| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya Wang, Jiayao Zhang, Xinyi Lv, Lei Wang, Zhihao Zhong, Da-Peng Yang, Weili Si, Ting Zhang, Xiaochen Don. Mitoxantrone as photothermal agents for ultrasound/fluorescence imaging-guided chemo-phototherapy enhanced by intratumoral H Biomaterials. vol 252. 2021-05-14. PMID:32422493. |
the nanoplatform encapsulating mto and manganese carbonyl (mnco), which denoted as mcma nps, could accumulate at tumor sites by enhanced permeability and retention (epr) effect and effectively induce cell apoptosis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jialong Fan, Bin Liu, Ying Long, Zhou Wang, Chunyi Tong, Wei Wang, Peidong You, Xuanming Li. Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. Acta biomaterialia. vol 113. 2021-05-14. PMID:32569637. |
in vivo assay indicated that the accumulation of gtdc@m-r nps in tumor sites increased about 2-fold compared to naked gtdc nps, which was accompanied by high tumor apoptosis rates through blocking chemotherapy-activated cyclooxygenase-2 (cox-2) and enhancing dox's anti-tumor activity of chemical drugs (85%). |
2021-05-14 |
2023-08-13 |
mouse |
| Wenting Cai, Qijing Chen, Tianyi Shen, Qian Yang, Weinan Hu, Peng Zhao, Jing Y. Intravenous anti-VEGF agents with RGD peptide-targeted core cross-linked star (CCS) polymers modified with indocyanine green for imaging and treatment of laser-induced choroidal neovascularization. Biomaterials science. vol 8. issue 16. 2021-05-14. PMID:32609105. |
there was no cellular toxicity, dead cells, apoptosis or genotoxicity in the studied concentration range in vitro; meanwhile, intravenous injection of the designed nps did not cause histological damage or apoptosis in the organs in vivo, including the heart, liver, spleen, lung, kidneys and brain. |
2021-05-14 |
2023-08-13 |
Not clear |
| Tong Yang, Shuangyu Yu, Lu Liu, Yue Sun, Yang Lan, Xueqin Ma, Rongyue Zhu, Li Li, Yanhui Hou, Yanhua Li. Dual polymeric prodrug co-assembled nanoparticles with precise ratiometric co-delivery of cisplatin and metformin for lung cancer chemoimmunotherapy. Biomaterials science. vol 8. issue 20. 2021-05-14. PMID:32930254. |
the synergistic effect of met and cddp in ha-cddp/pmet nps resulted in up-regulation of the cleaved poly(adp)-ribose polymerase (parp) protein to induce tumor cell apoptosis, and down-regulation of the excision repair cross-complementation group 1 (ercc1) protein level to decrease the resistance to cddp. |
2021-05-14 |
2023-08-13 |
mouse |
| Yang Liu, Jianqiu Jin, Hao Xu, Chao Wang, Yanping Yang, Yongjian Zhao, Haihui Han, Tong Hou, Guoliang Yang, Li Zhang, Yongjun Wang, Weian Zhang, Qianqian Lian. Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy. Acta biomaterialia. vol 121. 2021-05-14. PMID:33227489. |
in vitro tp@nps showed reduced cytotoxicity and cell apoptosis of treated raw264.7 cells compared to free tp. |
2021-05-14 |
2023-08-13 |
mouse |
| Zhian Chen, Yanrui Liang, Xiaoli Feng, Yu Liang, Guodong Shen, Huilin Huang, Zhaoyu Chen, Jiang Yu, Hao Liu, Tian Lin, Hao Chen, Dong Wu, Guoxin Li, Bingxia Zhao, Weihong Guo, Yanfeng H. Vitamin-B12-conjugated PLGA-PEG nanoparticles incorporating miR-532-3p induce mitochondrial damage by targeting apoptosis repressor with caspase recruitment domain (ARC) on CD320-overexpressed gastric cancer. Materials science & engineering. C, Materials for biological applications. vol 120. 2021-05-14. PMID:33545873. |
the plga-peg-vb12 nps with appropriate particle sizes and good bio-compatibility could be selectively delivered into cd320-overexpressed gc cells, and significantly decrease the expression of apoptosis repressor with caspase recruitment domain (arc). |
2021-05-14 |
2023-08-13 |
Not clear |
| Zhian Chen, Yanrui Liang, Xiaoli Feng, Yu Liang, Guodong Shen, Huilin Huang, Zhaoyu Chen, Jiang Yu, Hao Liu, Tian Lin, Hao Chen, Dong Wu, Guoxin Li, Bingxia Zhao, Weihong Guo, Yanfeng H. Vitamin-B12-conjugated PLGA-PEG nanoparticles incorporating miR-532-3p induce mitochondrial damage by targeting apoptosis repressor with caspase recruitment domain (ARC) on CD320-overexpressed gastric cancer. Materials science & engineering. C, Materials for biological applications. vol 120. 2021-05-14. PMID:33545873. |
