| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Shang, Siyan Wang, Yingying Jin, Wanlei Xue, Yufang Zhong, Hongli Wang, Jing An, Hui L. Polystyrene nanoparticles induced neurodevelopmental toxicity in Caenorhabditis elegans through regulation of dpy-5 and rol-6. Ecotoxicology and environmental safety. vol 222. 2021-08-19. PMID:34273852. |
in wild-type c. elegans, polystyrene nps (diameter 50 nm) could concentration-dependently induce significant inhibition in body length, survival rate, head thrashes, and body bending, accompanying with increase of reactive oxygen species (ros) production, lipofuscin accumulation, and apoptosis and decrease of dopamine (da) contents. |
2021-08-19 |
2023-08-13 |
human |
| Wensen Lin, Junai Zhang, Jun-Fa Xu, Jiang P. The Advancing of Selenium Nanoparticles Against Infectious Diseases. Frontiers in pharmacology. vol 12. 2021-08-17. PMID:34393776. |
taking the advantages of the strong ability to trigger apoptosis or autophagy by regulating reactive oxygen species (ros), se nps have been widely used for direct anticancer treatments and pathogen killing/clearance in host cells. |
2021-08-17 |
2023-08-13 |
human |
| Mahsa Shahriari, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani, Mona Aliboland. Self-targeted polymersomal co-formulation of doxorubicin, camptothecin and FOXM1 aptamer for efficient treatment of non-small cell lung cancer. Journal of controlled release : official journal of the Controlled Release Society. vol 335. 2021-08-11. PMID:34058270. |
the cytotoxicity experiment also indicated that the aptamer conjugation on the co-formulations surface could significantly increase the cytotoxicity and induce apoptosis in combination therapy on both a549 and sk-mes-1 cell lines while aptamer-conjugated blank nps did not show any cytotoxicity which emphasizes on the sensitization capability of the foxm1 dna aptamer against non-small cell lung cancer. |
2021-08-11 |
2023-08-13 |
Not clear |
| Basma Emad Aboulhoda, Dina Adel Abdeltawab, Laila Ahmed Rashed, Marwa Fathi Abd Alla, Hanan Dawood Yass. Hepatotoxic Effect of Oral Zinc Oxide Nanoparticles and the Ameliorating Role of Selenium in Rats: A histological, immunohistochemical and molecular study. Tissue & cell. vol 67. 2021-08-03. PMID:32949962. |
the role of selenium in ameliorating the hepatotoxicity, oxidative stress injury, and apoptosis induced by zno-nps, along with its role in modulating the jnk/p38mapk and the stat-3 signalling and improving the histopathological hepatic changes, offers selenium as a promising adjunctive therapy in individuals subjected to high concentrations of zno nps especially in cases of extensive occupational, medicinal and industrial exposure. |
2021-08-03 |
2023-08-13 |
rat |
| Ying Xiao, Yuewen Gao, Fajuan Li, Zhihe Den. Combinational dual drug delivery system to enhance the care and treatment of gastric cancer patients. Drug delivery. vol 27. issue 1. 2021-07-28. PMID:33100060. |
furthermore, gem-cpt-11 nps induced significant apoptosis in human gastric nci-n87 and sgc-791 cancer cells |
2021-07-28 |
2023-08-13 |
human |
| Dihui Xu, Yuhan Ma, Xiaodong Han, Yabing Che. Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells. Journal of hazardous materials. vol 417. 2021-07-28. PMID:34015712. |
in the present study, we observed accumulation of polystyrene nps (ps nps) in mice spleen, lung, kidney, small intestine, large intestine, testis, and brain after oral exposure to ps nps (~100 nm, 10 mg/ml, 100 μl) for 28 days, and nps were identified to induce cell apoptosis, inflammation, and structure disorder in these tissues. |
2021-07-28 |
2023-08-13 |
mouse |
