| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyle Meyer, Pavan Rajanahalli, Maqusood Ahamed, John J Rowe, Yiling Hon. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21903158. |
this study was designed to investigate the apoptosis induction by zno nps via mitogen-activated protein kinase p38 and cell cycle checkpoint protein p53 pathways in human dermal fibroblasts. |
2012-04-13 |
2023-08-12 |
human |
| Kyle Meyer, Pavan Rajanahalli, Maqusood Ahamed, John J Rowe, Yiling Hon. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21903158. |
our results suggest that zno nps have the potential to induce apoptosis in human dermal fibroblasts via p53-p38 pathways. |
2012-04-13 |
2023-08-12 |
human |
| Soukaina Réjiba, L Harivardhan Reddy, Christelle Bigand, Céline Parmentier, Patrick Couvreur, Amor Hajr. Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. Nanomedicine : nanotechnology, biology, and medicine. vol 7. issue 6. 2012-03-13. PMID:21419876. |
cell viability and apoptosis assays showed that sq-gem nps displayed higher antiproliferative and cytotoxic effects, particularly in chemoresistant panc1 tumor cells. |
2012-03-13 |
2023-08-12 |
mouse |
| Geetanjali Arya, Mallaredy Vandana, Sarbari Acharya, Sanjeeb K Saho. Enhanced antiproliferative activity of Herceptin (HER2)-conjugated gemcitabine-loaded chitosan nanoparticle in pancreatic cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. vol 7. issue 6. 2012-03-13. PMID:21550422. |
the targeted nps displayed superior antiproliferative activity along with an enhanced s-phase arrest, leading to apoptosis in comparison with unconjugated gemcitabine-loaded nanoparticles and free gemcitabine due to higher cellular binding with eventual uptake and prolonged intracellular retention. |
2012-03-13 |
2023-08-12 |
Not clear |
| Gen Zhang, Bin Bin Lai, Yan Yan Zhou, Bao An Chen, Xue Mei Wang, Qun Lu, Yan-Hua Che. Fe3O4 nanoparticles with daunorubicin induce apoptosis through caspase 8-PARP pathway and inhibit K562 leukemia cell-induced tumor growth in vivo. Nanomedicine : nanotechnology, biology, and medicine. vol 7. issue 5. 2012-02-03. PMID:21333751. |
here we investigate the synergistic effects of fe(3)o(4) nps with dnr on the induction of apoptosis using k562 leukemia cells. |
2012-02-03 |
2023-08-12 |
mouse |
| Gen Zhang, Bin Bin Lai, Yan Yan Zhou, Bao An Chen, Xue Mei Wang, Qun Lu, Yan-Hua Che. Fe3O4 nanoparticles with daunorubicin induce apoptosis through caspase 8-PARP pathway and inhibit K562 leukemia cell-induced tumor growth in vivo. Nanomedicine : nanotechnology, biology, and medicine. vol 7. issue 5. 2012-02-03. PMID:21333751. |
fe(3)o(4) nps increased the ability of dnr to induce apoptosis in both adriamycin-sensitive and adriamycin-resistant k562 cells through the caspase 8-poly(adp-ribose) polymerase pathway. |
2012-02-03 |
2023-08-12 |
mouse |
| Yilin Zhang, Weiqiang Yu, Xinquan Jiang, Kaige Lv, Shengjun Sun, Fuqiang Zhan. Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblasts. Journal of materials science. Materials in medicine. vol 22. issue 8. 2011-12-07. PMID:21681655. |
there was a significant increase in lactate dehydrogenase (ldh) release, apoptosis and mitochondrial membrane permeability following short-term exposure of the cells to tio(2) nps. |
2011-12-07 |
2023-08-12 |
Not clear |
| Yilin Zhang, Weiqiang Yu, Xinquan Jiang, Kaige Lv, Shengjun Sun, Fuqiang Zhan. Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblasts. Journal of materials science. Materials in medicine. vol 22. issue 8. 2011-12-07. PMID:21681655. |
compared with the 32 nm tio(2) nps, 5 nm tio(2) nps were more toxic, induced more apoptosis, increased mitochondrial membrane permeability and stimulated more gm-csf expression at a high concentration (≥100 μg/ml). |
2011-12-07 |
2023-08-12 |
Not clear |
| Shixian Huang, Jianfeng Li, Liang Han, Shuhuan Liu, Haojun Ma, Rongqin Huang, Chen Jian. Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials. vol 32. issue 28. 2011-11-21. PMID:21700333. |
furthermore, the tunel analysis showed a more wide-extended apoptosis in the pamam-peg-angiopep/porf-trail nps treated group, compared to other groups including commercial temozolomide-treated one. |
2011-11-21 |
2023-08-12 |
mouse |
