| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Xiao Xu, Zhi-Heng Li, Yan-Fang Tao, Rong-Hu Li, Fang Fang, He Zhao, Gang Li, Yan-Hong Li, Jian Wang, Xing Feng, Jian Pa. Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway. Journal of experimental & clinical cancer research : CR. vol 33. 2015-12-03. PMID:25523932. |
histone acetyltransferase inhibitor ii induces apoptosis in glioma cell lines via the p53 signaling pathway. |
2015-12-03 |
2023-08-13 |
Not clear |
| Jiang-Jiang Qin, Wei Wang, Sukesh Voruganti, Hui Wang, Wei-Dong Zhang, Ruiwen Zhan. Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation. Oncotarget. vol 6. issue 5. 2015-12-03. PMID:25739118. |
we further found that japa inhibited cell growth, decreased cell proliferation, and induced g2/m phase arrest and apoptosis in breast cancer cells through an mdm2-dependent mechanism, regardless of p53 status. |
2015-12-03 |
2023-08-13 |
human |
| Mohammad Bagher Pirouzpanah, Mehdi Sabzichi, Saeed Pirouzpanah, Hadi Chavoshi, Nasser Samad. Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 5. 2015-12-03. PMID:25773855. |
silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, bak and bcl-xl pathways. |
2015-12-03 |
2023-08-13 |
Not clear |
| Mohammad Bagher Pirouzpanah, Mehdi Sabzichi, Saeed Pirouzpanah, Hadi Chavoshi, Nasser Samad. Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 5. 2015-12-03. PMID:25773855. |
apoptosis was determined by flow cytometry and the impact of silibinin on the expression of pivotal genes including bak, p53, p21, brca1, bcl-x1 and atm was analyzed. |
2015-12-03 |
2023-08-13 |
Not clear |
| Mohammad Bagher Pirouzpanah, Mehdi Sabzichi, Saeed Pirouzpanah, Hadi Chavoshi, Nasser Samad. Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 5. 2015-12-03. PMID:25773855. |
taken together, the results suggest that silibinin inhibits the proliferation and induces apoptosis of mcf-7 cells by down-regulating bak, p53, p21, brca1, bcl-xl and thus may be considered as an effective adjuvant drug to produce a better chemopreventive response for the cancer therapy. |
2015-12-03 |
2023-08-13 |
Not clear |
| Cheppail Ramachandran, Karl-W Quirin, Enrique A Escalon, Ivonne V Lollett, Steven J Melnic. Therapeutic Effect of Supercritical CO2 Extracts of Curcuma Species with Cancer Drugs in Rhabdomyosarcoma Cell Lines. Phytotherapy research : PTR. vol 29. issue 8. 2015-12-03. PMID:25939344. |
ca also modulated the expression of genes associated with intrinsic pathway of apoptosis (bcl-2, bax, bak, and p53) and also inhibited the expression of genes associated with inflammation such as cox-2 and nf-κb. |
2015-12-03 |
2023-08-13 |
mouse |
| Quan Zhang, Li-Ye Cao, Shu-Jie Cheng, Ai-Min Zhang, Xiao-Shi Jin, Yong L. p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB. Oncology reports. vol 33. issue 3. 2015-12-01. PMID:25591821. |
we found that wild-type p53 regulated the expression of mir-1246 in hcc cell lines, and alteration of mir-1246 modulated cell proliferation, colony formation ability and apoptosis. |
2015-12-01 |
2023-08-13 |
human |
| Kyong-Jin Jung, Kyoung-jin Min, Jae Hoon Bae, Taeg Kyu Kwo. Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells. Oncotarget. vol 6. issue 3. 2015-12-01. PMID:25596735. |
furthermore, carnosic acid induced death receptor (dr)5, bcl-2 interacting mediator of cell death (bim), and p53 up-regulated modulator of apoptosis (puma) expression at the transcriptional levels via ccaat/enhancer-binding protein-homologous protein (chop). |
2015-12-01 |
2023-08-13 |
human |
| Zhaojun Wan, Huazheng Pan, Shihai Liu, Jingjuan Zhu, Weiwei Qi, Kai Fu, Teng Zhao, Jun Lian. Downregulation of SNAIL sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by regulating the NF-κB pathway. Oncology reports. vol 33. issue 3. 2015-12-01. PMID:25607597. |
to determine how to sensitize hcc cells to trail-induced apoptosis after silencing snail, p53 was assessed by western blot analysis. |
2015-12-01 |
2023-08-13 |
Not clear |
| Zhaojun Wan, Huazheng Pan, Shihai Liu, Jingjuan Zhu, Weiwei Qi, Kai Fu, Teng Zhao, Jun Lian. Downregulation of SNAIL sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by regulating the NF-κB pathway. Oncology reports. vol 33. issue 3. 2015-12-01. PMID:25607597. |
