| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David M Goncalves, D Girar. Zinc oxide nanoparticles delay human neutrophil apoptosis by a de novo protein synthesis-dependent and reactive oxygen species-independent mechanism. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 5. 2015-01-20. PMID:24759804. |
we conclude that zno nps are activators of several human neutrophil functions and that they inhibit apoptosis by a de novo protein synthesis-dependent and ros-independent mechanism. |
2015-01-20 |
2023-08-13 |
human |
| Dwaipayan Mukherjee, Steven G Royce, Srijata Sarkar, Andrew Thorley, Stephan Schwander, Mary P Ryan, Alexandra E Porter, Kian Fan Chung, Teresa D Tetley, Junfeng Zhang, Panos G Georgopoulo. Modeling in vitro cellular responses to silver nanoparticles. Journal of toxicology. vol 2014. 2014-12-26. PMID:25541583. |
the model considers basic cellular mechanisms including proliferation, apoptosis, and production of cytokines in response to nps. |
2014-12-26 |
2023-08-13 |
human |
| Sebastiano Di Bucchianico, Maria Rita Fabbrizi, Silvia Cirillo, Chiara Uboldi, Douglas Gilliland, Eugenia Valsami-Jones, Lucia Miglior. Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles. International journal of nanomedicine. vol 9. 2014-12-10. PMID:24855356. |
our results indicate that 5 nm and 15 nm au nps are able to inhibit cell proliferation by apoptosis and to induce chromosomal damage, in particular chromosome mis-segregation. |
2014-12-10 |
2023-08-13 |
human |
| Sebastiano Di Bucchianico, Maria Rita Fabbrizi, Silvia Cirillo, Chiara Uboldi, Douglas Gilliland, Eugenia Valsami-Jones, Lucia Miglior. Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles. International journal of nanomedicine. vol 9. 2014-12-10. PMID:24855356. |
results indicate that apoptosis, aneuploidy, and dna oxidation play a pivotal role in the cytotoxicity and genotoxicity exerted by au nps in our cell models. |
2014-12-10 |
2023-08-13 |
human |
| Rui Chen, Lingling Huo, Xiaofei Shi, Ru Bai, Zhenjiang Zhang, Yuliang Zhao, Yanzhong Chang, Chunying Che. Endoplasmic reticulum stress induced by zinc oxide nanoparticles is an earlier biomarker for nanotoxicological evaluation. ACS nano. vol 8. issue 3. 2014-11-18. PMID:24490819. |
furthermore, higher dosage of zno nps (240 μm) quickly rendered er stress response before inducing apoptosis. |
2014-11-18 |
2023-08-12 |
human |
| Lu Han, Cui Tang, Chunhua Yi. Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy. Biomaterials. vol 35. issue 15. 2014-11-12. PMID:24613049. |
in tumor-bearing mice, orally delivered gtc2 nps could effectively accumulate in the tumor tissues and silence the expression of survivin and vegf, evoking increased apoptosis, inhibited angiogenesis, and thus the most efficient tumor regression. |
2014-11-12 |
2023-08-12 |
mouse |
| Yang Zhao, Yan Ye, Xikun Zhou, Jiao Chen, Yuihui Jin, Aaron Hanson, Julia Xiaojun Zhao, Min W. Photosensitive fluorescent dye contributes to phototoxicity and inflammatory responses of dye-doped silica NPs in cells and mice. Theranostics. vol 4. issue 4. 2014-11-04. PMID:24578727. |
our results showed that the rubpy-doped silica nps could induce significant amount of ros, dna damage, apoptosis and impaired proliferation in mh-s cells. |
2014-11-04 |
2023-08-12 |
mouse |
| Tom L Broderick, Donghao Wang, Marek Jankowski, Jolanta Gutkowsk. Unexpected effects of voluntary exercise training on natriuretic peptide and receptor mRNA expression in the ob/ob mouse heart. Regulatory peptides. vol 188. 2014-10-21. PMID:24365091. |
after voluntary running, a downregulation in the expression of all three nps coupled with increased apoptosis was observed in ob/ob hearts. |
2014-10-21 |
2023-08-12 |
mouse |
| Tânia Gomes, Suze Chora, Catarina G Pereira, Cátia Cardoso, Maria João Bebiann. Proteomic response of mussels Mytilus galloprovincialis exposed to CuO NPs and Cu²⁺: an exploratory biomarker discovery. Aquatic toxicology (Amsterdam, Netherlands). vol 155. 2014-10-14. PMID:25089921. |
cuo nps alone also had a marked effect on other biological processes, namely oxidative stress (gst), proteolysis (cathepsin l) and apoptosis (caspase 3/7-1). |
2014-10-14 |
2023-08-13 |
Not clear |
| Tânia Gomes, Suze Chora, Catarina G Pereira, Cátia Cardoso, Maria João Bebiann. Proteomic response of mussels Mytilus galloprovincialis exposed to CuO NPs and Cu²⁺: an exploratory biomarker discovery. Aquatic toxicology (Amsterdam, Netherlands). vol 155. 2014-10-14. PMID:25089921. |
protein identification clearly showed that the toxicity of cuo nps is not solely due to cu(2+) dissolution and can result in mitochondrial and nucleus stress-induced cell signalling cascades that can lead to apoptosis. |
2014-10-14 |
2023-08-13 |
Not clear |
| A A Shumakova, É N Trushina, O K Mustaphina, S Kh Soto, I V Gmoshinskiĭ, S A Khotimchenk. [Influence of titanium dioxide and silica nanoparticles on accumulation and toxicity of lead in experiments with intragastric co-administration]. Voprosy pitaniia. vol 83. issue 2. 2014-09-04. PMID:25059070. |
