| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mi Ja Chung, Paul A Walker, Ray W Brown, Christer Hogstran. ZINC-mediated gene expression offers protection against H2O2-induced cytotoxicity. Toxicology and applied pharmacology. vol 205. issue 3. 2005-08-02. PMID:15922008. |
pretreatment with zinc protected the cells from subsequent cell damage and apoptosis, as assessed by lactate dehydrogenase leakage, mitochondrial dehydrogenase activity (mtt assay), caspase-3 activity, and dna fragmentation. |
2005-08-02 |
2023-08-12 |
Not clear |
| S Mijatovic, D Maksimovic-Ivanic, J Radovic, D Miljkovic, G N Kaludjerovic, T J Sabo, V Trajkovi. Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. Cellular and molecular life sciences : CMLS. vol 62. issue 11. 2005-07-28. PMID:15905960. |
the protective effect of ae was demonstrated by mtt and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of dna fragmentation or phosphatidylserine exposure. |
2005-07-28 |
2023-08-12 |
Not clear |
| Gautam Banerjee, Nishma Gupta, Arun Kapoor, Govindarajan Rama. UV induced bystander signaling leading to apoptosis. Cancer letters. vol 223. issue 2. 2005-07-21. PMID:15896462. |
human keratinocytes (hacat) were exposed to uv (a+b) (uva-350-400 mj/cm2 and uvb-30 mj/cm2) which induces apoptosis as evidenced by mtt assay, dna laddering, bax and fas up-regulation. |
2005-07-21 |
2023-08-12 |
human |
| J Subhashini, S V K Mahipal, P Reddann. Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. Cancer letters. vol 224. issue 1. 2005-07-19. PMID:15911099. |
celecoxib thus potentiates apoptosis as shown by mtt assay, cytochrome c leakage, parp cleavage, dna fragmentation, bcl-2 downregulation and possibly by inhibiting nf-kb activation. |
2005-07-19 |
2023-08-12 |
human |
| Ho-Joong Youn, Ho-Shik Kim, Mi-Hee Jeon, Jung-Hee Lee, Yun-Jee Seo, Yong-Joon Lee, Jeong-Hwa Le. Induction of caspase-independent apoptosis in H9c2 cardiomyocytes by adriamycin treatment. Molecular and cellular biochemistry. vol 270. issue 1-2. 2005-07-11. PMID:15792349. |
in contrast, caspase inhibition effectively blocked the apoptosis induced by h202 in h9c2 cells, as determined by an mtt assay or microscopy. |
2005-07-11 |
2023-08-12 |
Not clear |
| N Strakova, J Ehrmann, J Bartos, J Malikova, J Dolezel, Z Kola. Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors. Neoplasma. vol 52. issue 2. 2005-06-21. PMID:15800711. |
mtt, flow cytometry, tunel assay and immunoblotting were used for detection of changes in cell viability, proliferation, differentiation and apoptosis. |
2005-06-21 |
2023-08-12 |
human |
| Iwona Mitrus, Ewa Missol-Kolka, Andrzej Plucienniczak, Stanislaw Szal. Tumour therapy with genes encoding apoptin and E4orf4. Anticancer research. vol 25. issue 2A. 2005-06-09. PMID:15868950. |
mtt and tunel tests confirmed that both the synthesised apoptin gene and the e4orf4 gene indeed induced apoptosis in cos-7, renca and b16(f10) cell lines. |
2005-06-09 |
2023-08-12 |
Not clear |
| Fiorenza Minervini, Francesca Fornelli, Giacomo Lucivero, Ciro Romano, Angelo Viscont. T-2 toxin immunotoxicity on human B and T lymphoid cell lines. Toxicology. vol 210. issue 1. 2005-05-27. PMID:15804460. |
at a t-2 concentration of 0.01 microg/ml, apoptosis was seen in molt-4 cells by annexin v binding as early as after 4 h. t-2 toxin determined sustained (48 h) immunosuppression on both cell lines, as evaluated by brdu and mtt assays. |
2005-05-27 |
2023-08-12 |
human |
| Zoltán Marcsek, Zsuzsanna Kocsis, Mátyás Jakab, Béla Szende, Anna Tomp. The efficacy of tamoxifen in estrogen receptor-positive breast cancer cells is enhanced by a medical nutriment. Cancer biotherapy & radiopharmaceuticals. vol 19. issue 6. 2005-05-26. PMID:15665622. |
cytotoxicity was measured by mtt assay, the percentage of mitoses and apoptotic cells was determined morphologically, apoptosis and s-phase was measured by flow cytometry, and estrogen-receptor activity was determined by semiquantitative measurement of the estrogen-responsive ps2 gene mrna production. |
2005-05-26 |
2023-08-12 |
human |
| Erik Hankø, Thor Willy Ruud Hansen, Runar Almaas, Julie Lindstad, Terje Rootwel. Bilirubin induces apoptosis and necrosis in human NT2-N neurons. Pediatric research. vol 57. issue 2. 2005-05-24. PMID:15611354. |
we exposed a human teratocarcinoma-derived cell line, nt2-n neurons, to different concentrations of ucb and albumin at a 1.5 molar ratio and used multiple, independent measures of cell damage to evaluate neuronal injury after 6, 24, and 48 h. low doses of ucb (0.66, 2, and 5 microm) induced a moderate loss of 3-4[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide (mtt) cleavage accompanied by delayed morphologic changes consistent with apoptosis (2 and 5 microm). |
2005-05-24 |
2023-08-12 |
human |
