| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Li, Zhiwen Cao, Liuchunyang Yu, Qingcai Huang, Dongjie Zhu, Cheng Lu, Aiping Lu, Yuanyan Li. Hierarchical drug release designed Au @PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy. Journal of nanobiotechnology. vol 19. issue 1. 2021-11-08. PMID:34001161. |
au @pda-peg-mtx nps under near infra-red region (nir) irradiation showed effective photothermal therapy against mda-mb-231 human bc cells growth in vitro by inducing apoptosis through triggering reactive oxygen species (ros) overproduction and generating excessive heat. |
2021-11-08 |
2023-08-13 |
human |
| Wen Li, Zhiwen Cao, Liuchunyang Yu, Qingcai Huang, Dongjie Zhu, Cheng Lu, Aiping Lu, Yuanyan Li. Hierarchical drug release designed Au @PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy. Journal of nanobiotechnology. vol 19. issue 1. 2021-11-08. PMID:34001161. |
in vivo studies revealed deep penetration ability of au @pda-peg-mtx nps under nir irradiation to find application in cancer-targeted fluorescence imaging, and exhibited effective photothermal therapy against bc xenograft growth by inducing apoptosis. |
2021-11-08 |
2023-08-13 |
human |
| Wen Li, Zhiwen Cao, Liuchunyang Yu, Qingcai Huang, Dongjie Zhu, Cheng Lu, Aiping Lu, Yuanyan Li. Hierarchical drug release designed Au @PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy. Journal of nanobiotechnology. vol 19. issue 1. 2021-11-08. PMID:34001161. |
histopathological analysis, cellular uptake, cytotoxicity assay, and apoptosis experiments indicated that au @pda-peg-mtx nps possessed a good therapeutic effect with high biocompatibility and fewer side effects. |
2021-11-08 |
2023-08-13 |
human |
| Masomeh Maleki, Asal Golchin, Forough Alemi, Simin Younesi, Zatollah Asemi, Samira Javadi, Payam Ali Khiavi, Jafar Soleinmapour, Bahman Yousef. Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review. European journal of pharmacology. vol 904. 2021-11-05. PMID:33933464. |
in the present study, we systematically reviewed original studies, which investigated the cytotoxic effects and apoptosis of free nps (loaded with doxorubicin (dox)/or methotrexate (mtx)) via in vitro models. |
2021-11-05 |
2023-08-13 |
Not clear |
| Masomeh Maleki, Asal Golchin, Forough Alemi, Simin Younesi, Zatollah Asemi, Samira Javadi, Payam Ali Khiavi, Jafar Soleinmapour, Bahman Yousef. Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review. European journal of pharmacology. vol 904. 2021-11-05. PMID:33933464. |
involved nps in this systematic review for delivery of dox/or mtx to os cells have higher safety index and biocompatibility, although small and positively charged nps acted more toxic in comparison to larger and negative ones, apoptosis rate like cytotoxicity index was notable in drug/np group, to apply them in clinical works. |
2021-11-05 |
2023-08-13 |
Not clear |
| Dongmei Liu, Wenguang Zhang, Xinju Liu, Rongliang Qi. Precise engineering of hybrid molecules-loaded macromolecular nanoparticles shows Drug delivery. vol 28. issue 1. 2021-11-04. PMID:33866910. |
furthermore gem-pt nps induced significant apoptosis in human nasopharyngeal carcinoma cne2 and sune1 cancer cells by |
2021-11-04 |
2023-08-13 |
human |
| Zeting Yuan, Guohua Fan, Honglei Wu, Chaolian Liu, Yueping Zhan, Yanyan Qiu, Chenting Shou, Feng Gao, Jun Zhang, Peihao Yin, Ke X. Photodynamic therapy synergizes with PD-L1 checkpoint blockade for immunotherapy of CRC by multifunctional nanoparticles. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 10. 2021-11-02. PMID:34023507. |
