| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheol Park, Dong-Oh Moon, Il-Whan Choi, Byung Tae Choi, Taek-Jeong Nam, Chung-Ho Rhu, Taeg Kyu Kwon, Won Ho Lee, Gi-Young Kim, Yung Hyun Cho. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. International journal of molecular medicine. vol 20. issue 3. 2007-10-11. PMID:17671742. |
exposure of the synovial fibroblasts to curcumin resulted in growth inhibition and the induction of apoptosis, as measured by mtt assay, fluorescent microscopy and annexin-v-based assay. |
2007-10-11 |
2023-08-12 |
Not clear |
| Zhaohui Chen, Huafang Wang, Longjie Gu, Zhewei Ye, Yajun Xia. Tumor necrosis factor-related apoptosis ligand induces apoptosis in prostate cancer PC-3M cell line. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 4. 2007-10-09. PMID:16196298. |
our results showed that apoptosis of pc-3m cells could be induced by treatment with trail for at most 4 h. the results of flow cytometry and mtt colorimetry demonstrated a time- and concentration-dependent relationship between cell apoptosis rate and trail concentration. |
2007-10-09 |
2023-08-12 |
Not clear |
| Wei Xiang, Xianli Zhu, Hongyang Zha. Effect of wild-type p53 gene transfection on the growth and radiotherapeutic sensitivity of human glioma cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 4. 2007-10-09. PMID:16196300. |
p53 gene expression in transfected cells was detected by rt-pcr, and the cell growth inhibition and apoptosis in the absence or presence of irradiation were assessed by mtt and flow cytometry. |
2007-10-09 |
2023-08-12 |
human |
| Jyh-Ming Chow, Shing-Chuan Shen, Chin-Yen Wu, Yen-Chou Che. 12-o-Tetradecanoylphorbol 13-acetate prevents baicalein-induced apoptosis via activation of protein kinase C and JNKs in human leukemia cells. Apoptosis : an international journal on programmed cell death. vol 11. issue 11. 2007-09-19. PMID:17013757. |
in the present study, we found that baicalein (be), but not its glycoside baicalin (bi), induced apoptosis in human leukemia hl-60 and jurkat cells, but not in primary murine peritoneal macrophages (pms) or human polymorphonuclear (pmn) cells, by the mtt assay, ldh release assay, and flow cytometric analysis. |
2007-09-19 |
2023-08-12 |
human |
| Sang-Gyun Kang, Deog-Yong Lee, Mi Lan Kang, Han Sang Yo. Biological characteristics of Chinese hamster ovary cells transfected with bovine Prnp. Journal of veterinary science. vol 8. issue 2. 2007-09-06. PMID:17519565. |
cellular changes in the transfected cho-k1 cells were investigated using parameters such as mtt, lactate dehydrogenase (ldh), and superoxide dismutase (sod) activities, as well as nitric oxide (no) production, and an apoptosis assay. |
2007-09-06 |
2023-08-12 |
cattle |
| Xiang Liao, Shuhua Yang, Zengwu Shao, Jin Li, Yong Liu, Xiaoqian Xiong, Xin Li. Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 6. 2007-08-28. PMID:16696324. |
it was demonstrated with subg1 flow cytometric analysis and mtt method that p16ink4a and hrb1 genes cooperation more significantly inhibited cell growth and induced a more marked g1 arrest and apoptosis than p16ink4a/hrb1 alone (p < 0.01). |
2007-08-28 |
2023-08-12 |
Not clear |
| Eun-Kyung Kim, Kang-Beom Kwon, Mi-Jeong Han, Mi-Young Song, Ji-Hyun Lee, Youn-Suk Ko, Byung-Cheal Shin, Jiahua Yu, Young-Rae Lee, Do-Gon Ryu, Jin-Woo Park, Byung-Hyun Par. Induction of G1 arrest and apoptosis by Scutellaria barbata in the human promyelocytic leukemia HL-60 cell line. International journal of molecular medicine. vol 20. issue 1. 2007-08-23. PMID:17549398. |
