| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuerui Zhou, Xiuling Zhi, Ping Zhou, Sifeng Chen, Fengdi Zhao, Zhimin Shao, Zhouluo Ou, Lianhua Yi. Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo. Oncology reports. vol 17. issue 6. 2007-08-17. PMID:17487388. |
cell growth curve, cell cycle and apoptosis were observed with mtt assays and flow cytometry, respectively. |
2007-08-17 |
2023-08-12 |
mouse |
| Takashi Kumagai, Naoki Wakimoto, Dong Yin, Sigal Gery, Norihiko Kawamata, Noriyuki Takai, Naoki Komatsu, Alexy Chumakov, Yasufumi Imai, H Phillip Koeffle. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. International journal of cancer. vol 121. issue 3. 2007-08-16. PMID:17417771. |
saha inhibited the growth of 6 pancreatic cancer cell lines in a dose-dependent manner as measured by mtt and clonogenic assays (ed(50) approximately 10(-6) m) associated with induction of apoptosis, g2 cell cycle arrest and also induced differentiation as indicated by morphology and increased expression of cytokeratin 7. |
2007-08-16 |
2023-08-12 |
human |
| John H Stewart, Thai-Lan Tran, Nicole Levi, Wilson S Tsai, David S Schrump, Dao M Nguye. The essential role of the mitochondria and reactive oxygen species in Cisplatin-mediated enhancement of fas ligand-induced apoptosis in malignant pleural mesothelioma. The Journal of surgical research. vol 141. issue 1. 2007-08-09. PMID:17574045. |
cell viability and apoptosis were determined by mtt and terminal deoxynucleotidyl transferase-mediated dutp nick end labeling assays. |
2007-08-09 |
2023-08-12 |
mouse |
| G K Jayaprakasha, K K Mandadi, Shibu M Poulose, Y Jadegoud, G A Nagana Gowda, Bhimanagouda S Pati. Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf. Bioorganic & medicinal chemistry. vol 15. issue 14. 2007-08-08. PMID:17512744. |
cell proliferation and induction of apoptosis were determined by mtt assay and nuclear staining. |
2007-08-08 |
2023-08-12 |
human |
| Wuzhong Jiang, Yuping Liao, Suping Zhao, Bihong Wu, Rongrong Zhou, Rui Wei, Jing Zhang, Yuxiang He, Haijun W. Role of enhanced radiosensitivity and the tumor-specific suicide gene vector in gene therapy of nasopharyngeal carcinoma. Journal of radiation research. vol 48. issue 3. 2007-07-11. PMID:17464096. |
hoechst33258 staining of the nuclei and methylthiazolyl tetrazolium(mtt) assay were applied to detect apoptosis and cell survivability, respectively. |
2007-07-11 |
2023-08-12 |
mouse |
| Wei-Ping Mao, Ji-Lin Ye, Zheng-Bing Guan, Jie-Ming Zhao, Chao Zhang, Na-Na Zhang, Ping Jiang, Ting Tia. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 3. 2007-06-07. PMID:17052885. |
studies of morphology and oligonucleosomal dna fragmentation demonstrated that 30-60 microm cd induced apoptosis as early as 6-9h with strong effects on mtt activity, whereas 120 microm cd revealed mainly necrosis, and the result of flow cytometry confirmed it. |
2007-06-07 |
2023-08-12 |
human |
| Fu-Ming Tsai, Rong-Yaun Shyu, Shun-Yuan Jian. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Cellular signalling. vol 19. issue 5. 2007-06-06. PMID:17196792. |
expression of wild-type or golgi-targeted rig1 for 24 h induced cellular apoptosis in htta cells, as assessed by mtt assay, the release of lactate dehydrogenase, and chromatin condensation. |
2007-06-06 |
2023-08-12 |
Not clear |
| Mala Chauhan, Kakoli Banerjee, Farukh Arjman. DNA binding studies of novel Copper(II) complexes containing L-tryptophan as chiral auxiliary: in vitro antitumor activity of Cu-Sn2 complex in human neuroblastoma cells. Inorganic chemistry. vol 46. issue 8. 2007-06-04. PMID:17378549. |
