| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Yao Chang, Yu-Jen Yang, Chih-Han Chang, Alan C L Tang, Wei-Yin Liao, Fong-Yu Cheng, Chen-Sheng Yeh, James J Lai, Patrick S Stayton, Patrick C H Hsie. Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. Journal of controlled release : official journal of the Controlled Release Society. vol 170. issue 2. 2014-01-28. PMID:23665256. |
plga-igf-1 nps also prolonged akt activation in cardiomyocytes up to 24h and prevented cardiomyocyte apoptosis induced by doxorubicin in a dose-dependent manner. |
2014-01-28 |
2023-08-12 |
mouse |
| Ming-Yao Chang, Yu-Jen Yang, Chih-Han Chang, Alan C L Tang, Wei-Yin Liao, Fong-Yu Cheng, Chen-Sheng Yeh, James J Lai, Patrick S Stayton, Patrick C H Hsie. Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. Journal of controlled release : official journal of the Controlled Release Society. vol 170. issue 2. 2014-01-28. PMID:23665256. |
importantly, a single intramyocardial injection of plga-igf-1 nps was sufficient to prevent cardiomyocyte apoptosis (p<0.001), reduce infarct size (p<0.05), and improve left ventricle ejection fraction (p<0.01) 21 days after experimental mi in mice. |
2014-01-28 |
2023-08-12 |
mouse |
| Esmaiel Jabbari, Xiaoming Yang, Seyedsina Moeinzadeh, Xuezhong H. Drug release kinetics, cell uptake, and tumor toxicity of hybrid VVVVVVKK peptide-assembled polylactide nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 84. issue 1. 2014-01-16. PMID:23275111. |
dox-loaded pla-v6k2 nps showed higher toxicity to 4t1 cells and the dna damage response, and apoptosis was delayed compared to the free dox. |
2014-01-16 |
2023-08-12 |
mouse |
| Xianwei Su, Zhaohui Wang, Lili Li, Mingbin Zheng, Cuifang Zheng, Ping Gong, Pengfei Zhao, Yifan Ma, Qian Tao, Lintao Ca. Lipid-polymer nanoparticles encapsulating doxorubicin and 2'-deoxy-5-azacytidine enhance the sensitivity of cancer cells to chemical therapeutics. Molecular pharmaceutics. vol 10. issue 5. 2013-12-16. PMID:23570548. |
more importantly, incorporating dac into nps significantly enhanced the sensitivity of cancer cells to dox by inhibiting cell growth rate and inducing cell apoptosis. |
2013-12-16 |
2023-08-12 |
human |
| Amalie Thit, Henriette Selck, Henning F Bjerregaar. Toxicity of CuO nanoparticles and Cu ions to tight epithelial cells from Xenopus laevis (A6): effects on proliferation, cell cycle progression and cell death. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 5. 2013-12-03. PMID:23268107. |
dividing cells treated with poly-cuo, cuo nps (6 nm) or cu(2+) showed cell cycle arrest and caused significant increase in cell death via apoptosis after 48 h, 6 and 7 days of treatment, respectively. |
2013-12-03 |
2023-08-12 |
xenopus_laevis |
| Xiumei Jiang, Rasmus Foldbjerg, Teodora Miclaus, Liming Wang, Rajinder Singh, Yuya Hayashi, Duncan Sutherland, Chunying Chen, Herman Autrup, Christiane Bee. Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23872614. |
therefore, we here systematically investigated dna and chromosomal damage induced by bsa coated ag nps (15.9±7.6 nm) in cho-k1 cells in relation to cellular uptake and intracellular localization, their effects on mitochondrial activity and production of reactive oxygen species (ros), cell cycle, apoptosis and necrosis. |
2013-10-29 |
2023-08-12 |
Not clear |
| Xiumei Jiang, Rasmus Foldbjerg, Teodora Miclaus, Liming Wang, Rajinder Singh, Yuya Hayashi, Duncan Sutherland, Chunying Chen, Herman Autrup, Christiane Bee. Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23872614. |
annexin v/propidium iodide assay showed that ag nps and ag⁺ induced apoptosis and necrosis, which is in agreement with an increased fraction of cells in subg1 phase of the cell cycle. |
2013-10-29 |
2023-08-12 |
Not clear |
| Lipika Ray, Pradeep Kumar, Kailash C Gupt. The activity against Ehrlich's ascites tumors of doxorubicin contained in self assembled, cell receptor targeted nanoparticle with simultaneous oral delivery of the green tea polyphenol epigallocatechin-3-gallate. Biomaterials. vol 34. issue 12. 2013-08-15. PMID:23357370. |
further, we showed that these nps (hdd and hdha) were more active in the presence of egcg than dox alone in inducing apoptosis in eac cells as evident by an increase in sub-g1 cells (percent), annexin v positive cells and chromatin condensation along with the reduction in mitochondrial membrane potential (mmp). |
2013-08-15 |
2023-08-12 |
mouse |
| Hong Wook Cho, Seong Kook Park, Kyung Wook Heo, Dae Young Hu. Methotrexate induces apoptosis in nasal polyps via caspase cascades and both mitochondria-mediated and p38 mitogen-activated protein kinases/Jun N-terminal kinase pathways. American journal of rhinology & allergy. vol 27. issue 1. 2013-08-07. PMID:23406595. |
methotrexate (mtx) is a very effective treatment for chronic inflammatory diseases that induces apoptosis in nasal polyps (nps). |
2013-08-07 |
2023-08-12 |
Not clear |
| Sean Marrache, Shanta Dha. Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 23. 2013-08-06. PMID:23671083. |