| Nemany A N Hanaf. Optimally designed theranostic system based folic acids and chitosan as a promising mucoadhesive delivery system for encapsulating curcumin LbL nano-template against invasiveness of breast cancer. International journal of biological macromolecules. vol 182. 2021-07-21. PMID:34058209. |
cur-lbl nps were then used to investigate drug release inside human mammary carcinoma (mcf-7 cell lines) after their incubations for 3 h, 6 h and 24 h. flow cytometry indicated that the percentages of apoptosis, necrosis and cell cycle arrest were increased significantly in mcf-7 cell lines treated by cur-lbl nps. |
2021-07-21 |
2023-08-13 |
human |
| Ying Zhang, Jing Zhao, Obaid Afzal, Imran Kazmi, Fahad A Al-Abbasi, Abdulmalik S A Altamimi, Zhen Yan. Neuroprotective role of chrysin-loaded poly(lactic-co-glycolic acid) nanoparticle against kindling-induced epilepsy through Nrf2/ARE/HO-1 pathway. Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-20. PMID:32991785. |
the result showed chrysin nps treatment has counteracted oxidative stress, reduced neuronal apoptosis, and upregulated nuclear factor erythroid 2-related factor 2 (nrf2), heme oxygenase-1 (ho-1), and nad(p)h quinone oxidoreductase 1. |
2021-07-20 |
2023-08-13 |
rat |
| Zhe Zho. Co-drug delivery of regorafenib and cisplatin with amphiphilic copolymer nanoparticles: enhanced Drug delivery. vol 27. issue 1. 2021-07-14. PMID:32936009. |
furthermore rego-pt nps induced significant apoptosis in human lung a549 and ovarian a2780 cancer cells by in vitro. |
2021-07-14 |
2023-08-13 |
human |
| Zhe Zho. Co-drug delivery of regorafenib and cisplatin with amphiphilic copolymer nanoparticles: enhanced Drug delivery. vol 27. issue 1. 2021-07-14. PMID:32936009. |
rego-pt nps induced significant apoptosis in human lung a549 and ovarian a2780 cancer cells by in vitro. |
2021-07-14 |
2023-08-13 |
human |
| Sheau-Fung Thai, Carlton P Jones, Brian L Robinette, Hongzu Ren, Beena Vallant, Anna Fisher, Kirk T Kitchi. Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells. Journal of nanoscience and nanotechnology. vol 21. issue 10. 2021-06-28. PMID:33875094. |
the most significantly altered genes and pathways by cu nps exposure were nrf2 (nuclear factor erythroid 2 related factor 2)-mediated oxidative stress response, protein ubiquitination, tumor protein p53 (p53), phase i and ii metabolizing enzymes, antioxidant proteins and phase iii detoxifying gene pathways.messenger rna-microrna interaction from microrna target filter analyses revealed more signaling pathways altered in cu nps treated samples than transcriptomics alone, including cell proliferation, dna methylation, endoplasmic reticulum (er) stress, apoptosis, autophagy, reactive oxygen species, inflammation, tumorigenesis, extracellular matrix/angiogenesis and protein synthesis. |
2021-06-28 |
2023-08-13 |
human |
| Jiaming Li, Lei Han, Siwen Zhan, Ran Li, Yaowen Wang, Tong Qiu, Xueqiong Zhan. 1-MT grafted carboxymethyl chitosan and its nanoparticles: Preparation, characterization and evaluation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 162. 2021-06-21. PMID:33819624. |
cmcs-ester-1-mt nps can activate the atf4/chop pathway in endoplasmic reticulum stress, and achieve cancer suppression through mitochondrial-related apoptosis. |
2021-06-21 |
2023-08-13 |
Not clear |
| Yu Cheng, Yuanhui J. Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancer treatment with enhanced cytotoxicity. Journal of controlled release : official journal of the Controlled Release Society. vol 318. 2021-06-17. PMID:31830542. |
the better in vitro potency of ptx-ss-bbr nps against a549 cells might be ascribed to the simultaneous drug release and mitochondria-targeting delivery, which dissipated mitochondria membrane potential, upregulated ros levels in cancer cells, arrested cells in phase g2/m, elicited apoptosis of cancer cells and inhibited the growth of tumors. |
