| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen Liu, Junhong Ling, Nan Wang, Xiao-Kun Ouyan. Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy. Journal of colloid and interface science. vol 678. issue Pt A. 2024-09-05. PMID:39236435. |
in this paper, we developed novel copper-chelated polydopamine (pda) nanoparticles (nps) functionalized with hyaluronic acid (ha) (cu-pda-ha nps) to induce apoptosis and cuproptosis-induced cell death, synergistically combining ptt and cdt. |
2024-09-05 |
2024-09-08 |
Not clear |
| Anton L Popov, Danil D Kolmanovich, Nikita N Chukavin, Ivan V Zelepukin, Gleb V Tikhonowski, Andrei I Pastukhov, Anton A Popov, Alexander E Shemyakov, Sergey M Klimentov, Vladimir A Ryabov, Sergey M Deyev, Irina N Zavestovskaya, Andrei V Kabashi. Boron Nanoparticle-Enhanced Proton Therapy: Molecular Mechanisms of Tumor Cell Sensitization. Molecules (Basel, Switzerland). vol 29. issue 16. 2024-08-29. PMID:39203014. |
our experiments showed that the combined effect of b nps and proton irradiation induces an increased level of superoxide anion radical generation, which leads to the depolarization of mitochondria, a drop in their membrane mitochondrial potential, and the development of apoptosis. |
2024-08-29 |
2024-09-04 |
Not clear |
| Tian Zhu, Chunxia Yao, Shuang Hong, Weiguo Song, Norlaila Mohd Zanuri, Weiwei Lv, Qichen Jian. Multi-omics reveal toxicity mechanisms underpinning nanoplastic in redclaw crayfish (Cherax quadricarinatus). The Science of the total environment. 2024-08-22. PMID:39173758. |
transcriptomic analyses revealed that nps influenced apoptosis, drug metabolism-cytochrome p450, and p53 signaling pathways. |
2024-08-22 |
2024-08-25 |
Not clear |
| Tian Zhu, Chunxia Yao, Shuang Hong, Weiguo Song, Norlaila Mohd Zanuri, Weiwei Lv, Qichen Jian. Multi-omics reveal toxicity mechanisms underpinning nanoplastic in redclaw crayfish (Cherax quadricarinatus). The Science of the total environment. 2024-08-22. PMID:39173758. |
thus, nps induced apoptosis in c. quadricarinatus hepatopancreatic cells, concomitant with increasing np concentrations. |
2024-08-22 |
2024-08-25 |
Not clear |
| Liyan Yang, Yingying Zhang, Yuxin Lai, Wenjing Xu, Shizeng Lei, Guixiang Chen, Zhonglei Wan. A computer-aided, heterodimer-based "triadic" carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency. Journal of colloid and interface science. vol 677. issue Pt B. 2024-08-18. PMID:39154445. |
subsequently, we conducted case studies on docetaxel (dtx)-loaded erl-ss-cpt nanoparticles (denoted as dtx@erl-ss-cpt nps) and curcumin (cur)-loaded erl-ss-cpt nps (identified as cur@cpt-ss-eri nps) to comprehensively investigate their self-assembly mechanism, physicochemical properties, storage stability, gsh-responsive drug release, cellular uptake, apoptosis effects, biocompatibility, and cytotoxicity. |
2024-08-18 |
2024-08-21 |
human |
| Liyan Yang, Yingying Zhang, Yuxin Lai, Wenjing Xu, Shizeng Lei, Guixiang Chen, Zhonglei Wan. A computer-aided, heterodimer-based "triadic" carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency. Journal of colloid and interface science. vol 677. issue Pt B. 2024-08-18. PMID:39154445. |
the spherical nps enhance water solubility, reduce the required dosage of free drugs, and increase cellular drug accumulation while suppressing p-glycoprotein (p-gp) expression, leading to apoptosis. |
2024-08-18 |
2024-08-21 |
human |
| Xiaoxiao Shan, Shujie Lv, Hongyan Cheng, Lele Zhou, Yu Gao, Chengjie Xing, Dawei Li, Wenwen Tao, Caiyun Zhan. Evaluation of 3-O-β-D-galactosylated resveratrol-loaded polydopamine nanoparticles for hepatocellular carcinoma treatment. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024-08-14. PMID:39142541. |
