| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masakatsu Fukuda, Shin Tanaka, Seiji Suzuki, Kaoru Kusama, Tadayoshi Kaneko, Hideaki Sakashit. Cimetidine induces apoptosis of human salivary gland tumor cells. Oncology reports. vol 17. issue 3. 2007-05-02. PMID:17273750. |
expression of both ncam mrna and protein was found to decrease in a dose-dependent manner upon treatment with cimetidine for 24 h. the mtt assay and confocal laser microscopy clearly showed that hsg cells underwent apoptosis after treatment with cimetidine. |
2007-05-02 |
2023-08-12 |
human |
| Kostas V Floros, Hellinida Thomadaki, Dimitra Florou, Maroulio Talieri, Andreas Scorila. Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide. Annals of the New York Academy of Sciences. vol 1090. 2007-04-26. PMID:17384250. |
the kinetics of apoptosis induction and cell toxicity was evaluated by dna laddering and mtt method, respectively. |
2007-04-26 |
2023-08-12 |
human |
| Apichart Nanakin, Hirokazu Fukui, Shigehiko Fujii, Akira Sekikawa, Naoki Kanda, Hiroshi Hisatsune, Hiroshi Seno, Yoshitaka Konda, Takahiro Fujimori, Tsutomu Chib. Expression of the REG IV gene in ulcerative colitis. Laboratory investigation; a journal of technical methods and pathology. vol 87. issue 3. 2007-04-24. PMID:17260007. |
the effects of reg iv gene induction on cell growth and h(2)o(2)-induced apoptosis were examined in dld-1 cells by mtt and tunel assays, respectively. |
2007-04-24 |
2023-08-12 |
Not clear |
| Thomas R Zilz, Helen R Griffiths, Michael D Colema. Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH. Toxicology. vol 231. issue 2-3. 2007-04-17. PMID:17229511. |
with flow cytometry analysis, all three hexanediones showed increases in apoptosis within their respective concentration ranges of toxicity shown previously by mtt. |
2007-04-17 |
2023-08-12 |
human |
| Ji-Lin Peng, Sha Wu, Xiao-Ping Zhao, Min Wang, Wen-Han Li, Xin Shen, Jing Liu, Ping Lei, Hui-Fen Zhu, Guan-Xin She. Downregulation of transferrin receptor surface expression by intracellular antibody. Biochemical and biophysical research communications. vol 354. issue 4. 2007-04-17. PMID:17266924. |
further cell growth and apoptosis characteristics were evaluated by cell cycle analysis, nuclei staining and mtt assay. |
2007-04-17 |
2023-08-12 |
Not clear |
| Pasi I Jalava, Raimo O Salonen, Arto S Pennanen, Markus Sillanpää, Arja I Hälinen, Mikko S Happo, Risto Hillamo, Bert Brunekreef, Klea Katsouyanni, Jordi Sunyer, Maija-Riitta Hirvone. Heterogeneities in inflammatory and cytotoxic responses of RAW 264.7 macrophage cell line to urban air coarse, fine, and ultrafine particles from six European sampling campaigns. Inhalation toxicology. vol 19. issue 3. 2007-04-17. PMID:17365026. |
mouse raw 264.7 macrophages were exposed to the samples for 24 h. selected inflammatory mediators, nitric oxide (no) and cytokines (tumor necrosis factor alpha [tnfalpha], interleukin 6 [il-6], macrophage inflammatory protein-2 [mip-2]), were measured together with cytotoxicity (mtt test), and analysis of apoptosis and cell cycle (propidium iodide staining). |
2007-04-17 |
2023-08-12 |
mouse |
| b' J Mal\\xc3\\xadkov\\xc3\\xa1, A Zdarilov\\xc3\\xa1, A Hlobilkov\\xc3\\xa1, J Ulrichov\\xc3\\xa. The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine. Cell biology and toxicology. vol 22. issue 6. 2007-04-12. PMID:16964588.' |
