| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruchi Roy, Sunil Kumar Singh, L K S Chauhan, Mukul Das, Anurag Tripathi, Premendra D Dwived. Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition. Toxicology letters. vol 227. issue 1. 2014-06-17. PMID:24614525. |
this study demonstrates autophagy supports apoptosis on zno nps exposure. |
2014-06-17 |
2023-08-12 |
Not clear |
| Fengjuan Wang, Mariana G Bexiga, Sergio Anguissola, Patricia Boya, Jeremy C Simpson, Anna Salvati, Kenneth A Dawso. Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles. Nanoscale. vol 5. issue 22. 2014-06-06. PMID:24108393. |
using human astrocytoma cells, we have previously shown that 50 nm amine-modified polystyrene nps damage mitochondria and induce cell death by apoptosis. |
2014-06-06 |
2023-08-12 |
human |
| Fengjuan Wang, Mariana G Bexiga, Sergio Anguissola, Patricia Boya, Jeremy C Simpson, Anna Salvati, Kenneth A Dawso. Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles. Nanoscale. vol 5. issue 22. 2014-06-06. PMID:24108393. |
we demonstrate that the accumulation of nps in lysosomes plays a central role in the observed cell death, leading to swelling of the lysosomes and release of cathepsins into the cytosol, which ultimately propagates the damage to the mitochondria with subsequent activation of apoptosis. |
2014-06-06 |
2023-08-12 |
human |
| Maqusood Ahamed, Daoud Ali, Hisham A Alhadlaq, Mohd Javed Akhta. Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2). Chemosphere. vol 93. issue 10. 2014-05-28. PMID:24139157. |
to the best of our knowledge this is the first report demonstrating that nio nps caused cytotoxicity via ros and induced apoptosis in hepg2 cells, which is likely to be mediated through bax/bcl-2 pathway. |
2014-05-28 |
2023-08-12 |
human |
| Soo Kyung Cho, Ali Pedram, Ellis R Levin, Young Jik Kwo. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials. vol 34. issue 38. 2014-05-21. PMID:24055523. |
sensitization of tam-resistant mcf7-bk-tr breast cancer cells with (mnsod sirna/pamam)-pk nps restored tam-induced cellular apoptosis in vitro and significantly suppressed tumor growth in vivo, as confirmed by biochemical assays and histological observations. |
2014-05-21 |
2023-08-12 |
Not clear |
| Shouying Li, Shumin Yang, Geng Chen, Xiaodong Li, Jia Chen, Yuguang Ma, Yuguang M. Mechanism of cellular uptake, localization and cytotoxicity of organic nanoparticles. Journal of nanoscience and nanotechnology. vol 14. issue 5. 2014-05-13. PMID:24734543. |
our results demonstrated that the cells treated with dpa-tsb nps showed an increase in apoptosis accompanied by the increased expression of bax protein, decreased expression of bcl-2 protein and caspase-3 protein, the decreased mitochondrial membrane potential and the release of ros. |
2014-05-13 |
2023-08-13 |
Not clear |
| Sandra Gissela Márquez-Ramírez, Norma Laura Delgado-Buenrostro, Yolanda Irasema Chirino, Gisela Gutiérrez Iglesias, Rebeca López-Marur. Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:23044362. |
tio(2) nps induced apoptosis after 96h of treatment. |
2014-03-28 |
2023-08-12 |
human |
| Li Yuan, Yutang Wang, Jing Wang, Haifang Xiao, Xuebo Li. Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line. Toxicology letters. vol 225. issue 2. 2014-03-28. PMID:24374571. |
zno nps could synergistically potentiate iso to induce apoptosis through resulting in mitochondrial dysfunction, inhibiting the phosphorylation of akt and erk1/2, and enhancing the phosphorylation of jnk and p38. |
2014-03-28 |
2023-08-12 |
human |
| Jieting Wang, Xiaobei Deng, Fang Zhang, Deliang Chen, Wenjun Din. ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes. Nanoscale research letters. vol 9. issue 1. 2014-03-20. PMID:24624962. |
it has been documented in in vitro studies that zinc oxide nanoparticles (zno nps) are capable of inducing oxidative stress, which plays a crucial role in zno np-mediated apoptosis. |
2014-03-20 |
2023-08-12 |
Not clear |
| Jieting Wang, Xiaobei Deng, Fang Zhang, Deliang Chen, Wenjun Din. ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes. Nanoscale research letters. vol 9. issue 1. 2014-03-20. PMID:24624962. |