the results demonstrated that silencing snail can sensitize trail-induced apoptosis in hcc cells by upregulating p53 protein and by regulating related genes of the nf-κb pathway such as bcl-xl, survivin and raf-1. |
2015-12-01 |
2023-08-13 |
Not clear |
| Qun Lu, Wenjie Mei, Shaohong Luo, Weibin H. Apoptosis of Bel-7402 human hepatoma cells induced by a ruthenium(II) complex coordinated by cordycepin through the p53 pathway. Molecular medicine reports. vol 11. issue 6. 2015-12-01. PMID:25651236. |
apoptosis of bel-7402 human hepatoma cells induced by a ruthenium(ii) complex coordinated by cordycepin through the p53 pathway. |
2015-12-01 |
2023-08-13 |
human |
| Qun Lu, Wenjie Mei, Shaohong Luo, Weibin H. Apoptosis of Bel-7402 human hepatoma cells induced by a ruthenium(II) complex coordinated by cordycepin through the p53 pathway. Molecular medicine reports. vol 11. issue 6. 2015-12-01. PMID:25651236. |
subsequent experiments using fcm and western blot analysis indicated that cor‑ru(ii) induced cell apoptosis via suppression of bcl‑2 expression and stimulation of p53 expression. |
2015-12-01 |
2023-08-13 |
human |
| Diego Montagner, Valentina Gandin, Cristina Marzano, Andrea Erxlebe. DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex. Journal of inorganic biochemistry. vol 145. 2015-12-01. PMID:25660211. |
western blotting analysis indicated that the cu complex activates the p53 dependent pathway of apoptosis. |
2015-12-01 |
2023-08-13 |
human |
| Dadi Jiang, Edward L LaGory, Daniela Kenzelmann Brož, Kathryn T Bieging, Colleen A Brady, Nichole Link, John M Abrams, Amato J Giaccia, Laura D Attard. Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell reports. vol 10. issue 7. 2015-12-01. PMID:25704813. |
in response to diverse stress signals, p53 can trigger apoptosis to eliminate damaged cells or cell-cycle arrest to enable cells to cope with stress and survive. |
2015-12-01 |
2023-08-13 |
Not clear |
| J R Hall, Z J Messenger, H W Tam, S L Phillips, L Recio, R C Smar. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell death & disease. vol 6. 2015-11-30. PMID:25789975. |
p53 plays a key role in the response of skin keratinocytes to uvb-induced dna damage by inducing cell cycle arrest and apoptosis. |
2015-11-30 |
2023-08-13 |
mouse |
| J R Hall, Z J Messenger, H W Tam, S L Phillips, L Recio, R C Smar. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell death & disease. vol 6. 2015-11-30. PMID:25789975. |
in skin cancer development, uvb-induced mutation of p53 allows keratinocytes upon successive uvb exposures to evade apoptosis and cell cycle arrest. |
2015-11-30 |
2023-08-13 |
mouse |
| J R Hall, Z J Messenger, H W Tam, S L Phillips, L Recio, R C Smar. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell death & disease. vol 6. 2015-11-30. PMID:25789975. |
we observed that a mutant p53(+/r172h) allele expressed in mouse epidermis (k5cre(+/tg);lslp53(+/r172h)) showed a significant dominant-negative inhibitory effect on uvb-induced lincrna-p21 transcription and apoptosis in epidermis. |
2015-11-30 |
2023-08-13 |
mouse |
| J R Hall, Z J Messenger, H W Tam, S L Phillips, L Recio, R C Smar. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell death & disease. vol 6. 2015-11-30. PMID:25789975. |
we propose that the mutation of a single p53 allele provides a pro-oncogenic function early in skin cancer development through a dominant inhibitory effect on uvb-induced lincrna-p21 expression and the subsequent evasion of uvb-induced apoptosis. |
2015-11-30 |
2023-08-13 |
mouse |
| Xiaoyu Wang, Yiqian Zhang, Peng Lu, Hao Zhang, Yufeng Li, Hongyan Dong, Zhongming Zhan. PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277390. |
pedf attenuates hypoxia-induced apoptosis and necrosis in h9c2 cells by inhibiting p53 mitochondrial translocation via pedf-r. pigment epithelial-derived factor (pedf) is a multifunctional secreted glycoprotein, which could protect against hypoxia-induced cell death related to its anti-oxidative effect in cultured cardiomyocytes. |
2015-11-27 |
2023-08-13 |
Not clear |
| Xiaoyu Wang, Yiqian Zhang, Peng Lu, Hao Zhang, Yufeng Li, Hongyan Dong, Zhongming Zhan. PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277390. |
we conclude that pedf-r mediates pedf attenuates hypoxia-induced apoptosis and necrosis in h9c2 cells by inhibiting p53 mitochondrial translocation. |
2015-11-27 |
2023-08-13 |
Not clear |