after a 24-h incubation, cytotoxicity and apoptosis were determined by mtt and dna fragmentation assay, respectively. |
2007-08-23 |
2023-08-12 |
human |
| Xuerui Zhou, Xiuling Zhi, Ping Zhou, Sifeng Chen, Fengdi Zhao, Zhimin Shao, Zhouluo Ou, Lianhua Yi. Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo. Oncology reports. vol 17. issue 6. 2007-08-17. PMID:17487388. |
cell growth curve, cell cycle and apoptosis were observed with mtt assays and flow cytometry, respectively. |
2007-08-17 |
2023-08-12 |
mouse |
| Takashi Kumagai, Naoki Wakimoto, Dong Yin, Sigal Gery, Norihiko Kawamata, Noriyuki Takai, Naoki Komatsu, Alexy Chumakov, Yasufumi Imai, H Phillip Koeffle. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. International journal of cancer. vol 121. issue 3. 2007-08-16. PMID:17417771. |
saha inhibited the growth of 6 pancreatic cancer cell lines in a dose-dependent manner as measured by mtt and clonogenic assays (ed(50) approximately 10(-6) m) associated with induction of apoptosis, g2 cell cycle arrest and also induced differentiation as indicated by morphology and increased expression of cytokeratin 7. |
2007-08-16 |
2023-08-12 |
human |
| John H Stewart, Thai-Lan Tran, Nicole Levi, Wilson S Tsai, David S Schrump, Dao M Nguye. The essential role of the mitochondria and reactive oxygen species in Cisplatin-mediated enhancement of fas ligand-induced apoptosis in malignant pleural mesothelioma. The Journal of surgical research. vol 141. issue 1. 2007-08-09. PMID:17574045. |
cell viability and apoptosis were determined by mtt and terminal deoxynucleotidyl transferase-mediated dutp nick end labeling assays. |
2007-08-09 |
2023-08-12 |
mouse |
| G K Jayaprakasha, K K Mandadi, Shibu M Poulose, Y Jadegoud, G A Nagana Gowda, Bhimanagouda S Pati. Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf. Bioorganic & medicinal chemistry. vol 15. issue 14. 2007-08-08. PMID:17512744. |
cell proliferation and induction of apoptosis were determined by mtt assay and nuclear staining. |
2007-08-08 |
2023-08-12 |
human |
| Wuzhong Jiang, Yuping Liao, Suping Zhao, Bihong Wu, Rongrong Zhou, Rui Wei, Jing Zhang, Yuxiang He, Haijun W. Role of enhanced radiosensitivity and the tumor-specific suicide gene vector in gene therapy of nasopharyngeal carcinoma. Journal of radiation research. vol 48. issue 3. 2007-07-11. PMID:17464096. |
hoechst33258 staining of the nuclei and methylthiazolyl tetrazolium(mtt) assay were applied to detect apoptosis and cell survivability, respectively. |
2007-07-11 |
2023-08-12 |
mouse |
| Wei-Ping Mao, Ji-Lin Ye, Zheng-Bing Guan, Jie-Ming Zhao, Chao Zhang, Na-Na Zhang, Ping Jiang, Ting Tia. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 3. 2007-06-07. PMID:17052885. |
studies of morphology and oligonucleosomal dna fragmentation demonstrated that 30-60 microm cd induced apoptosis as early as 6-9h with strong effects on mtt activity, whereas 120 microm cd revealed mainly necrosis, and the result of flow cytometry confirmed it. |
2007-06-07 |
2023-08-12 |
human |
| Fu-Ming Tsai, Rong-Yaun Shyu, Shun-Yuan Jian. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Cellular signalling. vol 19. issue 5. 2007-06-06. PMID:17196792. |
expression of wild-type or golgi-targeted rig1 for 24 h induced cellular apoptosis in htta cells, as assessed by mtt assay, the release of lactate dehydrogenase, and chromatin condensation. |
2007-06-06 |
2023-08-12 |
Not clear |
| Mala Chauhan, Kakoli Banerjee, Farukh Arjman. DNA binding studies of novel Copper(II) complexes containing L-tryptophan as chiral auxiliary: in vitro antitumor activity of Cu-Sn2 complex in human neuroblastoma cells. Inorganic chemistry. vol 46. issue 8. 2007-06-04. PMID:17378549. |
