| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sunil K Malonia, Parul Dutta, Manas Kumar Santra, Michael R Gree. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 28. 2015-10-30. PMID:26124108. |
in response to genotoxic stress, p53 levels increase and induce cell-cycle arrest, senescence, or apoptosis, thereby preventing replication of damaged dna. |
2015-10-30 |
2023-08-13 |
Not clear |
| Dong-In Koh, Haemin An, Min-Young Kim, Bu-Nam Jeon, Seo-Hyun Choi, Sujin Susanne Hur, Man-Wook Hu. Transcriptional activation of APAF1 by KAISO (ZBTB33) and p53 is attenuated by RelA/p65. Biochimica et biophysica acta. vol 1849. issue 9. 2015-10-30. PMID:26183023. |
while kaiso enhances p53-dependent apoptosis by increasing apaf1 gene expression, rela/p65 decreases apoptosis by blocking interaction between kaiso and p53. |
2015-10-30 |
2023-08-13 |
Not clear |
| Peyker Temiz, Gizem Akkaş, Nalan Neşe, Fazilet Uğur Duman, Cansu Karakaş, Yamaç Erha. Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. Turkish journal of medical sciences. vol 45. issue 4. 2015-10-30. PMID:26422859. |
determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, bcl-2, bax, bcl-xl, and cyclin d1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. |
2015-10-30 |
2023-08-13 |
Not clear |
| B Gogebakan, R Bayraktar, M Ulaslı, S Oztuzcu, D Tasdemir, H Bayra. The role of bronchial epithelial cell apoptosis in the pathogenesis of COPD. Molecular biology reports. vol 41. issue 8. 2015-10-29. PMID:24871992. |
qrt-pcr was used to assess mrna expression for proteins involving apoptosis including p21(cip1/waf1), p53, caspase-8 and caspase-9. |
2015-10-29 |
2023-08-13 |
human |
| B Gogebakan, R Bayraktar, M Ulaslı, S Oztuzcu, D Tasdemir, H Bayra. The role of bronchial epithelial cell apoptosis in the pathogenesis of COPD. Molecular biology reports. vol 41. issue 8. 2015-10-29. PMID:24871992. |
these findings suggest that hbec apoptosis is increased in copd, and that this involves p53 and caspase-8 pathways. |
2015-10-29 |
2023-08-13 |
human |
| F Han, W Liu, X Jiang, X Shi, L Yin, L Ao, Z Cui, Y Li, C Huang, J Cao, J Li. SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer. Oncogene. vol 34. issue 33. 2015-10-29. PMID:25435374. |
sox30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer. |
2015-10-29 |
2023-08-13 |
Not clear |
| Zhichao Fu, Dongsheng Chen, Huihua Cheng, Fengmei Wan. Hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2015-10-29. PMID:25623525. |
hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia. |
2015-10-29 |
2023-08-13 |
human |
| Neslihan Tekin, Mehmet C Ustuner, Fahrettin Akyuz, Cansu S Ozbayer, Ozlem Aydın, Kadriye Benkli, Dilek Burukoglu, Irfan Degirmenci, Hilmi Ozde. Apoptotic effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats. Molecular biology reports. vol 41. issue 8. 2015-10-28. PMID:24756331. |
in conclusion, [au(dppz)cl2]cl complex induced apoptosis by elevating levels of caspase 3, p53, bax, and dna fragmentation. |
2015-10-28 |
2023-08-13 |
rat |
| Wenting Jiang, Yuanting Fu, Fang Yang, Yufeng Yang, Ting Liu, Wenjie Zheng, Lilan Zeng, Tianfeng Che. Gracilaria lemaneiformis polysaccharide as integrin-targeting surface decorator of selenium nanoparticles to achieve enhanced anticancer efficacy. ACS applied materials & interfaces. vol 6. issue 16. 2015-10-27. PMID:25073123. |
therefore, p53, mapks, and akt pathways were activated to advance cell apoptosis. |
2015-10-27 |
2023-08-13 |
Not clear |
| Mohamed A Haidara, Abdullah S Assiri, Mary A Youssef, Manal M Mahmoud, Eajaz Ahmed M S, Ahmed Al-Hakami, Harish C Chandramoorth. Differentiated mesenchymal stem cells ameliorate cardiovascular complications in diabetic rats. Cell and tissue research. vol 359. issue 2. 2015-10-27. PMID:25413785. |
the levels of pro-apoptotic makers p53 and bax were highly expressed in the diabetic groups indicating oxidative stress through ros induced by high cytosolic calcium skewing the cells towards apoptosis. |
