| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cong-Cong Hou, Jun-Quan Zh. Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development. Oncotarget. vol 8. issue 65. 2019-11-20. PMID:29312650. |
some nps can cross the placenta into the fetus by passive diffusion or endocytosis, which can trigger fetal inflammation, apoptosis, genotoxicity, cytotoxicity, low weight, reproductive deficiency, nervous damage, and immunodeficiency, among others. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ali Masjedi, Hadi Hassannia, Fatemeh Atyabi, Ali Rastegari, Mohammad Hojjat-Farsangi, Afshin Namdar, Hassan Soleimanpour, Gholamreza Azizi, Afshin Nikkhoo, Ghasem Ghalamfarsa, Abbas Mirshafiey, Farhad Jadidi-Niarag. Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway. International journal of biological macromolecules. vol 133. 2019-11-14. PMID:30936011. |
t cells were treated with a2ar sirna-loaded nps demonstrated suppressed expression of a2ar which was associated with increased proliferation, reduced apoptosis, increased production of inflammatory and reduced secretion of inhibitory cytokines compared to untreated t cells. |
2019-11-14 |
2023-08-13 |
mouse |
| Guanping He, Yunlong Ma, Ye Zhu, Lei Yong, Xiao Liu, Peng Wang, Chen Liang, Chenlong Yang, Zhigang Zhao, Bao Hai, Xiaoyu Pan, Zhongjun Liu, Xiaoguang Liu, Chuanbin Ma. Cross Talk Between Autophagy and Apoptosis Contributes to ZnO Nanoparticle-Induced Human Osteosarcoma Cell Death. Advanced healthcare materials. vol 7. issue 17. 2019-11-08. PMID:29900694. |
here, it is found that the nps induce cross talk between apoptosis and autophagy, which leads to osteosarcoma cell death. |
2019-11-08 |
2023-08-13 |
human |
| Yibing Jiang, Xiwei Yu, Chang Su, Liang Zhao, Yijie Sh. Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-10-17. PMID:30873872. |
in this study, we found that cs nps induced the massive generation of ros and resulted in apoptosis of hepatocellular carcinoma cells (smmc-7721) through activating the mitochondrial pathway and endoplasmic reticulum stress. |
2019-10-17 |
2023-08-13 |
Not clear |
| Yuquan Wang, Lanlan Li, Weibo Zhao, Yin Dou, Huijie An, Hui Tao, Xiaoqiu Xu, Yi Jia, Shan Lu, Jianxiang Zhang, Houyuan H. Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity. ACS nano. vol 12. issue 9. 2019-10-07. PMID:30114351. |
tpcd nps significantly attenuated ros-induced inflammation and cell apoptosis in macrophages, by eliminating overproduced intracellular ros. |
2019-10-07 |
2023-08-13 |
Not clear |
| Qiu-Yue Zhai, Wei Ge, Jun-Jie Wang, Xiao-Feng Sun, Jin-Mei Ma, Jing-Cai Liu, Yong Zhao, Yan-Zhong Feng, Paul W Dyce, Massimo De Felici, Wei She. Exposure to Zinc oxide nanoparticles during pregnancy induces oocyte DNA damage and affects ovarian reserve of mouse offspring. Aging. vol 10. issue 8. 2019-10-04. PMID:30153657. |
we found that the nanoparticles (nps) accumulated within the oocyte cytoplasm in a dose dependent manner, caused dna damage and apoptosis, and result in a significant decrease in oocyte numbers. |
2019-10-04 |
2023-08-13 |
mouse |
| Xiaofeng Lai, Hu Zhao, Yong Zhang, Kai Guo, Yuqiao Xu, Suning Chen, Jian Zhan. Intranasal Delivery of Copper Oxide Nanoparticles Induces Pulmonary Toxicity and Fibrosis in C57BL/6 mice. Scientific reports. vol 8. issue 1. 2019-09-30. PMID:29540716. |
cuo nps induced apoptosis of epithelial cells as indicated by tunel staining, flow cytometry and western blot analysis, which was partially caused by increased reactive oxygen species (ros). |
2019-09-30 |
2023-08-13 |
mouse |