| Francelyne Marano, Salik Hussain, Fernando Rodrigues-Lima, Armelle Baeza-Squiban, Sonja Bolan. Nanoparticles: molecular targets and cell signalling. Archives of toxicology. vol 85. issue 7. 2011-10-20. PMID:20502881. |
the induction of apoptosis is also closely related to the modulation of signalling pathways induced by nps. |
2011-10-20 |
2023-08-12 |
Not clear |
| Changyan Liang, Yuebo Yang, You Ling, Yueshan Huang, Tian Li, Xiaomao L. Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma. Bioorganic & medicinal chemistry. vol 19. issue 13. 2011-10-17. PMID:21641806. |
the fol-targeted ptx nps showed a greater cytotoxicity against hec-1a cancer cells in vitro and in vivo, which might be induced by apoptosis. |
2011-10-17 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
previous studies demonstrate that the exposure to titanium dioxide nanoparticles (tio(2) nps) damages the central nervous system of mice; however, very little is known about the effects of tio(2) nps on hippocampal apoptosis or its molecular mechanism. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
the present study investigated the molecular mechanism associated with hippocampal apoptosis in mice induced by intragastric administration of tio(2) nps for consecutive 60 days. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
our findings indicate that tio(2) nps accumulate in the mouse hippocampus, and this accumulation, in turn, led to hippocampal apoptosis and impairment in spatial recognition memory in mice. |
2011-09-21 |
2023-08-12 |
mouse |
| Manasi Das, Fahima Dilnawaz, Sanjeeb K Saho. Targeted nutlin-3a loaded nanoparticles inhibiting p53-MDM2 interaction: novel strategy for breast cancer therapy. Nanomedicine (London, England). vol 6. issue 3. 2011-08-26. PMID:21542687. |
the objective of the present study is to prepare and characterize nutlin-3a loaded polymeric poly(lactide-co-glycolide) nanoparticles (nps) surface functionalized with transferrin ligand, to deliver the encapsulated drug in a targeted manner to its site of action and to evaluate the efficacy of the nanoformulation in terms of its cellular uptake, cell cytotoxicity, cell cycle arrest, apoptosis and activation of p53 pathway at molecular level in mcf-7 breast cancer cell line. |
2011-08-26 |
2023-08-12 |
Not clear |
| Maqusood Ahame. Toxic response of nickel nanoparticles in human lung epithelial A549 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 4. 2011-08-18. PMID:21376802. |
further, activity of caspase-3 enzyme, marker of apoptosis was significantly higher in treated cells with time and ni nps dosage. |
2011-08-18 |
2023-08-12 |
human |
| Sung Mook Lim, Tae Hyung Kim, Hai Hua Jiang, Chan Woong Park, Seulki Lee, Xiaoyuan Chen, Kang Choon Le. Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles. Biomaterials. vol 32. issue 13. 2011-06-08. PMID:21306770. |
the trail-peg-np formulation efficiently suppressed tumor growth (>70%), and histological findings confirmed that nps induced significant tumor cell apoptosis without inducing liver toxicity. |
2011-06-08 |
2023-08-12 |
mouse |
| Pallab Sanpui, Arun Chattopadhyay, Siddhartha Sankar Ghos. Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier. ACS applied materials & interfaces. vol 3. issue 2. 2011-06-07. PMID:21280584. |
we report the development of a chitosan nanocarrier (nc)-based delivery of silver nanoparticles (ag nps) to mammalian cells for induction of apoptosis at very low concentrations of the nps. |
2011-06-07 |
2023-08-12 |
human |
| Nicole M Schaeublin, Laura K Braydich-Stolle, Amanda M Schrand, John M Miller, Jim Hutchison, John J Schlager, Saber M Hussai. Surface charge of gold nanoparticles mediates mechanism of toxicity. Nanoscale. vol 3. issue 2. 2011-06-03. PMID:21229159. |
in conclusion, these results indicate that surface charge is a major determinant of how au nps impact cellular processes, with the charged nps inducing cell death through apoptosis and neutral nps leading to necrosis. |
2011-06-03 |
2023-08-12 |
human |
| Ritesh K Shukla, Ashutosh Kumar, Alok K Pandey, Shashi S Singh, Alok Dhawa. Titanium dioxide nanoparticles induce oxidative stress-mediated apoptosis in human keratinocyte cells. Journal of biomedical nanotechnology. vol 7. issue 1. 2011-06-01. PMID:21485823. |
our study demonstrates oxidative stress mediated apoptosis in human keratinocyte cells exposed to tio2 nps. |
2011-06-01 |
2023-08-12 |
human |