| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Wu, Qin Tang, Shunyu Zhao, Fang Zheng, Yan Wu, Ge Tang, Swei Sunny Hah. Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24806432. |
in this study, we showed that curcumin significantly inhibited the growth of npc cells in a dose- and time-dependent manner as determined by mtt assays, while increasing apoptosis was also observed as measured by flow cytometry for the fitc-annexin v and propidium iodide (pi) label and hoechst 33258 staining. |
2015-01-15 |
2023-08-13 |
human |
| Koichi Shoji, Jun Teishima, Tetsutaro Hayashi, Shinya Ohara, Wallace L Mckeehan, Akio Matsubar. Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24839986. |
the effects of chemotherapeutic agents (docetaxel, cisplatin, 5-fluorouracil and zoledronic acid) on cell viability and apoptosis were examined by mtt assay and western blot analysis, respectively. |
2015-01-14 |
2023-08-13 |
human |
| Geping Qu, Changting Liu, Baojun Sun, Changxi Zhou, Zhijian Zhang, Peng Wan. Combination of BIBW2992 and ARQ 197 is effective against erlotinib-resistant human lung cancer cells with the EGFR T790M mutation. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24842595. |
cell growth, apoptosis and cell cycle distribution were evaluated by mtt assay, annexin v/propidium iodide (pi) double staining and flow cytometry, respectively. |
2015-01-14 |
2023-08-13 |
human |
| Xiang-Qi Chen, Yu-Lan Wang, Zhi-Ying Li, Ting-Yan Li. Therapeutic effects of sorafenib on the A549/DDP human lung adenocarcinoma cell line in vitro. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24788469. |
the mtt assay was used to determine the growth inhibition rate of the cells, which were respectively subjected to sorafenib treatment for 24, 48 and 72 h. flow cytometry was used to determine the rate of apoptosis of cells in each group following sorafenib treatment for 72 h. furthermore, the transwell invasion experiment was used to determine the effect on a549/ddp cell invasion following sorafenib treatment for 24 h. based on the mtt assay, it was found that the inhibition rates of a549/ddp cisplatin-resistant lung adenocarcinoma cells in groups s1-4 following sorafenib treatment for 24 h were 4.58±2.82, 14.93±2.62, 37.58±7.13 and 58.39±8.15%, respectively. |
2015-01-13 |
2023-08-13 |
human |
| Liang Xue, Shuyuan Yue, Jianning Zhan. FOXP1 has a low expression in human gliomas and its overexpression inhibits proliferation, invasion and migration of human glioma U251 cells. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24789678. |
mtt, cell invasion, transwell and scratch assays were utilized to investigate the cell growth activity and the rate of apoptosis of the cells was tested by flow cytometry. |
2015-01-13 |
2023-08-13 |
human |
| Yanan Sun, Xiaoyun Mao, Chuifeng Fan, Chong Liu, Ayao Guo, Shu Guan, Quanxiu Jin, Bo Li, Fan Yao, Feng Ji. CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 8. 2015-01-13. PMID:24810923. |
the cell proliferation of mda-mb-231-cxcl12 was accessed by mtt assay; the apoptosis was analyzed by an annexinv-fitc/propidium iodide double staining of flow cytometry method; and the cell invasive ability was examined by matrigel invasion assay. |
2015-01-13 |
2023-08-13 |
Not clear |
| Xiaoxiao Zuo, Yan Qin, Xiaojin Zhang, Qian Ning, Shan Shao, Minna Luo, Na Yuan, Shangke Huang, Xinhan Zha. Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. Oncology reports. vol 31. issue 5. 2015-01-12. PMID:24676336. |
levels of arhi were detected by western blotting, mtt assays were used to evaluate cell proliferation, and both cell cycle progression and apoptosis were detected using flow cytometry. |
2015-01-12 |
2023-08-12 |
Not clear |
| Li-Wei Zhao, Xiu-Hong Zhong, Shu-Yan Yang, Yi-Zhong Zhang, Ning-Jiang Yan. Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 7. 2015-01-10. PMID:24815470. |
the mtt assay was used to evaluate cell proliferating ability, flow cytometry (fcm) was employed for cell cycle analysis and cell apoptosis, while expression of cycline, p27, bcl-2 and bax was detected by immunocytochemistry. |
2015-01-10 |
2023-08-13 |
human |
| Licheng Jiang, Shengyun Huang, Dongsheng Zhang, Bin Zhang, Keyi Li, Wengang Li, Shizhou Zhang, Weidong Zhang, Peihui Zhen. Inhibition of autophagy augments chemotherapy in human salivary adenoid cystic carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 43. issue 4. 2015-01-09. PMID:24118359. |
in this study, apoptosis induced by ddp in sacc high metastatic cell line (acc-m) was revealed using mtt assay, flow cytometry, and caspase-3 immunoblotting. |
2015-01-09 |
2023-08-12 |
mouse |
| Zhao Zhang, Qiong Wu, Xiao-Hui Wu, Fen-Yong Sun, Lan-Mei Chen, Jin-Chan Chen, Shu-Ling Yang, Wen-Jie Me. Ruthenium(II) complexes as apoptosis inducers by stabilizing c-myc G-quadruplex DNA. European journal of medicinal chemistry. vol 80. 2015-01-09. PMID:24793882. |
the inhibitory activity evaluated by mtt assay shown that 2 can inhibit the growth of mda-mb-231 cells with inhibitory activity (ic50) of 16.3 μm, which was related to the induction of apoptosis. |
2015-01-09 |
2023-08-13 |
Not clear |
| Xiao-Jia Liu, Yun-Qian Li, Qiu-Yue Chen, Sheng-Jun Xiao, Si-En Zen. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 6. 2015-01-07. PMID:24761910. |
