| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guiyin Li, Liangli Cao, Zhide Zhou, Zhencheng Chen, Yong Huang, Yongxiang Zha. Rapamycin loaded magnetic Fe3O4/carboxymethylchitosan nanoparticles as tumor-targeted drug delivery system: Synthesis and in vitro characterization. Colloids and surfaces. B, Biointerfaces. vol 128. 2015-12-28. PMID:25779605. |
the morphology, composition, and properties of the fe3o4/cmcs-rapa nps were characterized by fourier transform infrared spectroscopy (ft-ir), transmission electron microscope (tem), x-ray diffraction (xrd), thermal analysis (tg/dsc), vibration sample magnetometer (vsm), and drug release kinetics, cytotoxicity, cellular uptake, apoptosis studies in vitro. |
2015-12-28 |
2023-08-13 |
human |
| Jian Wu, Xiangyuan Bu, Limei Dou, Liang Fang, Qi She. Co-Delivery of Docetaxel and Berbamine by Chitosan/Sulfobutylether-β-Cyclodextrin Nanoparticles for Enhancing Bioavailability and Anticancer Activities. Journal of biomedical nanotechnology. vol 11. issue 10. 2015-11-20. PMID:26502647. |
the dual-drug cd/cs nps exhibited higher cytotoxicity, cellular uptake, apoptosis and inhibition with the survivin mrna expression. |
2015-11-20 |
2023-08-13 |
Not clear |
| Raju Vivek, Ramar Thangam, Varukattu NipunBabu, Chandrababu Rejeeth, Srinivasan Sivasubramanian, Palani Gunasekaran, Krishnasamy Muthuchelian, Soundarapandian Kanna. Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant breast cancer therapy. ACS applied materials & interfaces. vol 6. issue 9. 2015-11-17. PMID:24780315. |
furthermore, the possible signaling pathway of apoptotic induction in mcf-7 cells was explored by western blotting, and it was demonstrated that drug-loaded plga nps were capable of inducing apoptosis in a caspase-dependent manner. |
2015-11-17 |
2023-08-13 |
Not clear |
| Sergio Anguissola, David Garry, Anna Salvati, Peter J O'Brien, Kenneth A Dawso. High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles. PloS one. vol 9. issue 9. 2015-11-16. PMID:25238162. |
cell lines representative of different organ cell types, including lung, endothelium, liver, kidney, macrophages, glia, and neuronal cells were exposed to 50 nm amine-modified polystyrene (ps-nh2) nps previously reported to induce apoptosis and to 50 nm sulphonated and carboxyl-modified polystyrene nps that were reported to be silent. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sergio Anguissola, David Garry, Anna Salvati, Peter J O'Brien, Kenneth A Dawso. High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles. PloS one. vol 9. issue 9. 2015-11-16. PMID:25238162. |
all cell lines apart from raw 264.7 executed apoptosis in response to ps-nh2 nps, showing specific sequences of ec50 thresholds; lysosomal acidification was the most sensitive parameter. |
2015-11-16 |
2023-08-13 |
Not clear |
| E M Grzincic, J A Yang, J Drnevich, P Falagan-Lotsch, C J Murph. Global transcriptomic analysis of model human cell lines exposed to surface-modified gold nanoparticles: the effect of surface chemistry. Nanoscale. vol 7. issue 4. 2015-11-12. PMID:25491924. |
coated au nps affect genes implicated in proliferation, angiogenesis, and metabolism in hdf cells, and inflammation, angiogenesis, proliferation apoptosis regulation, survival and invasion in pc3 cells. |
2015-11-12 |
2023-08-13 |
human |
| Manasi Das, Wei Duan, Sanjeeb K Saho. Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. vol 11. issue 2. 2015-11-06. PMID:25240596. |
a wide spectrum of in vitro analysis (cellular uptake study, cytotoxicity assay, cell cycle and apoptosis analysis, apoptosis associated proteins study) revealed superior therapeutic potentiality of targeted nps over other formulations in epcam expressing cells. |
