| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Shi, Yue Han, Fang Xie, Anna Wang, Xiaokun Feng, Ning Li, Hongliang Guo, Dexi Che. ASPP2 enhances oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy. Journal of cellular and molecular medicine. vol 19. issue 3. 2015-09-10. PMID:25534115. |
in this study, aspp2 was found to enhance l-ohp-induced apoptosis in hct116 p53(-/-) cells in a p53-independent manner. |
2015-09-10 |
2023-08-13 |
mouse |
| Ying Shi, Yue Han, Fang Xie, Anna Wang, Xiaokun Feng, Ning Li, Hongliang Guo, Dexi Che. ASPP2 enhances oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy. Journal of cellular and molecular medicine. vol 19. issue 3. 2015-09-10. PMID:25534115. |
further experiments with aspp2 rna interference and autophagy inhibitor (3-methyladenine, 3-ma) confirmed that aspp2 enhanced hct116 p53(-/-) cell apoptosis via inhibiting the autophagy. |
2015-09-10 |
2023-08-13 |
mouse |
| Hiroaki Takatori, Hirotoshi Kawashima, Kotaro Suzuki, Hiroshi Nakajim. Role of p53 in systemic autoimmune diseases. Critical reviews in immunology. vol 34. issue 6. 2015-09-10. PMID:25597313. |
the tumor suppressor p53 has been shown to play a central role in tumor suppression by inducing apoptosis, cell cycle arrest, senescence, and dna repair. |
2015-09-10 |
2023-08-13 |
human |
| Zhu Yuan, Wenhao Guo, Jun Yang, Lei Li, Meiliang Wang, Yi Lei, Yang Wan, Xinyu Zhao, Na Luo, Ping Cheng, Xinyu Liu, Chunlai Nie, Yong Peng, Aiping Tong, Yuquan We. PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25918161. |
in this work, we found that pnas-4 expression in lung tumor tissues is significantly lower than that in adjacent lung tissues; its expression is significantly increased in a549 cells after exposure to cisplatin, methyl methane sulfonate, and mitomycin; and its overexpression induces s phase arrest and apoptosis in a549 (p53 wt), nci-h460 (p53 wt), h526 (p53 mutation), and calu-1 (p53(-/-)) lung cancer cells, leading to proliferation inhibition irrespective of their p53 status. |
2015-09-10 |
2023-08-13 |
human |
| G G Sun, Y D Wang, Q Liu, W N H. Expression of Wip1 in kidney carcinoma and its correlation with tumor metastasis and clinical significance. Pathology oncology research : POR. vol 21. issue 1. 2015-09-09. PMID:24970693. |
mtt assay, cell apoptosis, cell cycles demonstrated that achn cell transfected wip1 sirna had a lower survival fraction, higher cell apoptosis, more percentage of the g0/g1 phases, significant decrease in migration and invasion, and higher p53 and p16 protein expression compared with achn cell untransfected wip1 sirna (p < 0.05). |
2015-09-09 |
2023-08-13 |
Not clear |
| G G Sun, Y D Wang, Q Liu, W N H. Expression of Wip1 in kidney carcinoma and its correlation with tumor metastasis and clinical significance. Pathology oncology research : POR. vol 21. issue 1. 2015-09-09. PMID:24970693. |
wip1 may involved in the biological processes of kidney cancer cell proliferation, apoptosis, and migration and invasion by regulation p53 and p16 protein expression. |
2015-09-09 |
2023-08-13 |
Not clear |
| Li Xie, Liping He, Zhiying Yang, Jinfeng Shi, Zhifeng Long, Yuanjie Xi. [Effect of PFT-α on apoptosis of spermatogenic cells caused by enorchia]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 39. issue 3. 2015-09-08. PMID:24748186. |
to determine the molecular mechanism of germ cell apoptosis via investigating the effect of pft-α on the expression of p53 and bcl-2/bax during experimental cryptorchid cell apoptosis. |
2015-09-08 |
2023-08-13 |
Not clear |
| Z-J Ren, X-Y Nong, Y-R Lv, H-H Sun, P-P An, F Wang, X Li, M Liu, H Tan. Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth. Cell death & disease. vol 5. 2015-09-08. PMID:25144722. |
here, we provide evidence that mir-509-5p, which is downregulated in a subset of newly diagnosed cervical cancer and hepatocellular carcinoma tissues compared with the adjacent nontumor tissue, can be activated by p53 through binding the promoter of mir-509-5p and it suppresses the growth and invasion/migration of cervical cancer and hepatoma cells by regulating apoptosis and the g1/s-phase transition of cell cycle. |
2015-09-08 |
2023-08-13 |
Not clear |
| Jong-Lyel Roh, Jin Young Park, Eun Hye Ki. XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25113507. |
xi-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer. |
2015-09-04 |
2023-08-13 |
mouse |
| Jong-Lyel Roh, Jin Young Park, Eun Hye Ki. XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25113507. |
therefore, the present study assessed the ability of the small molecule p53 activator xi-011 (nsc146109) to induce apoptosis in hnc by restoring p53 function. |
2015-09-04 |
2023-08-13 |
mouse |
| Jeanine L Van Nostrand, Laura D Attard. Guilty as CHARGED: p53's expanding role in disease. Cell cycle (Georgetown, Tex.). vol 13. issue 24. 2015-09-04. PMID:25483057. |
