| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
the generation of reactive oxygen species (ros) and its involvement in apoptosis when hepg2 cells were exposed to qds (6 nm) and nps of different sizes (15-20, 50, and 100 nm) was also investigated. |
2021-04-29 |
2023-08-13 |
human |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
quantitative real-time pcr data showed that the mrna levels of apoptotic marker genes such as p53, bax, and caspase-3 were upregulated, whereas bcl-2, an anti-apoptotic gene, was downregulated; therefore, apoptosis was mediated through the p53, bax, caspase-3, and bcl-2 pathways, suggesting a possible mechanism by which qds and nps of zno mediate their toxicity.graphic abstract. |
2021-04-29 |
2023-08-13 |
human |
| Yu Yan, Guang Wang, Xin Luo, Ping Zhang, Shuang Peng, Xin Cheng, Mengwei Wang, Xuesong Yan. Endoplasmic reticulum stress-related calcium imbalance plays an important role on Zinc oxide nanoparticles-induced failure of neural tube closure during embryogenesis. Environment international. vol 152. 2021-04-26. PMID:33730632. |
in this study, we discovered that zno nps exposure caused growth proportional failure of neural tube closure in mouse and chicken embryos and a simultaneous increase in apoptosis in the developing neural tubes of chicken embryos, which was verified in an in vitro experiment using the sh-sy5y cell line. |
2021-04-26 |
2023-08-13 |
mouse |
| Yawei Li, Yu Song, Wei Zhang, Junjie Xu, Jiancheng Hou, Xianmin Feng, Wenhe Zh. MOF nanoparticles with encapsulated dihydroartemisinin as a controlled drug delivery system for enhanced cancer therapy and mechanism analysis. Journal of materials chemistry. B. vol 8. issue 33. 2021-04-05. PMID:32648887. |
the results indicate that dha@zif-8 nps modify the expression of 7090 genes in hepg2 cells, and the mechanism may be related to the induction of apoptosis through a p53-mediated mitochondrial pathway and the suppression of glycolysis by inhibiting the pi3k/akt pathway. |
2021-04-05 |
2023-08-13 |
Not clear |
| Jiacheng Wang, Wenshu Qiao, Xu Li, Haitian Zhao, Hua Zhang, Aijun Dong, Xin Yan. A directed co-assembly of herbal small molecules into carrier-free nanodrugs for enhanced synergistic antitumor efficacy. Journal of materials chemistry. B. vol 9. issue 4. 2021-04-01. PMID:33392615. |
not only do co-assembled nps have rapid cellular uptake ability and passive targeting tumor ability based on the epr effect, but also their constituent units could arrest the cell cycle at different stages of tumor cells and induce apoptosis, showing synergistic anti-tumor effects (ci < 0.7). |
2021-04-01 |
2023-08-13 |
Not clear |
| Sanyog Jain, Mahesh R Desai, Bhargavi Nallamothu, Kaushik Kuche, Dasharath Chaudhari, Sameer S Katiya. Partial inclusion complex assisted crosslinked β-cyclodextrin nanoparticles for improving therapeutic potential of docetaxel against breast cancer. Drug delivery and translational research. 2021-03-28. PMID:33774776. |
increased cell uptake (~5-fold), cytotoxicity (~3.3-fold), and apoptosis were observed in mda-mb-231 cells when treated with dtx β-cd nps in comparison to free dtx. |
2021-03-28 |
2023-08-13 |
Not clear |
| Bashir Ahmad, Yaser Gamallat, Muhammad Fiaz Khan, Syed Riaz Din, Muhammad Israr, Manzoor Ahmad, Naeem Tahir, Nasir Azam, Khalil Ur Rahman, Wang Xin, Wang Zexu, Peng Linjie, Pengyu Su, Wang Lian. Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis. OncoTargets and therapy. vol 14. 2021-03-20. PMID:33732000. |
nps cure cancer by regulating different pathways, such as pi3k/akt/mtor, er stress, jnk, wnt, stat3, mapks, nf-kb, mek-erk, inflammation, oxidative stress, apoptosis, autophagy, mitophagy, and necroptosis. |
