| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng-lei Wu, Ru-Tian Li, Mi Yang, Guo-Feng Yue, Hui-yu Wang, Qin Liu, Fang-bo Cui, Pu-yuan Wu, Hui Ding, Li-Xia Yu, Xiao-Ping Qian, Bao-Rui Li. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer letters. vol 363. issue 1. 2015-07-20. PMID:25592042. |
thus, the incorporation of dac into nps significantly enhanced the sensitivity of gc cells to 5-fu by inhibiting cell growth rate and inducing cell apoptosis. |
2015-07-20 |
2023-08-13 |
Not clear |
| Yurong Wang, Haiyan Cui, Jiaping Zhou, Fengjuan Li, Jinju Wang, Mianhua Chen, Qingdai Li. Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environmental science and pollution research international. vol 22. issue 7. 2015-07-08. PMID:25339530. |
in this study, cytotoxicity, dna damage, and apoptosis induced by tio2 nps (5 nm) in a549 cells were investigated. |
2015-07-08 |
2023-08-13 |
human |
| Yurong Wang, Haiyan Cui, Jiaping Zhou, Fengjuan Li, Jinju Wang, Mianhua Chen, Qingdai Li. Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environmental science and pollution research international. vol 22. issue 7. 2015-07-08. PMID:25339530. |
taken together, these findings suggest that tio2 nps can inhibit a549 cell proliferation, cause dna damage, and induce apoptosis via a mechanism primarily involving the activation of the intrinsic mitochondrial pathway. |
2015-07-08 |
2023-08-13 |
human |
| Yurong Wang, Haiyan Cui, Jiaping Zhou, Fengjuan Li, Jinju Wang, Mianhua Chen, Qingdai Li. Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environmental science and pollution research international. vol 22. issue 7. 2015-07-08. PMID:25339530. |
the assay data provide strong evidence that tio2 nps can induce cytotoxicity, significant dna damage, and apoptosis of a549 cells, suggesting that exposure to tio2 nps could cause cell injury and be hazardous to health. |
2015-07-08 |
2023-08-13 |
human |
| Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang, Qiang Zhan. Novel free-paclitaxel-loaded redox-responsive nanoparticles based on a disulfide-linked poly(ethylene glycol)-drug conjugate for intracellular drug delivery: synthesis, characterization, and antitumor activity in vitro and in vivo. Molecular pharmaceutics. vol 11. issue 10. 2015-06-24. PMID:25208098. |
the influence of peg-ss-ptx/ptx nps on in vitro cytotoxicity, cell cycle progression, and cellular apoptosis was determined in the mcf-7 cell line, and the nps demonstrated a superior anti-proliferative activity associated with ptx-induced cell cycle arrest in g2/m phase and apoptosis compared to their nonresponsive counterparts. |
2015-06-24 |
2023-08-13 |
mouse |
| Alessandra Pulliero, Yun Wu, Daniela Fenoglio, Alessia Parodi, Massimo Romani, Christiane P Soares, Gilberto Filaci, James L Lee, Patrick N Sinkam, Alberto Izzott. Nanoparticles increase the efficacy of cancer chemopreventive agents in cells exposed to cigarette smoke condensate. Carcinogenesis. vol 36. issue 3. 2015-06-24. PMID:25653234. |
in contrast, this potentiating effect was observed at all tested doses of res, nps dramatically increasing res-induced apoptosis in csc-treated cells. |
2015-06-24 |
2023-08-13 |
mouse |
| Hafiz Muhammad Ali, Giorgia Urbinati, Hubert Chapuis, Didier Desmaele, Jean-Rémi Bertrand, Patrick Couvreur, Liliane Massaad-Massad. Effects of siRNA on RET/PTC3 junction oncogene in papillary thyroid carcinoma: from molecular and cellular studies to preclinical investigations. PloS one. vol 9. issue 4. 2015-06-19. PMID:24759995. |
after intravenous injection in nude mice, respective squalene (sq) nanoparticles (nps) of sirna ret/ptc3 significantly (p<0.001) reduced rp3 tumour growth, oncogene and oncoprotein expressions, induced apoptosis and partially restored differentiation (decrease in ki67). |