du-145 cells were treated with different concentrations of formononetin and cell proliferation was assessed by mtt assay, cell apoptosis by hoechst 33258 and flow cytometry, and protein levels of rasd1, bcl-2 and bax by western blotting. |
2015-01-07 |
2023-08-13 |
human |
| Lin Li, Fengling Li, Hui Tian, Weiming Yue, Shuhai Li, Guanqing Che. Human mesenchymal stem cells with adenovirus-mediated TRAIL gene transduction have antitumor effects on esophageal cancer cell line Eca-109. Acta biochimica et biophysica Sinica. vol 46. issue 6. 2015-01-05. PMID:24739635. |
our results showed that, in vitro, trail-expressing mscs were able to inhibit proliferation and induce apoptosis in eca-109 cells by an mtt assay, co-culture experiments and flow cytometry analysis. |
2015-01-05 |
2023-08-13 |
mouse |
| Xiao-Ping Yang, Tao-Yan Liu, Xiao-Yan Qin, Long-Chuan Y. Potential protection of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside against staurosporine-induced toxicity on cultured rat hippocampus neurons. Neuroscience letters. vol 576. 2015-01-05. PMID:24887581. |
the results showed that administration of 200μm of thsg significantly protected against 0.3μm of sts-induced apoptosis in cultured rat hippocampal neurons tested by methyl thiazolyl tetrazolium (mtt) and terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling (tunel) assays. |
2015-01-05 |
2023-08-13 |
rat |
| Li-Ya Su, Hong-Yi Xin, Yong-Lei Liu, Jia-Ling Zhang, Hong-Wu Xin, Xiu-Lan S. Anticancer bioactive peptide (ACBP) inhibits gastric cancer cells by upregulating growth arrest and DNA damage-inducible gene 45A (GADD45A). Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:25015188. |
next, gadd45a mrna and protein expressions were downregulated in the gastric cancer cells by lentivirus-mediated rnai; then, cell viability, cell cycle, and apoptosis were assayed by mtt and flow cytometry. |
2015-01-05 |
2023-08-13 |
human |
| Bin Li, Baolan Sun, Jianwei Zhu, Nina Zhou, Zhiping Yang, Jianhui G. Expression of RKIP in chronic myelogenous leukemia K562 cell and inhibits cell proliferation by regulating the ERK/MAPK pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:25015191. |
in addition, mtt, fcm, and cfu assay indicated that the overexpression of rkip significantly lowered the cell viability, cell proliferation and the clonogenic growth (p < 0.05), but improved cell apoptosis (p < 0.01). |
2015-01-05 |
2023-08-13 |
Not clear |
| Hongyi Liu, Peng Li, Bing Li, Peng Sun, Jiajin Zhang, Baishi Wang, Baoqing Ji. RKIP suppresses gastric cancer cell proliferation and invasion and enhances apoptosis regulated by microRNA-224. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:25017365. |
there were significant decreases in cell viability and the s-phase fraction (p < 0.05), concomitant with a significant increase in apoptosis (p < 0.01), as well as a significant reduction in cells migrating through transwell chambers (p < 0.05), as shown by mtt, flow cytometry, and transwell invasion chamber assays. |
2015-01-05 |
2023-08-13 |
human |
| Fan Zhang, Juanjuan Liu, Bei Lin, Qing Liu, Yue Zhao, Liancheng Zhu, Yingying Hao, Shulan Zhang, Masao Iwamor. Increase in docetaxel-resistance of ovarian carcinoma-derived RMG-1 cells with enhanced expression of Lewis Y antigen. International journal of molecular sciences. vol 12. issue 11. 2014-12-30. PMID:22174601. |
we determined the effects of docetaxel on the survival of cells by mtt assaying and observed the apoptosis of cells in the presence of docetaxel by flow cytometric analysis and by transmission electron microscopy. |
2014-12-30 |
2023-08-12 |
human |
| Li Xue, Ming Li, Teng Chen, Haifeng Sun, Jie Zhu, Xia Li, Feng Wu, Biao Wang, Juping Li, Yanjiong Che. PE‑induced apoptosis in SMMC‑7721 cells: involvement of Erk and Stat signalling pathways. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24821075. |
in the current study, mtt and flow cytometric assays were used to examine the effects of pe on apoptosis in smmc‑7721 cells. |
2014-12-30 |
2023-08-13 |
Not clear |
| Liu Ying, Zhu Zu-An, Liu Qing-Hua, Kong Qing-Yan, Liu Lei, Cui Tao, Wu Yong-Pin. RAD001 can reverse drug resistance of SGC7901/DDP cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24920069. |
to investigate the role of rad001 in the reversing of drug resistance of sgc7901/ddp, we cultured sgc7901/ddp cells with different groups of drugs (rad001, cisplatin (ddp) alone, or the combination of rad001 and ddp); after that, we detected the drug sensitivity, cell apoptosis, and levels of p-gp, mrp1, and survivin in the cells of sgc7901/ddp by mtt (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphe-nyltetrazolium bromide) assay, flow cytometry, immunohistochemical analysis, and western blot analysis. |
2014-12-29 |
2023-08-13 |
Not clear |
| Yihe Dou, Yangang Wang, Jian Xu, Zhaojian Li, Peng Sun, Qinghai Men. Experiment research on inhibition of glioma with sTRAIL in vitro. Artificial cells, nanomedicine, and biotechnology. vol 42. issue 3. 2014-12-24. PMID:24156316. |
the higher rate of apoptosis was demonstrated using short-term microculture tetrazoliun (mtt) assay and flow cytometry. |
2014-12-24 |
2023-08-12 |
Not clear |