| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rasmus Foldbjerg, Ping Olesen, Mads Hougaard, Duy Anh Dang, Hans Jürgen Hoffmann, Herman Autru. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicology letters. vol 190. issue 2. 2009-09-28. PMID:19607894. |
by using the flowcytometric annexin v/propidium iodide (pi) assay, both ag nps and ag+ were shown to induce apoptosis and necrosis in thp-1 cells depending on dose and exposure time. |
2009-09-28 |
2023-08-12 |
human |
| Jiao Sun, Tingting Din. p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. Journal of biomedical materials research. Part A. vol 88. issue 3. 2009-03-16. PMID:18335527. |
the effects and mechanism of hydroxyapatite (hap) nanoparticles (nps) on the induction of cytotoxicity and apoptosis in rat macrophages was evaluated by testing the antiproliferative effect of hap nps with agar overlay and direct contact methods. |
2009-03-16 |
2023-08-12 |
rat |
| Jiao Sun, Tingting Din. p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. Journal of biomedical materials research. Part A. vol 88. issue 3. 2009-03-16. PMID:18335527. |
the characteristic morphological changes of apoptosis were observed in macrophages after treatment with hap nps for 24 h. furthermore, p53 mrna levels significantly increased when macrophages were incubated with 200 microg/ml hap nps (p < 0.01). |
2009-03-16 |
2023-08-12 |
rat |
| Jiao Sun, Tingting Din. p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. Journal of biomedical materials research. Part A. vol 88. issue 3. 2009-03-16. PMID:18335527. |
the conclusion is that hap nps can induce p53 expression through phosphorylation, which promotes downstream genes and finally results in cell apoptosis. |
2009-03-16 |
2023-08-12 |
rat |
| Dadong Guo, Chunhui Wu, Xiaomao Li, Hui Jiang, Xuemei Wang, Baoan Che. In vitro cellular uptake and cytotoxic effect of functionalized nickel nanoparticles on leukemia cancer cells. Journal of nanoscience and nanotechnology. vol 8. issue 5. 2008-08-13. PMID:18572641. |
the results of 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide (mtt) assay, dna fragmentation and flow cytometry studies demonstrate that the ni nps could exert cytotoxicity to leukemia k562 cells at high concentration, and subsequently induce both apoptosis and necrosis of target cancer cells, whilst it had little impact on target cells when at low concentration. |
2008-08-13 |
2023-08-12 |
Not clear |
| Shyh-Dar Li, Yun-Ching Chen, Michael J Hackett, Leaf Huan. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 1. 2008-05-13. PMID:17923843. |
three daily injections (1.2 mg/kg) of sirna formulated in the targeted nps silenced the epidermal growth factor receptor (egfr) in the tumor and induced approximately 15% tumor cell apoptosis. |
2008-05-13 |
2023-08-12 |
Not clear |
| Dragan Maric, Alessandra Fiorio Pla, Yoong Hee Chang, Jeffery L Barke. Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 8. 2007-03-22. PMID:17314281. |
enumeration of nscs using comprehensive flow cytometric analysis demonstrated that their precipitous decline in vivo involved both active differentiation into nps and an increased propensity toward apoptosis. |
2007-03-22 |
2023-08-12 |
rat |
| Masahide Mizobuchi, Fumie Saji, Kazuhiro Shiizaki, Toshihiro Sato, Maki Shibata, Shigeo Negi, Tadao Akizawa, Ikuji Hatamura, Hiroaki Ogata, Eriko Kinugas. [Apoptosis: a possible mechanism of suppressing parathyroid hyperplasia by calcimimetics]. Clinical calcium. vol 15 Suppl 1. 2006-01-24. PMID:16272631. |
these results suggest that calcimimetic compounds, nps r-568 reduces pth secretion and induces apoptosis of hyperfunctional parathyroid cell in vitro. |
2006-01-24 |
2023-08-12 |
rat |
| Kazumasa Watanabe, Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Him. Effects of glucocorticoids on infiltrating cells and epithelial cells of nasal polyps. The Annals of otology, rhinology, and laryngology. vol 113. issue 6. 2004-07-22. PMID:15224831. |
to examine the mechanisms of their effect, we evaluated 1) the ability of glucocorticoids to induce the apoptosis of eosinophils and t lymphocytes in nps, and 2) the ability of dexamethasone to down-regulate epithelial cell functions that relate to eosinophilic inflammation. |
