fabian D Liechti, Nicolas Stüdle, Regula Theurillat, Denis Grandgirard, Wolfgang Thormann, Stephen L Lei. The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PloS one. vol 9. issue 11. 2015-12-22. PMID:25409333. |
in the hippocampus, licl significantly reduced apoptosis and gene expression of bax and p53 while it increased expression of bcl-2. |
2015-12-22 |
2023-08-13 |
rat |
| Kewei Wan. Molecular mechanisms of hepatic apoptosis regulated by nuclear factors. Cellular signalling. vol 27. issue 4. 2015-12-22. PMID:25499978. |
hepatic apoptosis alters relative levels of nuclear factors such as foxa2, nf-κb, c/ebpβ, and p53. |
2015-12-22 |
2023-08-13 |
Not clear |
| J-J Park, K-H Lim, K-H Bae. Annexin-1 regulated by HAUSP is essential for UV-induced damage response. Cell death & disease. vol 6. 2015-12-22. PMID:25695607. |
the involvement of hausp in ddr through p53 led us to investigate novel substrates for hausp, which is related to ddr or apoptosis. |
2015-12-22 |
2023-08-13 |
Not clear |
| U M Tran, U Rajarajacholan, J Soh, T-s Kim, S Thalappilly, C W Sensen, K Riabowo. LincRNA-p21 acts as a mediator of ING1b-induced apoptosis. Cell death & disease. vol 6. 2015-12-22. PMID:25741593. |
lincrna-p21 is also a target of p53 and can trigger apoptosis in mouse cell models. |
2015-12-22 |
2023-08-13 |
mouse |
| U M Tran, U Rajarajacholan, J Soh, T-s Kim, S Thalappilly, C W Sensen, K Riabowo. LincRNA-p21 acts as a mediator of ING1b-induced apoptosis. Cell death & disease. vol 6. 2015-12-22. PMID:25741593. |
thus, regulation at the level of lincrna-p21 may represent the point at which ing1b and p53 pathways converge to induce apoptosis under specific stress conditions. |
2015-12-22 |
2023-08-13 |
mouse |
| Xue-Tao Li, Rui-Jun Ju, Xiu-Ying Li, Fan Zeng, Ji-Feng Shi, Lei Liu, Cheng-Xiang Zhang, Meng-Ge Sun, Jin-Ning Lou, Wan-Liang L. Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells. Oncotarget. vol 5. issue 15. 2015-12-21. PMID:25153726. |
action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the bbb effectively; improving drug uptake by glioma cells and gscs; down-regulating the overexpressed abc transporters; inducing apoptosis of gscs via up-regulating apoptotic receptor/ligand (fas/fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (bax and bok), activating tumor suppressor protein (p53) and suppressing anti-apoptotic proteins (bcl-2 and mcl-1). |
2015-12-21 |
2023-08-13 |
mouse |
| Bin Zhu, Guang-Lu Liu, Lei Liu, Fei Ling, Gao-Xue Wan. Assessment of trifloxystrobin uptake kinetics, developmental toxicity and mRNA expression in rare minnow embryos. Chemosphere. vol 120. 2015-12-21. PMID:25240160. |
certain genes related to cell apoptosis (p53), metabolism (cyp1a), stress response (hsp70) and blood vessels (vezf1) development were all significantly up-regulated. |
2015-12-21 |
2023-08-13 |
Not clear |
| Guo-Wei Wang, Chao Lv, Zhi-Ran Shi, Ren-Tao Zeng, Xue-Yun Dong, Wei-Dong Zhang, Run-Hui Liu, Lei Shan, Yun-Heng She. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PloS one. vol 9. issue 12. 2015-12-21. PMID:25502685. |
flow cytometry and western blot analysis showed that the apoptosis was associated with cell cycle arrest during the g1 phase, up-regulation of p53 and p21, and down-regulation of cdk2 and cyclin d1. |
2015-12-21 |
2023-08-13 |
human |
| Tadamoto Isogai, Rob van der Kammen, Soenita S Goerdayal, Albert J R Heck, A F Maarten Altelaar, Metello Innocent. Proteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2). Molecular & cellular proteomics : MCP. vol 14. issue 4. 2015-12-21. PMID:25682332. |
increased mdia2 and fbxo3 levels elevate p53 activity and expression thereby sensitizing cells to p53-dependent apoptosis, whereas their decrease produces opposite effects. |
2015-12-21 |
2023-08-13 |
mouse |
| Jin-Xia Wu, Ding-Guo Zhang, Jun-Nian Zheng, Dong-Sheng Pe. Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion. Cellular signalling. vol 27. issue 6. 2015-12-21. PMID:25728512. |
the p53 transcription factor is a critical regulator of the cell cycle, dna repair, and apoptosis. |
2015-12-21 |
2023-08-13 |
Not clear |
| Jung Hye Kim, Byung Rho Chin, Seong Yong Kim, Jae Ryong Kim, Suk Hwan Bae. Differential Sensitivity of Taxol-induced Apoptosis in U2OS and SaOS2 Osteogenic Sarcoma Cells. Cancer research and treatment. vol 35. issue 2. 2015-12-19. PMID:26680929. |
in this study, to further demonstrate the differential effect of the tumor suppressor gene, p53, on the taxol-induced apoptosis in osteogenic sarcoma cell lines, we used p53-defected saos2 cells and wild type p53-expressed u2os cells. |
2015-12-19 |
2023-08-13 |
Not clear |
| Mokhtar I Yousef, Hend M Hussie. Cisplatin-induced renal toxicity via tumor necrosis factor-α, interleukin 6, tumor suppressor P53, DNA damage, xanthine oxidase, histological changes, oxidative stress and nitric oxide in rats: protective effect of ginseng. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 78. 2015-12-17. PMID:25640527. |
also, ginseng diminished p53 activation and improved renal cell apoptosis and nephrotoxicity. |
2015-12-17 |
2023-08-13 |
rat |
| Tong Zhu, Tian-Jing Liu, Yong-Yan Shi, Qun Zha. Vitamin D/VDR signaling pathway ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis by inhibiting intestinal epithelial apoptosis. International journal of molecular medicine. vol 35. issue 5. 2015-12-17. PMID:25813397. |
subsequently, we investigated p53 upregulated modulator of apoptosis (puma) and p53, two major independent pathways of apoptosis, as well as caspase-3. |
2015-12-17 |
2023-08-13 |
mouse |
| Xiaopan Chen, Jie Liu, Wen-ke Feng, Xiaoyang Wu, Shao-yu Che. MiR-125b protects against ethanol-induced apoptosis in neural crest cells and mouse embryos by targeting Bak 1 and PUMA. Experimental neurology. vol 271. 2015-12-17. PMID:26024858. |
in addition, over-expression of mir-125b significantly reduced ethanol-induced increase in bak1 and puma protein expression, caspase-3 activation, and apoptosis in nccs, indicating that mir-125b can modulate ethanol-induced apoptosis by the regulation of bcl-2 and p53 pathways. |
2015-12-17 |
2023-08-13 |
mouse |
| Dingding Shi, Vundavalli V Murty, Wei G. PCDH10, a novel p53 transcriptional target in regulating cell migration. Cell cycle (Georgetown, Tex.). vol 14. issue 6. 2015-12-15. PMID:25590240. |
cell cycle arrest, senescence and apoptosis are commonly regarded as the major tumor suppression mechanisms of p53. |
2015-12-15 |
2023-08-13 |
human |