che and sa treatment of cell lines for 24 h resulted in (1) inhibition of cell viability in a dose-dependent manner in all tested cells (as evaluated by mtt test and bromodeoxyuridine incorporation assay); (2) dose-dependent increase in dna damage in all tested cells (as evaluated by dna comet assay); (3) changes in apoptosis (assessed by western blot analysis and tunel assay); and (4) significant induction of cyclin kinase inhibitors p21(waf1/cip1) and p27(kip1) in prostate cancer cells (identified by western blot analysis). |
2007-04-12 |
2023-08-12 |
human |
| Dixan A Benitez, Eulalia Pozo-Guisado, Alberto Alvarez-Barrientos, Pedro M Fernandez-Salguero, Enrique A Castelló. Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines. Journal of andrology. vol 28. issue 2. 2007-04-12. PMID:17050787. |
apoptosis and cell cycle distribution were evaluated by flow cytometry and proliferation by mtt assay and direct cell counting. |
2007-04-12 |
2023-08-12 |
Not clear |
| Kyung-Mi Kim, Seung-Gyu Lee, Min-Gyu Park, Jea-Young Song, Hyung-Lyun Kang, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee, Hee-Shang Youn, Seung-Chul Bai. Gamma-glutamyltranspeptidase of Helicobacter pylori induces mitochondria-mediated apoptosis in AGS cells. Biochemical and biophysical research communications. vol 355. issue 2. 2007-04-12. PMID:17307146. |
recombinant ggt induced apoptosis in ags cells in a time-dependent manner, which was confirmed by tunel staining, the mtt assay and immunoblot analysis for caspases-9, -3, bax, bcl-2, bcl-xl and cytochrome c release. |
2007-04-12 |
2023-08-12 |
Not clear |
| Guido Seitz, Steven W Warmann, Sorin Armeanu, Heike Heitmann, Peter Ruck, Robert M Hoffman, Jörg Fuchs, Johannes T Wessel. In vitro photodynamic therapy of childhood rhabdomyosarcoma. International journal of oncology. vol 30. issue 3. 2007-03-29. PMID:17273762. |
cancer cells were investigated for cell viability (mtt assay), proliferative activity (ki-67 assay), and apoptosis (tunel test). |
2007-03-29 |
2023-08-12 |
Not clear |
| J D Arditi, M Venihaki, K P Karalis, G P Chrouso. Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 39. issue 1. 2007-03-28. PMID:17226107. |
the proliferation rate of the mcf7 cells was measured using the mtt method, while apoptosis was examined by quantifying the dna fragmentation using an elisa assay. |
2007-03-28 |
2023-08-12 |
human |
| A M Grabowska, J Hughes, S A Watso. Use of interfering RNA to investigate the role of endogenous gastrin in the survival of gastrointestinal cancer cells. British journal of cancer. vol 96. issue 3. 2007-03-21. PMID:17262081. |
the most effective sirna was tested in a panel of gi cancer cell lines at various concentrations and time points, and the effect on cell survival and apoptosis was measured using methyl thiazoyl tetrazolium (mtt) and caspase 3 activation assays. |
2007-03-21 |
2023-08-12 |
human |
| Wenzhu Li, Shengyu Wang, Caixia Chen, Guohong Zhuan. Induction of tumor cell apoptosis via Fas/DR5. Cellular & molecular immunology. vol 3. issue 6. 2007-03-20. PMID:17257501. |
cytotoxicity exerted by fasl/anti-dr5 mab on tumor cell lines was measured by mtt assay and the induced apoptosis was determined by agarose gel electrophoresis. |
2007-03-20 |
2023-08-12 |
Not clear |
| Liansheng Wang, Yongzhen Yang, Seema Dwivedi, Ya Xu, Etem T Chu, Jie Li, Kimberlyn Fitchett, Paul J Boo. Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerin. Cardiovascular toxicology. vol 6. issue 2. 2007-03-07. PMID:17303920. |
mtt cytotoxicity, apoptosis, nitric oxide (no) synthases, both endothelial no synthase (enos) and inducible no synthase (inos) and cyclic guanosine mono-phosphate (cgmp) were measured. |