2004-07-22 |
2023-08-12 |
Not clear |
| Kazumasa Watanabe, Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Him. Effects of glucocorticoids on infiltrating cells and epithelial cells of nasal polyps. The Annals of otology, rhinology, and laryngology. vol 113. issue 6. 2004-07-22. PMID:15224831. |
in vitro and in vivo, glucocorticoids increased the apoptosis of both eosinophils and t lymphocytes in nps. |
2004-07-22 |
2023-08-12 |
Not clear |
| Kazumasa Watanabe, Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Him. Effects of glucocorticoids on infiltrating cells and epithelial cells of nasal polyps. The Annals of otology, rhinology, and laryngology. vol 113. issue 6. 2004-07-22. PMID:15224831. |
these results suggest that the clinical efficacy of glucocorticoids on nps may be due to 1) induction of apoptosis in both eosinophils and t lymphocytes that infiltrate nps, and 2) down-regulation of epithelial gm-csf production, which prolongs eosinophil survival. |
2004-07-22 |
2023-08-12 |
Not clear |
| J Tfelt-Hansen, N Chattopadhyay, S Yano, D Kanuparthi, P Rooney, P Schwarz, E M Brow. Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy. Endocrinology. vol 145. issue 3. 2004-03-23. PMID:14645111. |
using terminal uridine deoxynucleotidyl nick end labeling staining, we demonstrated that high ca(2+) (7.5 mm) and nps r-467 indeed protect cells against apoptosis induced by serum withdrawal compared with low ca(2+) (0.5 mm). |
2004-03-23 |
2023-08-12 |
rat |
| Lisa C Costello-Boerrigter, Guido Boerrigter, John C Burnet. Revisiting salt and water retention: new diuretics, aquaretics, and natriuretics. The Medical clinics of North America. vol 87. issue 2. 2003-04-18. PMID:12693735. |
second, nps inhibit the sympathetic nervous system, the activation of which is associated with heart failure progression, myocyte necrosis and apoptosis, and arrhythmias. |
2003-04-18 |
2023-08-12 |
Not clear |
| V Calaora, B Rogister, K Bismuth, K Murray, H Brandt, P Leprince, M Marchionni, M Dubois-Dalc. Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 13. 2001-07-26. PMID:11425901. |
this inhibitor of nrg-1 bioactivity decreased mitosis of nps and increased their apoptosis, resulting in a significant reduction in neurosphere size and number. |
2001-07-26 |
2023-08-12 |
Not clear |
| P J Ciaccio, E Gicquel, P J O'Neill, H E Scribner, Y L Vandenbergh. Investigation of the positive response of ethyl acrylate in the mouse lymphoma genotoxicity assay. Toxicological sciences : an official journal of the Society of Toxicology. vol 46. issue 2. 1999-05-06. PMID:10048136. |
to develop a better understanding of the relationship between ethyl acrylate (ea)-induced cytotoxicity and mutation frequency in the mouse lymphoma assay (mla) we measured the effects of ea treatment to ml cells on: (1) nonprotein sulfhydryl (nps) levels; (2) mitochondrial rhodamine 123 (rh123) uptake; (3) the dna elution slope (single-strand breakage) and y intercept of fitted curves (cytotoxicity and double-strand breakage) in the alkaline elution assay; (4) the appearance of apoptosis; and (5) the pulsed-field gel electrophoretic resolution of high-molecular-weight dna. |
1999-05-06 |
2023-08-12 |
mouse |
| C Guichard, L Gilain, I Abd-Al Samad, G Piron, L Brugel, E Escudier, A Cost. Epithelial cell proliferation, apoptosis, and apoptosis inhibition in inverted papillomas. The Laryngoscope. vol 108. issue 5. 1998-05-29. PMID:9591552. |
the purpose of this study was to detect, quantify, and compare cell proliferation, apoptosis, and apoptosis inhibition in hyperplastic epithelium from ips and in inflammatory nasal polyps (nps). |
1998-05-29 |
2023-08-12 |
Not clear |
| C Guichard, L Gilain, I Abd-Al Samad, G Piron, L Brugel, E Escudier, A Cost. Epithelial cell proliferation, apoptosis, and apoptosis inhibition in inverted papillomas. The Laryngoscope. vol 108. issue 5. 1998-05-29. PMID:9591552. |
cell proliferation and apoptosis were significantly higher in ips than in nps (p = .0002 and p = .043, respectively), while apoptosis inhibition was significantly lower in ips than in nps (p = .001). |
1998-05-29 |
2023-08-12 |
Not clear |