to evaluate the mechanistic pathway of dna inhibition, counting experiments and mtt assay were employed to assess the induction of apoptosis by 1. |
2007-06-04 |
2023-08-12 |
human |
| Hyun-Ja Jeong, Su-Jin Kim, Phil-Dong Moon, Na-Hyun Kim, Jung-Sun Kim, Rae-Kil Park, Min-Sun Kim, Byung-Rim Park, Sejin Jeong, Jae-Young Um, Hyung-Min Kim, Seung-Heon Hon. Antiapoptotic mechanism of cannabinoid receptor 2 agonist on cisplatin-induced apoptosis in the HEI-OC1 auditory cell line. Journal of neuroscience research. vol 85. issue 4. 2007-05-22. PMID:17183590. |
by using mtt assay, dna fragmentation, and facs analysis, we demonstrated that apoptosis induced by cisplatin was inhibited by treatment with jwh-015 in a dose-dependent manner. |
2007-05-22 |
2023-08-12 |
Not clear |
| Zhuan-Hua Wang, Li Gao, Yu-Ying Li, Zheng Zhang, Jing-Ming Yuan, Hong-Wei Wang, Li Zhang, Lei Zh. Induction of apoptosis by buckwheat trypsin inhibitor in chronic myeloid leukemia K562 cells. Biological & pharmaceutical bulletin. vol 30. issue 4. 2007-05-22. PMID:17409520. |
here, the possible effects of a recombinant buckwheat trypsin inhibitor (rbti) on the induction of apoptosis of the human k562 cell line were investigated by mtt (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays and flow cytometric analysis. |
2007-05-22 |
2023-08-12 |
human |
| Jing J Wang, Barbara J S Sanderson, He Wan. Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutation research. vol 628. issue 2. 2007-05-14. PMID:17223607. |
the cytotoxicity and genotoxicity of uf-tio(2) were investigated using the methyl tetrazolium cytotoxicity (mtt) assay, the population growth assay, the apoptosis assay by flow cytometry, the cytokinesis block micronucleus (cbmn) assay, the comet assay, and the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene mutation assay. |
2007-05-14 |
2023-08-12 |
human |
| Ikusuke Hatsukari, Naoko Hitosugi, Rie Ohno, Ken Hashimoto, Shinichi Nakamura, Kazue Satoh, Hiroshi Nagasaka, Isao Matsumoto, Hiroshi Sakagam. Induction of apoptosis by morphine in human tumor cell lines in vitro. Anticancer research. vol 27. issue 2. 2007-05-10. PMID:17465212. |
cytotoxicity was tested by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) assay, induction of early apoptosis and necrosis by fluorescence-activated cell sorter (facs) analysis with annexin v and propidium iodide (pi), activation of caspase -2, -3, -8 and -9 by cleavage of specific substrates, dna fragmentation by agarose gel electrophoresis, radical intensity and o2- scavenging activity by esr spectroscopy. |
2007-05-10 |
2023-08-12 |
human |
| Graziella Bellone, Anna Carbone, Valeria Busso, Tiziana Scirelli, Alessandra Buffolino, Carlo Smirne, Anna Novarino, Oscar Bertetto, Luciano Tosetti, Giorgio Emanuell. Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line Capan-2. Cancer biology & therapy. vol 5. issue 10. 2007-05-03. PMID:16929163. |
we measured in-vitro growth inhibition, cell cycle distribution, gene and protein expression of apoptosis regulators bcl-2, bcl-x and survivin, nfkappab and telomerase activities of human pancreatic carcinoma cell line capan-2 following exposure to gem and 5-fu singly or combined, by mtt assay and median effect analysis, flow cytometry, real-time rt-pcr, western blotting, electrophoretic mobility shift assay (emsa) and telomeric repeat amplification protocol (trap) assay, respectively. |
2007-05-03 |
2023-08-12 |
human |
| Masakatsu Fukuda, Shin Tanaka, Seiji Suzuki, Kaoru Kusama, Tadayoshi Kaneko, Hideaki Sakashit. Cimetidine induces apoptosis of human salivary gland tumor cells. Oncology reports. vol 17. issue 3. 2007-05-02. PMID:17273750. |