2015-10-27 |
2023-08-13 |
rat |
| W Shen, A Chang, J Wang, W Zhou, R Gao, J Li, Y Xu, X Luo, R Xiang, N Luo, D G Stupac. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. vol 4. 2015-10-27. PMID:26501855. |
reconstituting tifa expression in hcc cell lines promoted two independent apoptosis signaling pathways: the induction of p53 and cell cycle arrest, and the activation of caspase-8 and caspase-3. |
2015-10-27 |
2023-08-13 |
mouse |
| Momoe Itsumi, Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Eiji Kashiwagi, Takashi Dejima, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi, Seiji Nait. PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells. Journal of molecular endocrinology. vol 53. issue 1. 2015-10-26. PMID:24780839. |
furthermore, pma activated jnk and p53 signaling, resulting in the induction of cellular apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Suna Sabuncuogl. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24839208. |
reactive oxygen species (ros) and reactive nitrogen species generations have been proposed to be an important mechanism of dox-induced cardiotoxicity and cardiomyocyte apoptosis, which may be mediated by p53 protein. |
2015-10-26 |
2023-08-13 |
Not clear |
| Ying-Jiun Lai, Chien-I Lin, Chia-Lin Wang, Jui-I Cha. Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24905183. |
expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. |
2015-10-26 |
2023-08-13 |
human |
| Ying-Jiun Lai, Chien-I Lin, Chia-Lin Wang, Jui-I Cha. Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24905183. |
here, we show that survivin and p53 display the opposite role on the regulation of honokiol-induced apoptosis in the human colorectal cancer cells. |
2015-10-26 |
2023-08-13 |
human |
| Ying-Jiun Lai, Chien-I Lin, Chia-Lin Wang, Jui-I Cha. Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24905183. |
together, these findings demonstrate that the existence of survivin and p53 can modulate the honokiol-induced apoptosis in the human colorectal cancer cells. |
2015-10-26 |
2023-08-13 |
human |
| b' Radomir Zivadinovi\\xc4\\x87, Aleksandra Petri\\xc4\\x87, Goran Lili\\xc4\\x87, Vekoslav Lili\\xc4\\x87, Biljana Djordjevi\\xc4\\x8. [Persistent human papillomavirus infection in the etiology of cervical carcinoma: the role of immunological, genetic, viral and cellular factors]. Srpski arhiv za celokupno lekarstvo. vol 142. issue 5-6. 2015-10-26. PMID:25033599.' |
the e6 protein binds to p53 protein (product of tumor-suppressor gene) blocking and degrading it, which in turn prevents cell cycle arrest and apoptosis induction. |
2015-10-26 |
2023-08-13 |
human |
| Seon-Mi Yu, Song-Ja Ki. Withaferin A-caused production of intracellular reactive oxygen species modulates apoptosis via PI3K/Akt and JNKinase in rabbit articular chondrocytes. Journal of Korean medical science. vol 29. issue 8. 2015-10-26. PMID:25120312. |
we also determined that wfa markedly leads to apoptosis as evidenced by accumulation of p53 by western blot analysis. |
2015-10-26 |
2023-08-13 |
rabbit |
| Seon-Mi Yu, Song-Ja Ki. Withaferin A-caused production of intracellular reactive oxygen species modulates apoptosis via PI3K/Akt and JNKinase in rabbit articular chondrocytes. Journal of Korean medical science. vol 29. issue 8. 2015-10-26. PMID:25120312. |
n-acetyl-l-cystein (nac), an antioxidant, prevented wfa-caused expression of p53 and inhibited apoptosis of chondrocytes. |
2015-10-26 |
2023-08-13 |
rabbit |
| Katherine L Misuraca, Kelly L Barton, Alexander Chung, Alexander K Diaz, Simon J Conway, David L Corcoran, Suzanne J Baker, Oren J Beche. Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma. Acta neuropathologica communications. vol 2. 2015-10-26. PMID:25330836. |
pax3-induced inhibition of apoptosis is p53-dependent, however, and in the absence of p53, pax3 promotes proliferation of brainstem progenitors. |
2015-10-26 |
2023-08-13 |
mouse |