2021-03-20 |
2023-08-13 |
Not clear |
| Vivek K Chaturvedi, Navneet Yadav, Neeraj K Rai, Raghvendra A Bohara, Sachchida Nand Rai, Lotfi Aleya, Mohan P Sing. Two birds with one stone: oyster mushroom mediated bimetallic Au-Pt nanoparticles for agro-waste management and anticancer activity. Environmental science and pollution research international. vol 28. issue 11. 2021-03-18. PMID:33196993. |
furthermore, we examined the cytotoxic activity of au-pt nps using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) assay, intracellular reactive oxygen species (ros) generation, and apoptosis by propidium iodide assay. |
2021-03-18 |
2023-08-13 |
human |
| Huijuan Kuang, Wanyi Zhang, Lin Yang, Zoraida P Aguilar, Hengyi X. Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine. Environmental toxicology. vol 36. issue 4. 2021-03-12. PMID:33236829. |
in the ovary, zno nps induce cell apoptosis in shh pathway activated ovary cells, and affect the synthesis of steroidogenesis. |
2021-03-12 |
2023-08-13 |
mouse |
| Huijuan Kuang, Wanyi Zhang, Lin Yang, Zoraida P Aguilar, Hengyi X. Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine. Environmental toxicology. vol 36. issue 4. 2021-03-12. PMID:33236829. |
in the testes, zno nps effectively changed the expression level of genes related to oxidant stress, detox/metabolic process, and apoptosis. |
2021-03-12 |
2023-08-13 |
mouse |
| Lu Kong, Yongya Wu, Wangcheng Hu, Lin Liu, Yuying Xue, Geyu Lian. Mechanisms underlying reproductive toxicity induced by nickel nanoparticles identified by comprehensive gene expression analysis in GC-1 spg cells. Environmental pollution (Barking, Essex : 1987). vol 275. 2021-03-10. PMID:33588191. |
the effects of pir-mmu-32362259 on the viability, cycle and apoptosis as well as related protein expression levels of gc-1 cells induced by ni nps were detected using cck8, flow cytometry and western blot assay, respectively. |
2021-03-10 |
2023-08-13 |
mouse |
| Zahra Hasanpoor, Ali Mostafaie, Iraj Nikokar, Zuhair Mohammad Hassa. Curcumin-human serum albumin nanoparticles decorated with PDL1 binding peptide for targeting PDL1-expressing breast cancer cells. International journal of biological macromolecules. vol 159. 2021-03-09. PMID:32335119. |
the cell viability and apoptosis determination demonstrated higher cytotoxicity of hsa/cur nps relative to free curcumin in breast cancer cells. |
2021-03-09 |
2023-08-13 |
human |
| Nai-Sheng Hsu, Moeava Tehei, Md Shahriar Hossain, Anatoly Rosenfeld, Muhammad J A Shiddiky, Ronald Sluyter, Shi Xue Dou, Yusuke Yamauchi, Konstantin Konstantino. Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress. ACS applied materials & interfaces. vol 13. issue 2. 2021-03-04. PMID:33399455. |
we demonstrate that the synthesized ito nps can selectively increase the generation of reactive oxygen species (ros) in both breast tumor cell lines, resulting in activation of apoptosis, and can also greatly suppress the cellular proliferation in both types of tumor cells. |
2021-03-04 |
2023-08-13 |
human |
| Xuanbo Zhang, Jianchen Xiong, Kaiyuan Wang, Han Yu, Bingjun Sun, Hao Ye, Zhiqiang Zhao, Ning Wang, Yuequan Wang, Shenwu Zhang, Wutong Zhao, Haotian Zhang, Zhonggui He, Cong Luo, Jin Su. Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy. Bioactive materials. vol 6. issue 8. 2021-02-10. PMID:33553816. |
under cascaded laser irradiation (808-660 nm), tumor-localizing temperature rise following laser irradiation on dir not only induces tumor cell apoptosis but also facilitates the tumor penetration of nps, relieves tumor hypoxia, and promotes the pdt efficacy of ce6. |
