| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Faizan Ahmed, Syed Mohammad Faisal, Anees Ahmed, Qayyum Husai. Beta galactosidase mediated bio-enzymatically synthesized nano-gold with aggrandized cytotoxic potential against pathogenic bacteria and cancer cells. Journal of photochemistry and photobiology. B, Biology. vol 209. 2021-06-07. PMID:32559647. |
cell nuclear morphology associated with apoptosis after treatment with nps was assessed against mcf-7 cells through 4,6-diamidino-2-phenylindole staining. |
2021-06-07 |
2023-08-13 |
human |
| Zhao-Hui Yu, Yi-Chao Ji, Kun Li, Ting Liang, Bo Liu, Hai-Lei Chen, Li Ni, Zong-Ping Luo, Hui-Lin Yan. Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein. Cellular signalling. vol 84. 2021-05-31. PMID:33862152. |
at the same time, mitochondria released cytochrome c (cyt c) and activated caspase proteins to promote the apoptosis of nps. |
2021-05-31 |
2023-08-13 |
Not clear |
| Yugang Xue, Guangwei Zeng, Jin Cheng, Jianqiang Hu, Mingming Zhang, Yan L. Engineered macrophage membrane-enveloped nanomedicine for ameliorating myocardial infarction in a mouse model. Bioengineering & translational medicine. vol 6. issue 2. 2021-05-26. PMID:34027086. |
we evaluate the effects of these nps on apoptosis and cell proliferation |
2021-05-26 |
2023-08-13 |
mouse |
| Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang, Jie Li. Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy. Biomaterials. vol 268. 2021-05-24. PMID:33271451. |
as the result, the highly elevated intracellular ros concentration can both directly induce apoptosis of ros-stressed tumor cells and magnify acceleration of the drug release from the ros-responsive peg-m-ppmt nps to gain extraordinary therapeutic efficacy. |
2021-05-24 |
2023-08-13 |
mouse |
| Jun Zhang, Jie Yang, Tiantian Zuo, Siyu Ma, Nadira Xokrat, Zongwei Hu, Zhihua Wang, Rui Xu, Yawen Wei, Qi She. Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy. Biomaterials. vol 266. 2021-05-24. PMID:33035717. |
dox and fc loaded in nlc/h(d + f + s) nps effectively enhanced intracellular ros level to activate ferroptosis pathway, the enhanced ros also induced the apoptosis pathway and decreased mmp-9 expression to synergize with ferroptosis for tumor therapy. |
2021-05-24 |
2023-08-13 |
Not clear |
| Zhian Chen, Yanrui Liang, Xiaoli Feng, Yu Liang, Guodong Shen, Huilin Huang, Zhaoyu Chen, Jiang Yu, Hao Liu, Tian Lin, Hao Chen, Dong Wu, Guoxin Li, Bingxia Zhao, Weihong Guo, Yanfeng H. Vitamin-B12-conjugated PLGA-PEG nanoparticles incorporating miR-532-3p induce mitochondrial damage by targeting apoptosis repressor with caspase recruitment domain (ARC) on CD320-overexpressed gastric cancer. Materials science & engineering. C, Materials for biological applications. vol 120. 2021-05-14. PMID:33545873. |
the plga-peg-vb12 nps with appropriate particle sizes and good bio-compatibility could be selectively delivered into cd320-overexpressed gc cells, and significantly decrease the expression of apoptosis repressor with caspase recruitment domain (arc). |
2021-05-14 |
2023-08-13 |
Not clear |
| Zhian Chen, Yanrui Liang, Xiaoli Feng, Yu Liang, Guodong Shen, Huilin Huang, Zhaoyu Chen, Jiang Yu, Hao Liu, Tian Lin, Hao Chen, Dong Wu, Guoxin Li, Bingxia Zhao, Weihong Guo, Yanfeng H. Vitamin-B12-conjugated PLGA-PEG nanoparticles incorporating miR-532-3p induce mitochondrial damage by targeting apoptosis repressor with caspase recruitment domain (ARC) on CD320-overexpressed gastric cancer. Materials science & engineering. C, Materials for biological applications. vol 120. 2021-05-14. PMID:33545873. |