therefore, our designed mir-532-3p@plga-peg-vb12 nps showed enhanced gc targeting ability, and could induce apoptosis through activating arc/bax/mitochondria-mediated apoptosis signaling pathway, finally remarkably suppressed proliferation of gc cells both in vitro and in vivo, which presented a promising treatment for gc. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chao Xin, Cuilin Cheng, Kexin Hou, Meili Bao, Hua Zhang, Zhenyu Wan. A novel melanin complex displayed the affinity to HepG2 cell membrane and nucleus. Materials science & engineering. C, Materials for biological applications. vol 122. 2021-05-14. PMID:33641916. |
interestingly, cmc displayed strong affinity for cell membrane by binding the phosphatidylserine, glycoprotein, glycolipids and glycosaminoglycans accumulated on the surface of tumor cells, notably, cmc nps could enter cells and mainly target the nucleus by interacting with dna and/or rna substrates located around the nucleus to disrupt the proliferation and apoptosis processes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Liuhui Zhang, Shiqiang Zhang, Mengxiong Li, Yamei Li, Haiyun Xiong, Donggen Jiang, Lujing Li, Hai Huang, Yang Kang, Jun Pan. Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy. Materials science & engineering. C, Materials for biological applications. vol 123. 2021-05-14. PMID:33812584. |
in vitro experiments showed that pcl-ss@dtx nps had robust prostate cancer cell cytotoxicity, induced cell apoptosis, inhibited cell migration and invasion and exhibited satisfactory biocompatibility. |
2021-05-14 |
2023-08-13 |
mouse |
| Liuhui Zhang, Shiqiang Zhang, Mengxiong Li, Yamei Li, Haiyun Xiong, Donggen Jiang, Lujing Li, Hai Huang, Yang Kang, Jun Pan. Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy. Materials science & engineering. C, Materials for biological applications. vol 123. 2021-05-14. PMID:33812584. |
in mice bearing orthotopic prostate cancer, pcl-ss@dtx nps could accumulate in orthotopic tumor sites and then significantly weaken tumor growth by inhibiting prostate cancer cell proliferation and inducing cell apoptosis, without obvious damages to major organs. |
2021-05-14 |
2023-08-13 |
mouse |
| Ramesh Chaudhari, Pal Patel, Nikita Meghani, Simran Nasra, Ashutosh Kuma. Fabrication of methotrexate-loaded gold nanoconjugates and its enhanced anticancer activity in breast cancer. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927966. |
different assays like cell viability assay, cell cycle analysis, apoptosis, real-time pcr and western blot were carried out to evaluate the anti-cancer effect of mtx-gold nps on mcf-7 and mda-mb-231 cells. |
2021-05-02 |
2023-08-13 |
Not clear |
| Li-Xing Yang, Ya-Na Wu, Pei-Wen Wang, Kuang-Jing Huang, Wu-Chou Su, Dar-Bin Shie. Silver-coated zero-valent iron nanoparticles enhance cancer therapy in mice through lysosome-dependent dual programed cell death pathways: triggering simultaneous apoptosis and autophagy only in cancerous cells. Journal of materials chemistry. B. vol 8. issue 18. 2021-04-30. PMID:32267258. |
the assessment of the intracellular dynamics of iron species revealed that the uptake of zvi@ag was similar between cancerous cells and nonmalignant cells during the first 2 h; however, only cancerous cells rapidly converted nps into iron ions and generated large amounts of intracellular ros, which was followed by apoptosis and autophagy induction. |
2021-04-30 |
2023-08-13 |
mouse |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
the generation of reactive oxygen species (ros) and its involvement in apoptosis when hepg2 cells were exposed to qds (6 nm) and nps of different sizes (15-20, 50, and 100 nm) was also investigated. |
2021-04-29 |
2023-08-13 |
human |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