2021-02-10 |
2023-08-13 |
Not clear |
| Amin Al-Doaiss, Qais Jarrar, Said Moshawi. Hepatic histopathological and ultrastructural alterations induced by 10 nm silver nanoparticles. IET nanobiotechnology. vol 14. issue 5. 2021-02-08. PMID:32691743. |
exposure to ag nps induced kupffer cells hyperplasia, sinusoidal dilatation, apoptosis, ground glass hepatocytes appearance, nuclear changes, inflammatory cells infiltration, hepatocytes degeneration and necrosis. |
2021-02-08 |
2023-08-13 |
mouse |
| Afshin Nikkhoo, Narges Rostami, Shohreh Farhadi, Maryam Esmaily, Sadaf Moghadaszadeh Ardebili, Fatemeh Atyabi, Masoumeh Baghaei, Navideh Haghnavaz, Mehdi Yousefi, Mohammad Reza Aliparasti, Ghasem Ghalamfarsa, Hamed Mohammadi, Mozhdeh Sojoodi, Farhad Jadidi-Niarag. Codelivery of STAT3 siRNA and BV6 by carboxymethyl dextran trimethyl chitosan nanoparticles suppresses cancer cell progression. International journal of pharmaceutics. vol 581. 2021-02-01. PMID:32240809. |
the present study has investigated the combination therapy of cancer cells using carboxymethyl dextran-conjugated trimethyl chitosan (tmc-cmd) nanoparticles (nps) loaded with nik/stat3-specific sirna and bv6 to synergistically induce apoptosis in the breast, colorectal and melanoma cancer cell lines. |
2021-02-01 |
2023-08-13 |
Not clear |
| Polina V Maximchik, Konstantin Tamarov, Eugene V Sheval, Elen Tolstik, Tatiana Kirchberger-Tolstik, Zhang Yang, Vladimir Sivakov, Boris Zhivotovsky, Liubov A Osminkin. Biodegradable Porous Silicon Nanocontainers as an Effective Drug Carrier for Regulation of the Tumor Cell Death Pathways. ACS biomaterials science & engineering. vol 5. issue 11. 2021-01-14. PMID:33405660. |
at the same time, the obtained results demonstrate the possibility of regulating the initiation of apoptosis or necrosis in tumor cells after treatment with different concentrations of dox-psi nps, as revealed by the analysis of the caspase-3 processing, the accumulation of sub-g1 cell fraction, and morphological changes determined by electron and light microscopy. |
2021-01-14 |
2023-08-13 |
Not clear |
| Deepanjalee Dutta, Arun Chattopadhyay, Siddhartha Sankar Ghos. Cationic BSA Templated Au-Ag Bimetallic Nanoclusters As a Theranostic Gene Delivery Vector for HeLa Cancer Cells. ACS biomaterials science & engineering. vol 2. issue 11. 2021-01-14. PMID:33440544. |
while successful delivery of a suicide gene (cd-uprt) into cells by pdna loaded composite nps initiates a therapeutic response cascade by converting prodrug 5-fc to 5-fu, au-ag ncs results in ros (reactive oxygen species) triggered apoptosis mediated cell death. |
2021-01-14 |
2023-08-13 |
Not clear |
| Qinglian Hu, Hui Wang, Chao He, Yuanxiang Jin, Zhengwei F. Polystyrene nanoparticles trigger the activation of p38 MAPK and apoptosis via inducing oxidative stress in zebrafish and macrophage cells. Environmental pollution (Barking, Essex : 1987). vol 269. 2021-01-06. PMID:33316494. |
furthermore, ps nps also induced oxidative damage and inflammatory response in raw 264.7 cells, which activated p38 mapk signal pathway and finally induced cell apoptosis. |
2021-01-06 |
2023-08-13 |
zebrafish |
| M Sendra, A Saco, M P Yeste, A Romero, B Novoa, A Figuera. Nanoplastics: From tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination. Journal of hazardous materials. vol 388. 2020-12-31. PMID:31813690. |
the hemocytes exposed to nps had changes in motility, apoptosis, ros and phagocytic capacity. |
2020-12-31 |
2023-08-13 |
Not clear |