in vitro uptake, detection of apoptosis, and cholesterol binding studies indicated promising detection ability and therapeutic potential of tpp-hdl-apoa-i-qd nps. |
2013-08-06 |
2023-08-12 |
rat |
| Vanessa Valdiglesias, Carla Costa, Gözde Kiliç, Solange Costa, Eduardo Pásaro, Blanca Laffon, João Paulo Teixeir. Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles. Environment international. vol 55. 2013-08-02. PMID:23535050. |
results obtained by flow cytometry showed that zno nps do not enter the neuronal cells, but their presence in the medium induced cytotoxicity, including viability decrease, apoptosis and cell cycle alterations, and genotoxicity, including micronuclei production, h2ax phosphorylation and dna damage, both primary and oxidative, on human neuronal cells in a dose- and time-dependent manner. |
2013-08-02 |
2023-08-12 |
human |
| Jiang Pi, Hua Jin, Ruiying Liu, Bing Song, Qing Wu, Li Liu, Jinhuan Jiang, Fen Yang, Huaihong Cai, Jiye Ca. Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells. Applied microbiology and biotechnology. vol 97. issue 3. 2013-07-03. PMID:22945264. |
then, the fa-se nps entered into mitochondria; triggered the mitochondria-dependent apoptosis of mcf-7 cells which involved oxidative stress, ca(2)+ stress changes, and mitochondrial dysfunction; and finally caused the damage of mitochondria. |
2013-07-03 |
2023-08-12 |
Not clear |
| Maqusood Ahame. Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells. Human & experimental toxicology. vol 32. issue 2. 2013-06-13. PMID:23315277. |
the aim of this study was to investigate the induction of cytotoxicity, oxidative stress and apoptosis by sio(2) nps (size 15 nm) in human skin epithelial (a431) and human lung epithelial (a549) cells. |
2013-06-13 |
2023-08-12 |
human |
| Maqusood Ahame. Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells. Human & experimental toxicology. vol 32. issue 2. 2013-06-13. PMID:23315277. |
this study suggested that sio(2) nps induce cytotoxicity and apoptosis in a431 and a549 cells, which is likely to be mediated through ros generation and oxidative stress. |
2013-06-13 |
2023-08-12 |
human |
| A Anitha, Saji Uthaman, Shantikumar V Nair, R Jayakumar, Vinoth-Kumar Lakshmana. Enhanced delivery system of flutamide loaded chitosan-dextran sulphate nanoparticles for prostate cancer. Journal of biomedical nanotechnology. vol 9. issue 3. 2013-06-13. PMID:23620988. |
the cell death mechanism of drug loaded nanoparticles for a concentration of 50 and 75 nm showed 28 +/- 2 and 35.2 +/- 4% apoptosis in samples treated with the pc3 cells after 24 h. fluorescent microscopic imaging and flow cytometry confirmed the preferential uptake of the nanoparticles (nps) in the prostate cancer cells (pc3) unlike in normal (l929) cells. |
2013-06-13 |
2023-08-12 |
mouse |
| Ritesh K Shukla, Ashutosh Kumar, Deepak Gurbani, Alok K Pandey, Shashi Singh, Alok Dhawa. TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology. vol 7. issue 1. 2013-06-07. PMID:22047016. |
furthermore, immunoblot analysis revealed an increased expression of p53, bax, cyto-c, apaf-1, caspase-9 and caspase-3 and decreased the level of bcl-2 thereby indicating that apoptosis induced by tio(2) nps occurs via the caspase-dependent pathway. |
2013-06-07 |
2023-08-12 |
human |
| Ritesh K Shukla, Ashutosh Kumar, Deepak Gurbani, Alok K Pandey, Shashi Singh, Alok Dhawa. TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology. vol 7. issue 1. 2013-06-07. PMID:22047016. |
this study systematically shows that tio(2) nps induce dna damage and cause apoptosis in hepg2 cells even at very low concentrations. |
2013-06-07 |
2023-08-12 |
human |
| D Jeevitha, Kanchana Amarnat. Chitosan/PLA nanoparticles as a novel carrier for the delivery of anthraquinone: synthesis, characterization and in vitro cytotoxicity evaluation. Colloids and surfaces. B, Biointerfaces. vol 101. 2013-05-09. PMID:22796782. |
our results also suggest that upon cs/pla-aq nps exposure the cell viability decreased due to apoptosis, as demonstrated by the formation of apoptotic bodies, sub-g1 hypodiploid cells, and dna fragmentation. |
2013-05-09 |
2023-08-12 |
human |
| Lu Han, Li-Bo Du, Anil Kumar, Hong-Ying Jia, Xing-Jie Liang, Qiu Tian, Guang-Jun Nie, Yang Li. Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis. Biomaterials. vol 33. issue 33. 2013-02-06. PMID:22922024. |
the effects of trolox-cs nps on raw264.7 cells damaged by tert-butylhydroperoxide (t-bhp) were determined by mtt assay for cell viability, mda assay for membrane lipid peroxidation, jc-1 probe and annexin v-fitc/pi double staining for mitochondria membrane potential (mmp) and raw264.7 apoptosis, respectively. |
2013-02-06 |
2023-08-12 |
Not clear |
| Lu Han, Li-Bo Du, Anil Kumar, Hong-Ying Jia, Xing-Jie Liang, Qiu Tian, Guang-Jun Nie, Yang Li. Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis. Biomaterials. vol 33. issue 33. 2013-02-06. PMID:22922024. |
the trolox-cs nps treatment inhibited mmp collapse and raw264.7 apoptosis more obviously than free trolox. |
2013-02-06 |
2023-08-12 |
Not clear |