| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-fu Miao, Yong-liang Cui, Yan-ping Yin, Lian-feng Chen, Hua Zhang, Pei-mao Liu, Wen-ling Zhu, Cun-Xian Song, Jing Yan. [Effects of Rapamycin and Rapamycin-loaded Poly(lactic-co-glycolic)Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27(kip1) Proteins of Human Umbilical Arterial Vascular Smooth Muscle Cell]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 37. issue 6. 2016-05-20. PMID:26725384. |
to investgate the effects of rapamycin(rpm)and rpm-loaded poly(lactic-co-glycolic)acid(plga)nanoparticles(nps)on the apoptosis of human umbilical arterial vascular smooth muscle cells(huasmcs)in vitro and expression of bcl-2 and p27(kip1) protein. |
2016-05-20 |
2023-08-13 |
human |
| Caixia Wang, Xiaoke Hu, Yan Gao, Yinglu J. ZnO Nanoparticles Treatment Induces Apoptosis by Increasing Intracellular ROS Levels in LTEP-a-2 Cells. BioMed research international. vol 2015. 2016-05-18. PMID:26339612. |
results showed that zno nps (≥ 0.01 μg/ml) significantly inhibited proliferation (p < 0.05) and induced substantial apoptosis in ltep-a-2 cells after 4 h of exposure. |
2016-05-18 |
2023-08-13 |
human |
| Caixia Wang, Xiaoke Hu, Yan Gao, Yinglu J. ZnO Nanoparticles Treatment Induces Apoptosis by Increasing Intracellular ROS Levels in LTEP-a-2 Cells. BioMed research international. vol 2015. 2016-05-18. PMID:26339612. |
the intracellular ros level rose up to 30-40% corresponding to significant depletion (approximately 70-80%) in gsh content in ltep-a-2 cells (p < 0.05), suggesting that zno nps induced apoptosis mainly through increased ros production. |
2016-05-18 |
2023-08-13 |
human |
| Violet Aileen Senapati, Abhishek Kumar Jain, Govind Sharan Gupta, Alok Kumar Pandey, Alok Dhawa. Chromium oxide nanoparticle-induced genotoxicity and p53-dependent apoptosis in human lung alveolar cells. Journal of applied toxicology : JAT. vol 35. issue 10. 2016-05-17. PMID:26086747. |
further, the oxygen species led to a decrease in mitochondrial membrane potential and an increase in the ratio of bax/bcl-2 leading to mitochondria-mediated apoptosis induced by cr2 o3 nps, which ultimately leads to cell death. |
2016-05-17 |
2023-08-13 |
human |
| Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun, Xianzheng Wu, Liming Cheng, Jing Zhang, Shilong Wan. Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cells through the PI3K signaling pathway. Nanoscale. vol 7. issue 25. 2016-05-13. PMID:26060037. |
evaluation of cell viability, lactate dehydrogenase release, ros generation and apoptosis demonstrated the low cytotoxicity of ldh nps. |
2016-05-13 |
2023-08-13 |
mouse |
| S Sruthi, P V Mohana. Investigation on cellular interactions of astrocytes with zinc oxide nanoparticles using rat C6 cell lines. Colloids and surfaces. B, Biointerfaces. vol 133. 2016-05-02. PMID:26057374. |
the mode of cell death induced by zno nps was apoptosis as revealed by the nuclear condensation studies, live dead assay using acridine orange/ethidium bromide and apoptosis detection kit. |
2016-05-02 |
2023-08-13 |
rat |
| Wen Bao, Ran Liu, Yonglu Wang, Fei Wang, Guohua Xia, Haijun Zhang, Xueming Li, Haixiang Yin, Baoan Che. PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway. International journal of nanomedicine. vol 10. 2016-04-21. PMID:25609961. |
in summary, the results obtained from this study showed that the novel nps dds could improve the efficacy of dnr in the treatment of leukemia and induce apoptosis via intrinsic pathway. |
2016-04-21 |
2023-08-13 |
Not clear |
| Abhishek Aggarwal, Julia Höbaus, Samawansha Tennakoon, Maximilian Prinz-Wohlgenannt, João Graça, Sally A Price, Petra Heffeter, Walter Berger, Sabina Baumgartner-Parzer, Enikö Kálla. Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt B. 2016-04-19. PMID:25758239. |
1,25-d3 enhanced the anti-proliferative effects of ca(2+) and induced differentiation and apoptosis only in cells with a functional casr, which were further enhanced in the presence of nps r-568, a positive allosteric modulator of casr. |
2016-04-19 |
2023-08-13 |
mouse |
| Deepti Soodgupta, Dipanjan Pan, Grace Cui, Angana Senpan, Xiaoxia Yang, Lan Lu, Katherine N Weilbaecher, Edward V Prochownik, Gregory M Lanza, Michael H Tomasso. Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma. Molecular cancer therapeutics. vol 14. issue 6. 2016-04-12. PMID:25824336. |
an sn 2 lipase-labile prodrug inhibitor of myc-max dimerization (mi1-pd) was developed which decreased cell proliferation and induced apoptosis in cultured multiple myeloma cell lines alone (p < 0.05) and when incorporated into integrin-targeted lipid-encapsulated nps (p < 0.05). |
2016-04-12 |
2023-08-13 |
mouse |
| Kasivelu Govindaraju, Karthikeyan Krishnamoorthy, Suliman A Alsagaby, Ganesan Singaravelu, Mariappan Premanatha. Green synthesis of silver nanoparticles for selective toxicity towards cancer cells. IET nanobiotechnology. vol 9. issue 6. 2016-04-08. PMID:26647807. |
