| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shohei Shinozaki, Kyungho Chang, Michihiro Sakai, Nobuyuki Shimizu, Marina Yamada, Tomokazu Tanaka, Harumasa Nakazawa, Fumito Ichinose, Yoshitsugu Yamada, Akihito Ishigami, Hideki Ito, Yasuyoshi Ouchi, Marlene E Starr, Hiroshi Saito, Kentaro Shimokado, Jonathan S Stamler, Masao Kanek. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Science signaling. vol 7. issue 351. 2015-07-13. PMID:25389371. |
inhibition of sirt1 reduced deacetylation and promoted activation of p53 and p65, leading to apoptosis and increased expression of proinflammatory genes. |
2015-07-13 |
2023-08-13 |
Not clear |
| S Ferrandon, N Magné, P Battiston-Montagne, N-H Hau-Desbat, O Diaz, M Beuve, J Constanzo, C Chargari, D Poncet, E Chautard, D Ardail, G Alphonse, C Rodriguez-Lafrass. Cellular and molecular portrait of eleven human glioblastoma cell lines under photon and carbon ion irradiation. Cancer letters. vol 360. issue 1. 2015-07-10. PMID:25657111. |
statistical analysis demonstrated that: (i) the sf2(2) and the d10(3) values for photon are correlated with that obtained in response to carbon ions; (ii) regardless of the p53, mgmt status, and radiosensitivity, the release of ceramide is associated with the induction of late apoptosis; and (iii) the appearance of polyploid cells after photon irradiation could predict the relative biological efficiency(4) to carbon ions. |
2015-07-10 |
2023-08-13 |
human |
| X-H Hu, Q Nie, M Yi, T-T Li, Z-F Wang, Z-X Huang, X-D Gong, L Zhou, W-K Ji, W-F Hu, J-F Liu, L Wang, Z Woodward, J Zhu, W-B Liu, Q D Nguyen, D W-C L. The tumor suppressor, p53 regulates the γA-crystallin gene during mouse lens development. Current molecular medicine. vol 14. issue 9. 2015-07-09. PMID:25336329. |
the tumor suppressor, p53 regulates a large number of target genes to control cell proliferation and apoptosis. |
2015-07-09 |
2023-08-13 |
mouse |
| Meital Charni, Noa Rivlin, Alina Molchadsky, Ronit Aloni-Grinstein, Varda Rotte. p53 in liver pathologies-taking the good with the bad. Journal of molecular medicine (Berlin, Germany). vol 92. issue 12. 2015-07-09. PMID:25404244. |
the stressful environment in the liver frequently leads to the activation of p53, which is associated with alterations in metabolic pathways and induction of apoptosis. |
2015-07-09 |
2023-08-13 |
Not clear |
| Yihan Wan, Xiaobin Zheng, Haiyang Chen, Yuxuan Guo, Hao Jiang, Xiaonan He, Xueliang Zhu, Yixian Zhen. Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. The Journal of cell biology. vol 209. issue 2. 2015-07-09. PMID:25918225. |
although studies suggest that perturbing mitotic progression leads to dna damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. |
2015-07-09 |
2023-08-13 |
human |
| Yihan Wan, Xiaobin Zheng, Haiyang Chen, Yuxuan Guo, Hao Jiang, Xiaonan He, Xueliang Zhu, Yixian Zhen. Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. The Journal of cell biology. vol 209. issue 2. 2015-07-09. PMID:25918225. |
thus, r-loop-mediated dna damage and p53 activation offer a mechanistic explanation for apoptosis of cancer cells and senescence of primary cells upon disruption of the dual-function mitotic regulators. |
2015-07-09 |
2023-08-13 |
human |
| Lauy Al-Anati, Sandeep Kadekar, Johan Högberg, Ulla Steniu. PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954032. |
we found that inhibition of pp2a phosphatase restored levels of phosphorylated foxo3a, led to cytosolic translocation of p53, and activated bap-induced p53-mediated apoptosis. |
2015-07-08 |
2023-08-13 |
Not clear |
| Lauy Al-Anati, Sandeep Kadekar, Johan Högberg, Ulla Steniu. PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954032. |
our data indicate interplay between p53, foxo3a and 14-3-3 leading to an attenuated bap induced apoptosis in cells co-exposed to tcdd, pcb 153 or estradiol. |
2015-07-08 |
2023-08-13 |
Not clear |
| Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Aginor Spanoulis, Vassilios Liakopoulos, Ioannis Stefanidi. Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation. International immunology. vol 26. issue 12. 2015-07-08. PMID:25064493. |
in addition, both ido and p53 decreased glucose transporter 1 and tp53-induced glycolysis and apoptosis regulator and increased synthesis of cytochrome c oxidase 2. |
2015-07-08 |
2023-08-13 |
human |
| Qiuge Wu, Yan Kang, Hui Zhang, Hongmin Wang, Yuanhua Liu, Jing Wan. The anticancer effects of hispolon on lung cancer cells. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25268766. |
our results indicate that hispolon inhibits the cell viability, induces g0/g1 cell cycle arrest and apoptosis in lung cancer cells and p53 plays a critical role in hispolon-mediated antitumor activity. |
2015-07-08 |
2023-08-13 |
Not clear |
| Emiro Caicedo-Granados, Rui Lin, Caitlin Fujisawa, Bevan Yueh, Veena Sangwan, Ashok Saluj. Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma. Oral oncology. vol 50. issue 12. 2015-07-08. PMID:25311433. |