2021-06-17 |
2023-08-13 |
Not clear |
| Yu Cheng, Yuanhui Ji, Jiwei Ton. Triple stimuli-responsive supramolecular nanoassembly with mitochondrial targetability for chemophotothermal therapy. Journal of controlled release : official journal of the Controlled Release Society. vol 327. 2021-06-17. PMID:32781173. |
the better therapy effect of cpt-ss-bbr/icg nps on a549 cells might be attributed to triply stimuli-responsive rapid disassembly, preferable accumulation into mitochondria and combined chemotherapy and photothermal therapy, all of which directly rendered the notable loss of mitochondria membrane potential, high level of reactive oxygen species in cancer cells, accelerated the apoptosis of cancer cells and repressed the growth of tumors. |
2021-06-17 |
2023-08-13 |
Not clear |
| Le Thi Minh Phuc, Akiyoshi Taniguch. Polystyrene Nanoparticles Induce Apoptosis or Necrosis With or Without Epidermal Growth Factor. Journal of nanoscience and nanotechnology. vol 19. issue 8. 2021-06-09. PMID:30913794. |
the results also suggested that without egf, ps nps internalized in the cells cause cell death by necrosis, whereas egf enhances the uptake ratio of ps nps, and ps nps in the cytoplasm together with egf-egfr complexes may inhibit receptors recycling, leading to apoptosis. |
2021-06-09 |
2023-08-13 |
human |
| Faizan Ahmed, Syed Mohammad Faisal, Anees Ahmed, Qayyum Husai. Beta galactosidase mediated bio-enzymatically synthesized nano-gold with aggrandized cytotoxic potential against pathogenic bacteria and cancer cells. Journal of photochemistry and photobiology. B, Biology. vol 209. 2021-06-07. PMID:32559647. |
cell nuclear morphology associated with apoptosis after treatment with nps was assessed against mcf-7 cells through 4,6-diamidino-2-phenylindole staining. |
2021-06-07 |
2023-08-13 |
human |
| Zhao-Hui Yu, Yi-Chao Ji, Kun Li, Ting Liang, Bo Liu, Hai-Lei Chen, Li Ni, Zong-Ping Luo, Hui-Lin Yan. Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein. Cellular signalling. vol 84. 2021-05-31. PMID:33862152. |
at the same time, mitochondria released cytochrome c (cyt c) and activated caspase proteins to promote the apoptosis of nps. |
2021-05-31 |
2023-08-13 |
Not clear |
| Yugang Xue, Guangwei Zeng, Jin Cheng, Jianqiang Hu, Mingming Zhang, Yan L. Engineered macrophage membrane-enveloped nanomedicine for ameliorating myocardial infarction in a mouse model. Bioengineering & translational medicine. vol 6. issue 2. 2021-05-26. PMID:34027086. |
we evaluate the effects of these nps on apoptosis and cell proliferation |
2021-05-26 |
2023-08-13 |
mouse |
| Jun Zhang, Jie Yang, Tiantian Zuo, Siyu Ma, Nadira Xokrat, Zongwei Hu, Zhihua Wang, Rui Xu, Yawen Wei, Qi She. Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy. Biomaterials. vol 266. 2021-05-24. PMID:33035717. |
dox and fc loaded in nlc/h(d + f + s) nps effectively enhanced intracellular ros level to activate ferroptosis pathway, the enhanced ros also induced the apoptosis pathway and decreased mmp-9 expression to synergize with ferroptosis for tumor therapy. |
2021-05-24 |
2023-08-13 |
Not clear |
| Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang, Jie Li. Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy. Biomaterials. vol 268. 2021-05-24. PMID:33271451. |
as the result, the highly elevated intracellular ros concentration can both directly induce apoptosis of ros-stressed tumor cells and magnify acceleration of the drug release from the ros-responsive peg-m-ppmt nps to gain extraordinary therapeutic efficacy. |
2021-05-24 |
2023-08-13 |
mouse |