to evaluate the mechanistic pathway of dna inhibition, counting experiments and mtt assay were employed to assess the induction of apoptosis by 1. |
2007-06-04 |
2023-08-12 |
human |
| Hyun-Ja Jeong, Su-Jin Kim, Phil-Dong Moon, Na-Hyun Kim, Jung-Sun Kim, Rae-Kil Park, Min-Sun Kim, Byung-Rim Park, Sejin Jeong, Jae-Young Um, Hyung-Min Kim, Seung-Heon Hon. Antiapoptotic mechanism of cannabinoid receptor 2 agonist on cisplatin-induced apoptosis in the HEI-OC1 auditory cell line. Journal of neuroscience research. vol 85. issue 4. 2007-05-22. PMID:17183590. |
by using mtt assay, dna fragmentation, and facs analysis, we demonstrated that apoptosis induced by cisplatin was inhibited by treatment with jwh-015 in a dose-dependent manner. |
2007-05-22 |
2023-08-12 |
Not clear |
| Zhuan-Hua Wang, Li Gao, Yu-Ying Li, Zheng Zhang, Jing-Ming Yuan, Hong-Wei Wang, Li Zhang, Lei Zh. Induction of apoptosis by buckwheat trypsin inhibitor in chronic myeloid leukemia K562 cells. Biological & pharmaceutical bulletin. vol 30. issue 4. 2007-05-22. PMID:17409520. |
here, the possible effects of a recombinant buckwheat trypsin inhibitor (rbti) on the induction of apoptosis of the human k562 cell line were investigated by mtt (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays and flow cytometric analysis. |
2007-05-22 |
2023-08-12 |
human |
| Jing J Wang, Barbara J S Sanderson, He Wan. Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutation research. vol 628. issue 2. 2007-05-14. PMID:17223607. |
the cytotoxicity and genotoxicity of uf-tio(2) were investigated using the methyl tetrazolium cytotoxicity (mtt) assay, the population growth assay, the apoptosis assay by flow cytometry, the cytokinesis block micronucleus (cbmn) assay, the comet assay, and the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene mutation assay. |
2007-05-14 |
2023-08-12 |
human |
| Ikusuke Hatsukari, Naoko Hitosugi, Rie Ohno, Ken Hashimoto, Shinichi Nakamura, Kazue Satoh, Hiroshi Nagasaka, Isao Matsumoto, Hiroshi Sakagam. Induction of apoptosis by morphine in human tumor cell lines in vitro. Anticancer research. vol 27. issue 2. 2007-05-10. PMID:17465212. |
cytotoxicity was tested by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) assay, induction of early apoptosis and necrosis by fluorescence-activated cell sorter (facs) analysis with annexin v and propidium iodide (pi), activation of caspase -2, -3, -8 and -9 by cleavage of specific substrates, dna fragmentation by agarose gel electrophoresis, radical intensity and o2- scavenging activity by esr spectroscopy. |
2007-05-10 |
2023-08-12 |
human |
| Graziella Bellone, Anna Carbone, Valeria Busso, Tiziana Scirelli, Alessandra Buffolino, Carlo Smirne, Anna Novarino, Oscar Bertetto, Luciano Tosetti, Giorgio Emanuell. Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line Capan-2. Cancer biology & therapy. vol 5. issue 10. 2007-05-03. PMID:16929163. |
we measured in-vitro growth inhibition, cell cycle distribution, gene and protein expression of apoptosis regulators bcl-2, bcl-x and survivin, nfkappab and telomerase activities of human pancreatic carcinoma cell line capan-2 following exposure to gem and 5-fu singly or combined, by mtt assay and median effect analysis, flow cytometry, real-time rt-pcr, western blotting, electrophoretic mobility shift assay (emsa) and telomeric repeat amplification protocol (trap) assay, respectively. |
2007-05-03 |
2023-08-12 |
human |