this study suggested that a mechanism underlying the toxicity of ag nps towards cancer cells is due to dna damage and apoptosis. |
2016-04-08 |
2023-08-13 |
human |
| Nilanjana Chatterjee, Baibaswata Bhattacharje. Revelation of ZnS Nanoparticles Induces Follicular Atresia and Apoptosis in the Ovarian Preovulatory Follicles in the Catfish Mystus tengara (Hamilton, 1822). Scientifica. vol 2016. 2016-04-07. PMID:27051555. |
due to exposure at relatively lower concentration of zns nps (250 μg/l), most of the maturing follicles of m. tengara failed to complete the process of vitellogenesis properly and underwent preovulatory atresia followed by oocytic apoptosis. |
2016-04-07 |
2023-08-13 |
Not clear |
| Liting Guo, Haijun Zhang, Fei Wang, Ping Liu, Yonglu Wang, Guohua Xia, Ran Liu, Xueming Li, Haixiang Yin, Hulin Jiang, Baoan Che. Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system. International journal of nanomedicine. vol 10. 2016-04-01. PMID:26213467. |
injection of dnr-tet-tf-peg-pll-plga nps into nude mice bearing mdr leukemia cell k562/a02 xenografts was shown to inhibit tumor growth, and contemporaneous immunohistochemical analysis of tumor tissue showed the targeted nps induced apoptosis in tumor cells. |
2016-04-01 |
2023-08-13 |
mouse |
| Dede K W Man, Luca Casettari, Marco Cespi, Giulia Bonacucina, Giovanni Filippo Palmieri, Stephen C W Sze, George P H Leung, Jenny K W Lam, Philip C L Kwo. Oleanolic Acid Loaded PEGylated PLA and PLGA Nanoparticles with Enhanced Cytotoxic Activity against Cancer Cells. Molecular pharmaceutics. vol 12. issue 6. 2016-03-22. PMID:25881668. |
the oa-loaded nps produced significant cytotoxic effects through apoptosis in cancer cell lines. |
2016-03-22 |
2023-08-13 |
Not clear |
| Bing-Feng Zhang, Lei Xing, Peng-Fei Cui, Feng-Zhen Wang, Rong-Lin Xie, Jia-Liang Zhang, Mei Zhang, Yu-Jing He, Jin-Yuan Lyu, Jian-Bin Qiao, Bao-An Chen, Hu-Lin Jian. Mitochondria apoptosis pathway synergistically activated by hierarchical targeted nanoparticles co-delivering siRNA and lonidamine. Biomaterials. vol 61. 2016-03-02. PMID:26004233. |
remarkably, the tcpl/sirna/ppf nps simultaneously released sibcl-2 into the cytoplasm and delivered lnd to mitochondria in the same cancer cell after fa-directed internalization, and even synergistically activated mitochondria apoptosis pathway. |
2016-03-02 |
2023-08-13 |
Not clear |
| A A Shumakova, E N Trushina, O K Mustafina, S Kh Soto, I V Gmoshinsky, S Aa Khotimchenk. [Lead toxicity at its joint administration with nanostructured silica]. Voprosy pitaniia. vol 84. issue 2. 2016-03-01. PMID:26841551. |
no additional adverse effect was noticed in pb co-administration with nps on haematological parameters and hepatocyte apoptosis. |
2016-03-01 |
2023-08-13 |
rat |
| Chao Yu, Zhiguo Zhou, Jun Wang, Jin Sun, Wei Liu, Yanan Sun, Bin Kong, Hong Yang, Shiping Yan. In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro. Journal of hazardous materials. vol 283. 2016-02-23. PMID:25464291. |
firstly, reactive oxygen species (ros) is generated induced by mno@sio2 nps, then p53 is activated followed by an increase in the bax and a decrease in the bcl-2, ultimately leading to g2/m phase arrest, increasing the activity of caspase-3 and inducing apoptosis. |
2016-02-23 |
2023-08-13 |
mouse |
| Qi Wang, Ying Sun, Zhirong Zhang, Yourong Dua. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. vol 56. 2016-02-16. PMID:25934295. |
comparison between peg-modified and non-peg-modified nps showed that peg-modified nps increased k(+) efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. |
2016-02-16 |
2023-08-13 |
Not clear |
| Qi Wang, Ying Sun, Zhirong Zhang, Yourong Dua. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. vol 56. 2016-02-16. PMID:25934295. |
non-peg-modified nps induce the endoplasmic reticulum apoptosis pathway. |
2016-02-16 |
2023-08-13 |
Not clear |
| Qi Wang, Ying Sun, Zhirong Zhang, Yourong Dua. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. vol 56. 2016-02-16. PMID:25934295. |
comparison between positively and negatively charged nps showed that negatively charged nps have less effect on the k(+) efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. |
2016-02-16 |
2023-08-13 |
Not clear |
| Priyanka Khare, Madhavi Sonane, Yogendra Nagar, Nida Moin, Shakir Ali, Kailash Chand Gupta, Aruna Satis. Size dependent toxicity of zinc oxide nano-particles in soil nematode Caenorhabditis elegans. Nanotoxicology. vol 9. issue 4. 2016-02-12. PMID:25051332. |
taken together, our study provides evidence that exposure to zno nps disrupts various physiological processes and causes apoptosis in the germ-line even at very low concentration in a size dependent manner. |
2016-02-12 |
2023-08-13 |
caenorhabditis_elegans |