2015-11-06 |
2023-08-13 |
Not clear |
| Jiashing Yu, Che-Hao Hsu, Chih-Chia Huang, Po-Yang Chan. Development of therapeutic Au-methylene blue nanoparticles for targeted photodynamic therapy of cervical cancer cells. ACS applied materials & interfaces. vol 7. issue 1. 2015-11-04. PMID:25494339. |
cellular staining examinations showed that the hela cells reacted with au@polymer/mb-tf nps and the 660 nm light excitation triggered pdt, which caused the cells to undergo apoptosis ("programmed" cell death). |
2015-11-04 |
2023-08-13 |
Not clear |
| Shutao Guo, C Michael Lin, Zhenghong Xu, Lei Miao, Yuhua Wang, Leaf Huan. Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation. ACS nano. vol 8. issue 5. 2015-11-02. PMID:24720540. |
furthermore, plga nps containing both cisplatin cores and rapa induced significant apoptosis on a375-luc human melanoma cells in vitro. |
2015-11-02 |
2023-08-13 |
human |
| Yi Xie, Binbin Wang, Fanchi Li, Lie Ma, Min Ni, Weide Shen, Fashui Hong, Bing L. Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971466. |
furthermore, digital gene expression profile (dge) analysis and real time quantitative pcr (qrt-pcr) assay revealed that tio2 nps pretreatment inhibited the up-regulated expression of ace1, cytochrome c, caspase-9, caspase-3, bm109 and down-regulated expression of bmiap caused by phoxim; these genes are involved in nerve conduction, oxidative stress and apoptosis. |
2015-10-28 |
2023-08-13 |
Not clear |
| Lei Sheng, Yuguan Ze, Ling Wang, Xiaohong Yu, Jie Hong, Xiaoyang Zhao, Xiao Ze, Dong Liu, Bingqing Xu, Yunting Zhu, Yi Long, Anan Lin, Chi Zhang, Yue Zhao, Fashui Hon. Mechanisms of TiO2 nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons. Journal of biomedical materials research. Part A. vol 103. issue 3. 2015-10-26. PMID:25045142. |
in this study, primary cultured hippocampal neurons from one-day-old fetal sprague-dawley rats were exposed to 5, 15, or 30 µg/ml tio2 nps for 24 h, we investigated cell viability, ultrastructure, and mitochondrial membrane potential (mmp), calcium homeostasis, oxidative stress, antioxidant capacity, apoptotic signaling pathway associated with the primary cultured hippocamal neuron apoptosis. |
2015-10-26 |
2023-08-13 |
rat |
| Lei Sheng, Yuguan Ze, Ling Wang, Xiaohong Yu, Jie Hong, Xiaoyang Zhao, Xiao Ze, Dong Liu, Bingqing Xu, Yunting Zhu, Yi Long, Anan Lin, Chi Zhang, Yue Zhao, Fashui Hon. Mechanisms of TiO2 nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons. Journal of biomedical materials research. Part A. vol 103. issue 3. 2015-10-26. PMID:25045142. |
these findings suggested that hippocampal neuron apoptosis caused by tio2 nps may be associated with mitochondria-mediated signal pathway and endoplasmic reticulum-mediated signal pathway. |
2015-10-26 |
2023-08-13 |
rat |
| J Xiao, X M Tian, C Yang, P Liu, N Q Luo, Y Liang, H B Li, D H Chen, C X Wang, L Li, G W Yan. Ultrahigh relaxivity and safe probes of manganese oxide nanoparticles for in vivo imaging. Scientific reports. vol 3. 2015-10-16. PMID:24305731. |
we for the first time demonstrate these mn3o4 nps biocompatibilities both in vitro and in vivo are satisfactory based on systematical studies of the intrinsic toxicity including cell viability of human nasopharyngeal carcinoma cells, normal nasopharyngeal epithelium, apoptosis in cells and in vivo immunotoxicity. |
2015-10-16 |
2023-08-12 |
human |
| Caterina Fede, Caterina Millino, Beniamina Pacchioni, Barbara Celegato, Chiara Compagnin, Paolo Martini, Francesco Selvestrel, Fabrizio Mancin, Lucia Celotti, Gerolamo Lanfranchi, Maddalena Mognato, Stefano Cagni. Altered gene transcription in human cells treated with Ludox® silica nanoparticles. International journal of environmental research and public health. vol 11. issue 9. 2015-09-15. PMID:25170680. |