in this study, we investigated the potential mechanisms of apoptosis provoked by zno nps in cultured primary astrocytes by exploring the molecular signaling pathways triggered after zno np exposure. |
2014-03-20 |
2023-08-12 |
Not clear |
| Jing Yao, Yuan Zhang, Srinivas Ramishetti, Yuhua Wang, Leaf Huan. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. Journal of controlled release : official journal of the Controlled Release Society. vol 170. issue 3. 2014-03-11. PMID:23791977. |
it was also found that the high efficacy of a-lcp nps was associated with the ability to induce dramatic apoptosis of the tumor cells, as well as significantly inhibit tumor cell proliferation and cell cycle progression. |
2014-03-11 |
2023-08-12 |
Not clear |
| Maqsood A Siddiqui, Hisham A Alhadlaq, Javed Ahmad, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PloS one. vol 8. issue 8. 2014-03-05. PMID:23940521. |
however, the underlying mechanism of apoptosis in liver cells due to cuo nps exposure is largely lacking. |
2014-03-05 |
2023-08-12 |
human |
| Maqsood A Siddiqui, Hisham A Alhadlaq, Javed Ahmad, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PloS one. vol 8. issue 8. 2014-03-05. PMID:23940521. |
we explored the possible mechanisms of apoptosis induced by cuo nps in human hepatocellular carcinoma hepg2 cells. |
2014-03-05 |
2023-08-12 |
human |
| Maqsood A Siddiqui, Hisham A Alhadlaq, Javed Ahmad, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PloS one. vol 8. issue 8. 2014-03-05. PMID:23940521. |
decrease in mitochondrial membrane potential with a concomitant increase in the gene expression of bax/bcl2 ratio suggested that mitochondria mediated pathway involved in cuo nps induced apoptosis. |
2014-03-05 |
2023-08-12 |
human |
| Maqsood A Siddiqui, Hisham A Alhadlaq, Javed Ahmad, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PloS one. vol 8. issue 8. 2014-03-05. PMID:23940521. |
this study has provided valuable insights into the possible mechanism of apoptosis caused by cuo nps at in vitro level. |
2014-03-05 |
2023-08-12 |
human |
| Maqsood A Siddiqui, Hisham A Alhadlaq, Javed Ahmad, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PloS one. vol 8. issue 8. 2014-03-05. PMID:23940521. |
underlying mechanism(s) of apoptosis due to cuo nps exposure should be further invested at in vivo level. |
2014-03-05 |
2023-08-12 |
human |
| M Manikandan, Nazim Hasan, Hui-Fen W. Platinum nanoparticles for the photothermal treatment of Neuro 2A cancer cells. Biomaterials. vol 34. issue 23. 2014-02-04. PMID:23642996. |
the maldi-ms was used to prove the possibility of apoptosis related triggering of cell death in the presence of the pt nps. |
2014-02-04 |
2023-08-12 |
Not clear |
| Ming-Yao Chang, Yu-Jen Yang, Chih-Han Chang, Alan C L Tang, Wei-Yin Liao, Fong-Yu Cheng, Chen-Sheng Yeh, James J Lai, Patrick S Stayton, Patrick C H Hsie. Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. Journal of controlled release : official journal of the Controlled Release Society. vol 170. issue 2. 2014-01-28. PMID:23665256. |
plga-igf-1 nps also prolonged akt activation in cardiomyocytes up to 24h and prevented cardiomyocyte apoptosis induced by doxorubicin in a dose-dependent manner. |
2014-01-28 |
2023-08-12 |
mouse |
| Ming-Yao Chang, Yu-Jen Yang, Chih-Han Chang, Alan C L Tang, Wei-Yin Liao, Fong-Yu Cheng, Chen-Sheng Yeh, James J Lai, Patrick S Stayton, Patrick C H Hsie. Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. Journal of controlled release : official journal of the Controlled Release Society. vol 170. issue 2. 2014-01-28. PMID:23665256. |
importantly, a single intramyocardial injection of plga-igf-1 nps was sufficient to prevent cardiomyocyte apoptosis (p<0.001), reduce infarct size (p<0.05), and improve left ventricle ejection fraction (p<0.01) 21 days after experimental mi in mice. |
2014-01-28 |
2023-08-12 |
mouse |
| Esmaiel Jabbari, Xiaoming Yang, Seyedsina Moeinzadeh, Xuezhong H. Drug release kinetics, cell uptake, and tumor toxicity of hybrid VVVVVVKK peptide-assembled polylactide nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 84. issue 1. 2014-01-16. PMID:23275111. |
dox-loaded pla-v6k2 nps showed higher toxicity to 4t1 cells and the dna damage response, and apoptosis was delayed compared to the free dox. |
2014-01-16 |
2023-08-12 |
mouse |