| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammed I Alhazmi, Tarique N Hasan, Gowhar Shafi, Abdullah H Al-Assaf, Mohammed A Alfawaz, Ali A Alshatw. Roles of p53 and caspases in induction of apoptosis in MCF- 7 breast cancer cells treated with a methanolic extract of Nigella sativa seeds. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 22. 2015-08-24. PMID:25520084. |
roles of p53 and caspases in induction of apoptosis in mcf- 7 breast cancer cells treated with a methanolic extract of nigella sativa seeds. |
2015-08-24 |
2023-08-13 |
Not clear |
| Visa Thongrakard, Rossella Titone, Carlo Follo, Federica Morani, Apichart Suksamrarn, Tewin Tencomnao, Ciro Isidor. Turmeric toxicity in A431 epidermoid cancer cells associates with autophagy degradation of anti-apoptotic and anti-autophagic p53 mutant. Phytotherapy research : PTR. vol 28. issue 12. 2015-08-21. PMID:25044209. |
here, we show that the crude extract of turmeric (curcuma longa), similarly to its bioactive component curcumin, could induce both apoptosis and autophagy in a431 cells, and these effects were concomitant with degradation of p53. |
2015-08-21 |
2023-08-13 |
Not clear |
| Bihui Yang, Li Wang, Xiaohua Luo, Liping Chen, Zesong Yang, Lin Li. SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis. International journal of oncology. vol 46. issue 2. 2015-08-21. PMID:25405588. |
spag6 silencing inhibits the growth of the malignant myeloid cell lines skm-1 and k562 via activating p53 and caspase activation-dependent apoptosis. |
2015-08-21 |
2023-08-13 |
mouse |
| Bihui Yang, Li Wang, Xiaohua Luo, Liping Chen, Zesong Yang, Lin Li. SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis. International journal of oncology. vol 46. issue 2. 2015-08-21. PMID:25405588. |
these findings demonstrate that spag6 might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase proteins and p53, suggesting that spag6 may be a potential therapeutic target. |
2015-08-21 |
2023-08-13 |
mouse |
| Tieliang Ma, Jun Xu, Yuan Wang, Hao Yu, Yong Yang, Yang Liu, Weiliang Ding, Wenjiao Zhu, Ruhua Chen, Zhijun Ge, Yongfei Tan, Lei Jia, Taofeng Zh. Ternary copper(II) complexes with amino acid chains and heterocyclic bases: DNA binding, cytotoxic and cell apoptosis induction properties. Journal of inorganic biochemistry. vol 144. 2015-08-21. PMID:25555321. |
cell apoptosis were detected by annexinv/pi flow cytometry and by western blotting with the protein expression of p53, bax and bcl-2. |
2015-08-21 |
2023-08-13 |
human |
| Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, Saripella Srikrishn. Folic acid supplementation rescues anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinson's disease. Biochemical and biophysical research communications. vol 460. issue 3. 2015-08-21. PMID:25824034. |
elevated p53 is involved in mitochondrial mediated apoptosis of neuronal cells in parkinson's patients who are folate deficient as well. |
2015-08-21 |
2023-08-13 |
drosophila_melanogaster |
| Ebrahim Eskandari-Nasab, Mohammad Hashemi, Shadi Amininia, Mahboubeh Ebrahimi, Maryam Rezaei, Seyed Mehdi Hashem. Effect of TP53 16-bp and β-TrCP 9-bp INS/DEL polymorphisms in relation to risk of breast cancer. Gene. vol 568. issue 2. 2015-08-21. PMID:26003292. |
p53 as a tumor suppressor and an apoptosis modulator, is the regulator of the cell cycle and apoptosis, and contributes to mammary gland development and breast cancer (bc) progression. |
2015-08-21 |
2023-08-13 |
Not clear |
| T A Saedi, S Ghafourian, M Jafarlou, M N Sabariah, P Ismail, R M T Eusni, F Othma. BERBERIS VULGARIS FRUIT CRUDE EXTRACT AS A NOVEL ANTI-LEUKAEMIC AGENT. Journal of biological regulators and homeostatic agents. vol 29. issue 2. 2015-08-21. PMID:26122228. |
tumor protein p53 encoded by the tp53 gene in humans is known as a cancer biomarker in patients diagnosed with cancer, and it plays an essential role in apoptosis, genomic stability, and inhibition of angiogenesis. |
2015-08-21 |
2023-08-13 |
Not clear |
| Tamer Zeren, Sevinc Inan, H Seda Vatansever, Sevil Sayha. Significance of apoptosis related proteins on malignant transformation of ovarian tumors: A comparison between Bcl-2/Bax ratio and p53 immunoreactivity. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25108507. |
significance of apoptosis related proteins on malignant transformation of ovarian tumors: a comparison between bcl-2/bax ratio and p53 immunoreactivity. |