| Na Li, Qiaoqiao Sun, Zhengze Yu, Xiaonan Gao, Wei Pan, Xiuyan Wan, Bo Tan. Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles. ACS nano. vol 12. issue 6. 2019-09-30. PMID:29894162. |
under the irradiation of 980 nm near-infrared laser, the nps rapidly increase the temperature of the nucleus, destroy the genetic substances, and ultimately lead to an exhaustive apoptosis of the cancer cells. |
2019-09-30 |
2023-08-13 |
Not clear |
| Tzlil Bejerano, Sharon Etzion, Sigal Elyagon, Yoram Etzion, Smadar Cohe. Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction. Nano letters. vol 18. issue 9. 2019-09-12. PMID:30141949. |
following intravenous administration, the mirna-21 nps were targeted to cardiac macrophages at the infarct zone, elicited their phenotype switch from pro-inflammatory to reparative, promoted angiogenesis, and reduced hypertrophy, fibrosis and cell apoptosis in the remote myocardium. |
2019-09-12 |
2023-08-13 |
Not clear |
| Shefang Ye, Fanfan Wang, Zhongxiong Fan, Qixin Zhu, Haina Tian, Yubin Zhang, Beili Jiang, Zhenqing Hou, Yang Li, Guanghao S. Light/pH-Triggered Biomimetic Red Blood Cell Membranes Camouflaged Small Molecular Drug Assemblies for Imaging-Guided Combinational Chemo-Photothermal Therapy. ACS applied materials & interfaces. vol 11. issue 17. 2019-08-20. PMID:30964624. |
consequently, compared with individual treatment, rbcs@icg-hcpt nps under dual-stimuli accomplished highly efficient apoptosis in cancer cells and remarkable ablation of tumors by chemo-ptt. |
2019-08-20 |
2023-08-13 |
Not clear |
| Jeevitha Dhanapal, Malathy Balaraman Ravindrra. Chitosan/poly (lactic acid)-coated piceatannol nanoparticles exert an in vitro apoptosis activity on liver, lung and breast cancer cell lines. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup1. 2019-08-19. PMID:29298541. |
these results suggested that upon cs/pla-pic nps exposure leads to decrease in cancer cell viability due to apoptosis. |
2019-08-19 |
2023-08-13 |
Not clear |
| Hao Wang, Xiwei Yu, Chang Su, Yijie Shi, Liang Zha. Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup1. 2019-08-19. PMID:29313384. |
the addition of blank nps produced a negative effect on cytotoxicity and cellular apoptosis of free dox, and with the pre-treatment of chloroquine (cq) as a known autophagy inhibitor, the inhibition rates of cells treated with the combination of dox and blank cs nps had been significantly increased. |
2019-08-19 |
2023-08-13 |
Not clear |
| Liuxiang Chu, Aiping Wang, Ling Ni, Xiuju Yan, Yina Song, Mingyu Zhao, Kaoxiang Sun, Hongjie Mu, Sha Liu, Zimei Wu, Chunyan Zhan. Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting. Drug delivery. vol 25. issue 1. 2019-08-14. PMID:30176744. |
glioma-bearing rats treated with anti-epha3-modified nps resulted in significantly higher tumor cell apoptosis (p < .01) than that observed with other formulations and prolonged the median survival time of glioma-bearing rats to 26 days, which was 1.37-fold longer than that of plga nps. |
2019-08-14 |
2023-08-13 |
rat |
| Mei-Lang Kung, Pei-Ying Lin, Shih-Tsung Huang, Ming-Hong Tai, Shu-Ling Hsieh, Chih-Chung Wu, Bi-Wen Yeh, Wen-Jeng Wu, Shuchen Hsie. Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines. ACS applied materials & interfaces. vol 11. issue 1. 2019-07-31. PMID:30566322. |
our results demonstrated that zingerone nps significantly inhibit akt activity and nfκb expression as well as activate the caspases cascade signaling pathway which are involved in the antiproliferation, antitumorigenicity, disturbing cell cycle progression, and induction of dna damage as well as cell apoptosis. |