quantitative real-time pcr data showed that the mrna levels of apoptotic marker genes such as p53, bax, and caspase-3 were upregulated, whereas bcl-2, an anti-apoptotic gene, was downregulated; therefore, apoptosis was mediated through the p53, bax, caspase-3, and bcl-2 pathways, suggesting a possible mechanism by which qds and nps of zno mediate their toxicity.graphic abstract. |
2021-04-29 |
2023-08-13 |
human |
| Yu Yan, Guang Wang, Xin Luo, Ping Zhang, Shuang Peng, Xin Cheng, Mengwei Wang, Xuesong Yan. Endoplasmic reticulum stress-related calcium imbalance plays an important role on Zinc oxide nanoparticles-induced failure of neural tube closure during embryogenesis. Environment international. vol 152. 2021-04-26. PMID:33730632. |
in this study, we discovered that zno nps exposure caused growth proportional failure of neural tube closure in mouse and chicken embryos and a simultaneous increase in apoptosis in the developing neural tubes of chicken embryos, which was verified in an in vitro experiment using the sh-sy5y cell line. |
2021-04-26 |
2023-08-13 |
mouse |
| Yawei Li, Yu Song, Wei Zhang, Junjie Xu, Jiancheng Hou, Xianmin Feng, Wenhe Zh. MOF nanoparticles with encapsulated dihydroartemisinin as a controlled drug delivery system for enhanced cancer therapy and mechanism analysis. Journal of materials chemistry. B. vol 8. issue 33. 2021-04-05. PMID:32648887. |
the results indicate that dha@zif-8 nps modify the expression of 7090 genes in hepg2 cells, and the mechanism may be related to the induction of apoptosis through a p53-mediated mitochondrial pathway and the suppression of glycolysis by inhibiting the pi3k/akt pathway. |
2021-04-05 |
2023-08-13 |
Not clear |
| Jiacheng Wang, Wenshu Qiao, Xu Li, Haitian Zhao, Hua Zhang, Aijun Dong, Xin Yan. A directed co-assembly of herbal small molecules into carrier-free nanodrugs for enhanced synergistic antitumor efficacy. Journal of materials chemistry. B. vol 9. issue 4. 2021-04-01. PMID:33392615. |
not only do co-assembled nps have rapid cellular uptake ability and passive targeting tumor ability based on the epr effect, but also their constituent units could arrest the cell cycle at different stages of tumor cells and induce apoptosis, showing synergistic anti-tumor effects (ci < 0.7). |
2021-04-01 |
2023-08-13 |
Not clear |
| Sanyog Jain, Mahesh R Desai, Bhargavi Nallamothu, Kaushik Kuche, Dasharath Chaudhari, Sameer S Katiya. Partial inclusion complex assisted crosslinked β-cyclodextrin nanoparticles for improving therapeutic potential of docetaxel against breast cancer. Drug delivery and translational research. 2021-03-28. PMID:33774776. |
increased cell uptake (~5-fold), cytotoxicity (~3.3-fold), and apoptosis were observed in mda-mb-231 cells when treated with dtx β-cd nps in comparison to free dtx. |
2021-03-28 |
2023-08-13 |
Not clear |
| Bashir Ahmad, Yaser Gamallat, Muhammad Fiaz Khan, Syed Riaz Din, Muhammad Israr, Manzoor Ahmad, Naeem Tahir, Nasir Azam, Khalil Ur Rahman, Wang Xin, Wang Zexu, Peng Linjie, Pengyu Su, Wang Lian. Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis. OncoTargets and therapy. vol 14. 2021-03-20. PMID:33732000. |
nps cure cancer by regulating different pathways, such as pi3k/akt/mtor, er stress, jnk, wnt, stat3, mapks, nf-kb, mek-erk, inflammation, oxidative stress, apoptosis, autophagy, mitophagy, and necroptosis. |
2021-03-20 |
2023-08-13 |
Not clear |
| Vivek K Chaturvedi, Navneet Yadav, Neeraj K Rai, Raghvendra A Bohara, Sachchida Nand Rai, Lotfi Aleya, Mohan P Sing. Two birds with one stone: oyster mushroom mediated bimetallic Au-Pt nanoparticles for agro-waste management and anticancer activity. Environmental science and pollution research international. vol 28. issue 11. 2021-03-18. PMID:33196993. |
furthermore, we examined the cytotoxic activity of au-pt nps using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) assay, intracellular reactive oxygen species (ros) generation, and apoptosis by propidium iodide assay. |
2021-03-18 |
2023-08-13 |
human |