in coadministration of pb with nps of tio2 at both doses (rats with initial body mass 80 +/- 8 g) there was a decrease in hemoglobin concentration on 24% (p < 0.05), number of lymphocytes on 13% (p < 0.05), and platelets on 10% (p < 0.05) in the blood, together with the activation of apoptosis in hepatocytes. |
2014-09-04 |
2023-08-13 |
rat |
| Yuguan Ze, Renping Hu, Xiaochun Wang, Xuezi Sang, Xiao Ze, Bi Li, Junju Su, Yuan Wang, Ning Guan, Xiaoyang Zhao, Suxin Gui, Liyuan Zhu, Zhe Cheng, Jie Cheng, Lei Sheng, Qingqing Sun, Ling Wang, Fashui Hon. Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. Journal of biomedical materials research. Part A. vol 102. issue 2. 2014-08-18. PMID:23533084. |
our findings showed that tio2 nps could be translocated and accumulated in brain, led to oxidative stress, overproliferation of all glial cells, tissue necrosis as well as hippocampal cell apoptosis. |
2014-08-18 |
2023-08-12 |
mouse |
| Yuguan Ze, Renping Hu, Xiaochun Wang, Xuezi Sang, Xiao Ze, Bi Li, Junju Su, Yuan Wang, Ning Guan, Xiaoyang Zhao, Suxin Gui, Liyuan Zhu, Zhe Cheng, Jie Cheng, Lei Sheng, Qingqing Sun, Ling Wang, Fashui Hon. Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. Journal of biomedical materials research. Part A. vol 102. issue 2. 2014-08-18. PMID:23533084. |
furthermore, microarray data showed significant alterations in the expression of 249 known function genes, including 113 genes upregulation and 136 genes downregulation following exposure to 10 mg/kg bw tio2 nps, which were associated with oxidative stress, immune response, apoptosis, memory and learning, brain development, signal transduction, metabolic process, dna repair, response to stimulus, and cellular process. |
2014-08-18 |
2023-08-12 |
mouse |
| Jiang Pi, Fen Yang, Hua Jin, Xun Huang, Ruiying Liu, Peihui Yang, Jiye Ca. Selenium nanoparticles induced membrane bio-mechanical property changes in MCF-7 cells by disturbing membrane molecules and F-actin. Bioorganic & medicinal chemistry letters. vol 23. issue 23. 2014-08-17. PMID:24140445. |
in this letter, we prepared se nps for investigating the intracellular localization of se nps in mcf-7 cells and determined the effects of se nps on apoptosis and necrosis in mcf-7 cells. |
2014-08-17 |
2023-08-12 |
Not clear |
| S Maya, Bruno Sarmento, Vinoth-Kumar Lakshmanan, Deepthy Menon, R Jayakuma. Actively targeted cetuximab conjugated gamma-poly(glutamic acid)-docetaxel nanomedicines for epidermal growth factor receptor over expressing colon cancer cells. Journal of biomedical nanotechnology. vol 10. issue 8. 2014-08-05. PMID:25016642. |
the mechanism of cancer cell death was analyzed via apoptotic and mitochondrial membrane potential assays and showed that targeted nps treatment reduced the mitochondrial membrane potential thereby inducing enhanced ht-29 cell death (apoptosis and necrosis). |
2014-08-05 |
2023-08-13 |
mouse |
| Shilpa Sharma, S Chockalingam, Pallab Sanpui, Arun Chattopadhyay, Siddhartha Sankar Ghos. Silver nanoparticles impregnated alginate-chitosan-blended nanocarrier induces apoptosis in human glioblastoma cells. Advanced healthcare materials. vol 3. issue 1. 2014-08-04. PMID:23852919. |
the induction of apoptosis at low concentration of ag nps present in ag nps-alg-chi nc in comparison with free ag nps makes it a promising tool for cancer therapy. |
2014-08-04 |
2023-08-12 |
human |
| Shutao Guo, Yuhua Wang, Lei Miao, Zhenghong Xu, C Michael Lin, Yuan Zhang, Leaf Huan. Lipid-coated Cisplatin nanoparticles induce neighboring effect and exhibit enhanced anticancer efficacy. ACS nano. vol 7. issue 11. 2014-07-25. PMID:24083505. |
the neighboring effect regards an observation made in vivo when the tumor cells that took up cddp nps released active drug following apoptosis. |
2014-07-25 |
2023-08-12 |
human |
| Shutao Guo, Yuhua Wang, Lei Miao, Zhenghong Xu, C Michael Lin, Yuan Zhang, Leaf Huan. Lipid-coated Cisplatin nanoparticles induce neighboring effect and exhibit enhanced anticancer efficacy. ACS nano. vol 7. issue 11. 2014-07-25. PMID:24083505. |
this observation was also made in vitro when a375m melanoma tumor cells incubated with cddp nps exhibited release of active drug and induced apoptosis on untreated neighboring cells. |
2014-07-25 |
2023-08-12 |
human |
| Xianghui Zeng, Ralf Morgenstern, Andreas M Nyströ. Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-mediated drug resistance. Biomaterials. vol 35. issue 4. 2014-07-09. PMID:24210875. |
these results suggest that hbdl nps can modulate subcellular drug distribution by specific endocytic and trafficking pathways and that this results in drug delivery that alters enzyme levels and cellular signaling pathways and, most importantly, increases the induction of apoptosis. |
2014-07-09 |
2023-08-12 |
Not clear |
| Ruchi Roy, Sunil Kumar Singh, L K S Chauhan, Mukul Das, Anurag Tripathi, Premendra D Dwived. Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition. Toxicology letters. vol 227. issue 1. 2014-06-17. PMID:24614525. |
zno nps also activated the cleavage of apoptosis markers like caspases 3, 8 and 9. |
2014-06-17 |
2023-08-12 |
Not clear |