| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nisha Bara, Gautam Kau. Enhanced steroidogenic and altered antioxidant response by ZnO nanoparticles in mouse testis Leydig cells. Toxicology and industrial health. vol 34. issue 8. 2018-11-20. PMID:29768980. |
our findings confirm the adverse effects of zno nps by being cytotoxic, enhancing apoptosis, causing steroidogenic effect in leydig cells and increasing autophagic vacuole formation possibly via alteration of antioxidant enzyme activity in tm3 cells. |
2018-11-20 |
2023-08-13 |
mouse |
| Hongying Liang, Tong He, Jimin Long, Liangliang Liu, Guochao Liao, Yanhuai Ding, Yi Ca. Influence of bovine serum albumin pre-incubation on toxicity and ER stress-apoptosis gene expression in THP-1 macrophages exposed to ZnO nanoparticles. Toxicology mechanisms and methods. vol 28. issue 8. 2018-11-08. PMID:29783874. |
exposure to zno nps promoted the expression of endoplasmic reticulum (er) stress markers (ddit3 and xbp-1s) and apoptosis genes (casp9 and casp12). |
2018-11-08 |
2023-08-13 |
cattle |
| Manisha Kumari, Mahaveer Prasad Purohit, Satyakam Patnaik, Yogeshwer Shukla, Pradeep Kumar, Kailash Chand Gupt. Curcumin loaded selenium nanoparticles synergize the anticancer potential of doxorubicin contained in self-assembled, cell receptor targeted nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 130. 2018-11-05. PMID:29969665. |
combination of these nanoparticles (nps) increased ros level, decreased mitochondrial membrane potential, induced cell cycle arrest and apoptosis in hct116 cells. |
2018-11-05 |
2023-08-13 |
mouse |
| Rammohan Devulapally, Kira Foygel, Thillai V Sekar, Juergen K Willmann, Ramasamy Paulmuruga. Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy. ACS applied materials & interfaces. vol 8. issue 49. 2018-11-01. PMID:27960411. |
flow cytometry analysis showed that control nps and antisense-mirna-21-loaded nps are not cytotoxic to both hcc cell lines, whereas treatment with free gem and gem-loaded nps resulted in ∼9% and ∼15% apoptosis, respectively. |
2018-11-01 |
2023-08-13 |
human |
| Yanqiu Liu, Xiujuan Zhang, Mengjiao Zhou, Xueyan Nan, Xianfeng Chen, Xiaohong Zhan. Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance. ACS applied materials & interfaces. vol 9. issue 50. 2018-11-01. PMID:29171954. |
detailed mechanism studies reveal that tpp-lnd-dox nps could induce significant reactive oxygen species production, mitochondrial membrane potential decrease, and mitochondrial apoptosis pathway, thereby leading to great cytotoxicity in cancer cells. |
2018-11-01 |
2023-08-13 |
Not clear |
| Yanqiu Liu, Xiujuan Zhang, Mengjiao Zhou, Xueyan Nan, Xianfeng Chen, Xiaohong Zhan. Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance. ACS applied materials & interfaces. vol 9. issue 50. 2018-11-01. PMID:29171954. |
this work demonstrates the potential use of our tpp-lnd-dox nps to jointly promote the mitochondria apoptosis pathway and contribute to conquer drug resistance in cancer therapy. |
2018-11-01 |
2023-08-13 |
Not clear |
| Vanna Sanna, Chandra K Singh, Rahime Jashari, Vaqar M Adhami, Jean Christopher Chamcheu, Islam Rady, Mario Sechi, Hasan Mukhtar, Imtiaz A Siddiqu. Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapy. Scientific reports. vol 7. 2018-10-18. PMID:28145499. |
the behavior of egcg encapsulated in nps in modulating apoptosis and cell-cycle, was also determined. |
2018-10-18 |
2023-08-13 |
mouse |
| Hongliang Yu, Jian He, Qian Lu, Da Huo, Shanmei Yuan, Zhengyang Zhou, Peipei Xu, Yong H. Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS applied materials & interfaces. vol 8. issue 44. 2018-10-16. PMID:27754664. |
due to the high level of mmp expressed by tumor cells inside the tumor tissue, these nps would shed their peg layers, resulting in the exposure of anti-fas antibody to bind the fas receptor and triggering the apoptosis of tumor cells. |
2018-10-16 |
2023-08-13 |
Not clear |
| Hongliang Yu, Jian He, Qian Lu, Da Huo, Shanmei Yuan, Zhengyang Zhou, Peipei Xu, Yong H. Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS applied materials & interfaces. vol 8. issue 44. 2018-10-16. PMID:27754664. |
results of western blot confirmed that these nps could mimic the function of activated cytotoxic lymphocyte (ctl) to activate the fas-fasl apoptosis pathway of tumor cells. |
2018-10-16 |
2023-08-13 |
Not clear |
| Priyanka Bhatnagar, Manisha Kumari, Richa Pahuja, A B Pant, Y Shukla, Pradeep Kumar, K C Gupt. Hyaluronic acid-grafted PLGA nanoparticles for the sustained delivery of berberine chloride for an efficient suppression of Ehrlich ascites tumors. Drug delivery and translational research. vol 8. issue 3. 2018-10-15. PMID:29441466. |
brb-d(ha)-g-plga nps were found to significantly enhance apoptosis, sub-g1 content, life span, mean survival time, and ros levels in eac cells with subsequent decrease in mitochondrial membrane potential and tumor burden ion tumor-bearing mice. |