therefore, our designed mir-532-3p@plga-peg-vb12 nps showed enhanced gc targeting ability, and could induce apoptosis through activating arc/bax/mitochondria-mediated apoptosis signaling pathway, finally remarkably suppressed proliferation of gc cells both in vitro and in vivo, which presented a promising treatment for gc. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chao Xin, Cuilin Cheng, Kexin Hou, Meili Bao, Hua Zhang, Zhenyu Wan. A novel melanin complex displayed the affinity to HepG2 cell membrane and nucleus. Materials science & engineering. C, Materials for biological applications. vol 122. 2021-05-14. PMID:33641916. |
interestingly, cmc displayed strong affinity for cell membrane by binding the phosphatidylserine, glycoprotein, glycolipids and glycosaminoglycans accumulated on the surface of tumor cells, notably, cmc nps could enter cells and mainly target the nucleus by interacting with dna and/or rna substrates located around the nucleus to disrupt the proliferation and apoptosis processes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Liuhui Zhang, Shiqiang Zhang, Mengxiong Li, Yamei Li, Haiyun Xiong, Donggen Jiang, Lujing Li, Hai Huang, Yang Kang, Jun Pan. Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy. Materials science & engineering. C, Materials for biological applications. vol 123. 2021-05-14. PMID:33812584. |
in vitro experiments showed that pcl-ss@dtx nps had robust prostate cancer cell cytotoxicity, induced cell apoptosis, inhibited cell migration and invasion and exhibited satisfactory biocompatibility. |
2021-05-14 |
2023-08-13 |
mouse |
| Liuhui Zhang, Shiqiang Zhang, Mengxiong Li, Yamei Li, Haiyun Xiong, Donggen Jiang, Lujing Li, Hai Huang, Yang Kang, Jun Pan. Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy. Materials science & engineering. C, Materials for biological applications. vol 123. 2021-05-14. PMID:33812584. |
in mice bearing orthotopic prostate cancer, pcl-ss@dtx nps could accumulate in orthotopic tumor sites and then significantly weaken tumor growth by inhibiting prostate cancer cell proliferation and inducing cell apoptosis, without obvious damages to major organs. |
2021-05-14 |
2023-08-13 |
mouse |
| Jiani Xie, Chengyan Wang, Ning Wang, Shuang Zhu, Linqiang Mei, Xiao Zhang, Yuan Yong, Lele Li, Chunying Chen, Changshui Huang, Zhanjun Gu, Yuliang Li, Yuliang Zha. Graphdiyne nanoradioprotector with efficient free radical scavenging ability for mitigating radiation-induced gastrointestinal tract damage. Biomaterials. vol 244. 2021-05-14. PMID:32200103. |
furthermore, we also deeply studied the gastrointestinal radioprotective mechanism of gdy-bsa nps, which indicated that the gdy-bsa nps effectively inhibited reactive oxygen species (ros)-induced apoptosis signal pathway, and thus reduced gastrointestinal cell apoptosis. |
2021-05-14 |
2023-08-13 |
mouse |
| Rui-Rui Zhao, Yi-Fan Fang, Zi-Xuan Chen, Jing-Qing Le, Long-Guang Jiang, Jing-Wei Sha. Self-assembled amphiphile-based nanoparticles for the inhibition of hepatocellular carcinoma metastasis via ICAM-1 mediated cell adhesion. Acta biomaterialia. vol 111. 2021-05-14. PMID:32413580. |
meanwhile, up12 and these therapeutic amphiphile-based nanoparticles could induce cell apoptosis more efficiently than that of ua and ua nps. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ya Wang, Jiayao Zhang, Xinyi Lv, Lei Wang, Zhihao Zhong, Da-Peng Yang, Weili Si, Ting Zhang, Xiaochen Don. Mitoxantrone as photothermal agents for ultrasound/fluorescence imaging-guided chemo-phototherapy enhanced by intratumoral H Biomaterials. vol 252. 2021-05-14. PMID:32422493. |
the nanoplatform encapsulating mto and manganese carbonyl (mnco), which denoted as mcma nps, could accumulate at tumor sites by enhanced permeability and retention (epr) effect and effectively induce cell apoptosis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jialong Fan, Bin Liu, Ying Long, Zhou Wang, Chunyi Tong, Wei Wang, Peidong You, Xuanming Li. Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. Acta biomaterialia. vol 113. 2021-05-14. PMID:32569637. |
