| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo-Kyoung Choi, Youngsok Choi, HeeBum Kang, Eun-Jin Lim, Soo-Yeon Park, Hyun-Seob Lee, Ji-Min Park, Jisook Moon, Yoon-Jung Kim, Insup Choi, Eun-Hye Joe, Kyung-Chul Choi, Ho-Geun Yoo. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Human molecular genetics. vol 24. issue 4. 2015-09-22. PMID:25305081. |
dysregulation of p53 levels has been implicated in neuronal apoptosis. |
2015-09-22 |
2023-08-13 |
Not clear |
| Hyo-Kyoung Choi, Youngsok Choi, HeeBum Kang, Eun-Jin Lim, Soo-Yeon Park, Hyun-Seob Lee, Ji-Min Park, Jisook Moon, Yoon-Jung Kim, Insup Choi, Eun-Hye Joe, Kyung-Chul Choi, Ho-Geun Yoo. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Human molecular genetics. vol 24. issue 4. 2015-09-22. PMID:25305081. |
the role of histone deacetylase 3 (hdac3) in suppressing p53-dependent apoptosis has been recently emphasized; however, the molecular basis of modulation of p53 function by hdac3 remains unclear. |
2015-09-22 |
2023-08-13 |
Not clear |
| Peng-Cheng Lv, Juan Sun, Hai-Liang Zh. Recent advances of p53-MDM2 small molecule inhibitors (2011-present). Current medicinal chemistry. vol 22. issue 5. 2015-09-21. PMID:25439588. |
p53 is an important transcriptional factor that plays a pivotal role in different biological process (cell cycle, apoptosis, dna repair, angiogenesis and cellular metabolism). |
2015-09-21 |
2023-08-13 |
Not clear |
| Yang Shen, Linyi Meng, Huajun Sun, Yizhun Zhu, Hongrui Li. Cochinchina momordica seed suppresses proliferation and metastasis in human lung cancer cells by regulating multiple molecular targets. The American journal of Chinese medicine. vol 43. issue 1. 2015-09-21. PMID:25649746. |
ecms-induced apoptosis was accompanied by up-regulation of p53, bax and the down-regulation of bcl-2, pi-3k/akt signal pathway, and resulted in the dissipation of mitochondrial membrane potential (ΔΨm) and sequentially activated caspase-3 cascade. |
2015-09-21 |
2023-08-13 |
human |
| Yang Shen, Linyi Meng, Huajun Sun, Yizhun Zhu, Hongrui Li. Cochinchina momordica seed suppresses proliferation and metastasis in human lung cancer cells by regulating multiple molecular targets. The American journal of Chinese medicine. vol 43. issue 1. 2015-09-21. PMID:25649746. |
in conclusion, the current data demonstrated ecms inhibited the proliferation of a549 cells by inducing apoptosis, at least partly through the activation of p53 and inactivation of pi-3k/akt signaling. |
2015-09-21 |
2023-08-13 |
human |
| Jiaqi Li, Manabu Kurokaw. Regulation of MDM2 Stability After DNA Damage. Journal of cellular physiology. vol 230. issue 10. 2015-09-21. PMID:25808808. |
however, upon dna damage or other stressors, p53 is released from its inhibitory state to induce an array of apoptosis and cell cycle genes. |
2015-09-21 |
2023-08-13 |
Not clear |
| Hiroko P Indo, Tsukasa Tomiyoshi, Shigeaki Suenaga, Kazuo Tomita, Hiromi Suzuki, Daisuke Masuda, Masahiro Terada, Noriaki Ishioka, Oleg Gusev, Richard Cornette, Takashi Okuda, Chiaki Mukai, Hideyuki J Majim. MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. Journal of clinical biochemistry and nutrition. vol 57. issue 2. 2015-09-21. PMID:26388666. |
a quantitative real-time reverse transcription polymerase chain reaction (qrt-pcr) examination was performed for apoptosis related factors (bax, cytc, apaf1, vdac1-3, casp3, casp8, casp9 p53, aif, ant1 and 2, bcl2, mnsod, autophagy related becn and necrosis related cyp-40. |
2015-09-21 |
2023-08-13 |
human |
| Sarah Ali Azouaou, Fathi Emhemmed, Noureddine Idris-Khodja, Annelise Lobstein, Valérie Schini-Kerth, Christian D Muller, Guy Fuhrman. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells. Investigational new drugs. vol 33. issue 1. 2015-09-18. PMID:25404486. |
rooperol-induced apoptosis was associated with activation of p53 and concentration-dependent changes of the expression levels of both caspase 3 and poly adp ribose polymerase type 1 cleaved subunits. |
2015-09-18 |
2023-08-13 |
human |
| Sarah Ali Azouaou, Fathi Emhemmed, Noureddine Idris-Khodja, Annelise Lobstein, Valérie Schini-Kerth, Christian D Muller, Guy Fuhrman. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells. Investigational new drugs. vol 33. issue 1. 2015-09-18. PMID:25404486. |