molecular analyses revealed that wild-type p53 is inappropriately activated in p53(5,26,53,54/)(+) embryos, triggering cell-cycle arrest or apoptosis during development to cause charge phenotypes. |
2015-09-04 |
2023-08-13 |
Not clear |
| Ye Tian, Ying-Ze Zhang, Wei Che. MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells. Bioscience reports. vol 34. issue 4. 2015-09-01. PMID:24957404. |
the results demonstrated that mir-199a and mir-34a could induce the apoptosis of human osteosarcoma cells via p53 signalling pathway. |
2015-09-01 |
2023-08-13 |
human |
| Rami Abou Zeinab, Hong Wu, Consolato Sergi, Roger Len. UBE4B: a promising regulatory molecule in neuronal death and survival. International journal of molecular sciences. vol 13. issue 12. 2015-08-31. PMID:23222733. |
because neuronal programmed death is apoptotic in nature, indicating that apoptosis is a key regulatory process, the p53 family members (p53, p73, p63) act as checkpoints in neurons due to their role in apoptosis. |
2015-08-31 |
2023-08-12 |
mouse |
| Zhi-Jun Dai, Jie Gao, Xiao-Bin Ma, Hua-Feng Kang, Bao-Feng Wang, Wang-Feng Lu, Shuai Lin, Xi-Jing Wang, Wen-Ying W. Antitumor effects of rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy. International journal of molecular sciences. vol 14. issue 1. 2015-08-31. PMID:23344033. |
rt-pcr revealed that the expression levels of p53, bax and beclin 1 were up-regulated in a dose-dependent manner, indicating that beclin 1 was involved in rapa induced autophagy and rapa induced apoptosis as well as p53 up-regulation in pc-2 cells. |
2015-08-31 |
2023-08-12 |
Not clear |
| Lymor Ringer, Paul Sirajuddin, Lucas Tricoli, Sarah Waye, Muhammad Umer Choudhry, Erika Parasido, Angiela Sivakumar, Mary Heckler, Aisha Naeem, Iman Abdelgawad, Xuefeng Liu, Adam S Feldman, Richard J Lee, Chin-Lee Wu, Venkata Yenugonda, Bhaskar Kallakury, Anatoly Dritschilo, John Lynch, Richard Schlegel, Olga Rodriguez, Richard G Pestell, Maria Laura Avantaggiati, Chris Albanes. The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25296977. |
as p53 elicits cell cycle arrest, senescence or apoptosis, the integrity of the p53 pathway is considered a key determinant of anti-tumor responses. |
2015-08-31 |
2023-08-13 |
human |
| Shuang Liu, Feng-ping Xu, Zi-jiang Yang, Ming Li, Ya-hong Min, Shu L. Cadmium-induced injury and the ameliorative effects of selenium on chicken splenic lymphocytes: mechanisms of oxidative stress and apoptosis. Biological trace element research. vol 160. issue 3. 2015-08-28. PMID:25035189. |
the population of apoptosis cells demonstrated that cd induces the apoptosis of chicken splenic lymphocytes; in addition, increased mrna level of bak, p53, caspase-3, caspase-9, and cytochrome c (cyt c) and decreased bcl-2, bcl-xl, and cam were observed in cd treatment group. |
2015-08-28 |
2023-08-13 |
cat |
| Alexander Cecil, Ivaylo Gentschev, Marion Adelfinger, Ingo Nolte, Thomas Dandekar, Aladar A Szala. Antigen profiling analysis of vaccinia virus injected canine tumors: oncolytic virus efficiency predicted by boolean models. Bioengineered. vol 5. issue 5. 2015-08-25. PMID:25482233. |
our model combines networks for apoptosis, mapk, p53, wnt, hedgehog, tk cell, interferon, and interleukin signaling networks. |
2015-08-25 |
2023-08-13 |
mouse |
| Wenming Wu, Qiao Wu, Xiafei Hong, Li Zhou, Jie Zhang, Lei You, Wenze Wang, Huanwen Wu, Hongmei Dai, Yupei Zha. Catechol-O-methyltransferase, a new target for pancreatic cancer therapy. Cancer science. vol 106. issue 5. 2015-08-25. PMID:25711924. |
in vitro experiments showed that comt inhibited cell proliferation, enhanced gemcitabine-induced apoptosis, and inhibited cell invasion in stably transduced and transiently transfected cell lines by regulating the pi3k/akt pathway, p53, and e-cadherin. |
2015-08-25 |
2023-08-13 |
mouse |
| Eshvendar Reddy Kasala, Lakshmi Narendra Bodduluru, Chandana C Barua, Ranadeep Gogo. Chrysin and its emerging role in cancer drug resistance. Chemico-biological interactions. vol 236. 2015-08-25. PMID:25912556. |
this letter illustrates the significant chemosensitizing effects of chrysin to resistance cancer cells and refers to the article on "combination of chrysin and cisplatin promotes the apoptosis of hep g2 cells by up-regulating p53" by li et al., published in your journal recently. |
2015-08-25 |
2023-08-13 |
human |
| Siriluck Ponsuksili, Dawit Tesfaye, Karl Schellander, Michael Hoelker, Frieder Hadlich, Manfred Schwerin, Klaus Wimmer. Differential expression of miRNAs and their target mRNAs in endometria prior to maternal recognition of pregnancy associates with endometrial receptivity for in vivo- and in vitro-produced bovine embryos. Biology of reproduction. vol 91. issue 6. 2015-08-24. PMID:25253731. |
the mirna-mrna target pairs had roles in response to hormonal stimuli and oxidative stress, chromatin organization, mirna-mediated epigenetic histone changes, cell proliferation, p53 signaling, and apoptosis. |
2015-08-24 |
2023-08-13 |
cattle |