2015-06-19 |
2023-08-13 |
mouse |
| Qingqing Chen, Yang Xue, Jiao Su. Hepatotoxicity and liver injury induced by hydroxyapatite nanoparticles. Journal of applied toxicology : JAT. vol 34. issue 11. 2015-06-19. PMID:25225040. |
our results showed that exposure to ha nps at a concentration above 200 µg ml(-1) decreased cell viability, increased levels of lactate dehydrogenase (ldh) leakage, induced apoptosis and necrosis, and triggered the mapk signaling pathway in brl cells in a dose-dependent manner. |
2015-06-19 |
2023-08-13 |
rat |
| Priyanka Bhatnagar, Soma Patnaik, Amit K Srivastava, Mohan K R Mudiam, Yogeshwer Shukla, Amulya K Panda, Aditya B Pant, Pradeep Kumar, Kailash C Gupt. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of biomedical nanotechnology. vol 10. issue 12. 2015-06-18. PMID:26000370. |
altered expression of marker proteins associated with apoptosis and cell death (p53, p21, bcl2, bax) also confirmed the enhanced anti-carcinogenic potential of formulated nps. |
2015-06-18 |
2023-08-13 |
mouse |
| Priyanka Bhatnagar, Soma Patnaik, Amit K Srivastava, Mohan K R Mudiam, Yogeshwer Shukla, Amulya K Panda, Aditya B Pant, Pradeep Kumar, Kailash C Gupt. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of biomedical nanotechnology. vol 10. issue 12. 2015-06-18. PMID:26000370. |
the generation of reactive oxygen species, induction of apoptosis and impaired mitochondrial membrane potential in eac cells treated with nps confirmed the suitability of eudragit coated bl-nps as a promising candidate for oral chemotherapy. |
2015-06-18 |
2023-08-13 |
mouse |
| Xiao Li, Fei Qin, Li Yang, Liqian Mo, Lei Li, Lianbing Ho. Sulfatide-containing lipid perfluorooctylbromide nanoparticles as paclitaxel vehicles targeting breast carcinoma. International journal of nanomedicine. vol 9. 2015-05-15. PMID:25170267. |
the cytotoxicity study and cell apoptosis assay revealed that blank sulfatide-containing lipid perfluorooctylbromide nps (snps) had no cytotoxicity, whereas ptx-snps had greater emt6 cytotoxicity levels than ptx-lipid perfluorooctylbromide nps (ptx-nps) and free ptx. |
2015-05-15 |
2023-08-13 |
Not clear |
| Xuezi Sang, Min Fei, Lei Sheng, Xiaoyang Zhao, Xiaohong Yu, Jie Hong, Yuguan Ze, Suxin Gui, Qingqing Sun, Xiao Ze, Ling Wang, Fashui Hon. Immunomodulatory effects in the spleen-injured mice following exposure to titanium dioxide nanoparticles. Journal of biomedical materials research. Part A. vol 102. issue 10. 2015-05-12. PMID:24243549. |
the findings showed that tio₂ nps exposure resulted in significant increases in spleen and thymus indices, and titanium accumulation, in turn led to histopathological changes and splenocyte apoptosis. |
2015-05-12 |
2023-08-12 |
mouse |
| Xuezi Sang, Min Fei, Lei Sheng, Xiaoyang Zhao, Xiaohong Yu, Jie Hong, Yuguan Ze, Suxin Gui, Qingqing Sun, Xiao Ze, Ling Wang, Fashui Hon. Immunomodulatory effects in the spleen-injured mice following exposure to titanium dioxide nanoparticles. Journal of biomedical materials research. Part A. vol 102. issue 10. 2015-05-12. PMID:24243549. |
furthermore, the exposure of tio₂ nps could significantly increase the levels of macrophage inflammatory protein (mip)-1α, mip-2, eotaxin, monocyte chemotactic protein-1, interferon-γ, vascular cell adhesion molecule-1, interleukin-13, interferon-γ-inducible protein-10, migration inhibitory factor, cd69, major histocompatibility complex, protein tyrosine phosphatase, protein tyrosine kinase 1, basic fibroblast growth factor, fasl, and gzmb expression, whereas markedly decrease the levels of nkg2d, nkp46, 2b4 expression involved in immune responses, lymphocyte healing and apoptosis. |