2015-08-20 |
2023-08-13 |
Not clear |
| Xiaoguang Zhou, Yanis Tolstov, Aysenur Arslan, Wilfried Roth, Carsten Grüllich, Sascha Pahernik, Markus Hohenfellner, Stefan Duensin. Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma. Neoplasia (New York, N.Y.). vol 16. issue 12. 2015-08-20. PMID:25499216. |
here, we show that apoptosis-resistant rcc cells have a disconnect between activation of p53 and upregulation of the downstream proapoptotic protein p53 upregulated modulator of apoptosis (puma). |
2015-08-20 |
2023-08-13 |
Not clear |
| Giuseppa Visalli, Barbara Baluce, Maria Bertuccio, Isa Picerno, Angela Di Pietr. Mitochondrial-mediated apoptosis pathway in alveolar epithelial cells exposed to the metals in combustion-generated particulate matter. Journal of toxicology and environmental health. Part A. vol 78. issue 11. 2015-08-19. PMID:26039747. |
in apoptosis induced by poorly genotoxic metal v, p53 did not play a significant role. |
2015-08-19 |
2023-08-13 |
Not clear |
| Jia-ying Ke, Cong-jie Dai, Wen-lin Wu, Jin-hua Gao, Ai-juan Xia, Guang-ping Liu, Kao-sheng Lv, Chun-lin W. USP11 regulates p53 stability by deubiquitinating p53. Journal of Zhejiang University. Science. B. vol 15. issue 12. 2015-08-18. PMID:25471832. |
the p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to dna repair, cell cycle arrest or apoptosis. |
2015-08-18 |
2023-08-13 |
Not clear |
| Yeyejide Adeleye, Melvin Andersen, Rebecca Clewell, Michael Davies, Matthew Dent, Sue Edwards, Paul Fowler, Sophie Malcomber, Beate Nicol, Andrew Scott, Sharon Scott, Bin Sun, Carl Westmoreland, Andrew White, Qiang Zhang, Paul L Carmichae. Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment. Toxicology. vol 332. 2015-08-13. PMID:24582757. |
the data presented include high throughput pathway biomarkers (p-h2ax, p-atm, p-atr, p-chk2, p53, p-p53, mdm2 and wip1) and markers of cell-cycle, apoptosis and micronuclei formation, plus gene transcription in ht1080 cells. |
2015-08-13 |
2023-08-12 |
human |
| Zhong Yun, Peter M Glaze. Tumor suppressor p53 stole the AKT in hypoxia. The Journal of clinical investigation. vol 125. issue 6. 2015-08-13. PMID:25961449. |
in the presence of functional p53, hypoxic conditions promote apoptosis; however, the p53-dependent genes that mediate this process are not well understood. |
2015-08-13 |
2023-08-13 |
Not clear |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
hypoxia-induced p53 modulates both apoptosis and radiosensitivity via akt. |
2015-08-12 |
2023-08-13 |
human |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
restoration of hypoxia-induced apoptosis in tumors harboring p53 mutations has been proposed as a potential therapeutic strategy; however, the transcriptional targets that mediate hypoxia-induced p53-dependent apoptosis remain elusive. |
2015-08-12 |
2023-08-13 |
human |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
here, we demonstrated that hypoxia-induced p53-dependent apoptosis is reliant on the dna-binding and transactivation domains of p53 but not on the acetylation sites k120 and k164, which, in contrast, are essential for dna damage-induced, p53-dependent apoptosis. |
2015-08-12 |
2023-08-13 |
human |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
induction of p53 targets, phlda3, and a specific inpp5d transcript mediated apoptosis in response to hypoxia through akt inhibition. |
2015-08-12 |
2023-08-13 |
human |
| Michal W Luczak, Anatoly Zhitkovic. Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II). Free radical biology & medicine. vol 65. 2015-08-11. PMID:23792775. |
we found that nac displayed a broad-spectrum chemoprotective activity against all three metals, including suppression of cytotoxicity, apoptosis, p53 activation, and hsp72 and hif-1α upregulation. |
2015-08-11 |
2023-08-12 |
human |
| Cundong Fan, Jingjing Chen, Yi Wang, Yum-Shing Wong, Yibo Zhang, Wenjie Zheng, Wenqiang Cao, Tianfeng Che. Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway. Free radical biology & medicine. vol 65. 2015-08-11. PMID:23837948. |
this study demonstrates that sec acts as an effective enhancer of 5-fu-induced apoptosis in a375 human melanoma cells through induction of mitochondria-mediated apoptosis with the involvement of dna damage-mediated p53 phosphorylation and erk inactivation. |
2015-08-11 |
2023-08-12 |
human |