the experimental results of hoechst 33342/propyl iodide (pi) double staining and flow cytometry both revealed that gal-res nps could remarkably promote cell apoptosis. |
2024-08-14 |
2024-08-17 |
mouse |
| Rui Zong, Rui Wang, Mengting Wu, Hainan Ruan, Wanqing Ou, Weiyu Dong, Peng Zhang, Shaohua Fan, Jun L. Enhancement of the anticancer potential and biosafety of BSA-modified, bacterial membrane-coated curcumin nanoparticles. Colloids and surfaces. B, Biointerfaces. vol 243. 2024-08-13. PMID:39137532. |
the bsa-omv cur nps exhibited high storage stability, low cytotoxicity, sustained release, enhanced cellular uptake of cur, induction of tumor cell apoptosis, and inhibition of tumor cell proliferation and migration. |
2024-08-13 |
2024-08-16 |
cattle |
| Ping Zhu, Zhaoji Wu, Zhilu Yang, Tingting Tang, Yunhui Liao, Wen Zhao, Ying Huang, Tao Chen, Junjie Li, Chunmei Nong, Zhenzhen Wu, Guodong Hu, Yanshan Liu, Yinghua Che. Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis. Research (Washington, D.C.). vol 7. 2024-08-07. PMID:39109246. |
we demonstrate that tbtdc nps effectively generate reactive oxygen species upon light irradiation and lead to significant apoptosis of psoriatic keratinocytes. |
2024-08-07 |
2024-08-09 |
Not clear |
| Ping Zhu, Zhaoji Wu, Zhilu Yang, Tingting Tang, Yunhui Liao, Wen Zhao, Ying Huang, Tao Chen, Junjie Li, Chunmei Nong, Zhenzhen Wu, Guodong Hu, Yanshan Liu, Yinghua Che. Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis. Research (Washington, D.C.). vol 7. 2024-08-07. PMID:39109246. |
furthermore, tbtdc nps exhibit high cellular uptake in diseased keratinocytes and induce endoplasmic reticulum stress (ers)-mediated autophagy, which can also enhance apoptosis. |
2024-08-07 |
2024-08-09 |
Not clear |
| Yixuan Wang, Shijia Fu, Yao Zeng, Siwen Jiao, Guihong Chai, Yuehong X. Tea polyphenols nanoparticles integrated with microneedles multifunctionally boost 5-aminolevulinic acid photodynamic therapy for skin cancer. Journal of colloid and interface science. vol 677. issue Pt A. 2024-08-04. PMID:39098278. |
subsequently, the photosensitizer protoporphyrin ix derived from ala accumulates in the tumor cells in a dose-dependent manner with tp nps, generating reactive oxygen species to promote apoptosis and necrosis of a375 and a431 cells. |
2024-08-04 |
2024-08-07 |
Not clear |
| Anel Urazaliyeva, Perizat Kanabekova, Almaz Beisenbayev, Gulsim Kulsharova, Timur Atabaev, Sehoon Kim, Chang-Keun Li. All organic nanomedicine for PDT-PTT combination therapy of cancer cells in hypoxia. Scientific reports. vol 14. issue 1. 2024-07-31. PMID:39080400. |
tests on a549 cancer cell lines have revealed that combi nps exhibit superior cytotoxicity and induce apoptosis in hypoxic conditions, outperforming ptt-only nps. |
2024-07-31 |
2024-08-02 |
Not clear |
| Dongxin Peng, Sujing Sun, Man Zhao, Linsheng Zhan, Xiaohui Wan. Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets. Journal of functional biomaterials. vol 15. issue 7. 2024-07-26. PMID:39057309. |
this review is intended to summarize the effects of nps on platelet activation, aggregation, release, and apoptosis, as well as their effects on membrane proteins and morphology in order to shed light on such key issues as how to reduce their adverse reactions in the blood system, which should be taken into consideration in np engineering. |
2024-07-26 |
2024-07-28 |
Not clear |