2007-03-07 |
2023-08-12 |
mouse |
| Jun Chen, Xin-Qiang Xiao, Chun-Ming Deng, Xian-Shi Su, Gui-Yuan L. Downregulation of xIAP expression by small interfering RNA inhibits cellular viability and increases chemosensitivity to methotrexate in human hepatoma cell line HepG2. Journal of chemotherapy (Florence, Italy). vol 18. issue 5. 2007-03-02. PMID:17127230. |
t he suppression efficiency o f xiapby rnai was evaluated using the mtt assay for cellular viability and annexin v-pi binding assay for apoptosis. |
2007-03-02 |
2023-08-12 |
human |
| Jan-Ying Yeh, Bor-Rung Ou, Yu-Chuan Liang, Joel Burchfiel, Judy A Butler, Neil E Forsberg, Philip D Whange. Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 19. issue 6. 2007-02-26. PMID:16951906. |
c6 rat glial cells were incubated with graded concentrations up to 1000 nm of selenite, selenate, selenomethionine (sem), se-methyl-selenocysteine (semcys), high-se broccoli (h-seb) extract or low-se broccoli (l-seb) extract for 24 and 48 h. mtt results indicated that all se sources and levels examined inhibited c6 cell proliferation at 48 h. the results from cell cycle progression and apoptosis analysis indicated that sem, semcys, h-seb or l-seb treatments at the concentration of 1000 nm reduced the cell population in g(0)/g(1) phase, but induced g(2)/m phase arrest and increased apoptosis and secondary necrosis in c6 cells at 24 h. the populations of apoptotic cells and secondary necrotic cells were increased by all se sources examined. |
2007-02-26 |
2023-08-12 |
rat |
| Jia-Jun Liu, Dong-Jun Lin, Pei-Qing Liu, Min Huang, Xu-Dong Li, Ren-Wei Huan. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Journal of biomedical science. vol 13. issue 6. 2007-02-22. PMID:16955348. |
cell proliferation was assessed by mtt assay, cell apoptosis was observed by hoechst 33258 staining and flow cytometry (fcm); the variation of caspase-3 and apoptotic related genes were assayed by western blotting, cell mitochondrial membrane potential as well as cell adhesive and invasive effects were also investigated by using standard methods. |
2007-02-22 |
2023-08-12 |
Not clear |
| O H Temmink, H-J Prins, E van Gelderop, G J Peter. The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. British journal of cancer. vol 96. issue 1. 2007-02-22. PMID:17179993. |
the cells were retrieved from the fibres and assayed for growth (mtt assay), cell cycle distribution (flow cytometry) and apoptosis induction (fragel method). |
2007-02-22 |
2023-08-12 |
mouse |
| András Hrabák, Gyöngyi Bökönyi, László Orfi, Tamás Bajor, György Kér. Comparison of the cytotoxic effects of receptor tyrosine kinase inhibitors on macrophage functions; possible side effects in the immune defense. Immunology letters. vol 107. issue 2. 2007-02-05. PMID:17098294. |
nevertheless, these damaging effects of the inhibitors did not reduce the anti-tumor effect of the rtk inhibitors on cos 7 cells as evidenced by mtt test and apoptosis study. |
2007-02-05 |
2023-08-12 |
rat |
| G Bartolini, M Orlandi, A Papi, K Ammar, F Guerra, A M Ferreri, P Rocch. A search for multidrug resistance modulators: the effects of retinoids in human colon carcinoma cells. In vivo (Athens, Greece). vol 20. issue 6A. 2007-01-26. PMID:17203756. |
cell proliferation was measured by mtt assay, apoptosis was evaluated using dna fragmentation and annexin v detection assay. |
2007-01-26 |
2023-08-12 |
human |