by gene-by-gene and gene set analyses, we evidenced a specific cell response in relation to nps size and elapsed time after treatment, with the smaller nps (sm30) having higher impact on inflammatory and apoptosis processes than the bigger ones. |
2015-09-15 |
2023-08-13 |
human |
| Adeline Tarantini, Rachelle Lanceleur, Annick Mourot, Marie-Thérèse Lavault, Gérald Casterou, Gérard Jarry, Kevin Hogeveen, Valérie Fessar. Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 2. 2015-09-14. PMID:25448807. |
the ability of these nps to induce cytotoxicity (xtt viability test), genotoxicity (γh2ax and micronucleus assay), apoptosis (caspase 3), oxidative stress (oxidation of 2,7-dichlorodihydrofluorescein diacetate probe) and proinflammatory effects (interleukin il-8 secretion) was evaluated. |
2015-09-14 |
2023-08-13 |
human |
| Sourav Chattopadhyay, Sandeep Kumar Dash, Satyajit Tripathy, Panchanan Pramanik, Somenath Ro. Phosphonomethyl iminodiacetic acid-conjugated cobalt oxide nanoparticles liberate Co(++) ion-induced stress associated activation of TNF-α/p38 MAPK/caspase 8-caspase 3 signaling in human leukemia cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 20. issue 1. 2015-09-14. PMID:25534662. |
pmida-coo nps caused dna damage in leukemic cell lines, which was reflected by an increase in apoptosis of jurkat, kg-1a and k562 cells. |
2015-09-14 |
2023-08-13 |
human |
| Sourav Chattopadhyay, Sandeep Kumar Dash, Satyajit Tripathy, Panchanan Pramanik, Somenath Ro. Phosphonomethyl iminodiacetic acid-conjugated cobalt oxide nanoparticles liberate Co(++) ion-induced stress associated activation of TNF-α/p38 MAPK/caspase 8-caspase 3 signaling in human leukemia cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 20. issue 1. 2015-09-14. PMID:25534662. |
pmida-coo nps induced apoptosis by increasing pro-inflammatory cytokines, primarily tnf-α. |
2015-09-14 |
2023-08-13 |
human |
| Xueqin Wang, Liang Wang, Xiaorong Tan, Huiru Zhang, Guibin Su. Construction of doxorubicin-loading magnetic nanocarriers for assaying apoptosis of glioblastoma cells. Journal of colloid and interface science. vol 436. 2015-09-08. PMID:25280371. |
in this study, the biodegradable chitosan-modified magnetite (fe3o4) nps (cs-mnps) are firstly synthesized using as nanocarriers, and then encapsulated with anti-tumor drug doxorubicin (dox) to construct dox-loaded cs-mnps (dox-cs-mnps), which are further applied to assay apoptosis of glioblastoma multiforme u251 cells. |
2015-09-08 |
2023-08-13 |
human |
| Hui Yao, Kaiyuan Wang, Yi Wang, Shanshan Wang, Jianfeng Li, Jinning Lou, Liya Ye, Xueying Yan, Weiyue Lu, Rongqin Huan. Enhanced blood-brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system. Biomaterials. vol 37. 2015-08-17. PMID:25453963. |
furthermore, lnp-modified nps mediated strongest and most intensive apoptosis on the tumor site, and the longest median survival time of glioma-bearing mice. |
2015-08-17 |
2023-08-13 |
mouse |
| Chang Su, Hongdan Li, Yijie Shi, Guan Wang, Liwei Liu, Liang Zhao, Rongjian S. Carboxymethyl-β-cyclodextrin conjugated nanoparticles facilitate therapy for folate receptor-positive tumor with the mediation of folic acid. International journal of pharmaceutics. vol 474. issue 1-2. 2015-08-07. PMID:25149123. |
from in vitro cytotoxicity assay, cell apoptosis study, intracellular atp level assay and western blot, we can see that fa-cm-β-cd-bsa nps as good monodispersity, negative charge, and homogenous particle size have a high encapsulation efficiency. |
2015-08-07 |
2023-08-13 |
Not clear |