in vivo assay indicated that the accumulation of gtdc@m-r nps in tumor sites increased about 2-fold compared to naked gtdc nps, which was accompanied by high tumor apoptosis rates through blocking chemotherapy-activated cyclooxygenase-2 (cox-2) and enhancing dox's anti-tumor activity of chemical drugs (85%). |
2021-05-14 |
2023-08-13 |
mouse |
| Wenting Cai, Qijing Chen, Tianyi Shen, Qian Yang, Weinan Hu, Peng Zhao, Jing Y. Intravenous anti-VEGF agents with RGD peptide-targeted core cross-linked star (CCS) polymers modified with indocyanine green for imaging and treatment of laser-induced choroidal neovascularization. Biomaterials science. vol 8. issue 16. 2021-05-14. PMID:32609105. |
there was no cellular toxicity, dead cells, apoptosis or genotoxicity in the studied concentration range in vitro; meanwhile, intravenous injection of the designed nps did not cause histological damage or apoptosis in the organs in vivo, including the heart, liver, spleen, lung, kidneys and brain. |
2021-05-14 |
2023-08-13 |
Not clear |
| Tong Yang, Shuangyu Yu, Lu Liu, Yue Sun, Yang Lan, Xueqin Ma, Rongyue Zhu, Li Li, Yanhui Hou, Yanhua Li. Dual polymeric prodrug co-assembled nanoparticles with precise ratiometric co-delivery of cisplatin and metformin for lung cancer chemoimmunotherapy. Biomaterials science. vol 8. issue 20. 2021-05-14. PMID:32930254. |
the synergistic effect of met and cddp in ha-cddp/pmet nps resulted in up-regulation of the cleaved poly(adp)-ribose polymerase (parp) protein to induce tumor cell apoptosis, and down-regulation of the excision repair cross-complementation group 1 (ercc1) protein level to decrease the resistance to cddp. |
2021-05-14 |
2023-08-13 |
mouse |
| Yang Liu, Jianqiu Jin, Hao Xu, Chao Wang, Yanping Yang, Yongjian Zhao, Haihui Han, Tong Hou, Guoliang Yang, Li Zhang, Yongjun Wang, Weian Zhang, Qianqian Lian. Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy. Acta biomaterialia. vol 121. 2021-05-14. PMID:33227489. |
in vitro tp@nps showed reduced cytotoxicity and cell apoptosis of treated raw264.7 cells compared to free tp. |
2021-05-14 |
2023-08-13 |
mouse |
| Ramesh Chaudhari, Pal Patel, Nikita Meghani, Simran Nasra, Ashutosh Kuma. Fabrication of methotrexate-loaded gold nanoconjugates and its enhanced anticancer activity in breast cancer. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927966. |
different assays like cell viability assay, cell cycle analysis, apoptosis, real-time pcr and western blot were carried out to evaluate the anti-cancer effect of mtx-gold nps on mcf-7 and mda-mb-231 cells. |
2021-05-02 |
2023-08-13 |
Not clear |
| Li-Xing Yang, Ya-Na Wu, Pei-Wen Wang, Kuang-Jing Huang, Wu-Chou Su, Dar-Bin Shie. Silver-coated zero-valent iron nanoparticles enhance cancer therapy in mice through lysosome-dependent dual programed cell death pathways: triggering simultaneous apoptosis and autophagy only in cancerous cells. Journal of materials chemistry. B. vol 8. issue 18. 2021-04-30. PMID:32267258. |
the assessment of the intracellular dynamics of iron species revealed that the uptake of zvi@ag was similar between cancerous cells and nonmalignant cells during the first 2 h; however, only cancerous cells rapidly converted nps into iron ions and generated large amounts of intracellular ros, which was followed by apoptosis and autophagy induction. |
2021-04-30 |
2023-08-13 |
mouse |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
the generation of reactive oxygen species (ros) and its involvement in apoptosis when hepg2 cells were exposed to qds (6 nm) and nps of different sizes (15-20, 50, and 100 nm) was also investigated. |
2021-04-29 |
2023-08-13 |
human |