the inactivation of the p53 tumor suppressor gene promotes a chain of molecular events, including cell cycle progression and apoptosis resistance. |
2015-07-08 |
2023-08-13 |
human |
| Guerry J Cook, David L Caudell, Howard L Elford, Timothy S Parde. The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML. PloS one. vol 9. issue 11. 2015-07-08. PMID:25402485. |
didox exposure resulted in dna damage and p53 induction culminating in apoptosis. |
2015-07-08 |
2023-08-13 |
human |
| E Ondroušková, B Vojtěše. [Programmed cell death in cancer cells]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 27 Suppl 1. 2015-07-07. PMID:24945531. |
in most cancer cells, mutations or aberrant expression of proteins directly or indirectly involved in induction and execution of cell death can be detected - p53, bcl 2 family proteins, inhibitors of apoptosis, death receptors/ ligands and other proteins. |
2015-07-07 |
2023-08-13 |
Not clear |
| b' Maja Jazvin\\xc5\\xa1\\xc4\\x87ak Jembrek, Josipa Vlaini\\xc4\\x87, Vedrana Radovanovi\\xc4\\x87, Julija Erhardt, Nada Or\\xc5\\xa1oli\\xc4\\x8. Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 6. 2015-07-07. PMID:25216733.' |
in a dose-dependent manner copper also provoked transcriptional changes of genes involved in intracellular signaling and induction of apoptosis (p53, c-fos, bcl-2 and bax). |
2015-07-07 |
2023-08-13 |
Not clear |
| J-X Cao, Y Lu, J-J Qi, G-S An, Z-B Mao, H-T Jia, S-Y Li, J-H N. MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells. Cell death & disease. vol 5. 2015-07-07. PMID:25255219. |
on the one hand, mir-630 promoted apoptosis by downregulation of cdc7; on the other hand, it reduced apoptosis by downregulating several apoptotic modulators such as parp3, ddit4, ep300 and ep300 downstream effector p53, thereby maintaining the apoptotic balance. |
2015-07-07 |
2023-08-13 |
human |
| Zhiyuan Wu, Bin Liu, Cailing E, Jie Liu, Qingyu Zhang, Juntao Liu, Nianping Chen, Rongyi Chen, Runzhi Zh. Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Molecular medicine reports. vol 11. issue 1. 2015-07-07. PMID:25333673. |
western blot analysis demonstrated that res induced the apoptosis of human melanoma a375 and sk-mel-31 cells by upregulating the expression of bcl-2-associated x protein and b-cell lymphoma 2, possibly via the p53 pathway and activation of caspase-9 and caspase-3. |
2015-07-07 |
2023-08-13 |
human |
| Liang Li, Binquan Wan. Overexpression of microRNA-30b improves adenovirus-mediated p53 cancer gene therapy for laryngeal carcinoma. International journal of molecular sciences. vol 15. issue 11. 2015-07-07. PMID:25356506. |
together, results suggested that mir-30b could modulate p53 pathway and enhance p53 gene therapy-induced apoptosis in laryngeal carcinoma, which could provide a novel microrna target in tumor therapy. |
2015-07-07 |
2023-08-13 |
Not clear |
| Chunyan Zhu, Ping Xie, Fei Zhao, Lingqiang Zhang, Wei An, Yutao Zha. Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol. International journal of clinical and experimental pathology. vol 7. issue 10. 2015-07-07. PMID:25400762. |
however, the apoptosis rate (p < 0.01) of the cholesterol group was significantly higher than that of the normal group or the steatosis group, and the protein expressions of bax and caspase-3, but not p53, bcl-2, cyclin a, cyclin b1 and cyclin e, were also increased in the cholesterol group. |
2015-07-07 |
2023-08-13 |
Not clear |
| Lin Wang, Juxiang Huang, Minghu Jiang, Qingchun Chen, Zhenfu Jiang, Haitao Fen. CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24825433. |
we proposed that camk1 activated network enhanced endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, golgi to endosome transport, intracellular protein transmembrane transport, intracellular protein transport, ion transport, mrna transport, plasma membrane to endosome transport, potassium ion transport, protein transport, vesicle-mediated transport, anion transport, intracellular transport, androgen receptor signaling pathway, cell surface receptor-linked signal transduction, hormone-mediated signaling, induction of apoptosis by extracellular signals, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, signal transduction resulting in induction of apoptosis, phosphoinositide-mediated signaling, wnt receptor signaling pathway, as a result of inducing phosphoinositide signal-mediated protein sorting, and transport in hcc. |
2015-07-02 |
2023-08-13 |
human |
| Zhongyong Jiang, Jie Xion. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24845152. |
we measured human hepatocarcinoma cell viability by mtt assay and annexin v-fitc/pi double staining, and evaluated the activity of caspase 3 and the expression of p53, bax, and bcl-2 proteins, involved in regulating cell apoptosis. |
2015-07-02 |
2023-08-13 |
human |