2019-07-31 |
2023-08-13 |
human |
| Zhigao Wang, Rui Xue Zhang, Tian Zhang, Chunsheng He, Rong He, Xingrong Ju, Xiao Yu W. In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer. ACS applied materials & interfaces. vol 10. issue 48. 2019-07-30. PMID:30387987. |
in an orthotopic breast tumor model of cathb-overexpressing breast cancer, dox-arpi/cs nps remarkably inhibit tumor growth, enhance tumor cell apoptosis and prolong host survival without eliciting any systemic toxicity. |
2019-07-30 |
2023-08-13 |
Not clear |
| Hadi Esmaeili Govarchin Ghaleh, Leila Zarei, Bahman Mansori Motlagh, Nasrollah Jabbar. Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-07-22. PMID:30964344. |
a significant (p < .01) decrease in proliferation index (0.124 ± 0.021), a significant (p < .01) increase in apoptosis (42% ± 1.54) of mcf7 cells, a significant (p < .03) increase in ros formation (32.16 ± 1.9) and a significant (p < .01) increase in ldh release (33.28 ± 1.56) were recorded in the adjacency of mcf-7 cells by a combination of cuo nps (100 µg/ml) and r + h compared to control and other treatments. |
2019-07-22 |
2023-08-13 |
Not clear |
| Hadi Esmaeili Govarchin Ghaleh, Leila Zarei, Bahman Mansori Motlagh, Nasrollah Jabbar. Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-07-22. PMID:30964344. |
based on these observations, a combination of cuo nps, hyperthermia, and irradiation could suppress the growth of mcf-7 cells and evoke cell apoptosis via mitochondrial membrane potential. |
2019-07-22 |
2023-08-13 |
Not clear |
| Lulu Fan, Bingchen Zhang, Aixiao Xu, Zhichun Shen, Yan Guo, Ruirui Zhao, Huilu Yao, Jing-Wei Sha. Carrier-Free, Pure Nanodrug Formed by the Self-Assembly of an Anticancer Drug for Cancer Immune Therapy. Molecular pharmaceutics. vol 15. issue 6. 2019-07-03. PMID:29727577. |
ua nps exhibited higher antiproliferative activity; significantly caused apoptosis; decreased the expression of cox-2/vegfr2/vegfa; and increased the immunostimulatory activity of tnf-α, il-6, and ifn-β and decreased the activity of stat-3 in a549 cells in vitro. |
2019-07-03 |
2023-08-13 |
Not clear |
| Nasrollah Jabbari, Leila Zarei, Hadi Esmaeili Govarchin Galeh, Bahman Mansori Motlag. Assessment of synergistic effect of combining hyperthermia with irradiation and calcium carbonate nanoparticles on proliferation of human breast adenocarcinoma cell line (MCF-7 cells). Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup2. 2019-06-24. PMID:29616844. |
our findings revealed that cc nps in combination with irradiation and hyperthermia could significantly reduce the cell viability and enhance the apoptosis of the mcf-7 breast cancer cells, the same as doxorubicin anti-cancer drug. |
2019-06-24 |
2023-08-13 |
human |
| Meeta Gera, Nameun Kim, Mrinmoy Ghosh, Neelesh Sharma, Do Luong Huynh, Nisansala Chandimali, Hyebin Koh, Jiao Jiao Zhang, Tae Yoon Kang, Yang Ho Park, Taeho Kwon, Dong Kee Jeon. Synthesis and evaluation of the antiproliferative efficacy of BRM270 phytocomposite nanoparticles against human hepatoma cancer cell lines. Materials science & engineering. C, Materials for biological applications. vol 97. 2019-06-17. PMID:30678901. |
taken together, our findings demonstrated that these uniquely engineered brm270 nps effectively enter into the cancer cells due to its acidic microenvironment thereby inducing apoptosis and regulate the cell-proliferation in-vitro at extremely low dosages. |
2019-06-17 |
2023-08-13 |
human |