in this study, the mthpc@vec/t-rgd nps under the 660-nm near infrared (nir) laser could kill tumor cells by inducing apoptosis and/or necrosis and stimulating systemic immune response, which could be further promoted by the pd-l1 blockade to inhibit primary and distant tumor growth, as well as building long-term host immunological memory to prevent tumor recurrence. |
2021-11-02 |
2023-08-13 |
Not clear |
| Huaiying Zhang, Winant L van Os, Xiaobo Tian, Guangyue Zu, Laís Ribovski, Reinier Bron, Jeroen Bussmann, Alexander Kros, Yong Liu, Inge S Zuhor. Development of curcumin-loaded zein nanoparticles for transport across the blood-brain barrier and inhibition of glioblastoma cell growth. Biomaterials science. vol 9. issue 21. 2021-10-28. PMID:33538729. |
fluorescence microscopy and flow cytometry studies showed that the cur-zpd-g23 nps increased cellular ros production and induced apoptosis of c6 glioma cells. |
2021-10-28 |
2023-08-13 |
Not clear |
| Ertan Kucuksayan, Fatih Bozkurt, Mustafa Tahsin Yilmaz, Aslinur Sircan-Kucuksayan, Aysegul Hanikoglu, Tomris Ozbe. A new combination strategy to enhance apoptosis in cancer cells by using nanoparticles as biocompatible drug delivery carriers. Scientific reports. vol 11. issue 1. 2021-10-27. PMID:34158544. |
we studied the effects of drug encapsulated nps on cellular accumulation, intracellular drug levels, oxidative stress status, cellular viability, drug resistance, 20s proteasome activity, cytosolic nuclear factor kappa b (nf-κb-p65), and apoptosis in breast cancer and normal cells. |
2021-10-27 |
2023-08-13 |
Not clear |
| Ertan Kucuksayan, Fatih Bozkurt, Mustafa Tahsin Yilmaz, Aslinur Sircan-Kucuksayan, Aysegul Hanikoglu, Tomris Ozbe. A new combination strategy to enhance apoptosis in cancer cells by using nanoparticles as biocompatible drug delivery carriers. Scientific reports. vol 11. issue 1. 2021-10-27. PMID:34158544. |
the apoptotic index of free dox and epo increased 50% through their encapsulation into nps, proving combination strategy to enhance apoptosis in breast cancer cells. |
2021-10-27 |
2023-08-13 |
Not clear |
| Man Yan, Mostafa Heidari Maj. Evaluation of Induced Apoptosis by Biosynthesized Zinc Oxide Nanoparticles in MCF-7 Breast Cancer Cells Using Bak1 and Bclx Expression. Doklady. Biochemistry and biophysics. vol 500. issue 1. 2021-10-27. PMID:34697744. |
therefore, we successfully synthesized zno nps by acacia luciana flower extract as stabilizing, reducing and capping agent, to investigate the antiproliferative potential and apoptosis induction in breast cancer cell lines. |
2021-10-27 |
2023-08-13 |
Not clear |
| Adam Yuh Lin, Jonathan Scott Rink, Reem Karmali, Jiahui Xu, Masha Kocherginsky, Colby Shad Thaxton, Leo I Gordo. Tri-ethylene glycol modified class B and class C CpG conjugated gold nanoparticles for the treatment of lymphoma. Nanomedicine : nanotechnology, biology, and medicine. vol 30. 2021-10-26. PMID:32798731. |
both classes of tmcpg nps reduced viability of human and murine lymphoma cells via apoptosis compared with free cpgs, while having no toxic effects on dendritic cells. |
2021-10-26 |
2023-08-13 |
human |
| Linxi Wu, Xinwei Yu, Amin Feizpour, Björn M Reinhar. Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced Apoptosis. Biomaterials science. vol 2. issue 2. 2021-10-21. PMID:24683470. |
the size-compatibility of nanoparticles (nps) with cellular components provides new opportunities for regulating cellular processes, potentially including apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Linxi Wu, Xinwei Yu, Amin Feizpour, Björn M Reinhar. Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced Apoptosis. Biomaterials science. vol 2. issue 2. 2021-10-21. PMID:24683470. |
