| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Chen, Min Niu, Xuelong Jiao, Kejun Zhang, Jun Liang, Dianliang Zhan. Inhibition of AKT2 enhances sensitivity to gemcitabine via regulating PUMA and NF-κB signaling pathway in human pancreatic ductal adenocarcinoma. International journal of molecular sciences. vol 13. issue 1. 2015-02-26. PMID:22312312. |
mtt, tunel, emsa and nf-κb reporter assays were used to detect tumor cell proliferation, apoptosis and nf-κb activity. |
2015-02-26 |
2023-08-12 |
human |
| Lei Peng, Xingzhen Zhang, Xianping Cui, Dexiao Zhu, Jintao Wu, Dong Sun, Qingwei Yue, Zeyan Li, Haili Liu, Guibao Li, Jing Zhang, Hongyan Xu, Fuchen Liu, Chengkun Qin, Mingfeng Li, Jinhao Su. Paliperidone protects SK-N-SH cells against glutamate toxicity via Akt1/GSK3β signaling pathway. Schizophrenia research. vol 157. issue 1-3. 2015-02-26. PMID:24962437. |
we examined the effects of the drugs on cell viability (measured by mtt metabolism assay and lactate dehydrogenase (ldh) activity assay), apoptosis rate, ros levels and gene expression and phosphorylation of akt1 and gsk3β. |
2015-02-26 |
2023-08-13 |
Not clear |
| Conghong Shi, Jing Wu, Min Fu, Baohong Zhang, Juan Wang, Xi Yang, Yunpeng Ch. Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25117440. |
cell apoptosis and viability were measured by annexin-v and pi staining and mtt assays. |
2015-02-25 |
2023-08-13 |
Not clear |
| P Zhang, H Pan, J Wang, X Liu, X H. Telomerase activity-independent function of telomerase reverse transcriptase is involved in acrylamide-induced neuron damage. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 89. issue 5. 2015-02-23. PMID:24279610. |
we found that acr 1) significantly reduced the viability of cortical neurons as measured by mtt assay, 2) induced neuron apoptosis as revealed by fitc-conjugated annexin v/pi double staining and flow cytometry (facs) analysis, 3) elevated expression of cleaved caspase-3, and 4) decreased bcl-2 expression of cortical neurons. |
2015-02-23 |
2023-08-12 |
human |
| Dongdong Zhang, Zhe Wang, Chenxia Sheng, Weijun Peng, Shan Hui, Wei Gong, Shuai Che. Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-02-23. PMID:25705234. |
our results showed that icariin dose-dependently increased cell viability and decreased aβ 25-35-induced apoptosis, as assessed by mtt assay and annexin v/propidium iodide staining, respectively. |
2015-02-23 |
2023-08-13 |
rat |
| Yongfu Ma, Hui Xia, Yang Liu, Min L. Silencing miR-21 sensitizes non-small cell lung cancer A549 cells to ionizing radiation through inhibition of PI3K/Akt. BioMed research international. vol 2014. 2015-02-12. PMID:24804226. |
after ionizing radiation (ir), the survival fractions, proliferation, apoptosis, and expression of phosphorylated-akt of a549 cells were determined by clonogenic survival analysis, mtt assay, flow cytometry, and western blotting. |
2015-02-12 |
2023-08-13 |
Not clear |
| Chang-Feng Li, Li-Bo Chen, Dan-Dan Li, Lei Yang, Bao-Gang Zhang, Jing-Peng Jin, Ying Zhang, Bin Zhan. Dual‑sensitive HRE/Egr1 promoter regulates Smac overexpression and enhances radiation‑induced A549 human lung adenocarcinoma cell death under hypoxia. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24842518. |
an mtt assay was performed to detect cell proliferation and an annexin v‑fluorescein isothiocyanate apoptosis detection kit was used to detect apoptosis. |
2015-02-12 |
2023-08-13 |
human |
| Stephanie M J Fliedner, Tobias Engel, Nikoletta K Lendvai, Uma Shankavaram, Svenja Nölting, Robert Wesley, Abdel G Elkahloun, Hendrik Ungefroren, Angela Oldoerp, Gary Lampert, Hendrik Lehnert, Henri Timmers, Karel Paca. Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells. PloS one. vol 9. issue 5. 2015-02-12. PMID:24846270. |
lovastatin has been shown to effectively induce apoptosis in mouse pheo cells (mpc) and the more aggressive mouse tumor tissue-derived cells (mtt), which was accompanied by decreased phosphorylation of mitogen-activated kinase (mapk) pathway players. |
2015-02-12 |
2023-08-13 |
mouse |
| Qiujun Liu, Xinli Shi, Xianyao Zhou, Da Wang, Li Wang, Changlong L. Effect of autophagy inhibition on cell viability and cell cycle progression in MDA‑MB‑231 human breast cancer cells. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24898397. |
the cell viability and apoptosis of each group was determined by mtt assay and flow cytometry. |
2015-02-12 |
2023-08-13 |
human |
| A M Zou, H F Wang, W F Zhu, F X Wang, J J She. Effect of RNAi-mediated silencing of Livin gene on biological properties of colon cancer cell line LoVo. Genetics and molecular research : GMR. vol 13. issue 2. 2015-02-12. PMID:24938471. |
the apoptosis, cell cycle, colony formation, proliferation of lovo cells, as well as their sensitivity to cisplatin, were detected by flow cytometry, colony formation assay and mtt. |
2015-02-12 |