2018-10-15 |
2023-08-13 |
mouse |
| Xiaoye Yang, Xiaoqun Shi, Jianbo Ji, Guangxi Zha. Development of redox-responsive theranostic nanoparticles for near-infrared fluorescence imaging-guided photodynamic/chemotherapy of tumor. Drug delivery. vol 25. issue 1. 2018-10-02. PMID:29542333. |
the improved therapeutic effect of ptx/cht nps compared with mono-photodynamic or mono-chemotherapy was observed in vitro via mtt and apoptosis assays. |
2018-10-02 |
2023-08-13 |
mouse |
| Peng Tian, Fan Wu, Jingyi Wang, Huashuang Ou, Xiang Liu, Qiujian Chen, Hua Dang, Yiqing Zheng, Xianghong Zhang, Hua Zo. Intralesional bleomycin A5 injection for the treatment of nasal polyps through inducing apoptosis. Acta oto-laryngologica. vol 138. issue 5. 2018-09-26. PMID:29490557. |
ble-induced apoptosis might play an important role in shrinkage of nps. |
2018-09-26 |
2023-08-13 |
Not clear |
| Yawei Li, Na Xu, Wenhe Zhu, Lei Wang, Bin Liu, Jianxu Zhang, Zhigang Xie, Wensen Li. Nanoscale Melittin@Zeolitic Imidazolate Frameworks for Enhanced Anticancer Activity and Mechanism Analysis. ACS applied materials & interfaces. vol 10. issue 27. 2018-09-17. PMID:29920061. |
the mechanism is well investigated by a series of transcriptome analysis, which indicates that mlt@zif-8 nps can regulate the expression of 3383 genes, and the pi3k/akt-regulated p53 pathway is involved in mlt@zif-8 nps induced a549 cells apoptosis. |
2018-09-17 |
2023-08-13 |
Not clear |
| P Chhay, M Murphy-Marion, Y Samson, D Girar. Activation of human eosinophils with palladium nanoparticles (Pd NPs): importance of the actin cytoskeleton in Pd NPs-induced cellular adhesion. Environmental toxicology and pharmacology. vol 57. 2018-08-27. PMID:29245060. |
pd nps did not significantly induce cell necrosis and apoptosis in eosinophils (0.5-150μg/ml) as assessed by trypan blue exclusion assay, flow cytometry after staining with fitc-annexin v and propidium iodide and by morphological observations by optical microscopy. |
2018-08-27 |
2023-08-13 |
human |
| Rohit Bisht, Ilva D Rupentha. PLGA nanoparticles for intravitreal peptide delivery: statistical optimization, characterization and toxicity evaluation. Pharmaceutical development and technology. vol 23. issue 4. 2018-08-21. PMID:27670289. |
developed nps were evaluated for potential toxicity and cell apoptosis using the zebrafish embryo toxicity (zet) model with titanium dioxide nps and ethanol (1% v/v) serving as positive controls. |
2018-08-21 |
2023-08-13 |
zebrafish |
| Rohit Bisht, Ilva D Rupentha. PLGA nanoparticles for intravitreal peptide delivery: statistical optimization, characterization and toxicity evaluation. Pharmaceutical development and technology. vol 23. issue 4. 2018-08-21. PMID:27670289. |
cellular apoptosis studies also endorsed the non-cytotoxic nature of the nps. |
2018-08-21 |
2023-08-13 |
zebrafish |
| Hanh Thuy Nguyen, Cao Dai Phung, Raj Kumar Thapa, Tung Thanh Pham, Tuan Hiep Tran, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Ki. Multifunctional nanoparticles as somatostatin receptor-targeting delivery system of polyaniline and methotrexate for combined chemo-photothermal therapy. Acta biomaterialia. vol 68. 2018-08-17. PMID:29292170. |
notably, lt-mtx/pani nps showed a greater uptake into sstr-positive cancer cells and thereby better inhibited cell viability and induced higher levels of apoptosis than mtx, pani np, and mtx/pani np treatments did. |
2018-08-17 |
2023-08-13 |
mouse |
| Jinsong Guo, Feihong Dong, Lian Ding, Kaile Wang, Jue Zhang, Jing Fan. A novel drug-free strategy of nano-pulse stimulation sequence (NPSS) in oral cancer therapy: In vitro and in vivo study. Bioelectrochemistry (Amsterdam, Netherlands). vol 123. 2018-08-15. PMID:29719274. |
nano-pulse stimulation (nps) is a novel technology to induce cancer apoptosis. |
2018-08-15 |
2023-08-13 |
Not clear |
| S Aurosman Pappus, Monalisa Mishr. A Drosophila Model to Decipher the Toxicity of Nanoparticles Taken Through Oral Routes. Advances in experimental medicine and biology. vol 1048. 2018-08-14. PMID:29453546. |
the nps, after oral route of exposure enter into the gut, crosses the barrier of peritrophic membrane and induces apoptosis. |
2018-08-14 |
2023-08-13 |
drosophila_melanogaster |
| Jun Kinoda, Masayuki Ishihara, Shingo Nakamura, Masanori Fujita, Koichi Fukuda, Yoko Sato, Hidetaka Yoko. Protective effect of FGF-2 and low-molecular-weight heparin/protamine nanoparticles on radiation-induced healing-impaired wound repair in rats. Journal of radiation research. vol 59. issue 1. 2018-08-10. PMID:29121251. |
we examined the effectiveness of localized administration of fibroblast growth factor-2 containing low-molecular-weight heparin/protamine nanoparticles (fgf-2&lmwh/p nps) on apoptosis in vivo and on healing of radiation-induced skin injury in a rat model. |
2018-08-10 |
2023-08-13 |
rat |