we investigated the impact of the covalent attachment of epidermal growth factor (egf) to 40 nm diameter au nps on cellular apoptosis levels, quantified as caspase-3 activity, in two |
2021-10-21 |
2023-08-12 |
Not clear |
| Jin Tao, Lu Diao, Fangcheng Chen, Ao Shen, Shutian Wang, Hongyan Jin, Danwei Cai, Ying H. pH-Sensitive Nanoparticles Codelivering Docetaxel and Dihydroartemisinin Effectively Treat Breast Cancer by Enhancing Reactive Oxidative Species-Mediated Mitochondrial Apoptosis. Molecular pharmaceutics. vol 18. issue 1. 2021-10-05. PMID:33084332. |
d/d nps significantly increased the apoptosis of 4t1 cells with a synergistic effect of dtx and dha. |
2021-10-05 |
2023-08-13 |
Not clear |
| Chen Gao, Chang Liu, Yuwei Chen, Qingtao Wang, Zhihui Ha. Protective effects of natural products against drug-induced nephrotoxicity: A review in recent years. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 153. 2021-10-05. PMID:33989732. |
however, in recent years, a number of studies have shown that many natural products (nps), including phytochemicals, various plants extracts, herbal formulas, and nps derived from animals, confer protective effects against din through multi-targeting therapeutic mechanisms, such as inhibition of oxidative stress, inflammation, apoptosis, fibrosis, and necroptosis, regulation of autophagy, maintenance of cell polarity, etc., by regulating multiple signaling pathways and novel molecular targets. |
2021-10-05 |
2023-08-13 |
Not clear |
| Wene Wei, Qijing Guo, Cuiping Guo, Xianshu Cui, Xuemei Ma, Xianliang Shen, Yushuang Lu. Ginsenoside Rh2 Suppresses Metastasis and Growth of Colon Cancer via miR-491. Journal of oncology. vol 2021. 2021-10-05. PMID:34603449. |
first, ginsenoside rh2 chitosan tripolyphosphate (cs-rh2-tpp) nanoparticles (nps) were constructed, and mtt, transwell, scratch adhesion, and flow cytometry assays were carried out for determining the impact of cs-rh2-tpp at various concentrations on growth, metastasis, and apoptosis of colon cancer cells (cccs). |
2021-10-05 |
2023-08-13 |
human |
| Sumaira Anjum, Mariam Hashim, Sara Asad Malik, Maha Khan, José M Lorenzo, Bilal Haider Abbasi, Christophe Han. Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment. Cancers. vol 13. issue 18. 2021-10-01. PMID:34572797. |
zno nps showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. |
2021-10-01 |
2023-08-13 |
Not clear |
| Hemapriyadarshini Vadarevu, Ridhima Juneja, Zachary Lyles, Juan L Vivero-Escot. Light-Activated Protoporphyrin IX-Based Polysilsesquioxane Nanoparticles Induce Ferroptosis in Melanoma Cells. Nanomaterials (Basel, Switzerland). vol 11. issue 9. 2021-10-01. PMID:34578640. |
our data obtained from different assays that analyzed annexin v binding, glutathione peroxidase activity, and lipid peroxidation demonstrate that the cell death in pdt using ppix-psilq nps is regulated by apoptosis and ferroptosis. |
2021-10-01 |
2023-08-13 |
Not clear |
| Yavar Yousefi, Zohreh Mortezania, Mojdeh Abolmolouki, Amin Daem. A novel form of anti-angiogenic molecular antibody drug induces apoptosis in myeloma cells after cultivation upon endothelial feeder cells. Leukemia research. vol 108. 2021-09-21. PMID:34022745. |
the endothelial monolayer co-culture showed protection of myeloma cells from apoptosis when exposed to nps or without any treatment. |
2021-09-21 |
2023-08-13 |
human |