2023-08-13 |
Not clear |
| Ritika Prasad, Biplob Koc. Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study. BioMed research international. vol 2014. 2015-02-12. PMID:24959588. |
in vitro cytotoxicity was determined by mtt assay, apoptosis was determined by fluorescence microscopy, and cell cycle progression was analysed using flow cytometry; in vivo antitumor activity was performed in dalton's lymphoma bearing mice. |
2015-02-12 |
2023-08-13 |
mouse |
| Ying Guo, Hongli An, Liuxin Feng, Qi Liu, Sicen Wang, Tao Zhan. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 67. 2015-02-09. PMID:24607798. |
the results of the mtt assay and apoptosis showed that sinapine increased the sensitivity of caco-2 cells to doxorubicin in a dose-dependent manner, whereas no or less effect was observed in the cells treated with doxorubicin alone. |
2015-02-09 |
2023-08-12 |
Not clear |
| Tie-Long Chen, Guang-Li Zhu, Jian-An Wang, Yu Wang, Xiao-Long He, Jun Jian. Apoptosis of bone marrow mesenchymal stem cells caused by hypoxia/reoxygenation via multiple pathways. International journal of clinical and experimental medicine. vol 7. issue 12. 2015-02-09. PMID:25663966. |
tunel, hoechst staining and mtt were used for the evaluation of morphological changes, cell viability and apoptosis. |
2015-02-09 |
2023-08-13 |
Not clear |
| Yi Hao, Li Guo, Abulizi Abudula, Wuliyati Saidoula, Xia Gu. Proliferation inhibition and apoptosis enhancement of human cervical cancer cells by ultrasound-targeted microbubble destruction delivered double suicide genes. International journal of clinical and experimental medicine. vol 7. issue 12. 2015-02-09. PMID:25664039. |
cell proliferation was determined by mtt assay and apoptosis was detected by flow cytometry. |
2015-02-09 |
2023-08-13 |
human |
| Jiying Jiang, Shuna Yu, Zhengchen Jiang, Cuihong Liang, Wenbo Yu, Jin Li, Xiaodong Du, Hailiang Wang, Xianghong Gao, Xin Wan. N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide. Oxidative medicine and cellular longevity. vol 2014. 2015-02-04. PMID:25013541. |
to determine whether pretreatment with nas could reduce hydrogen peroxide- (h2o2-) induced oxidative stress in hepg2 cells by inhibiting the mitochondrial apoptosis pathway, we investigated the h2o2-induced oxidative damage to hepg2 cells with or without nas using mtt, hoechst 33342, rhodamine 123, terminal dutp nick end labeling assay (tunel), dihydrodichlorofluorescein (h2dcf), annexin v and propidium iodide (pi) double staining, immunocytochemistry, and western blot. |
2015-02-04 |
2023-08-13 |
Not clear |
| Claudio Poggio, Carla Renata Arciola, Riccardo Beltrami, Annachiara Monaco, Alberto Dagna, Marco Lombardini, Livia Visa. Cytocompatibility and antibacterial properties of capping materials. TheScientificWorldJournal. vol 2014. 2015-02-02. PMID:24959601. |
cytocompatibility of the assayed materials towards rat mdpc-23 cells was evaluated at different times by both mtt and apoptosis assays. |
2015-02-02 |
2023-08-13 |
rat |
| Alireza Abdanipour, Taki Tiraihi, Ali Noori-Zadeh, Arezo Majdi, Ramin Gosail. Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1α genes in neural stem cells treated with hydrogen peroxide. Molecular neurobiology. vol 49. issue 3. 2015-01-26. PMID:24390568. |
using mtt, tunel assay, and real-time rt-pcr, we evaluated the effects of lovastatin on cell survival, apoptosis, and pgc-1α and nrf2 expression rates in pretreated bmsc-derived nscs compared to control groups. |
2015-01-26 |
2023-08-12 |
Not clear |
| Qiang Huang, Zhen Liu, Fang Xie, Chenhai Liu, Feng Shao, Cheng-lin Zhu, Sanyuan H. Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway. TheScientificWorldJournal. vol 2014. 2015-01-26. PMID:24757411. |
the viability and apoptosis of qbc939 cells were then assessed using mtt assays and flow cytometry. |
2015-01-26 |
2023-08-13 |
Not clear |
| Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. |
utilizing smosirna transfected esophageal squamous carcinoma ec9706 cells, adopting rt-pcr and western blot technology to detect smo, gli1 mrna and protein expression in each group of cells, employing mtt and fcm to detect the influence of smosirna on cell proliferation and apoptosis. |
2015-01-22 |
2023-08-13 |
human |
| Raniere Fagundes Melo-Silveira, Gabriel Pereira Fidelis, Rony Lucas Silva Viana, Vinícius Campelo Soeiro, Rodrigo Augusto da Silva, Daisy Machado, Leandro Silva Costa, Carmen Veríssima Ferreira, Hugo Alexandre Oliveira Roch. Antioxidant and antiproliferative activities of methanolic extract from a neglected agricultural product: corn cobs. Molecules (Basel, Switzerland). vol 19. issue 4. 2015-01-16. PMID:24879583. |
furthermore, its antiproliferative property against tumor cells was assessed through mtt assays and proteins related to apoptosis in tumor cells were examined by western blot. |
2015-01-16 |
2023-08-13 |
cat |