| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annapina Russo, Sara Maiolino, Valentina Pagliara, Francesca Ungaro, Fabiana Tatangelo, Alessandra Leone, Giulia Scalia, Alfredo Budillon, Fabiana Quaglia, Giulia Russ. Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles. Oncotarget. vol 7. issue 48. 2018-02-22. PMID:27835895. |
analysis of cytotoxicity and apoptotic induction potential of combined nps clearly showed that the 5-fu plus l3 were more effective in inducing apoptosis than 5-fu or l3 alone. |
2018-02-22 |
2023-08-13 |
Not clear |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
effects of zno nps and ionic zn on germline apoptosis and the regulation of genes in the apoptosis pathway were investigated in vivo using the model organism caenorhabditis elegans.age synchronized bristol n2 worms were exposed to zno nps and zncl2 at concentrations of 6.14 × 10-1, 61.4, and 614 μm form larval stage 1 (l1) to early adulthood. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
however, zno nps induced more apoptotic cells in the 61.4 μm treatment than zncl2 (p < .05), suggesting zno np is more potent in inducing apoptosis at specific exposure concentration. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
therefore, the increased apoptosis resulting from zno nps exposure is likely cep-1/p53 dependent. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |
| Kyung Wook Heo, Seong Kook Park, Yeo Myeong Lee, Si Hong Choe, Pyung Mo Gu, Tae Ui Hong, Dae Young Hu. Methotrexate Induces Apoptosis in Organ-Cultured Nasal Polyps Via the Fas Pathway. The Journal of craniofacial surgery. vol 28. issue 3. 2018-02-09. PMID:28468172. |
methotrexate (mtx) is very effective when used to treat chronic inflammatory diseases, and also induces apoptosis in nasal polyps (nps). |
2018-02-09 |
2023-08-13 |
Not clear |
| Yan Li, Ruilong Zhang, Zhiguo Lu, Guanghui Ma, Lei Chen, Qunwei Tang, Xin Zhan. Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy. Small (Weinheim an der Bergstrasse, Germany). vol 12. issue 40. 2018-02-05. PMID:27552926. |
the nps induce the apoptosis of differentiated cancer cells, cancer stem cells, and vascular niches simultaneously. |
2018-02-05 |
2023-08-13 |
Not clear |
| Jiang Pi, Jinhuan Jiang, Huaihong Cai, Fen Yang, Hua Jin, Peihui Yang, Jiye Cai, Zheng W Che. GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways. Drug delivery. vol 24. issue 1. 2018-02-05. PMID:29019267. |
ge11-ori-se nps were found to induce cancer cell apoptosis by inducting reactive oxygen species (ros) production, activating mitochondria-dependent pathway, inhibiting egfr-mediated pi3k/akt and inhibiting ras/raf/mek/erk pathways. |
2018-02-05 |
2023-08-13 |
mouse |
| Huijuan Kuang, Pengfei Yang, Lin Yang, Zoraida P Aguilar, Hengyi X. Size dependent effect of ZnO nanoparticles on endoplasmic reticulum stress signaling pathway in murine liver. Journal of hazardous materials. vol 317. 2018-02-02. PMID:27262279. |
these findings implied that the smaller zno nps (30nm) activated er stress responses that signified severe apoptosis in murine liver. |
2018-02-02 |
2023-08-13 |
mouse |
| Qingbo Yang, Yinfa M. Irradiation-Enhanced Cytotoxicity of Zinc Oxide Nanoparticles. International journal of toxicology. vol 33. issue 3. 2018-01-17. PMID:24700570. |
although recent studies have shown the cytotoxic effects of these nps, including oxidative stress, apoptosis and necrosis induction, genotoxicity, and others, irradiation-induced cytotoxicity has not been systematically studied. |
2018-01-17 |
2023-08-13 |
Not clear |
| Andrew M Hall, Ruth Hemmer, Robert Spaulding, Hanna N Wetzel, Joseph Curcio, Bernhard A Sabel, Petra Henrich-Noack, Sarah Pixley, Tracy Hopkins, Richard L Boyce, Patrick J Schultheis, Kristi L Hai. Cytotoxicity and apoptotic gene expression in an in vitro model of the blood-brain barrier following exposure to poly(butylcyanoacrylate) nanoparticles. Journal of drug targeting. vol 24. issue 7. 2018-01-17. PMID:26707984. |
methods the co-cultures were exposed to uncoated pbca nps, pbca-ps80 nps or pbca-ps80-dox nps at varying concentrations and evaluated using a resazurin-based cytotoxicity assay and an 84-gene apoptosis rt-pcr array. |
2018-01-17 |
2023-08-13 |
rat |
| Ankit Saneja, Robin Kumar, Amarinder Singh, Ravindra Dhar Dubey, Mubashir J Mintoo, Gurdarshan Singh, Dilip M Mondhe, Amulya K Panda, Prem N Gupt. Development and evaluation of long-circulating nanoparticles loaded with betulinic acid for improved anti-tumor efficacy. International journal of pharmaceutics. vol 531. issue 1. 2018-01-10. PMID:28823888. |
the enhanced cytotoxicity of ba nps was also supported by increased cellular apoptosis, mitochondrial membrane potential loss, generation of high reactive oxygen species (ros) and cell cycle arrest. |
2018-01-10 |