2015-05-12 |
2023-08-12 |
mouse |
| Wen Gao, Wenhua Cao, Huaibin Zhang, Ping Li, Kehua Xu, Bo Tan. Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au-ZnO hybrid nanoparticles. Chemical communications (Cambridge, England). vol 50. issue 60. 2015-05-11. PMID:24924212. |
we have developed multifunctional au-zno hybrid nanoparticles (nps) for targeted induction lysosomal membrane permeabilization (lmp)-dependent apoptosis in cancer cells and real-time imaging. |
2015-05-11 |
2023-08-13 |
Not clear |
| Yi-Reng Lin, Chao-Jen Kuo, Hugo You-Hsien Lin, Chin-Jen Wu, Shih-Shin Lian. A proteomics analysis to evaluate cytotoxicity in NRK-52E cells caused by unmodified Nano-Fe₃O₄. TheScientificWorldJournal. vol 2014. 2015-04-20. PMID:25197711. |
we suggested that, in the indigenous cellular environment, fe₃o₄ nps treatment induced an antagonistic effect for cell lines to go to which avoids apoptosis. |
2015-04-20 |
2023-08-13 |
rat |
| Zahra Saffari, Maryam Farahnak Zarabi, Hasan Aryapour, Alireza Foroumadi, Ali Farhangi, Soheil Ghassemi, Azim Akbarzade. Cytotoxicity and Apoptosis Inducing Activities of 2-Amino-4H-chromene-3-carbonitrile Derivatives Loaded on Gold Nanoparticles Against Human Breast Cancer Cell Line T47D. Indian journal of clinical biochemistry : IJCB. vol 30. issue 2. 2015-04-17. PMID:25883420. |
the effect of conjugation with gold nps and the induction of apoptosis were studied with the best compound. |
2015-04-17 |
2023-08-13 |
human |
| Francesca A Cupaioli, Fabio A Zucca, Diana Boraschi, Luigi Zecc. Engineered nanoparticles. How brain friendly is this new guest? Progress in neurobiology. vol 119-120. 2015-03-31. PMID:24820405. |
nps can also affect the respiratory chain of mitochondria and bax protein levels, thereby causing apoptosis. |
2015-03-31 |
2023-08-13 |
mouse |
| S Maya, Bruno Sarmento, Vinoth-Kumar Lakshmanan, Deepthy Menon, Vitor Seabra, R Jayakuma. Chitosan cross-linked docetaxel loaded EGF receptor targeted nanoparticles for lung cancer cells. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24950310. |
the a549 cells treated with cet-dtxl-γ-pga nps underwent a g2/m phase cell cycle arrest followed by reduction in mitochondrial membrane potential of a549 cells, inducing apoptosis and necrosis resulting in enhanced cancer cell death. |
2015-03-12 |
2023-08-13 |
Not clear |
| Shantanu V Lale, Aswathy R G, Athulya Aravind, D Sakthi Kumar, Veena Kou. AS1411 aptamer and folic acid functionalized pH-responsive ATRP fabricated pPEGMA-PCL-pPEGMA polymeric nanoparticles for targeted drug delivery in cancer therapy. Biomacromolecules. vol 15. issue 5. 2015-03-10. PMID:24689987. |
dual targeting with folate and the as1411 aptamer increased the cancer-targeting efficiency of the nanoparticles, resulting in enhanced cellular uptake (10- and 100-fold increase in uptake compared to single-targeted nps and non-targeted nps, respectively) and a higher payload of doxorubicin in epithelial cancer cell lines (mcf-7 and panc-1), with subsequent higher apoptosis, whereas a normal (noncancerous) cell line (l929) was spared from the adverse effects of doxorubicin. |
2015-03-10 |
2023-08-12 |
Not clear |
| Chun-li Wu, Qiu-yue Wu, Jing-jing Du, Jing-ya Zeng, Ting-ting Li, Chang-qing Xu, Yi-hua Su. Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis. Molecular immunology. vol 63. issue 2. 2015-03-05. PMID:25256599. |
simultaneously, the apoptotic ratio of t cells in clp increased, and nps r 568 exacerbated the apoptosis degree. |
2015-03-05 |
2023-08-13 |
rat |