these modifications were accompanied by a downregulation of oct4 and its two partners involved in the maintenance of cell pluripotency and self-renewal, nanog and sox2.treatment with intracellular membrane permeant o2 (-) scavengers prevented rooperol-induced apoptosis and upregulation of the expression of p53 and active caspase-3. |
2015-09-18 |
2023-08-13 |
human |
| Dong-Il Kim, Min-Jung Park, Joo-Hee Choi, Seul-Ki Lim, Hak-Jong Choi, Soo-Hyun Par. Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis. The international journal of biochemistry & cell biology. vol 59. 2015-09-18. PMID:25483438. |
such a decrease generates intracellular ros, which increases er stress-mediated p53 expression, and subsequently causes apoptosis by increasing bax promoter activity. |
2015-09-18 |
2023-08-13 |
human |
| Hyun-Young Lee, Kyu Jin Chung, In Hyun Hwang, Jungsuk Gwak, Seoyoung Park, Bong Gun Ju, Eunju Yun, Dong-Eun Kim, Young-Hwa Chung, MinKyun Na, Gyu-Yong Song, Sangtaek O. Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells. Marine drugs. vol 13. issue 1. 2015-09-18. PMID:25603347. |
activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells. |
2015-09-18 |
2023-08-13 |
human |
| Hyun-Young Lee, Kyu Jin Chung, In Hyun Hwang, Jungsuk Gwak, Seoyoung Park, Bong Gun Ju, Eunju Yun, Dong-Eun Kim, Young-Hwa Chung, MinKyun Na, Gyu-Yong Song, Sangtaek O. Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells. Marine drugs. vol 13. issue 1. 2015-09-18. PMID:25603347. |
the tumor suppressor, p53, plays an essential role in the cellular response to stress through regulating the expression of genes involved in cell cycle arrest, apoptosis and autophagy. |
2015-09-18 |
2023-08-13 |
human |
| Peng Xia, Yifu Sun, Changjun Zheng, Tingting Hou, Mingyang Kang, Xiaoyu Yan. p53 mediated apoptosis in osteosarcoma MG-63 cells by inhibition of FANCD2 gene expression. International journal of clinical and experimental medicine. vol 8. issue 7. 2015-09-18. PMID:26379910. |
p53 mediated apoptosis in osteosarcoma mg-63 cells by inhibition of fancd2 gene expression. |
2015-09-18 |
2023-08-13 |
Not clear |
| Jie Feng, Chengbo Meng, Da Xin. Aβ induces PUMA activation: a new mechanism for Aβ-mediated neuronal apoptosis. Neurobiology of aging. vol 36. issue 2. 2015-09-17. PMID:25457551. |
p53 upregulated modulator of apoptosis (puma) is a promising tumor therapy target because it elicits apoptosis and profound sensitivity to radiation and chemotherapy. |
2015-09-17 |
2023-08-13 |
mouse |
| Haraldur H Sigurðsson, Christina W Olesen, Rie Dybboe, Gitte Lauritzen, Stine F Pederse. Constitutively active ErbB2 regulates cisplatin-induced cell death in breast cancer cells via pro- and antiapoptotic mechanisms. Molecular cancer research : MCR. vol 13. issue 1. 2015-09-16. PMID:25143433. |
cisplatin treatment elicited apoptosis, atm phosphorylation, upregulation of p53, noxa (pmaip1), and puma (bbc3), and cleavage of caspase-9, -7, fodrin, and parp-1 in mcf-7 cells. |
2015-09-16 |
2023-08-13 |
Not clear |
| Hai-Bo Yang, Wei Song, Mei-Die Cheng, Hai-Fang Fan, Xu Gu, Ying Qiao, Xin Lu, Rui-He Yu, Lan-Ying Che. Deoxycholic acid inhibits the growth of BGC-823 gastric carcinoma cells via a p53‑mediated pathway. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25434397. |
these results suggest that dca induces apoptosis in gastric carcinoma cells through activation of an intrinsic mitochondrial‑dependent pathway, in which p53 is involved. |
2015-09-16 |
2023-08-13 |
human |
| Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis, Carl G Mak. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25482935. |
cp induced apoptosis to varying extents and activated akt and chk1 in multiple p53 wild-type and p53-null os cell lines. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis, Carl G Mak. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25482935. |
a chk1 inhibitor increased cp-induced apoptosis in all os cell lines regardless of p53 status. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis, Carl G Mak. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25482935. |
in contrast, an akt inhibitor increased cp-induced apoptosis only in p53 wild-type os cells, but not p53 nulll cells. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis, Carl G Mak. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25482935. |
the increased apoptosis in p53 wild-type cells was coincident with decreased p53 protein levels, but increased expression of p53-responsive apoptotic genes noxa and puma. |
2015-09-16 |
2023-08-13 |
Not clear |