| Zhenjun Zhu, Yaqing Zhang, Ruomeng Wang, Yijia Dong, Junrong Wu, Longquan Sha. Zinc oxide nanoparticles disrupt the mammary epithelial barrier via Z-DNA binding protein 1-triggered PANoptosis. Ecotoxicology and environmental safety. vol 283. 2024-07-25. PMID:39053182. |
in vivo, we also found that zno nps can simultaneously induce apoptosis, necroptosis, and pyroptosis, called panoptosis. |
2024-07-25 |
2024-07-28 |
mouse |
| Ruirui Li, Cheng Zhang, Wenping Xu, Liming Tao, Jiagao Cheng, Zhong Li, Yang Zhan. Natural pyrethrins induced developmental toxicity of zebrafish swim bladder in vivo and genotoxicity of lung cells in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2024-07-18. PMID:39025157. |
the results showed that nps induced cytotoxicity, caused oxidative dna damage and triggered mitochondria-mediated apoptosis. |
2024-07-18 |
2024-07-21 |
human |
| Jincheng Pei, Shannan Chen, Li Li, Kailun Wang, Anning Pang, Mengmeng Niu, Xueyun Peng, Nan Li, Hongjuan Wu, Pin Ni. Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective. The Science of the total environment. 2024-07-14. PMID:39004365. |
however, studies investigating mechanisms underlying oxidative stress (os), apoptosis, and inflammation induced by nps in fish remain limited. |
2024-07-14 |
2024-07-18 |
zebrafish |
| Jincheng Pei, Shannan Chen, Li Li, Kailun Wang, Anning Pang, Mengmeng Niu, Xueyun Peng, Nan Li, Hongjuan Wu, Pin Ni. Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective. The Science of the total environment. 2024-07-14. PMID:39004365. |
short-term exposure to nps also triggered apoptosis and inflammation in zebrafish larvae, evident from significant up-regulation in mrna expressions of proapoptotic factors and nf-κb proinflammatory signaling pathway, as well as increased transcription and protein levels of pro-inflammatory factors in larvae. |
2024-07-14 |
2024-07-18 |
zebrafish |
| Jincheng Pei, Shannan Chen, Li Li, Kailun Wang, Anning Pang, Mengmeng Niu, Xueyun Peng, Nan Li, Hongjuan Wu, Pin Ni. Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective. The Science of the total environment. 2024-07-14. PMID:39004365. |
inhibition of intracellular excessive ros effectively reduced the induction of apoptosis, nf-κb p65 nuclear migration levels, and cytokine secretion, underscoring os as a pivotal factor throughout the process of apoptosis and inflammatory responses induced by nps. |
2024-07-14 |
2024-07-18 |
zebrafish |
| Yisheng Chen, Lei Huang, Zhiwen Luo, Dan Han, Wei Luo, Renwen Wan, Yan Li, Yunshen Ge, Wei-Wei Lin, Yuchun Xie, Mingming Sun, Qian Wang, Zhiwei Li, Shiyi Chen, Yi Yang, Bin Huang, Yuzhen X. Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy. Journal of controlled release : official journal of the Controlled Release Society. 2024-07-12. PMID:38996921. |
the pan@trf@liposome nps exhibit notable biocompatibility, showing no liver or kidney toxicity in vivo, while demonstrating stability and effectiveness in modulating crm1-mediated pkm2 nuclear translocation, thereby reducing neuroinflammation and neuronal apoptosis. |
2024-07-12 |
2024-07-15 |
Not clear |
| Ben Wang, Hui Zhou, Lu Chen, Yancheng Ding, Xinyue Zhang, Huiyu Chen, Hanyu Liu, Ping Li, Ying Chen, Chao Yin, Quli Fa. A Mitochondria-Targeted Photosensitizer for Combined Pyroptosis and Apoptosis with NIR-II Fluorescence/Photoacoustic Imaging-Guided Phototherapy. Angewandte Chemie (International ed. in English). 2024-07-07. PMID:38972844. |
through nano-precipitation method, z1 nanoparticles (nps) also demonstrated high ros generation (especially type-i ros) upon 808 nm laser irradiation, leading to efficient mitochondria dysfunction and combined pyroptosis and apoptosis. |
2024-07-07 |
2024-07-11 |
Not clear |