2023-08-13 |
mouse |
| Mahboubeh Ebrahimian, Sahar Taghavi, Ahad Mokhtarzadeh, Mohammad Ramezani, Maryam Hashem. Co-delivery of Doxorubicin Encapsulated PLGA Nanoparticles and Bcl-xL shRNA Using Alkyl-Modified PEI into Breast Cancer Cells. Applied biochemistry and biotechnology. vol 183. issue 1. 2018-01-02. PMID:28236188. |
in this study, alkyl-modified polyethylenimine (pei 10 kd) was used for co-delivery of doxorubicin (dox) encapsulated into poly lactic-co-glycolic acid (plga) nanoparticles (nps) and bcl-xl shrna (one class of molecules that block apoptosis of tumor cells) into breast cancer cells. |
2018-01-02 |
2023-08-13 |
Not clear |
| Lei Zhao, Guojun Chen, Jun Li, Yingmei Fu, Timur A Mavlyutov, Annie Yao, Robert W Nickells, Shaoqin Gong, Lian-Wang Gu. An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration. Journal of controlled release : official journal of the Controlled Release Society. vol 247. 2017-12-28. PMID:28063892. |
consistent with s1r functions, targeted nps relative to non-targeted nps showed markedly better inhibitory effects on apoptosis and oxidative/inflammatory stresses in the rgc layer. |
2017-12-28 |
2023-08-13 |
mouse |
| Shiqian Gao, Huayu Tian, Zhenkai Xing, Dawei Zhang, Ye Guo, Zhaopei Guo, Xiaojuan Zhu, Xuesi Che. A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment. Journal of controlled release : official journal of the Controlled Release Society. vol 243. 2017-12-27. PMID:27794494. |
moreover, the ppa/hsv-tk nps showed remarkably anti-glioma effect and survival benefit in an invasive orthotopic human gbm mouse model through inhibiting proliferation and inducing apoptosis (p<0.05 vs control). |
2017-12-27 |
2023-08-13 |
mouse |
| Cong Luo, Lei Miao, Yi Zhao, Sara Musetti, Yuhua Wang, Kai Shi, Leaf Huan. A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA. Biomaterials. vol 102. 2017-12-19. PMID:27344367. |
dobp-lpd-trail nps demonstrated distinct superiority in delaying tumor progression over dotap-lpd-trail nps, due to the intrinsic antitumor activity combined with trail-induced apoptosis in the tumor. |
2017-12-19 |
2023-08-13 |
human |
| Jing Yang, Shifu Hu, Meng Rao, Lixia Hu, Hui Lei, Yanqing Wu, Yingying Wang, Dandan Ke, Wei Xia, Chang-Hong Zh. Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats. International journal of nanomedicine. vol 12. 2017-12-18. PMID:28860760. |
the results demonstrated that the cu nps exhibited obvious accumulation in the rat ovaries, leading to ovarian injury, an imbalance of sex hormones, and ovarian cell apoptosis. |
2017-12-18 |
2023-08-13 |
rat |
| Divya Arora, Amit Kumar, Prasoon Gupta, Gousia Chashoo, Sundeep Jagla. Preparation, characterization and cytotoxic evaluation of bovine serum albumin nanoparticles encapsulating 5-methylmellein: A secondary metabolite isolated from Xylaria psidii. Bioorganic & medicinal chemistry letters. vol 27. issue 23. 2017-12-18. PMID:29100800. |
the enhancement in cytotoxicity of 5-mm bsa nps was also supported by increase in cellular apoptosis, mitochondrial membrane potential loss and generation of high reactive oxygen species (ros). |
2017-12-18 |
2023-08-13 |
human |
| Nisar Ul Khaliq, Febrina Carolina Sandra, Dal Yong Park, Jae Young Lee, Keun Sang Oh, Dongkyu Kim, Youngro Byun, In-San Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yu. Doxorubicin/heparin composite nanoparticles for caspase-activated prodrug chemotherapy. Biomaterials. vol 101. 2017-12-12. PMID:27286189. |
with the accumulation of the composite nps in the tumor tissue by the enhanced permeation and retention (epr) effect, a small exposure of dox in the tumor cells initiated apoptosis in a localized area of the tumor tissue, which induced caspase-3 activation. |
2017-12-12 |
2023-08-13 |
Not clear |
| Sandesh Chibber, Rishi Shanke. Can CuO nanoparticles lead to epigenetic regulation of antioxidant enzyme system? Journal of applied toxicology : JAT. vol 37. issue 1. 2017-12-04. PMID:27687502. |
accordingly, the main cause for induction of toxicity by cuo nps is the generation of reactive oxygen species (ros) followed by the mitochondrial destruction that leads to apoptosis via the intrinsic pathway or under the condition such as hypoxia cell on exposure to cuo nps may commit to necrosis. |
2017-12-04 |
2023-08-13 |
human |
| Basmah A Othman, Christina Greenwood, Ayman F Abuelela, Anil A Bharath, Shu Chen, Ioannis Theodorou, Trevor Douglas, Maskai Uchida, Mary Ryan, Jasmeen S Merzaban, Alexandra E Porte. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Advanced healthcare materials. vol 5. issue 11. 2017-11-20. PMID:27275627. |
correlative light-electron microscopy shows that nps dissolve into ionic zn(2+) (blue) upon uptake and cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. |
2017-11-20 |
2023-08-13 |
Not clear |