expression of both ncam mrna and protein was found to decrease in a dose-dependent manner upon treatment with cimetidine for 24 h. the mtt assay and confocal laser microscopy clearly showed that hsg cells underwent apoptosis after treatment with cimetidine. |
2007-05-02 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, Dimitra Florou, Maroulio Talieri, Andreas Scorila. Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide. Annals of the New York Academy of Sciences. vol 1090. 2007-04-26. PMID:17384250. |
the kinetics of apoptosis induction and cell toxicity was evaluated by dna laddering and mtt method, respectively. |
2007-04-26 |
2023-08-12 |
human |
| Apichart Nanakin, Hirokazu Fukui, Shigehiko Fujii, Akira Sekikawa, Naoki Kanda, Hiroshi Hisatsune, Hiroshi Seno, Yoshitaka Konda, Takahiro Fujimori, Tsutomu Chib. Expression of the REG IV gene in ulcerative colitis. Laboratory investigation; a journal of technical methods and pathology. vol 87. issue 3. 2007-04-24. PMID:17260007. |
the effects of reg iv gene induction on cell growth and h(2)o(2)-induced apoptosis were examined in dld-1 cells by mtt and tunel assays, respectively. |
2007-04-24 |
2023-08-12 |
Not clear |
| Thomas R Zilz, Helen R Griffiths, Michael D Colema. Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH. Toxicology. vol 231. issue 2-3. 2007-04-17. PMID:17229511. |
with flow cytometry analysis, all three hexanediones showed increases in apoptosis within their respective concentration ranges of toxicity shown previously by mtt. |
2007-04-17 |
2023-08-12 |
human |
| Ji-Lin Peng, Sha Wu, Xiao-Ping Zhao, Min Wang, Wen-Han Li, Xin Shen, Jing Liu, Ping Lei, Hui-Fen Zhu, Guan-Xin She. Downregulation of transferrin receptor surface expression by intracellular antibody. Biochemical and biophysical research communications. vol 354. issue 4. 2007-04-17. PMID:17266924. |
further cell growth and apoptosis characteristics were evaluated by cell cycle analysis, nuclei staining and mtt assay. |
2007-04-17 |
2023-08-12 |
Not clear |
| Pasi I Jalava, Raimo O Salonen, Arto S Pennanen, Markus Sillanpää, Arja I Hälinen, Mikko S Happo, Risto Hillamo, Bert Brunekreef, Klea Katsouyanni, Jordi Sunyer, Maija-Riitta Hirvone. Heterogeneities in inflammatory and cytotoxic responses of RAW 264.7 macrophage cell line to urban air coarse, fine, and ultrafine particles from six European sampling campaigns. Inhalation toxicology. vol 19. issue 3. 2007-04-17. PMID:17365026. |
mouse raw 264.7 macrophages were exposed to the samples for 24 h. selected inflammatory mediators, nitric oxide (no) and cytokines (tumor necrosis factor alpha [tnfalpha], interleukin 6 [il-6], macrophage inflammatory protein-2 [mip-2]), were measured together with cytotoxicity (mtt test), and analysis of apoptosis and cell cycle (propidium iodide staining). |
2007-04-17 |
2023-08-12 |
mouse |
| b' J Mal\\xc3\\xadkov\\xc3\\xa1, A Zdarilov\\xc3\\xa1, A Hlobilkov\\xc3\\xa1, J Ulrichov\\xc3\\xa. The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine. Cell biology and toxicology. vol 22. issue 6. 2007-04-12. PMID:16964588.' |
che and sa treatment of cell lines for 24 h resulted in (1) inhibition of cell viability in a dose-dependent manner in all tested cells (as evaluated by mtt test and bromodeoxyuridine incorporation assay); (2) dose-dependent increase in dna damage in all tested cells (as evaluated by dna comet assay); (3) changes in apoptosis (assessed by western blot analysis and tunel assay); and (4) significant induction of cyclin kinase inhibitors p21(waf1/cip1) and p27(kip1) in prostate cancer cells (identified by western blot analysis). |
2007-04-12 |
2023-08-12 |
human |