| Erik Hankø, Thor Willy Ruud Hansen, Runar Almaas, Julie Lindstad, Terje Rootwel. Bilirubin induces apoptosis and necrosis in human NT2-N neurons. Pediatric research. vol 57. issue 2. 2005-05-24. PMID:15611354. |
moderate concentrations of ucb (10 and 25 microm) resulted in early (6 h) necrosis in a subset of neurons, while remaining neurons underwent progressive impairment of mtt cleavage and increasing lactate dehydrogenase (ldh) release accompanied by predominantly delayed apoptosis. |
2005-05-24 |
2023-08-12 |
human |
| Erik Hankø, Thor Willy Ruud Hansen, Runar Almaas, Julie Lindstad, Terje Rootwel. Bilirubin induces apoptosis and necrosis in human NT2-N neurons. Pediatric research. vol 57. issue 2. 2005-05-24. PMID:15611354. |
high concentrations of ucb (100 microm) induced severe impairment of mtt cleavage, extensive ldh release, and morphologic changes consistent with necrosis within 6 h. used as a positive control for apoptosis, 2 microm sts induced progressive impairment of mtt cleavage and morphologic changes consistent with apoptosis over the entire observation period. |
2005-05-24 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, Nikos Katsaros, Maroulio Talieri, Andreas Scorila. mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biological chemistry. vol 385. issue 11. 2005-05-17. PMID:15576332. |
the kinetics of apoptosis induction and cell toxicity was investigated by dna laddering and by the mtt method, respectively. |
2005-05-17 |
2023-08-12 |
human |
| Stephen Hsu, Kajuana Farrey, John Wataha, Jill Lewis, James Borke, Baldev Singh, Haiyan Qin, Carol Lapp, David Lapp, Tuan Nguyen, George Schuste. Role of p21WAF1 in green tea polyphenol-induced growth arrest and apoptosis of oral carcinoma cells. Anticancer research. vol 25. issue 1A. 2005-05-16. PMID:15816520. |
the current study determined the impact of sirna-suppressed p21waf1 and its response to egcg on cell growth, dna synthesis and apoptosis by rt-pcr, western blot, brdu incorporation, mtt and caspase 3 activity assays. |
2005-05-16 |
2023-08-12 |
Not clear |
| Ajay K Yadav, Bholanath N Paul, Sita Naik, Ashok K Saxena, Devendra Kumar Pate. Human hemoglobin shares bioactivities ascribed to human tumor necrosis factor-alpha. Immunopharmacology and immunotoxicology. vol 26. issue 4. 2005-05-11. PMID:15658605. |
both species of hemoglobin, hemoglobin a2 and hemoglobin a0 induced apoptosis and cytotoxicity in u937 cell as measured by flow cytometry and 3-(4,5-dihydro-6-(4-(3,4-dimethoxybenzooyl)-1-piperazinyl)-2(1h)-quinoline (mtt) assay respectively. |
2005-05-11 |
2023-08-12 |
human |
| Nicole M Chandler, Jonathan J Canete, Mark P Caller. Caspase-3 drives apoptosis in pancreatic cancer cells after treatment with gemcitabine. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 8. issue 8. 2005-05-05. PMID:15585396. |
proliferation was measured by mtt assay and apoptosis by propidium iodine staining. |
2005-05-05 |
2023-08-12 |
Not clear |
| Hye Joung Choi, Song-Ja Bae, Nam Deuk Kim, Jee H Jung, Yung Hyun Cho. Induction of apoptosis by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., in human skin melanoma cells. International journal of molecular medicine. vol 14. issue 6. 2005-04-28. PMID:15547680. |
exposure of sk-mel-2 cells to dideoxypetrosynol a resulted in growth inhibition and induction of apoptosis in a dose-dependent manner as measured by mtt assay, fluorescent microscopy and flow cytometry analysis. |
2005-04-28 |
2023-08-12 |
human |
| Zhi-Hua Yin, Cai-Ping Ren, Feng Li, Xu-Yu Yang, Hui Li, Ming Zhao, Kai-Tai Ya. Suppression of bcl-2 gene by RNA interference increases chemosensitivity to cisplatin in nasopharyngeal carcinoma cell line CNE1. Acta biochimica et biophysica Sinica. vol 36. issue 11. 2005-04-18. PMID:15514848. |
the effect of suppressing bcl-2 by rnai on cell growth was studied, the apoptosis induction and the sensitization of cne1 cells to cisplatin were quantified by mtt assays and flow cytometry. |
2005-04-18 |
2023-08-12 |
Not clear |
| Ting Zhang, Xiaolan Chen, Lingbo Qu, Jinglan Wu, Ran Cui, Yufen Zha. Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Bioorganic & medicinal chemistry. vol 12. issue 23. 2005-04-13. PMID:15519155. |
the proliferation and apoptosis were detected using mtt assay, hcl denatured-methyl green-pyronin staining, pcna immunohistochemistry and tunel techniques. |
2005-04-13 |
2023-08-12 |
human |
| G G Chen, N-C Liang, J F Y Lee, U P F Chan, S H Wang, B C S Leung, K L Leun. Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. Apoptosis : an international journal on programmed cell death. vol 9. issue 5. 2005-04-12. PMID:15314290. |
the result demonstrated that 5f significantly induced apoptosis of ht-29, as shown by mtt assay and dna fragmentation measurement. |
2005-04-12 |
2023-08-12 |
human |